Uso de redes neuro-borrosas RFNN para la aproximación del comportamiento de una neuroprótesis de antebrazo en pacientes con daño cerebral

Las neuroprótesis son sistemas basados en la técnica de estimulación eléctrica funcional que provocan contracciones musculares mediante la excitación artificial de nervios periféricos, y son utilizadas para sustituir funciones motrices/sensoriales en aplicaciones tanto asistivas como terapéuticas. Este trabajo presenta la posibilidad de utilizar redes neuro-borrosas recurrentes para obtener modelos capaces de extraer las características principales del resultado de la aplicación de una neuroprótesis de miembro superior en distintos pacientes. Se ha entrenado una Recurrent Fuzzy Neural Network (RFNN) con datos reales obtenidos de pacientes crónicos de daño cerebral adquirido. Se han analizado distintas estrategias y estructuras y los resultados preliminares muestran la capacidad de estas redes de aprender las características principales de distintos sujetos y de proporcionar información fácilmente interpretable

Metamorphic gradient modification in the Early Cretaceous Northern Andes subduction zone: A record from thermally overprinted high-pressure rocks

New field observations and petrological data from Early Cretaceous metamorphic rocks in the Central Cordillera of the Colombian Andes allowed the recognition of thermally overprinted high-pressure rocks derived from oceanic crust protoliths. The obtained metamorphic path suggests that the rocks evolved from blueschist to eclogite facies towards upper amphibolite to high-pressure granulite facies transitional conditions. Eclogite facies conditions, better recorded in mafic protoliths, are revealed by relic lawsonite and phengite, bleb- to worm-like diopside-albite symplectites, as well as garnet core composition. Upper amphibolite to high pressure granulite facies overprinting is supported by coarse-grained brown-colored Ti-rich amphibole, augite, and oligoclase recrystallization, as well as the record of partial melting leucosomes. Phase equilibria and pressure-temperature (P-T) path modeling suggest initial high-pressure metamorphic conditions M1 yielding 18.2–24.5 kbar and 465–580 °C, followed by upper amphibolite to high pressure granulite facies overprinting stage M2 yielding 6.5–14.2 kbar and 580–720 °C. Retrograde conditions M3 obtained through chlorite thermometry yield temperatures ranging around 286–400 °C at pressures below 6.5–11 kbar. The obtained clockwise P-T path, the garnet zonation pattern revealing a decrease in Xgrs/Xprp related to Mg# increment from core to rim, the presence of partial melting veins, as well as regional constraints, document the modification of the thermal structure of the active subduction zone in Northern Andes during the Early Cretaceous. Such increment of the metamorphic gradient within the subduction interface is associated with slab roll-back geodynamics where hot mantle inflow was triggered. This scenario is also argued by the reported trench-ward magmatic arc migration and multiple extensional basin formation during this period. The presented example constitutes the first report of Cretaceous roll-back-related metamorphism in the Caribbean and Andean realms, representing an additional piece of evidence for a margin-scale extensional event that modified the northwestern border of South America during the Early Cretaceous.The National University of Colombia is acknowledged for its financial support, providing execution of the Hermes 30362 project and a travel grant to D. S. Avellaneda-Jiménez for analytical data acquisition at the University of Arizona (Tucson, Arizona)

Tendencias actuales de los derechos humanos y el derecho internacional humanitario en Colombia

Este libro presenta, desde diversas perspectivas y con un tratamiento interdisciplinario, problemáticas relacionadas con los derechos humanos y el Estado social de derecho, conflictos de sobrada actualidad en el país. Para su estructura, se eligieron tres ejes investigativos: primero, temas y debates del posconflicto, como los derechos de las víctimas y el marco jurídico del posacuerdo; segundo, debates sobre derechos humanos y género, como la no discriminación y la violencia, y tercero, aquellos temas que por la coyuntura social o política son dejados al margen, como redes sociales y privacidad, educación en derechos humanos y defensa del Estado. Es, entonces, un aporte indiscutible en el avance de la reflexión sobre los derechos fundamentales y el derecho de la guerra en nuestras latitudes y nuestro tiempo

Measurement of charm production at central rapidity in proton-proton collisions at s=2.76\sqrt{s} = 2.76 TeV

The $p_{\rm T}$-differential production cross sections of the prompt (B feed-down subtracted) charmed mesons D$^0$, D$^+$, and D$^{*+}$ in the rapidity range $|y|<0.5$, and for transverse momentum $1< p_{\rm T} <12$ GeV/$c$, were measured in proton-proton collisions at $\sqrt{s} = 2.76$ TeV with the ALICE detector at the Large Hadron Collider. The analysis exploited the hadronic decays D$^0 \rightarrow$K$\pi$, D$^+ \rightarrow$K$\pi\pi$, D$^{*+} \rightarrow$D$^0\pi$, and their charge conjugates, and was performed on a $L_{\rm int} = 1.1$ nb$^{-1}$ event sample collected in 2011 with a minimum-bias trigger. The total charm production cross section at $\sqrt{s} = 2.76$ TeV and at 7 TeV was evaluated by extrapolating to the full phase space the $p_{\rm T}$-differential production cross sections at $\sqrt{s} = 2.76$ TeV and our previous measurements at $\sqrt{s} = 7$ TeV. The results were compared to existing measurements and to perturbative-QCD calculations. The fraction of cdbar D mesons produced in a vector state was also determined.Comment: 20 pages, 5 captioned figures, 4 tables, authors from page 15, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/307

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

Measurement of electroweak WZ boson production and search for new physics in WZ + two jets events in pp collisions at √s=13TeV

A measurement of WZ electroweak (EW) vector boson scattering is presented. The measurement is performed in the leptonic decay modes WZ→ℓνℓ′ℓ′, where ℓ,ℓ′=e,μ. The analysis is based on a data sample of proton-proton collisions at √s=13 TeV at the LHC collected with the CMS detector and corresponding to an integrated luminosity of 35.9 fb−1. The WZ plus two jet production cross section is measured in fiducial regions with enhanced contributions from EW production and found to be consistent with standard model predictions. The EW WZ production in association with two jets is measured with an observed (expected) significance of 2.2 (2.5) standard deviations. Constraints on charged Higgs boson production and on anomalous quartic gauge couplings in terms of dimension-eight effective field theory operators are also presented

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Search for an L-mu - L-tau gauge boson using Z -> 4 mu events in proton-proton collisions at root s=13 TeV

A search for a narrow Z' gauge boson with a mass between 5 and 70 GeV resulting from an L-mu - L-tau U (1) local gauge symmetry is reported. Theories that predict such a particle have been proposed as an explanation of various experimental discrepancies, including the lack of a dark matter signal in direct-detection experiments, tension in the measurement of the anomalous magnetic moment of the muon, and reports of possible lepton flavor universality violation in B meson decays. A data sample of proton-proton collisions at a center-of-mass energy of 13 TeV is used, corresponding to an integrated luminosity of 77.3 fb(-1) recorded in 2016 and 2017 by the CMS detector at the LHC. Events containing four muons with an invariant mass near the standard model Z boson mass are analyzed, and the selection is further optimized to be sensitive to the events that may contain Z -> Z'mu mu -> 4 mu decays. The event yields are consistent with the standard model predictions. Upper limits of 10(-8)-10(-7) at 95% confidence level are set on the product of branching fractions B(Z -> Z'mu mu)B(Z' -> mu mu), depending on the Z' mass, which excludes a Z' boson coupling strength to muons above 0.004-0.3. These are the first dedicated limits on L-mu - L-tau models at the LHC and result in a significant increase in the excluded model parameter space. The results of this search may also be used to constrain the coupling strength of any light Z' gauge boson to muons. (C) 2019 The Author(s). Published by Elsevier B.V.Peer reviewe