Brachial Artery Vasculitis and Associated Stenosis Presenting as Elbow Pain in a 16-Year-Old Soccer Player: A Case Report

Chronic vascular occlusion in the upper extremity can result from repetitive trauma, atherosclerosis, proximal embolic events, hypercoagulable states, and systemic diseases such as collagen vascular disease and vasculitis. Considerable functional impairment can result from these maladies; however, sometimes the condition develops slowly with minimal effect on the patient. We describe a 16-year-old soccer player with slow-progressing elbow pain and loss of range in motion caused by brachial artery vasculitis and resultant brachial arterial stenosis. Although vascular insults and lesions rarely cause chronic vascular occlusion, physicians should consider this possibility in patients with localized pain or atrophy, especially if the condition develops slowly

Diagnosing an Acute Quadratus Plantae Tear in a 37-Year-Old Athlete: A Case Report

Foot injuries occur frequently in distance runners and can notably impact training performance. Common diagnoses include plantar fasciitis, tendinopathies of the forefoot or midfoot, and stress fractures of the metatarsals. Occasionally, more obscure structures may be involved. We describe a 37-year-old male distance runner who presented with symptoms of heel pain and ecchymosis, suggesting an acute plantar fascia injury. However, findings of magnetic resonance imaging revealed a tear to the quadratus plantae (QP). The patient gradually returned to normal levels of physical activity, with complete resolution of symptoms by 4 months after the initial injury. Healthcare providers should be aware of the possible presence of a QP tear in patients who present with symptoms suggestive of acute plantar fascia rupture

Rhabdomyolysis of the Abdominal Wall in a 23-Year-Old Football Player: A Case Report

Rhabdomyolysis is a syndrome caused by injury to skeletal muscle, which results in leakage of large quantities of potentially toxic intracellular contents into plasma. Causes include direct trauma, drug use, genetic muscle diseases, hyperthermia, seizures, ischemia, and severe exertion. We describe a rare case of exercise related rhabdomyolysis of the abdominal wall in a 23-year-old football player. He presented with painless hematuria after starting a new abdominal workout routine to lose weight. Although the workout was not excessively strenuous, it involved new exercises targeting a poorly trained muscle group. Results of initial workup indicated severely elevated levels of creatine kinase. Furthermore, an abdominal computed tomography scan revealed intrafascial and intramuscular edema in and around both external oblique muscles. The patient required no hospitalization and was successfully treated with oral hydration, with recommended close follow-up

Guidelines for the use of flow cytometry and cell sorting in immunological studies

International audienceThe classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127(-) and CD127(+) early lymphoid progenitors (ELPs). Combining molecular analyses with in vitro and in vivo functional assays, we demonstrated that CD127(-) and CD127(+) ELPs emerged independently from lympho-mono-dendritic progenitors, responded differently to Notch1 signals, underwent divergent modes of lineage restriction, and displayed both common and specific differentiation potentials. Whereas CD127(-) ELPs comprised precursors of T cells, marginal zone B cells, and natural killer (NK) and innate lymphoid cells (ILCs), CD127(+) ELPs supported production of all NK cell, ILC, and B cell populations but lacked T potential. On the basis of these results, we propose a "two-family" model of human lymphoid development that differs from the prevailing model of hematopoiesis