Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn(2+) atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes

Spatial Representation of Economic and Financial Measures Used in Agriculture Via Wavelet Analysis

A foundation is set forth for use of the wavelet transform as a spatial analysis tool for modelling the geographic representation of economic and financial measures used in agriculture. This provides a framework from which to estimate a smooth nonparametric function which describes complex, multivariate relationships embedded in spatial data, with the resulting maps conveying large amounts of information in a familiar format. We illustrate this approach for tasks which include the graphical presentation of information, density estimation and wavelet- Author for correspondence. 1 INTRODUCTION 2 based nonparametric regression. A redundant wavelet transform is used, and we detail the properties which make it particularly appropriate for these objectives. Keywords: nonparametric regression, wavelets, multiresolution, spatial analysis 1 Introduction This paper explores the use of the wavelet transform as a spatial analysis tool for modelling the geographic representation of economic and..

Le Rapide de la Compagnie Pensylvanie (The Pennsylvania Limited) : New-York, Philadelphi, Baltimore, Washington, Chicago, Cincinnati.

Softcover edition, red cord binding, printed paper wrapper; title statement and illustration of a woman being helped down from a passenger car printed on front cover.Mode of access: Internet

Performance Improvements With Ibm Route Switching For Token-Ring: Peer And Client

In this paper, we will first discuss several performance problems facing network administrators and users today, as a result of emerging new technologies and applications, and how some of the newer IBM Token-Ring and MSS products address them. We will then describe the IBM route switching solutions for Token-Ring, Route Switching Peer and Route Switching Client, discussing the performance benefits both bring, as well as the differences between the two solutions. We will finally present round-trip delays, throughputs and processor utilizations, both with and without route switching, when a congested router is in the network data transmission path. ITIRC KEY WORDS Performance Token-Ring Routing Route Switching iv v CONTENTS ABSTRACT . . . . . . . . . . . . . . . . . . . . . iii ITIRC KEYWORDS . . . . . . . . . . . . . . . . . . iii INTRODUCTION . . . . . . . . . . . . . . . . . . . 1 ROUTE SWITCHING. . . . . . . . . . . . . . . . . . 2 THE NEED FOR MORE BANDWIDTH AND LOWE..