520 research outputs found
Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing
- Author
- Publication venue
- Publication date
- 03/12/2021
- Field of study
Machado-Joseph disease (MJD/SCA3) is a neurodegenerative polyglutamine disorder exhibiting a wide spectrum of phenotypes. The abnormal size of the (CAG)n at ATXN3 explains ~55% of the age at onset variance, suggesting the involvement of other factors, namely genetic modifiers, whose identification remains limited. Our aim was to find novel genetic modifiers, analyse their epistatic effects and identify disease-modifying pathways contributing to MJD variable expressivity. We performed whole-exome sequencing in a discovery sample of four age at onset-concordant and four discordant first-degree relative pairs of Azorean patients, to identify candidate variants which genotypes differed for each discordant pair but were shared in each concordant pair. Variants identified by this approach were then tested in an independent multi-origin cohort of 282 MJD patients. Whole-exome sequencing identified 233 candidate variants, from which 82 variants in 53 genes were prioritized for downstream analysis. Eighteen disease-modifying pathways were identified; two of the most enriched pathways were relevant for the nervous system, namely the neuregulin signaling and the agrin interactions at neuromuscular junction. Variants at PARD3, NFKB1, CHD5, ACTG1, CFAP57, DLGAP2, ITGB1, DIDO1 and CERS4 modulate age at onset in MJD, with those identified in CFAP57, ACTG1 and DIDO1 showing consistent effects across cohorts of different geographical origins. Network analyses of the nine novel MJD modifiers highlighted several important molecular interactions, including genes/proteins previously related with MJD pathogenesis, namely between ACTG1/APOE and VCP/ITGB1. We describe novel pathways, modifiers, and their interaction partners, providing a broad molecular portrait of age at onset modulation to be further exploited as new disease-modifying targets for MJD and related diseases
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- Smirnov SY
- Smirnov Y
- Smirnova LN
- Smirnova O
- Smith JW
- Smizanska M
- Smolek K
- Smykiewicz A
- Snesarev AA
- Snoek HL
- Snyder IM
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- Tsukerman II
- Tsulaia V
- Tsuno S
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- Tu Y
- Tudorache A
- Tudorache V
- Tulbure TT
- Tuna AN
- Turchikhin S
- Turgeman D
- Turner RJ
- Turra RT
- Tuts PM
- Tzamarias S
- Tzovara E
- Ucchielli G
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- Urban J
- Urquijo P
- Usai G
- Uysal Z
- Vacek V
- Vachon B
- Vadla KOH
- Vaidya A
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- Vale MAB
- Valente M
- Valentinetti S
- Valero A
- Valery L
- Vallance RA
- Vallier A
- Van Daalen TR
- Van Gemmeren P
- Van Vulpen I
- Vanadia M
- Vandelli W
- Vandenbroucke M
- Vandewall ER
- Vaniachine A
- Vannicola D
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- Varnes EW
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- Varol T
- Varouchas D
- Varvell KE
- Vasile ME
- Vasquez GA
- Vazeille F
- Vazquez Furelos D
- Vazquez CJB
- Vazquez JGP
- Veatch J
- Vecchio V
- Veen MJ
- Veloce LM
- Veloso F
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- Vera AMR
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- Vercesi V
- Verducci M
- Vergara JCR
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- Vermeulen AT
- Vermeulen JC
- Verzini MJA
- Vetterli MC
- Viaux Maira N
- Vickey T
- Viehhauser GHA
- Vigani L
- Villa M
- Vilucchi E
- Vincter MG
- Virdee GS
- Vishwakarma A
- Vittori C
- Vivarelli I
- Vogel M
- Vokac P
- von Buddenbrock SE
- Von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Vossebeld JH
- Vozak M
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahdan S
- Wahlberg H
- Walbrecht VM
- Walder J
- Walker R
- Walker SD
- Walkowiak W
- Wallangen V
- Wang AM
- Wang AZ
- Wang C
- Wang F
- Wang H
- Wang J
- Wang P
- Wang Q
- Wang R
- Wang R-J
- Wang SM
- Wang W
- Wang WT
- Wang WX
- Wang Y
- Wang Z
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warrack N
- Washbrook A
- Watson AT
- Watson MF
- Watts G
- Waugh BM
- Webb AF
- Webb S
- Weber C
- Weber MS
- Weber SA
- Weber SM
- Weidberg AR
- Weingarten J
- Weirich M
- Weiser C
- Wells PS
- Wenaus T
- Wengler T
- Wenig S
- Wermes N
- Werner MD
- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
- White AS
- White MJ
- Whiteson D
- Whitmore BW
- Wiedenmann W
- Wiel C
- Wielers M
- Wieseotte N
- Wiglesworth C
- Wiik-Fuchs LAM
- Wilkens HG
- Wilkins LJ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolf TMH
- Wolff R
- Wolker R
- Wollrath J
- Wolter MW
- Wolters H
- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
- Wozniak KW
- Wraight K
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xiao X
- Xiotidis I
- Xu D
- Xu H
- Xu L
- Xu T
- Xu W
- Xu Z
- Yabsley B
- Yacoob S
- Yajima K
- Yallup DP
- Yamaguchi N
- Yamaguchi Y
- Yamamoto A
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang Y
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye H
- Ye J
- Ye S
- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yuan R
- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Progression of the load of waterborne and intestinal parasitic diseases in the State of Amazonas
- Author
- Alecrim WD
- Alves AP
- Araújo CF
- Benetton MLFN
- Boia MN
- Braga WS
- Bóia MN
- Bóia MN
- Carvalho-Costa FA
- Chagas ECS
- Chaves CC
- Clemens SAC
- Correa MOA
- Costa OR
- Coura JR
- Coura JR
- Coura JR
- Deane MP
- Dias LC
- Eyde Cristianne Saraiva Santos
- Ferraroni MJ
- Ferraroni MJR
- Fonseca JCF
- Franco SRNS
- Genaro O
- Giugliano R
- Gonçalves AQ
- Homem VSF
- Hurtado-Guerrero AF
- Lins ZC
- Maia MM
- Maia MMM
- Marco Antonio Saboia Moura
- Marcus Vinícius Guimarães Lacerda
- Maria Graças Gomes Saraiva
- Marilaine Martins
- Marinho HA
- Martins M
- Martins M
- Martins M
- Martins M
- Martins M
- Melo GC
- Monteiro AMC
- Montenegro L
- Montoril-Filho M
- Moraes LA
- Moraes MA
- Mujica OJ
- Nunes HM
- Oliveira AA
- Oliveira CLM
- Oliveira WR
- Paula VS
- Paula VS
- Paula VS
- Penna ML
- Pereira FEL
- Pinheiro FP
- Pinheiro MFS
- Pinheiro MFS
- Rawlinson T
- Rios L
- Rocha YR
- Rojas LI
- Salles JM
- Santa Rosa CA
- Santos FS
- Saraiva MGG
- Saraiva MGG
- Saraiva MGG
- Saraiva MGG
- Seabra DMR
- Shrimpton R
- Silva DX
- Silva EF
- Silva EF
- Tavares AM
- Tavares AM
- Valéria Saraceni
- Villar LM
- Visser S
- Wuelton Marcelo Monteiro
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature
- Author
- A Guindo
- A Kumar
- AA Fernandes
- ACL Moura
- AJ Rodriguez-Morales
- AM Melo
- AM Siqueira
- AM Tavares
- AM Ventura
- AMRS Ventura
- Ana MRS Ventura
- André M Siqueira
- Antônio R Silva
- AP Costa
- AV Lomar
- B Genton
- BB Andrade
- BB Andrade
- BB Andrade
- BB Lakhkar
- BC Albuquerque
- BE Gama
- Belisa ML Magalhães
- BO Carvalho
- C Botelho
- C Chagas
- C Fernandez-Becerra
- C Fernandez-Becerra
- C Illamperuma
- C Mendes
- C Menendez
- CA Guerra
- CCBS Raposo
- CE Cavasini
- CE Cavasini
- CF Araujo
- CHAB Menezes
- CHAB Menezes
- CHL Park
- CJC Bastos
- CT Hamel
- D Batista
- DA Lampah
- DK Kochar
- DK Kochar
- DK Kochar
- DK Kochar
- DK Kochar
- DS Walsh
- E Tjitra
- EC Chagas
- EFA Moura
- EFC Lança
- EMN Kalmar
- F Nosten
- FE Martinez-Espinosa
- Flor E Martinez-Espinosa
- FM Campos
- FP Alves
- Franklin S Santana Filho
- FS Santana Filho
- FT Costa
- FY Khan
- GA Cardoso
- GC Melo
- GMC Viana
- GS Mello
- HH Marques
- HO Marques
- I Mueller
- IBA Silva
- IBA Silva
- IBA Silva
- J Oliveira-Ferreira
- J Penna
- J Wildig
- JC Fonseca
- JD Urbaez-Brito
- JF Zumpano
- JH Lee
- JJO Neves
- JP Quintero
- JR Poespoprodjo
- JR Poespoprodjo
- JY Song
- K Maitland
- K Mendis
- K Silamut
- K Takaki
- LK Tan
- LMP Borzacov
- LRP Campos
- M Echeverri
- MA Alexandre
- MA Cardoso
- Marcus VG Lacerda
- Maria GC Alecrim
- Maria PG Mourão
- Mauro S Tada
- MB Victoria
- MC Silva
- MCN Pinheiro
- MD Braga
- MDO Ohnishi
- MDO Ohnishi
- ME Curlin
- ME Ferreira
- MG Alecrim
- MG Saraiva
- MGC Alecrim
- MGC Alecrim
- MJF Gonçalves
- MP Mourao
- MR Galinski
- MS Oliveira
- MS Santana
- MS Santana
- MSS Pereira
- MT Cavasini
- MU Ferreira
- MV Lacerda
- MV Lacerda
- MV Lacerda
- MV Lacerda
- MVG Lacerda
- MVG Lacerda
- MVG Lacerda
- MVG Lacerda
- Márcia AA Alexandre
- ND Karunaweera
- NM Anstey
- NM Anstey
- NM Douglas
- NMA Evangelista
- NSV Guerreiro
- O Caicedo
- O Erel
- P Grynberg
- P Michon
- P Orjuela-Sanchez
- P Reiter
- PA Zimmerman
- Patrícia Brasil
- PC Pereira
- PD Santos-Ciminera
- PD Santos-Ciminera
- PHO Cabral
- PJ Poels
- PS Aragão
- Q Bassat
- Q Bassat
- R Jarude
- R Siqueira-Batista
- R Srinivas
- R Stoppacher
- R Vermehren
- Rita SU Silva
- RL Gurgel
- RN Charrel
- RN Price
- RN Price
- RSM Oliveira
- S Lewallen
- S Picot
- S Pukrittayakamee
- S Sahoo
- S Vitor-Silva
- SB Halstead
- SB Pessoa
- SBR Silva
- SC Austin
- SC Fragoso
- SCP Fragoso
- SJ Rogerson
- SK Kochar
- SL Silva
- SN Wickramasinghe
- SR Albuquerque
- T Leslie
- TH Katsuragawa
- TH Katsuragawa
- TN Williams
- V Bussaratid
- V Severo
- Vanja SCD Couto
- VS Santana
- W Piyaphanee
- WHO
- WHO
- WM Ramos Jr
- YF Sardinha
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the Plasmodium vivax infection. It is the most geographically widespread parasite causing human malaria, with around 2.85 billion people living under risk of infection. The Brazilian Amazon region reports more than 50% of the malaria cases in Latin America and since 1990 there is a marked predominance of this species, responsible for 85% of cases in 2009. However, only a few complicated cases of P. vivax have been reported from this region. A systematic review of the Brazilian indexed and non-indexed literature on complicated cases of vivax malaria was performed including published articles, masters' dissertations, doctoral theses and national congresses' abstracts. The following information was retrieved: patient characteristics (demographic, presence of co-morbidities and, whenever possible, associated genetic disorders); description of each major clinical manifestation. As a result, 27 articles, 28 abstracts from scientific events' annals and 13 theses/dissertations were found, only after 1987. Most of the reported information was described in small case series and case reports of patients from all the Amazonian states, and also in travellers from Brazilian non-endemic areas. The more relevant clinical complications were anaemia, thrombocytopaenia, jaundice and acute respiratory distress syndrome, present in all age groups, in addition to other more rare clinical pictures. Complications in pregnant women were also reported. Acute and chronic co-morbidities were frequent, however death was occasional. Clinical atypical cases of malaria are more frequent than published in the indexed literature, probably due to a publication bias. In the Brazilian Amazon (considered to be a low to moderate intensity area of transmission), clinical data are in accordance with the recent findings of severity described in diverse P. vivax endemic areas (especially anaemia in Southeast Asia), however in this region both children and adults are affected. Finally, gaps of knowledge and areas for future research are opportunely pointed out
Lutzomyia longipalpis urbanisation and control
- Author
- Acosta LA
- Afonso MMS
- Aguilar CM
- Alexander B
- Alexander B
- Alexander B
- Alexander B
- Almeida PS
- Almeida PS
- Alves GB
- Alves WA
- Andrade AR
- Andrade Filho JD
- Arias JR
- Arrivillaga J
- Arrivillaga J
- Arrivillaga J
- Barata RA
- Barata RA
- Bauzer LGSR
- Bejarano EE
- Belo VS
- Belo VS
- Bevilacqua PD
- Bravo AG
- Bray DP
- Bray DP
- Bray DP
- Brazil RP
- Brazil RP
- Brazil RP
- Brazil RP
- Brazil RP
- Camargo-Neves VLF
- Campos AM
- Campos MP
- Canese A
- Canese A
- Canese J
- Cardim MF
- Carrillo J
- Carvalho BM
- Carvalho GM
- Carvalho MR
- Casanova C
- Casanova C
- Cerbino Neto J
- Colla-Jacques FE
- Correa-Antonialli SA
- Cortes LA
- Costa CH
- Costa CH
- Costa PL
- Courtenay O
- Cousiño B
- Curtis CF
- Dantas-Torres F
- Davies CR
- De Silans LNMP
- Deane LM
- Deane LM
- Deane LM
- Delgado O
- Desjeux P
- Dias ES
- Duarte Z
- Elizabeth Ferreira Rangel
- Feliciangeli MD
- Feliciangeli MD
- Feliciangeli MD
- Feliciangeli MD
- Feliciangeli MD
- Feliciangeli MD
- Feliciangeli MD
- Fernández MS
- Ferreira AL
- Fischer D
- Flórez M
- Forattini OP
- Gaglio G
- Galati EAB
- Gama MEA
- García B
- Gomes AC
- González C
- Gould IT
- Holcman MM
- Kelly DW
- Killick-Kendrick R
- Lainson R
- Le Pont F
- Lima H
- Macedo-Silva VP
- Maia-Elkhoury AN
- Marcondes CB
- Marcondes CB
- Margarete Martins dos Santos Afonso
- Margonari C
- Maroli M
- Martín-Sánchez J
- Marzochi MCA
- María Dora Feliciangeli
- María Gabriela Quintana
- Mestre GL
- Michalsky EM
- Michalsky EM
- Missawa NA
- Missawa NA
- Monteiro PS
- Morrison AC
- Márquez LM
- Nascimento BW
- Nascimento MD
- Nieto P
- Noyes H
- Oliveira AG
- Oliveira AG
- Oliveira AG
- Oliveira AG
- Oliveira CD
- Oliveira EF
- Oliveira EF
- Oscar Daniel Salomón
- Paula MB
- Paula MB
- Perrotey S
- Peterkova-Koci K
- Pifano F
- Pinheiro MP
- Pinto IS
- Pita-Pereira D
- Queiroz MF
- Quesada BL
- Quintana MG
- Rangel EF
- Rangel O
- Reithinger R
- Rodrigues AA
- Rodríguez NM
- Romero GA
- Rêgo FD
- Salomón OD
- Salomón OD
- Salomón OD
- Salomón OD
- Salomón OD
- Salomón OD
- Salomón OD
- Santini MS
- Santini MS
- Santini MS
- Santos DR
- Sant’Anna MR
- Saraiva L
- Silva GA
- Silva RA
- Soares BR
- Soares RP
- Souza CF
- Souza GD
- Spada JC
- Szelag EA
- Valderrama A
- vigilância Manual de
- Vilela ML
- Von Zuben AP
- Warburg A
- Zerpa O
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov AV
- Al Khoury K
- Alberghi GL
- Alberich LC
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexandre D
- Alexopoulos T
- Alfonsi A
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Estevez M
- Alvarez Piqueras D
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Arabidze G
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armadans RC
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Artamonov A
- Artoni G
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
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- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
Measurement of the t¯tZ and t¯tW cross sections in proton-proton collisions at √s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
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- Zhemchugov A
- Zheng Z
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- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
A measurement of the associated production of a top-quark pair (t¯t) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb−1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The t¯tZ and t¯tW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σt¯tZ=0.95±0.08stat±0.10syst pb and σt¯tW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the t¯tZ cross section is used to set constraints on effective field theory operators which modify the t¯tZ vertex
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
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- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
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- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
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- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
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- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
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- Asim Oktay Ao
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- Atieh M
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- Avalos V
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- Awasthi Ak
- Axthelm C
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- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
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- Carabajal T
- Carr K
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- Casala J
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- Castillo J
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- Chang K
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- Chattin W
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- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
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- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
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- Christensen L
- Christenson S
- Chung A
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- Cioffi A
- Cislowski D
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- Clocotan M
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- Collier D
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- Commerford P
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- Conrado Y
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- Corona V
- Coronel J
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- Coufalova Z
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- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
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- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
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- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
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- Danik J
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- Dawood Sy
- Dayer M
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- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
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- Diago M
- Diaz M
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- Dickstein K
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- Diller P
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- Dimitrov G
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- Dobilas V
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- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
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- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
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- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
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- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
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- Faghih M
- Fail P
- Falcon D
- Fang C
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- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
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- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
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- Firek C
- Fischer Sm
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- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
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- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
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- Fu G
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- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
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- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
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- Garcia-Fragoso V
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- Gelb R
- Genest J
- Genova D
- George F
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- Ghosh N
- Ghosh S
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- Goette A
- Goff R
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- Gohel P
- Goldberg N
- Gomez Sanchez J
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- Gonzales D
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- Gonzalez E
- Gordeev I
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- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
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- Grabeau R
- Grable M
- Graham J
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- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
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- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
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- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
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- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
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- Hernández N
- Herrman Jp
- Herzog W
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- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
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- Hominal M
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- Hong T
- Hong T
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- Hornig M
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- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
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- Hutchens E
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- Ichisawa M
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- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
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- Inagaki M
- Indolfi C
- Infusino F
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- Ipp E
- Isaza D
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- Iteld B
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- J Jiang
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- Jagtap P
- Jaguszewska G
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- Jansen M
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- Jayasinghe R
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- Jeserich M
- Jia Z
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- Kamensky G
- Kamiya H
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- Kapp I
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- Karakai H
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- Karpuram M
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- Kastelein Jjp
- Kataoka M
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- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
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- Keenan S
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- Khan A
- Khan M
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- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
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- Kim M
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- King A
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- Kirkland S
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- Kitchens D
- Klamm M
- Klein C
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- Klemsdal To
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- Klugherz B
- Knight J
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- Koba M
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- Kodem Dr
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- Koenig W
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- Kok M
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- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
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- Kopaczewski J
- Kopczyńska M
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- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
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- Kotek L
- Kouz Sm
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- Kozak M
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- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
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- Kullal P
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- Kuzin A
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- L Lim
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- Labovitz R
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- Lail J
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- Libov I
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- Ligueros M
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- M Malek
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- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
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- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
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- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
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- Agaras MN
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- Aggarwal A
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- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
- Author
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
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