A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Experimental study on nitrification in a submerged aerated biofilter

The aim of the present work was to evaluate the performance of a semi-pilot scale BAF in order to obtain a highly polished effluent in terms of removal of organic matter, suspended solids and ammonia and to observe the influence of temperature, pH and nitrite accumulation on the nitrification process. The ammonia removal efficiency during summer and winter and the nitrite accumulation in presence of free ammonia were observed. The biomass density was measured at different filter bed heights and the sludge production from the effluent of the backwashing water was evaluated. The results obtained were used to calibrate a mathematical model for the prediction of the ammonia removal profile in the filter bed and of biomass thickness

The theorem of the complement for nested subpfaffian sets

Let R be an o-minimal expansion of the real field, and let L(R) be the language consisting of all nested Rolle leaves over R. We call a set nested subpfaffian over R if it is the projection of a boolean combination of definable sets and nested Rolle leaves over R. Assuming that R admits analytic cell decomposition, we prove that the complement of a nested subpfaffian set over R is again a nested subpfaffian set over R. As a corollary, we obtain that if R admits analytic cell decomposition, then the pfaffian closure P(R) of R is obtained by adding to R all nested Rolle leaves over R, a one-stage process, and that P(R) is model complete in the language L(R).Comment: final version before publicatio

El barrio porteño de Constitución en la poética cucurtiana: un espacio para la diversidad cultural latinoamericana

En el presente artículo analizo la poética de Santiago Vega/ Washington Cucurto en las 8 entregas que hiciera el autor en la página web de Eloísa Cartonera previo a publicarlas como libro por Emecé bajo el título Hasta quitarle Panamá a los yanquis. Para ello, parto de la siguiente hipótesis general: en la literatura argentina contemporánea se están configurando nuevas poéticas que se construyen a partir de la reinvención de topologías urbanas representadas en particularismos barriales. En este sentido, trabajo la poética cucurtiana en relación al barrio de Constitución de la ciudad de Buenos Aires. Con este fin, me sirvo de la categoría de imaginario urbano (García Canclini) a la que cruzo con la noción de sistema sinestésico (Susan Buck Morss). Asimismo, y para analizar dicha poética, es menester detenerse en la construcción de lenguaje a partir del cruce cultural (lo rioplatense, lo dominicano, lo peruano, boliviano, paraguayo) y del lugar que tiene la cumbia en su literatura.Fil: Rolle, Carolina. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin