GA-NIFS: JWST/NIRSpec IFU observations of HFLS3 reveal a dense galaxy group at z~6.3

Massive, starbursting galaxies in the early Universe represent some of the most extreme objects in the study of galaxy evolution. One such source is HFLS3 (z~6.34), which was originally identified as an extreme starburst galaxy with mild gravitational magnification. Here, we present new observations of HFLS3 with the JWST/NIRSpec IFU in both low (PRISM/CLEAR; R~100) and high spectral resolution (G395H/290LP; R~2700), with high spatial resolution (~0.1") and sensitivity. Thanks to the combination of the NIRSpec data and a new lensing model with accurate spectroscopic redshifts, we find that the 3"x3" field is crowded, with a lensed arc (C, z=6.3425+/-0.0002), two galaxies to the south (S1 and S2, z=6.3592+/-0.0001), two galaxies to the west (W1, z=6.3550+/-0.0001; W2, z=6.3628+/-0.0001), and two low-redshift interlopers (G1, z=3.4806+/-0.0001; G2, z=2.00+/-0.01). We present spectral fits and morpho-kinematic maps for each bright emission line (e.g., [OIII]5007, Halpha, [NII]6584) from the R2700 data for all sources except G2. From a line ratio analysis, the galaxies in C are likely powered by star formation, while we cannot rule out or confirm the presence of AGN in the other high-redshift sources. We perform gravitational lens modelling, finding evidence for a two-source composition of the lensed central object and a comparable magnification factor (mu=2.1-2.4) to previous work. The projected distances and velocity offsets of each galaxy suggest that they will merge within the next ~1Gyr. Finally, we examine the dust extinction-corrected SFR of each z>6 source, finding that the total star formation (460+/-90 Msol/yr, magnification-corrected) is distributed across the six z~6.34-6.36 objects over a region of diameter ~11kpc. Altogether, this suggests that HFLS3 is not a single starburst galaxy, but instead is a merging system of star-forming galaxies in the Epoch of Reionization.Comment: 23 pages, 14 figures, submitted to A&

Highly Anomalous Energetics of Protein Cold Denaturation Linked to Folding-Unfolding Kinetics

Despite several careful experimental analyses, it is not yet clear whether protein cold-denaturation is just a “mirror image” of heat denaturation or whether it shows unique structural and energetic features. Here we report that, for a well-characterized small protein, heat denaturation and cold denaturation show dramatically different experimental energetic patterns. Specifically, while heat denaturation is endothermic, the cold transition (studied in the folding direction) occurs with negligible heat effect, in a manner seemingly akin to a gradual, second-order-like transition. We show that this highly anomalous energetics is actually an apparent effect associated to a large folding/unfolding free energy barrier and that it ultimately reflects kinetic stability, a naturally-selected trait in many protein systems. Kinetics thus emerges as an important factor linked to differential features of cold denaturation. We speculate that kinetic stabilization against cold denaturation may play a role in cold adaptation of psychrophilic organisms. Furthermore, we suggest that folding-unfolding kinetics should be taken into account when analyzing in vitro cold-denaturation experiments, in particular those carried out in the absence of destabilizing conditions

Unemployment benefits : discursive convergence, distant realities

Production of INCASI Project H2020-MSCA-RISE-2015 GA 691004Unemployment protection systems have certain characteristics in common in Argentina, Uruguay, Spain and Italy: they are compulsory and contributory-proportional, although in Uruguay, it also has a capitalisation supplement. Despite the similarities, they work differently because the context of informal employment chiefly, and unemployment, low salaries and precariousness differ greatly. Consequently, the unemployment protection coverage rate varies. Theories of the Active Welfare State, the Investor State and the reforms of unemployment protection systems have led to a certain modernising language being adopted in these countries: activation, employability, conditionality, lifelong learning, flexibility, which are, among others, words shared with Europe. However, the meanings of these words differ according to the institutional context of each country. In Latin America the welfare state is low institutionalised even almost non-existent, while in Europe it is a diverse institution. Despite this, the four countries share an upward trend in benefit policies, in accordance with the increase in poverty risk

JADES: Probing interstellar medium conditions at z ∼ 5.5-9.5 with ultra-deep JWST/NIRSpec spectroscopy

We present emission-line ratios from a sample of 27 Lyman-break galaxies from z∼ 5.5-9.5 with-17.0< M1500<-20.4, measured from ultra-deep JWST/NIRSpec multi-object spectroscopy from the JWST Advanced Deep Extragalactic Survey (JADES). We used a combination of 28 h deep PRISM/CLEAR and 7 h deep G395M/F290LP observations to measure, or place strong constraints on, ratios of widely studied rest-frame optical emission lines including Hα, Hβ, [O II] λ3726, 3729, [Ne III] λ3869, [O III] λ4959, [O III] λ5007, [O I] λ6300, [N II] λ6583, and [S II] λ6716, 6731 in individual z> 5.5 spectra. We find that the emission-line ratios exhibited by these z∼ 5.5-9.5 galaxies occupy clearly distinct regions of line-ratio space compared to typical z∼ 0-3 galaxies, instead being more consistent with extreme populations of lower-redshift galaxies. This is best illustrated by the [O III]/[O II] ratio, tracing interstellar medium (ISM) ionisation, in which we observe more than half of our sample to have [O III]/[O II] > 10. Our high signal-to-noise spectra reveal more than an order of magnitude of scatter in line ratios such as [O II]/Hβ and [O III]/[O II], indicating significant diversity in the ISM conditions within the sample. We find no convincing detections of [N II] λ6583 in our sample, either in individual galaxies, or a stack of all G395M/F290LP spectra. The emission-line ratios observed in our sample are generally consistent with galaxies with extremely high ionisation parameters (log U∼-1.5), and a range of metallicities spanning from ∼0.1 × Z⊙ to higher than ∼0.3 × Z⊙, suggesting we are probing low-metallicity systems undergoing periods of rapid star formation, driving strong radiation fields. These results highlight the value of deep observations in constraining the properties of individual galaxies, and hence probing diversity within galaxy population

Decoding the Folding of Burkholderia glumae Lipase: Folding Intermediates En Route to Kinetic Stability

The lipase produced by Burkholderia glumae folds spontaneously into an inactive near-native state and requires a periplasmic chaperone to reach its final active and secretion-competent fold. The B. glumae lipase-specific foldase (Lif) is classified as a member of the steric-chaperone family of which the propeptides of α-lytic protease and subtilisin are the best known representatives. Steric chaperones play a key role in conferring kinetic stability to proteins. However, until present there was no solid experimental evidence that Lif-dependent lipases are kinetically trapped enzymes. By combining thermal denaturation studies with proteolytic resistance experiments and the description of distinct folding intermediates, we demonstrate that the native lipase has a kinetically stable conformation. We show that a newly discovered molten globule-like conformation has distinct properties that clearly differ from those of the near-native intermediate state. The folding fingerprint of Lif-dependent lipases is put in the context of the protease-prodomain system and the comparison reveals clear differences that render the lipase-Lif systems unique. Limited proteolysis unveils structural differences between the near-native intermediate and the native conformation and sets the stage to shed light onto the nature of the kinetic barrier

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured

Measurement of the flavour composition of dijet events in pp collisions at root s=7 TeV with the ATLAS detector

This paper describes a measurement of the flavour composition of dijet events produced in pp collisions at √s=7 TeV using the ATLAS detector. The measurement uses the full 2010 data sample, corresponding to an integrated luminosity of 39 pb−1. Six possible combinations of light, charm and bottom jets are identified in the dijet events, where the jet flavour is defined by the presence of bottom, charm or solely light flavour hadrons in the jet. Kinematic variables, based on the properties of displaced decay vertices and optimised for jet flavour identification, are used in a multidimensional template fit to measure the fractions of these dijet flavour states as functions of the leading jet transverse momentum in the range 40 GeV to 500 GeV and jet rapidity |y|<2.1. The fit results agree with the predictions of leading- and next-to-leading-order calculations, with the exception of the dijet fraction composed of bottom and light flavour jets, which is underestimated by all models at large transverse jet momenta. The ability to identify jets containing two b-hadrons, originating from e.g. gluon splitting, is demonstrated. The difference between bottom jet production rates in leading and subleading jets is consistent with the next-to-leading-order predictions