Building the Interstate

This PDF was downloaded from FHWA's Highway History website: https://www.fhwa.dot.gov/infrastructure/history.cfm.What follows is the documentation of the critical events during the building of the Interstate System. The record begins with the passage of the 1956 Highway Act, which kicked off the Interstate construction program. It ends in 1974 just after the passage of the 1973 Highway Act, which was landmark legislation for the Interstate System and the highway program in general

Biomarcadores tumorais de Câncer Colorretal: breve revisão bibliográfica

O câncer colorretal é o terceiro tipo de câncer mais incidente no Brasil e no mundo, e é uma das causas de morte em pessoas com menos de 70 anos. A incidência de casos em pacientes com idade menor que 50 anos aumentou, e com isso, a necessidade de fazer o rastreamento ainda mais precoce dessa doença, a fim de obter melhor prognóstico. As alterações genéticas, histológicas e morfológicas somadas tornam possível a detecção de pólipos pré-cancerosos, corroborando diagnóstico e tratamento precoces. O presente estudo é uma revisão de literatura qualitativa com finalidade de identificar biomarcadores promissores do câncer colorretal. Os tumores malignos se diferenciam dos tumores benignos pela presença de fator cancerígeno nesses. O tipo mais comum de câncer colorretal é o adenocarcinoma, desenvolvido a partir de células epiteliais. O sarcoma é outro tipo de câncer colorretal que se desenvolve a partir de tecido conjuntivo. Os biomarcadores MMP9, EFGR e PLAU são os mais específicos para o câncer colorretal. Os indicadores biológicos são importantes na educação, conscientização populacional, diagnóstico, tratamento e prevenção da doença. Uma abordagem individualizada, com base em biomarcadores, pode reduzir morbimortalidade e avançar no sentido de melhores prognósticos aos pacientes acometidos por essa doença

Prospectus, September 14, 1977

TWO VIE FOR VEEP POST: STUDENT GOVERNMENT ELECTIONS TODAY; Elections scheduled today and tomorrow; District 505 entitled to minimum credit grants; Activities postponed; Unopposed; Shiloh\u27s and Sonshine Circle to perform; Survival of democratic society topic at forum; Vets must go by book; \u27Self Defense\u27 is under attack; Youngest brew master is nun; Warners, women battle over \u27Jump On It\u27; Male prostitute makes history; News From \u27Her Say\u27: Ten women earn wings; UAW asks Congress for maternity benefits \u27as soon as possible\u27; Career Awareness Course for women Wednesday eve.; Instructors earn high grades from PC students; Back orders on home insulation cause woes; Blowing of the shofar means Rosh Hashanah, start of 5,738 New Year; Springfield news: senior citizens, equal language; The gas man cometh...; Holograph exhibit at PC tomorrow; Letting out some Slack...: Answers for queries on PC; Chicago painter displays at KCPA; Prospectus Pigskin Preview: Cobra Grid Schedule, Parkland Roster, Fight on Cobras; Alaskan wilderness is summer home to Basler; Parkland Learning Laboratory: Early help available to students; Stu-Go explores check cashing for PC people; PC music groups have many openings; Jumers: German touch; \u27Elite\u27 women to get public house; Home care topic to be presented; Classifieds; X-country opens Saturday; Spikettes look good; Sports shorts; Bio instructor Cox wins Fast Freddy; Intramural sign up closing; The continuing battle for Number 1; Parkland to host nationalshttps://spark.parkland.edu/prospectus_1977/1013/thumbnail.jp

Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer

Extracellular vesicles (EVs) shuttle microRNA (miRNA) throughout the circulation and are believed to represent a fingerprint of the releasing cell. We isolated and characterized serum EVs of breast tumour-bearing animals, breast cancer (BC) patients, and healthy controls. EVs were characterized using transmission electron microscopy (TEM), protein quantification, western blotting, and nanoparticle tracking analysis (NTA). Absolute quantitative (AQ)-PCR was employed to analyse EV-miR-451a expression. Isolated EVs had the appropriate morphology and size. Patient sera contained significantly more EVs than did healthy controls. In tumour-bearing animals, a correlation between serum EV number and tumour burden was observed. There was no significant relationship between EV protein yield and EV quantity determined by NTA, highlighting the requirement for direct quantification. Using AQ-PCR to relate miRNA copy number to EV yield, a significant increase in miRNA-451a copies/EV was detected in BC patient sera, suggesting potential as a novel biomarker of breast cancer

The role of shame and self-compassion in psychotherapy for narcissistic personality disorder: An exploratory study.

This process-outcome study aims at exploring the role of shame, self-compassion, and specific therapeutic interventions in psychotherapy for patients with narcissistic personality disorder (NPD). This exploratory study included a total of N = 17 patients with NPD undergoing long-term clarification-oriented psychotherapy. Their mean age was 39 years, and 10 were male. On average, treatments were 64 sessions long (range between 45 and 99). Sessions 25 and 36 were rated using the Classification of Affective Meaning States and the Process-Content-Relationship Scale. Outcome was assessed using the Symptom Check List-90 and Beck Depression Inventory-II. Between Sessions 25 and 36, a small decrease in the frequency of shame was found (d = .30). In Session 36, the presence of self-compassion was linked with a set of specific therapist interventions (process-guidance and treatment of behaviour-underlying assumptions; 51% of variance explained and adjusted). This study points to the possible central role of shame in the therapeutic process of patients with NPD. Hypothetically, one way of resolving shame is, for the patient, to access underlying self-compassion

Multivalent glycoconjugates as vaccines and potential drug candidates

Pathogens adhere to the host cells during the first steps of infection through multivalent interactions which involve protein–glycan recognition. Multivalent interactions are also involved at different stages of immune response. Insights into these multivalent interactions generate a way to use suitable carbohydrate ligands that are attached to a basic scaffold consisting of e.g., dendrimer, polymer, nanoparticle, etc., with a suitable linker. Thus a multivalent architecture can be obtained with controllable spatial and topology parameters which can interfere with pathogen adhesion. Multivalent glycoconjugates bearing natural or unnatural carbohydrate antigen epitopes have also been used as carbohydrate based vaccines to stimulate an innate and adaptive immune response. Designing and synthesizing an efficient multivalent architecture with optimal ligand density and a suitable linker is a challenging task. This review presents a concise report on the endeavors to potentially use multi- and polyvalent glycoconjugates as vaccines as well as anti-infectious and anti-inflammatory drug candidates