Recruitment in Social Network Sites: The Interplay Between Usefulness and Risks in Explaining Jobseekers\u27 Intentions

Employers are increasingly turning to social networking sites (SNSs) to find candidates for their workforce or to gather intelligence about potential employees. However, apart from assessing the extent to which human resource professionals scan SNSs for information about job candidates, research on online recruitment in the context of SNSs is almost non-existent. In this study, we are investigating predictors of jobseekers’ intentions to apply for jobs in the context of SNSs. We propose a model that integrates classic technology adoption/utilization theories with salient factors such as privacy concerns that have increased in significance with the growing use of SNSs as an online recruitment source. This study will make a methodological and theoretical contribution to information systems research with the validation of the proposed model and associated scales in the online social computing context. It will also have practical implications for SNSs offering recruitment services; recruiters/potential employers; and jobseekers

Recruitment in Social Networking Sites: A Theoretical Model of Jobseekers\u27 Intentions

We propose a risk-benefit model for studying jobseekers’ behavioral intentions to apply for a job in the context of social networking sites (SNSs). Our model integrates classic technology adoption/utilization theories with salient factors such as privacy concerns that have increased in significance with the growing use of SNSs as a recruitment source. We hypothesize that jobseekers’ outcome expectancy (degree of optimism with respect to finding a job) and perceived usefulness of SNSs are both impacted by the availability of information about social connections to potential employers and by perceptions of justice in the job candidate selection process. Further, perceived usefulness of SNSs is influenced by outcome expectancy. This model also suggests that perceived risks (in terms of uncertainty and possible adverse consequences) are affected by online information privacy concerns. Finally, outcome expectancy, perceived usefulness of SNSs and perceived risks directly predict intentions to use SNSs to apply for a job

The Design of an Online Social Network Site for Emergency Management: A One Stop Shop

Web 2.0 is rapidly creating new opportunities for communication and collaboration. Part of this explosion is the increase in popularity and use of Social Network Sites (SNSs) for general and domain-specific use. In the emergency domain there are a number of websites including wikis and SNSs. but they stand as silos in the field, unable to allow for cross-site collaboration. In this paper we describe ongoing design science research to develop and refine guiding principles for the design of an SNS that will bring together emergency domain professionals in a “one-stop-shop.” We surveyed emergency professionals who study crisis information systems, to ascertain potential functionalities of such an SNS. Preliminary results suggest that there is a need for the envisioned SNS. Future research will continue to explore possible solutions to issues addressed in this paper

Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines

BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer. METHODS: GIRK1-4 expression and levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR. GIRK protein levels were determined by western blots and cell proliferation was determined by a 5-bromo-2'-deoxyuridine (BrdU) assay. RESULTS: GIRK1 mRNA was expressed in three of six small cell lung cancer (SCLC) cell lines, and either GIRK2, 3 or 4 mRNA expression was detected in all six SCLC cell lines. Treatment of NCI-H69 with β(2)-adrenergic antagonist ICI 118,551 (100 μM) daily for seven days led to slight decreases of GIRK1 mRNA expression levels. Treatment of NCI-H69 with the β-adrenergic agonist isoproterenol (10 μM) decreased growth rates in these cells. The GIRK inhibitor U50488H (2 μM) also inhibited proliferation, and this decrease was potentiated by isoproterenol. In the SCLC cell lines that demonstrated GIRK1 mRNA expression, we also saw GIRK1 protein expression. We feel these may be important regulatory pathways since no expression of mRNA of the GIRK channels (1 & 2) was found in hamster pulmonary neuroendocrine cells, a suggested cell of origin for SCLC, nor was GIRK1 or 2 expression found in human small airway epithelial cells. GIRK (1,2,3,4) mRNA expression was also seen in A549 adenocarcinoma and NCI-H727 carcinoid cell lines. GIRK1 mRNA expression was not found in tissue samples from adenocarcinoma or squamous cancer patients, nor was it found in NCI-H322 or NCI-H441 adenocarcinoma cell lines. GIRK (1,3,4) mRNA expression was seen in three squamous cell lines, GIRK2 was only expressed in one squamous cell line. However, GIRK1 protein expression was not seen in any non-SCLC cells. CONCLUSION: We feel that this data may indicate that stimulation of GIRK1 or GIRK2 channels may be important in lung cancer. Stimulation of GIRK channels and β-adrenergic signaling may activate similar signaling pathways in both SCLC and breast cancer, but lead to different results

Transfusion-Associated Lyme Disease – Although Unlikely, It Is Still a Concern Worth Considering

Even though hematogenous spread of the Lyme disease spirochete, Borrelia burgdorferi, has been well documented, and there are more than 300,000 cases per year of Lyme disease in the United States, no evidence (anecdotal or published) of transfusion-associated Lyme disease has been reported. Such a possibility would seem to exist but various factors, as discussed in this perspective, make this less likely to occur. Nonetheless, if not done already, safeguards need to be put in place at blood collection and dispensing facilities, possibly with the assistance of diagnostic microbiology and immunology laboratories, to ensure that the potential for the transfer of the Lyme disease spirochete through a blood transfusion remains a theoretical consideration rather than a real possibility

Exploring Students’ Reactions to Virtual Worlds

Our research explores multi-user virtual environments for teaching university-level courses. This paper focuses on undergraduate students’ reactions to five virtual worlds explored as part of a Computers and Ethics course. Written reports from twenty-five students were qualitatively analyzed with respect to perceived ease of use, user satisfaction, and user concerns. Our preliminary findings indicate that students’ perceptions and attitudes were mixed. Some students perceived virtual worlds as relatively easy to use regarding object interactions, communication and user interaction. However, there were some instances of difficulty in navigation and in completing some tutorials. Furthermore, students expressed concerns beyond usability issues, such as user misbehavior and cheating. These issues could become significant barriers to using virtual worlds for college courses. We present suggestions for reducing such barriers

Interaction of Cowpea Mosaic Virus (CPMV) Nanoparticles with Antigen Presenting Cells In Vitro and In Vivo

(CPMV) are increasingly being developed for applications in nanobiotechnology including vaccine development because of their potential for producing large quantities of antigenic material in plant hosts. In order to improve efficacy of viral nanoparticles in these types of roles, an investigation of the individual cell types that interact with the particles is critical. In particular, it is important to understand the interactions of a potential vaccine with antigen presenting cells (APCs) of the immune system. CPMV was previously shown to interact with vimentin displayed on cell surfaces to mediate cell entry, but the expression of surface vimentin on APCs has not been characterized. by flow cytometry and fluorescence confocal microscopy. The association of the particles with mouse gastrointestinal epithelium and Peyer's patches was also examined by confocal microscopy. The expression of surface vimentin on APCs was also measured., and that further tuning the interaction with surface vimentin may facilitate increased uptake by APCs and priming of antibody responses. These studies also indicate that CPMV particles likely access the systemic circulation following oral delivery via the Peyer's patch

Researching Intimacies and New Media:Methodological Opportunities and Challenges

Researching intimacies and new media encompasses a wide variety of intersecting practices and relationships. This special issue presents contributions from researchers who are investigating practices of intimacy mediated either wholly or in part through new media in which a variety of different methodological opportunities and challenges are highlighted and discussed. Existing research has addressed different combinations of new media, intimacy, and methodology, but there remains space for a dedicated focus on the ways in which these areas are interrelated and entangled. The articles in this special issue build up a conversation around this particular intersection from a range of directions, from reflections on specific technological devices/apps and their promotion of particular forms of intimacies that may lead to (dis)comfort and (dis)connection, to the intimate—and sometimes risky—investments in research processes and fieldwork, as well as the ethical frameworks and decision-making processes guiding the research

HPV type infection in different anogenital sites among HIV-positive Brazilian women

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes