Myosin Va’s adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro

Significance Inner organization of eukaryotic cells intimately depends on the active transport of diverse intracellular cargo on the ubiquitous actin and microtubule networks. The underlying mechanisms of such directional transport processes have been of outstanding interest. We studied a motor complex composed of Rab27a, melanophilin, and myosin Va and found, surprisingly, that the adaptor protein melanophilin toggled the binding preference toward actin or microtubules in vitro. Our results offer unexpected mechanistic insights into biasing the directionality of a moving organelle on the cytoskeleton through phospho-targeting the adaptor protein rather than its motor in vivo.</jats:p

R&D Paths of Pixel Detectors for Vertex Tracking and Radiation Imaging

This report reviews current trends in the R&D of semiconductor pixellated sensors for vertex tracking and radiation imaging. It identifies requirements of future HEP experiments at colliders, needed technological breakthroughs and highlights the relation to radiation detection and imaging applications in other fields of science.Comment: 17 pages, 2 figures, submitted to the European Strategy Preparatory Grou

The State of Coral Reef Ecosystems of the United States and Pacific Freely Associated States: 2002

Called for by the U.S. Coral Reef Task Force’s (USCRTF) National Action Plan to Conserve Coral Reefs, this is the first biennial report on the condition of coral reefs. It is the scientific baseline for subsequent reports on the health of U.S. coral reef ecosystems that are to be used by NOAA and others to evaluate the efficacy of coral reef conservation and management practices. The National Oceanic and Atmospheric Administration’s National Ocean Service led the development of this report. It was authored by 38 experts and supported by 79 contributors from government agencies and non-governmental organizations across the nation and internationally. Over 100 Task Force members and other notable scientists have reviewed this document

Recent Region-wide Declines in Caribbean Reef Fish Abundance

Profound ecological changes are occurring on coral reefs throughout the tropics, with marked coral cover losses and concomitant algal increases, particularly in the Caribbean region. Historical declines in the abundance of large Caribbean reef fishes likely reflect centuries of overexploitation. However, effects of drastic recent degradation of reef habitats on reef fish assemblages have yet to be established. By using meta-analysis, we analyzed time series of reef fish density obtained from 48 studies that include 318 reefs across the Caribbean and span the time period 1955–2007. Our analyses show that overall reef fish density has been declining significantly for more than a decade, at rates that are consistent across all subregions of the Caribbean basin (2.7% to 6.0% loss per year) and in three of six trophic groups. Changes in fish density over the past half-century are modest relative to concurrent changes in benthic cover on Caribbean reefs. However, the recent significant decline in overall fish abundance and its consistency across several trophic groups and among both fished and nonfished species indicate that Caribbean fishes have begun to respond negatively to habitat degradation

Multi-frequency imaging of the galaxy cluster Abell 2163 using the Sunyaev-Zel'dovich effect

Context. Observations of the Sunyaev-Zel'dovich effect (SZE) from galaxy clusters are emerging as a powerful tool in cosmology. Besides large cluster surveys, resolved SZE images of individual clusters can shed light on the physics of the intra-cluster medium (ICM) and allow accurate measurements of the cluster gas and total masses. Aims. We used the APEX-SZ and LABOCA bolometer cameras on the APEX telescope to map both the decrement of the SZE at 150 GHz and the increment at 345 GHz toward the rich and X-ray luminous galaxy cluster Abell 2163 at redshift 0.203. The SZE images were used, in conjunction with archival XMM-Newton X-ray data, to model the radial density and temperature distribution of the ICM, as well as to derive the gas mass fraction in the cluster under the assumption of hydrostatic equilibrium. Methods. We describe the data analysis techniques developed to extract the faint and extended SZE signal. We used the isothermal model to fit the SZE decrement/increment radial profiles. We performed a simple, non-parametric de-projection of the radial density and temperature profiles, in conjunction with X-ray data, under the simplifying assumption of spherical symmetry. We combined the peak SZE signals derived in this paper with published SZE measurements of this cluster to derive the cluster line-of-sight bulk velocity and the central Comptonization, using priors on the ICM temperature. Results. We find that the best-fit isothermal model to the SZE data is consistent with the ICM properties implied by the X-ray data, particularly inside the central 1 Mpc radius. Inside a radius of ~1500 kpc from the cluster center, the mean gas temperature derived from our SZE/X-ray joint analysis is 10.4 1.4 keV. The error budget for the derived temperature profile is dominated by statistical errors in the 150 GHz SZE image. From the isothermal analysis combined with previously published data, we find a line-of-sight peculiar velocity consistent with zero; vr = -140 460 km s-1, and a central Comptonization y0 = 3.42 0.32 10-4 for Abell 2163. Conclusions. Although the assumptions of hydrostatic equilibrium and spherical symmetry may not be optimal for this complex system, the results obtained under these assumptions are consistent with X-ray and weak-lensing measurements. This shows the applicability of the simple joint SZE and X-ray de-projection technique described in this paper for clusters with a wide range of dynamical states

Urban coral reefs: Degradation and resilience of hard coral assemblages in coastal cities of East and Southeast Asia

© 2018 The Author(s) Given predicted increases in urbanization in tropical and subtropical regions, understanding the processes shaping urban coral reefs may be essential for anticipating future conservation challenges. We used a case study approach to identify unifying patterns of urban coral reefs and clarify the effects of urbanization on hard coral assemblages. Data were compiled from 11 cities throughout East and Southeast Asia, with particular focus on Singapore, Jakarta, Hong Kong, and Naha (Okinawa). Our review highlights several key characteristics of urban coral reefs, including “reef compression” (a decline in bathymetric range with increasing turbidity and decreasing water clarity over time and relative to shore), dominance by domed coral growth forms and low reef complexity, variable city-specific inshore-offshore gradients, early declines in coral cover with recent fluctuating periods of acute impacts and rapid recovery, and colonization of urban infrastructure by hard corals. We present hypotheses for urban reef community dynamics and discuss potential of ecological engineering for corals in urban areas