15 research outputs found
Modeling psychiatric disorders: from genomic findings to cellular phenotypes
Major programs in psychiatric genetics have identified 4150 risk loci for psychiatric disorders. These loci converge on a small
number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying
schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features
of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for
cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides
an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds
great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still
present multiple challenges. In this expert review, we critically review the challenges for modeling of psychiatric disorders, potential
solutions and how iPSC technology can be used to develop an analytical framework for the evaluation and therapeutic
manipulation of fundamental disease processes