75 research outputs found
Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
- Author
- A Maloverjan
- A Melendez
- A Simonsen
- A Terman
- A Terman
- AHV Schapira
- AL Wang
- AM Cuervo
- Andy T. Y. Lau
- ARJ Young
- B Levine
- B Levine
- C Zhang
- C-H Park
- CA Brady
- CJF Vannoorden
- CL Ren
- E Bergamini
- E Morselli
- ES Hwang
- F Cecconi
- FA Dolbeare
- FG Holz
- G Juhasz
- G Kroemer
- H Zhang
- Hae Ri Choi
- HT Kang
- HT Kang
- Hyun Tae Kang
- I Bjedov
- JF Passos
- JH Lee
- JJ Wu
- Ki Baek Lee
- KL Jia
- M Bergmann
- M Gamerdinger
- M Komatsu
- M Komatsu
- M Komatsu
- M Martinez-Vicente
- M Taneike
- N Chondrogianni
- N Sitte
- P Fabrizio
- PG Komarov
- S Ohkuma
- S Straniero
- Sang Chul Park
- SQ Zheng
- Sung Young Kim
- T Claudepierre
- T Eisenberg
- T Finkel
- T Hara
- V Deretic
- XP Qu
- Y Hashimoto
- Y Stroikin
- Z Yang
- ZP Xie
- ZY Yue
- Publication venue
- Public Library of Science
- Publication date
- 08/08/2011
- Field of study
BACKGROUND:Recent studies have demonstrated that activation of autophagy increases the lifespan of organisms from yeast to flies. In contrast to the lifespan extension effect in lower organisms, it has been reported that overexpression of unc-51-like kinase 3 (ULK3), the mammalian homolog of autophagy-specific gene 1 (ATG1), induces premature senescence in human fibroblasts. Therefore, we assessed whether the activation of autophagy would genuinely induce premature senescence in human cells. METHODOLOGY/PRINCIPAL FINDINGS:Depletion of ATG7, ATG12, or lysosomal-associated membrane protein 2 (Lamp2) by transfecting siRNA or infecting cells with a virus containing gene-specific shRNA resulted in a senescence-like state in two strains of primary human fibroblasts. Prematurely senescent cells induced by autophagy impairment exhibited the senescent phenotypes, similar to the replicatively senescent cells, such as increased senescence associated β-galactosidase (SA-β-gal) activity, reactive oxygen species (ROS) generation, and accumulation of lipofuscin. In addition, expression levels of ribosomal protein S6 kinase1 (S6K1), p-S6K1, p-S6, and eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) in the mammalian target of rapamycin (mTOR) pathway and beclin-1, ATG7, ATG12-ATG5 conjugate, and the sequestosome 1 (SQSTM1/p62) monomer in the autophagy pathway were decreased in both the replicatively and the autophagy impairment-induced prematurely senescent cells. Furthermore, it was found that ROS scavenging by N-acetylcysteine (NAC) and inhibition of p53 activation by pifithrin-α or knockdown of p53 using siRNA, respectively, delayed autophagy impairment-induced premature senescence and restored the expression levels of components in the mTOR and autophagy pathways. CONCLUSION:Taken together, we concluded that autophagy impairment induces premature senescence through a ROS- and p53-dependent manner in primary human fibroblasts
Mutant p53 as a guardian of the cancer cell
- Author
- A Ali
- A Kieser
- A Narendran
- A Parrales
- A Polotskaia
- A Restle
- AJ Wolpaw
- AK Frank
- BK Linderholm
- C Kandoth
- C Zhang
- CA Larsson
- CD Kamat
- D Bergamaschi
- D Li
- D Li
- D Li
- D Malkin
- D Senft
- D Walerych
- D Walerych
- D Walerych
- DP Liu
- E Campaner
- E Ingallina
- E Martynova
- E Morselli
- E Sahai
- EM Alexandrova
- F Kruiswijk
- F Mantovani
- F Mantovani
- F Rohrig
- F Valenti
- F Vogiatzi
- Fiamma Mantovani
- G Bossi
- G Fontemaggi
- G Minin Di
- G Sorrentino
- G Sorrentino
- G Zhou
- Giannino Del Sal
- H Rahnamoun
- H Song
- H Zhang
- HN Lee
- J Luo
- JE Girardini
- JL Chee
- K Lisek
- K Liu
- L Chen
- L Weisz
- Licio Collavin
- M Adorno
- M Cordani
- M Fang
- M McLaughlin
- M Wang
- MG Heiden Vander
- ML Mendillo
- MP Kim
- MW Pickup
- NN Pavlova
- OA O’Connor
- OC Rodriguez
- P Liao
- P Timpson
- PG Richardson
- PJ Mullen
- PM Neilsen
- PY Wang
- PY Wang
- R Gomez-Pastor
- RA Frum
- RM Connolly
- S Agostino Di
- S Basu
- S Choudhury
- S Kozono
- S Madar
- S Mizuarai
- S Singh
- S Wei
- T Cooks
- T Cooks
- T Koga
- T Terzian
- TA Nguyen
- TD Halazonetis
- V Garcia
- VJ Bykov
- VJN Bykov
- WA Freed-Pastor
- WA Yeudall
- X Peng
- X Zhang
- YA Suh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a complex framework of diverse effector pathways and processes that protect cellular homeostasis and genome stability. Missense mutations in the TP53 gene are extremely widespread in human cancers and give rise to mutant p53 proteins that lose tumor suppressive activities, and some of which exert trans-dominant repression over the wild-type counterpart. Cancer cells acquire selective advantages by retaining mutant forms of the protein, which radically subvert the nature of the p53 pathway by promoting invasion, metastasis and chemoresistance. In this review, we consider available evidence suggesting that mutant p53 proteins can favor cancer cell survival and tumor progression by acting as homeostatic factors that sense and protect cancer cells from transformation-related stress stimuli, including DNA lesions, oxidative and proteotoxic stress, metabolic inbalance, interaction with the tumor microenvironment, and the immune system. These activities of mutant p53 may explain cancer cell addiction to this particular oncogene, and their study may disclose tumor vulnerabilities and synthetic lethalities that could be exploited for hitting tumors bearing missense TP53 mutations
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
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- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
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- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
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- Berge D
- Berger BK
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- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
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- Bernardini MG
- Bernhard S
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- Bero JJ
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- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
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- Bisht A
- Bissaldi E
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- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
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- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
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- Bond IA
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- Bonino R
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- Bonnefoy S
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- Booler T
- Boom BA
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- Bottcher M
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- Botticella MT
- Bouffanais Y
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- Bretz H-P
- Bretz T
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- Briechle FL
- Briggs MS
- Brillet A
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- Bueno A
- Bufano F
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- Buitink S
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- Buonanno A
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- Bustillo J Caldern
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- Butler NR
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- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
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- Cancio A
- Canepa M
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- Canizares P
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- Capano CD
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- Cattaneo PW
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- Chatterjee D
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- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
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- Chen TX
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- Chen YP
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- Cheng H-P
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- Clearwater P
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- Cohen D
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- Colafrancesco S
- Colafrancesco S
- Colalillo R
- Colazo C
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- Collaboration Insight-Hxmt
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- Collaboration Swift
- Collaboration VINROUGE
- Collette CG
- Collica L
- Collin GH
- Colmenero E Romero
- Coluccia MR
- Cominsky LR
- Cominsky LR
- Conceicao R
- Concu R
- Condon B
- Coniglione R
- Connaughton V
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- Conti L
- Contreras F
- Cook DO
- Cook ER
- Cooke J
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- Cooper SJ
- Copperwheat C
- Corban P
- Corbitt TR
- Cordero-Carrion I
- Corley KR
- Cornish N
- Corongiu A
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- Costa CA
- Costa CF Da Silva
- Costa E
- Costa-Duarte MV
- Costantin D
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- Cotzomi J
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- de Oliveira C Mendes
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Localization and broadband follow-up of the gravitational-wave transient GW150914
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- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Zhivotovsky B
- Zhong Q
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- Zhu B
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- Zhu H
- Zhu H
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- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Yale-Brown Obsessive Compulsive Scale modified for Body Dysmorphic Disorder (BDD-YBOCS): Brazilian Portuguese translation, cultural adaptation and validation
- Author
- Alavi M
- Beaton DE
- Bjornsson AS
- Crerand CE
- da Silva DB
- de Brito MJ
- de Brito MJ
- de Brito MJ
- de Brito MJ
- Dyl J
- Fang A
- Felix GA
- Gabriel A. Felix
- Gandek B
- Goodman WK
- Goodman WK
- Guillemin F
- Guillemin F
- Jorge RT
- Kelly MM
- Leandro S. Duarte
- Lydia M. Ferreira
- Maria F. Rosella
- Maria J. de Brito
- Marques L
- Michalczuk R
- Miguel Sabino Neto
- Morselli PG
- Mário F. de Oliveira
- Phillips KA
- Phillips KA
- Phillips KA
- Phillips KA
- Phillips KA
- Picavet VA
- Reese HE
- Sarwer DB
- Shridharani SM
- Táki A. Cordás
- Veale D
- Vindigni V
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Congenital cystic eye associated with a low-grade cerebellar lesion that spontaneously regressed
- Author
- Alessandra Modugno
- AM Mansour
- Angela Mastronuzzi
- Antonino Romanzo
- B Bilginer
- BS Shastry
- C Di Rocco
- C Perret
- CF Parsa
- CJ McLean
- Giovanna Stefania Colafati
- H Ogiwara
- I Mann
- I Tsitouridis
- IA Chaudhry
- IF Pollack
- JA Shields
- JC Allen
- JC Kernan
- JG Sacks
- JR Singer
- K Gündüz
- LR Pasquale
- M Benharbit
- M Gallucci
- M Mehta
- M Piccirilli
- MA Dollfus
- Maria Giuseppina Cefalo
- N Hayashi
- P Bandopadhayay
- P Steinbok
- PD Brown
- PG Morselli
- R Gupta
- R Guthoff
- RB Lowry
- RG Dash
- Rita De Vito
- RM Robb
- S Duke-Elder
- S Gaudino
- SH Goldberg
- SM Schmandt
- UK Raina
- VP Gupta
- WM Rozen
- Y Shukla
- ZS Ali
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Body mass index and musculoskeletal pain: is there a connection?
- Author
- A Basu
- A Bierhaus
- A Lebovits
- A Norman
- AA Stone
- AC Guyton
- AH Miller
- AM Petersen
- AV Nedeltcheva
- AW Barclay
- B Antuna-Puente
- BD Lamon
- BJ Nicklas
- BS Jhawar
- C Darviri
- C Leboeuf-Yde
- C Nathan
- C Sommer
- C Sommer
- CD Rethorst
- CN Serhan
- CS Bonnet
- D Giugliano
- D Robinson
- DI Rubin
- DL Goldenberg
- DR Seaman
- E Hypponen
- EA Lucassen
- EE Helminen
- EL Campbell
- ES Ford
- F Berenbaum
- FS Facchini
- G Egger
- G Schwalfenberg
- H Bays
- H Koponen
- H Nakamura
- H Saudny
- H Sell
- HD Adkisson
- HE Bays
- HE Bays
- HS Park
- HS Schipper
- I Heuch
- I Heuch
- I Heuch
- J Helmersson
- J Maniam
- J Miettola
- J Nijs
- J Oliveira
- JE Gaida
- JE Gaida
- JH O’Keefe
- JH O’Keefe
- JM Mullington
- JN Fain
- K Esposito
- K Esposito
- K Masuko
- K Nishioka
- K Spiegel
- KA Harford
- KL Knutson
- KS Ahn
- L Cordain
- L Cordain
- L Morselli
- LA Frassetto
- LI Kauppila
- LI Kauppila
- LI Kauppila
- LJ Wright
- LM Biasucci
- LM Christian
- M Abate
- M Babyak
- M Blaha
- M Chandran
- M Kurunlahti
- M Lekander
- M Maes
- M Rechardt
- M Saraiva
- M Sodergren
- MF Dallman
- MJ Zhang
- MK Wium-Andersen
- ML Tiku
- ML Tiku
- MM de la Llera
- MR Irwin
- MR Irwin
- MS Briggs
- N Mathur
- N Sakellaridis
- N Sakellaridis
- N Simpson
- N Uceyler
- P Dandona
- P Leino-Arjas
- P Leino-Arjas
- P Leino-Arjas
- P Malliaras
- P Mantyselka
- P Mantyselka
- P Mantyselka
- P Mantyselka
- PG Conaghan
- PH Black
- PJ Pussinen
- PM Ridker
- PW Wilson
- R Chou
- R Dantzer
- R Edwards
- R Krishnadas
- R Lotan
- R Ross
- R Shiri
- R Shiri
- R Shiri
- RA Khairova
- RF Grimble
- RG Baker
- RR Ji
- RV Santos
- S Bonaccorso
- S Cowy
- S Galic
- S Golbidi
- SD Glassman
- SJ Lees
- SJ Motivala
- T Kato
- T Sturmer
- T Suganami
- TC Adam
- TH Heiskanen
- TN Akbaraly
- UN Das
- UN Das
- V Gkretsi
- W Bouwmeester
- WM Bonner
- X Guillot
- Y Anekstein
- Y Lustig
- ZZ Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases
- Author
- A Duenas-Gonzalez
- A Duenas-Gonzalez
- A Dumont
- A Elimadi
- A Faggiano
- A Ferree
- A Gross
- A Guidarelli
- A Liacini
- A Palumbo
- A Peter
- A Roscic
- A Vasquez
- A Williams
- AA Adjei
- AD Balgi
- AE Chernoff
- AF Cashen
- AJ Mastrangelo
- Alex Zhavoronkov
- Alexey Moskalev
- AM Pendas
- AO Konrady
- AP Ugalde
- AS Chan
- AS Tsvetkov
- AY Bedikian
- B Becattini
- B Calabretta
- B Fontaine-Bisson
- B Fuks
- B Klein
- B Ravikumar
- BB Jesus de
- BC Capell
- BC Capell
- BG Hoffstrom
- BM Wasko
- C Hu
- C Huynh
- C Newman
- C Rose
- C Sessa
- C Stey
- C Travelli
- C Weyer
- C Wurthmann
- CB Page
- CD Ragnauth
- CD Zorrilla
- CE Ashley
- CH Hsu
- CJ Kenyon
- CL Bjornson
- CL Moulson
- CM Hartford
- CP Zhang
- CQ Zhao
- CR Arnt
- CR Burtner
- CY Chen
- D Chen
- D Constantinescu
- D Constantinescu
- D Ioan
- D Kuck
- D Kuck
- D Lee
- D Mereles
- D Ofori-Adjei
- D Vara
- D Yang
- DC Butler
- DJ Goussetis
- DJ Stravopodis
- DM Heijink
- DR Gough
- DS Kim
- DS Scherr
- DS Sharpe
- E Kaminskas
- E Maubec
- E Meshorer
- E Morselli
- E Petit
- E Raymond
- E Strom
- EA Curry 3rd
- EA Komarova
- EA Olsen
- EC Kivuva
- EK Benson
- ET Lam
- ET Tsilou
- F Christian
- F Lin
- F Lyko
- FG Osorio
- FG Osorio
- FG Osorio
- FI Arnaldez
- FV Din
- G Chouinard
- G Marino
- G Wu
- GD Pennock
- GR Campbell
- GV Naccarelli
- H Akasaka
- H Cheong
- H Kawakita
- H Kim
- H Kimura
- H Liang
- H Merskey
- H Mitsuhashi
- H Takeuchi
- H Xi
- HG Xia
- HJ Jung
- HL Yeh
- I Jialal
- I Varela
- I Weidenfeld
- IC Lopez-Mejia
- ID Podmore
- IG Stiell
- IJ Diel
- IJ Furlong
- IM Shih
- IS Mehta
- IV Bijnsdorp
- J Candelario
- J Espada
- J Grohm
- J Halaschek-Wiener
- J Halaschek-Wiener
- J Haspel
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- JB Kelley
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- JG Pastorino
- JH Lai
- JH Scarpello
- JH Yoon
- JJ Gills
- JJ Graziotto
- JK Molitoris
- JK Wolford
- JL Mesa
- JL Scarlett
- JM Bridger
- JM Li
- JN Badham
- JP Gagne
- JP Magalhaes de
- JP Magalhaes de
- JR Berenson
- JW Tullai
- K Ariyoshi-Kishino
- K Cao
- K Cao
- K Duesing
- K Jing
- K McLean
- K Shimada
- Kieran J. Guinan
- KN Conneely
- KR Owen
- L Cai
- L Jia
- L Lim
- L Silva
- L Wegner
- LG Fong
- LG Fong
- LP Xia
- LR Goldfrank
- M Bahro
- M Columbaro
- M Dam
- M Deininger
- M Eriksson
- M McCall
- M Urbanek
- Maria Litovchenko
- MC Wei
- MD Bareford
- ML Marino
- MP Curran
- MV Blagosklonny
- N Bae
- N Khunger
- N Meng
- N Savaraj
- N Singh
- N Sylvius
- N Takebe
- N Xiong
- NI Steinle
- NR Pumford
- P Hundeshagen
- P Mainguet
- P Major
- P Maycotte
- P Scaffidi
- P Scaffidi
- PB Tirupathi Pichiah
- PG Komarov
- PL Cole
- PM Perera
- PO Bauer
- Q Jiang
- Q Lin
- Q Remijsen
- Q Wang
- Q Zhang
- R Damico
- R Gunaratne
- R Siman
- R Varga
- R Vieth
- RA Hegele
- RA Rober
- RA Rober
- RD Goldman
- RJ Lutz
- RJ Yanez-Munoz
- RK Lin
- RL Pollex
- RS Sandler
- S Cherqui
- S Claerhout
- S Daido
- S Kobayashi
- S Komatsu
- S Lee
- S Pattingre
- S Pattingre
- S Phuphanich
- S Reddy
- S Rodriguez
- S Schenone
- S Shen
- S Shen
- S Suzuki
- SA Lee
- SA Richards
- SD Georgatos
- SE Nsimba
- SG Pfisterer
- SH Yang
- SH Yang
- SH Yang
- SR Vink
- SS Ramalingam
- SY Chen
- SY Liu
- T Dechat
- T Dechat
- T Dechat
- T Tomita
- T Zhang
- TB Brunner
- The International HapMap Consortium
- TS Bekaii-Saab
- U Kruger
- V Cenni
- V Deretic
- V Krishnan
- VA Rao
- VL Verstraeten
- W Bursch
- W Chu
- WA Vloten van
- WE Stehbens
- WX Ding
- WY Shi
- X Feng
- X Li
- X Zeng
- Y Chen
- Y Fujisaka
- Y Maekawa
- Y Murase
- Y Pan
- Y Rajawat
- Y Rajawat
- Y Tong
- YC Ye
- YH Han
- Z Liu
- Z Liu
- Zeljka Smit-McBride
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Localization and broadband follow-up of the gravitational-wave transient GW150914
- Author
- Abbott BP
- Abbott FTBOOTESCTMC
- Abdalla FB
- Abe FTINF
- Ackermann FTFGBMCM
- Ackley K
- Adame JA
- Adams C
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- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar OD
- Aiello L
- Ain A
- Ajello M
- Ajith P
- Albert A
- Allam S
- Allen B
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- Allison TVCJ
- Allocca A
- Altin PA
- Amati L
- Anderson B
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- Anderson SB
- Anderson WG
- Annis J
- Antonelli LA
- Aptekar RL
- Arai K
- Araya MC
- Arceneaux CC
- Areeda JS
- Armstrong R
- Arnaud N
- Array FTLF
- Array FTMW-F
- Arun KG
- Ascenzi S
- Ashton G
- Ast M
- Aston SM
- Astone P
- Atwood WB
- Aufmuth P
- Aulbert C
- Axelsson M
- Babak S
- Bacon P
- Bader MKM
- Bai J
- Baiardi LC
- Bakel NV
- Baker PT
- Balanutsa P
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Baltay FTJ-GEMCC
- Banerji M
- Bannister K
- Barayoga JC
- Barbiellini G
- Barclay SE
- Barish BC
- Barker D
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- Barr B
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy S
- Bartlett J
- Bartos I
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Baune C
- Bavigadda V
- Bazzan M
- Bazzano A
- Behnke B
- Bejger M
- Bell AS
- Bell CJ
- Bell ME
- Bellazzini R
- Bellm E
- Benacquista M
- Benoit-Lévy A
- Berger BK
- Berger E
- Bergman J
- Bergmann G
- Bernstein RA
- Beroiz CCM
- Berry CPL
- Bersanetti D
- Bersier D
- Bertin E
- Bertolini A
- Betzwieser J
- Beuzekom MV
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhat PN
- Bilenko IA
- Billingsley G
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- Birney R
- Biscans S
- Bisht A
- Bissaldi E
- Bissaldi E
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blair CD
- Blair DG
- Blair RM
- Blandford RD
- Bloemen S
- Bloom ED
- Bock O
- Bode MF
- Bodiya TP
- Boer M
- Bogaert G
- Bogan C
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- Boschi V
- Bose S
- Bottacini E
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- Bouffanais Y
- Bozzi A
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- Bradaschia C
- Brady PR
- Braginsky VB
- Branchesi M
- Brand JFJVD
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- Brandt TJ
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- Briant T
- Briggs MS
- Brillet A
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- Brockill P
- Broeck CVD
- Brooks AF
- Brout D
- Brown DA
- Brown DD
- Brown NM
- Bruel P
- Buchanan CC
- Buckley D
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- Budnev NM
- Buikema A
- Bulik T
- Bulten HJ
- Buonanno A
- Burke DL
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- Caballero-García MD
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- Cahillane C
- Caliandro GA
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- Camp JB
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- Cano Z
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- Capano CD
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- Publication venue
- IOP PUBLISHING LTD
- Publication date
- Field of study
A gravitational-wave transient was identified in data recorded by the Advanced LIGO detectors on 2015 September 14. The event candidate, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the gravitational wave data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network Circulars, giving an overview of the participating facilities, the gravitational wave sky localization coverage, the timeline and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the electromagnetic data and results of the electromagnetic follow-up campaign will be disseminated in the papers of the individual teams
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