67 research outputs found
Inteligencia emocional en los trabajadores de una empresa privada del rubro de servicios de Lima Metropolitana, 2019
La presente investigación titulada “Inteligencia emocional en los trabajadores de una
empresa privada del rubro de servicios de Lima Metropolitana, 2019”, tuvo como objetivo
general determinar el nivel de la variable Inteligencia Emocional, en los trabajadores.
El tipo de estudio es descriptivo, el diseño es no experimental y de corte transversal.
La población está conformada por 65 trabajadores. Para la medición de la Inteligencia
emocional se utilizó el inventario ICE de Bar-On adaptado a la realidad peruana por Nelly
Ugarriza Chávez. Está formado de 133 ítems, tipo Likert con cinco opciones de respuesta,
evalúa el cociente emocional general compuesto por cinco componentes: intrapersonal,
interpersonal, adaptabilidad, manejo de estrés y estado de ánimo. A través del Alfa de
Cronbach, se confirmó la confiabilidad de la prueba, cuyo resultado fue 0,885. La base de
datos se procesó en el software estadístico SPSS versión 24.
Finalmente, los resultados de la investigación, de acuerdo con el objetivo general
planteado, el nivel de la inteligencia emocional en los trabajadores es de 50.77% (nivel
promedio), 46.15% (nivel bajo) y 3.08% (nivel extremadamente bajo). Existe un mayor
porcentual del nivel promedio
The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent.
BACKGROUND AND AIMS
Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as a mediator for ALD progression and hypothesize that targeting MCJ may help in recovering mitochondrial fitness without collateral oxidative damage.
APPROACH AND RESULTS
C57BL/6 mice [wild-type (Wt)] Mcj knockout and Mcj liver-specific silencing (MCJ-LSS) underwent the NIAAA dietary protocol (Lieber-DeCarli diet containing 5% (vol/vol) ethanol for 10 days, plus a single binge ethanol feeding at day 11). To evaluate the impact of a restored mitochondrial activity in ALD, the liver, gut, and pancreas were characterized, focusing on lipid metabolism, glucose homeostasis, intestinal permeability, and microbiota composition. MCJ, a protein acting as an endogenous negative regulator of mitochondrial respiration, is downregulated in the early stages of ALD and increases with the severity of the disease. Whole-body deficiency of MCJ is detrimental during ALD because it exacerbates the systemic effects of alcohol abuse through altered intestinal permeability, increased endotoxemia, and dysregulation of pancreatic function, which overall worsens liver injury. On the other hand, liver-specific Mcj silencing prevents main ALD hallmarks, that is, mitochondrial dysfunction, steatosis, inflammation, and oxidative stress, as it restores the NAD + /NADH ratio and SIRT1 function, hence preventing de novo lipogenesis and improving lipid oxidation.
CONCLUSIONS
Improving mitochondrial respiration by liver-specific Mcj silencing might become a novel therapeutic approach for treating ALD.This work was supported by grants from Ministerio de
Ciencia e Innovación, Programa Retos-Colaboración
RTC2019-007125-1 (for Jorge Simon and Maria Luz
Martinez-Chantar); Ministerio de Economía, Industria y
Competitividad, Retos a la Sociedad AGL2017-
86927R (for F.M.); Instituto de Salud Carlos III,
Proyectos de Investigación en Salud DTS20/00138
and DTS21/00094 (for Jorge Simon and Maria Luz
Martinez-Chantar, and Asis Palazon. respectively);
Instituto de Salud Carlos III, Fondo de Investigaciones
Sanitarias co-founded by European Regional
Development Fund/European Social Fund, “Investing
in your future” PI19/00819, “Una manera de
hacer Europa” FIS PI20/00765, and PI21/01067 (for
Jose J. G. Marin., Pau Sancho-Bru,. and Mario F.
Fraga respectively); Departamento de Industria del
Gobierno Vasco (for Maria Luz Martinez-Chantar);
Asturias Government (PCTI) co-funding 2018-2023/
FEDER IDI/2021/000077 (for Mario F. Fraga.);
Ministerio de Ciencia, Innovación y Universidades
MICINN: PID2020-117116RB-I00, CEX2021-001136-S
PID2020-117941RB-I00, PID2020-11827RB-I00 and
PID2019-107956RA-100 integrado en el Plan Estatal
de Investigación Científica y Técnica y Innovación,
cofinanciado con Fondos FEDER (for Maria Luz Martinez-Chantar, Francisco J Cubero., Yulia A Nevzorova
and Asis Palazon); Ayudas Ramón y Cajal de la Agencia
Estatal de Investigación RY2013-13666 and RYC2018-
024183-I (for Leticia Abecia and Asis Palazon); European Research Council Starting Grant 804236 NEXTGEN-IO (for Asis Palazon); The German Research
Foundation SFB/TRR57/P04, SFB1382-403224013/
A02 and DFG NE 2128/2-1 (for Francisco J Cubero
and Yulia A Nevzorova); National Institute of Health (NIH)/National Institute of Alcohol Abuse and Alcoholism
(NIAAA) 1U01AA026972-01 (For Pau Sancho-Bru);
Junta de Castilla y León SA074P20 (for Jose J. G.
Marin); Junta de Andalucía, Grupo PAIDI BIO311 (for
Franz Martin); CIBERER Acciones Cooperativas y
Complementarias Intramurales ACCI20-35 (for Mario F.
Fraga); Ministerio de Educación, Cultura y Deporte
FPU17/04992 (for Silvia Ariño); Fundació Marato TV3
201916-31 (for Jose J. G. Marin.); Ainize Pena-Cearra is
a fellow of the University of the Basque Country (UPV/
EHU); BIOEF (Basque Foundation for Innovation and
Health Research); Asociación Española contra el Cáncer
(Maria Luz Martinez-Chantar and Teresa C. Delgado.);
Fundación Científica de la Asociación Española Contra
el Cáncer (AECC Scientific Foundation) Rare Tumor
Calls 2017 (for Maria Luz Martinez-Chantar); La Caixa
Foundation Program (for Maria Luz Martinez-Chantar);
Proyecto Desarrollo Tecnologico CIBERehd (for Maria
Luz Martinez-Chantar); Ciberehd_ISCIII_MINECO is
funded by the Instituto de Salud Carlos III.S
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences
The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported
by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on
18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based
researchers who signed it in the short time span from 20 September to 6 October 2016
Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV
Peer reviewe
Inteligencia emocional en los trabajadores de una empresa privada del rubro de servicios de Lima Metropolitana, 2019
La presente investigación titulada “Inteligencia emocional en los trabajadores de una
empresa privada del rubro de servicios de Lima Metropolitana, 2019”, tuvo como objetivo
general determinar el nivel de la variable Inteligencia Emocional, en los trabajadores.
El tipo de estudio es descriptivo, el diseño es no experimental y de corte transversal.
La población está conformada por 65 trabajadores. Para la medición de la Inteligencia
emocional se utilizó el inventario ICE de Bar-On adaptado a la realidad peruana por Nelly
Ugarriza Chávez. Está formado de 133 ítems, tipo Likert con cinco opciones de respuesta,
evalúa el cociente emocional general compuesto por cinco componentes: intrapersonal,
interpersonal, adaptabilidad, manejo de estrés y estado de ánimo. A través del Alfa de
Cronbach, se confirmó la confiabilidad de la prueba, cuyo resultado fue 0,885. La base de
datos se procesó en el software estadístico SPSS versión 24.
Finalmente, los resultados de la investigación, de acuerdo con el objetivo general
planteado, el nivel de la inteligencia emocional en los trabajadores es de 50.77% (nivel
promedio), 46.15% (nivel bajo) y 3.08% (nivel extremadamente bajo). Existe un mayor
porcentual del nivel promedio
Discovering HIV related information by means of association rules and machine learning
Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts
Comprensión y Producción de Lenguaje I - HU543 - 202102
Descripción:
Comprensión y Producción de Lenguaje 1 es un curso de primer ciclo, que busca desarrollar las habilidades
vinculadas con la comprensión lectora y la redacción de textos escritos formales y adecuados a una situación
comunicativa determinada. Por ello, durante el curso, las actividades posibilitarán que el estudiante reflexione
sobre cómo el lenguaje es una herramienta que nos permite entender la realidad (comprensión) y comunicar
adecuadamente nuestras ideas sobre ella (producción). Esta reflexión se realizará con énfasis en el uso del
lenguaje en las redes sociales, espacio que se ha constituido como un nuevo lugar para la divulgación de asuntos
diversos: desde temas de ocio o entretenimiento hasta temas académicos, científicos y políticos. En ese sentido,
este curso propone que el alumno asuma el rol de un ciudadano crítico, es decir, aquella persona que no solo
consume información, sino que produce contenido a partir de una investigación en fuentes confiables.
Considerando lo explicado, nuestros alumnos no solo serán capaces de redactar un texto escrito formal de
acuerdo con las necesidades comunicativas del ámbito universitario y de la sociedad actual, sino que podrán
transformarlo en un texto multimodal (el cual involucra diferentes medios de comunicación: visual, auditivo,
imagen, texto, entre otros) que tenga sentido en las redes sociales, lugar de interacción real con sus lectores.
Estos productos comunicativos deberán presentar una organización conveniente, un desarrollo sólido y
suficiente (lo que implica una lectura crítica de las fuentes de información), y una escritura acorde con la
normativa vigente.
Propósito:
El curso desarrolla la competencia de comunicación escrita, en el nivel 1; es decir, el estudiante es capaz de
construir mensajes coherentes y sólidos que se adecúan a la situación y propósito comunicativo. Este desarrollo
le permite la generación y construcción de nuevas ideas, lo cual es relevante para su vida académica y
profesional. La actual sociedad de la información y el conocimiento, caracterizada por la disrupción, la
innovación y la complejidad en las formas de comunicación mediadas por la tecnología, enfrenta al estudiante y
al profesional a nuevos retos en las maneras de comunicar aquello que conoce y que construye. En este
escenario, la competencia comunicativa escrita adquiere protagonismo como herramienta para transmitir el
conocimiento creado. El curso se alinea con esta exigencia, pues contribuye a que el estudiante responda
exitosamente a las demandas comunicativas del contexto académico, y a que el egresado pueda desenvolverse
idóneamente en el campo profesional y laboral
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