Examining the Interplay of Knowledge, Attitudes, Practices, and Clinical Indicators in Obesity, Diabetes, and Hypertension among Overweight and Obese Individuals in Douala, Cameroon

Background: Global obesity has risen significantly since 1975, with a marked increase in Cameroon. This leads to metabolic syndrome (MetS) due to energy imbalance and other factors. Addressing MetS requires a comprehensive approach involving lifestyle changes and medical interventions. This study investigates the Knowledge, Attitude, and Practice (KAP) related to obesity, diabetes, and hypertension, and examines clinical parameters among overweight and obese individuals in Douala, Cameroon.Methodology: A cross-sectional study was conducted using structured questionnaires to gather data on KAP. Clinical parameters including glycaemia, blood pressure, and pulse rate were measured. The data was analyzed to understand the correlation between KAP and clinical parameters, and the impact of socio-demographic factors and medical history.Results: The study found that despite having sufficient knowledge and a positive attitude, a significant number of individuals don’t apply preventive or management measures for obesity, diabetes, and hypertension. Socio-demographic factors and medical history also influence these health indicators. Interestingly, over half of the participants had high blood pressure, while most had normal glycaemia and pulse rate. The study highlights the complex relationship between KAP and clinical parameters, stressing the need for comprehensive education and intervention. The findings suggest that improving KAP could indirectly help control clinical parameters.Conclusion: This study emphasizes the role of KAP in managing obesity-related conditions. It calls for strategies that improve these aspects and regular health monitoring. The findings can guide healthcare strategies for obesity management

Le Perthus – Panissars

Date de l'opération : 1985 - 1993 (FP) ; 1984 (SD) Inventeur(s) : Castellvi Georges ; Nolla Josep Maria ; Rodà Isabel Localisation Les ruines superposées des édifices sont situées au col de Panissars (335 m), partie en France (pour les 2/3), partie en Espagne (pour 1/3) [ (Fig. n°1 : Plan des ruines du trophée de Pompée et du prieuré médiéval Sainte-Marie) et (Fig. n°2 : Ruines du prieuré médiéval et du trphée républicain de Panissars)]. Depuis plus de deux mille ans, ce col et son voisin, l..

The Importance of Diagenetic Processes in Sandstones Facies of the Hamakoussou Sedimentary Basin in North Cameroon: Influence on Reservoir Quality.

Published studies in the Hamakoussou reservoir sandstones are very few and the characterization of the reservoir quality including diagenesis is unknown. In this paper, after lithological reports, classical petrographic techniques have been used to study the diagenesis and reservoir quality of the Hamakoussou sandstones: Diagenetic processes within and around detrital grains show that early cementation by calcite come from volcanic veins and late cementation originating from silicification. Diagenetic phenomena (early cementation, compaction, fracturation and late cementation) show that these sandstones have a low porosity due to the blockage of intergranular pore spaces by cement. Intense volcanic activity associated with the circulation of fluids (silica and calcite) as well as the dissolution along the contacts of quartz grains are the principal sources of early and late cements which are responsible for the decrease in porosity observed in these sandstones. The immediate consequence is the sudden drying up of boreholes drilled for water supply

Somatic genetic alterations predict hematological progression in GATA2 deficiency

Germline GATA2 mutations predispose to myeloid malignancies resulting from the progressive acquisition of additional somatic mutations. Here we describe clinical and biological features of 78 GATA2-deficient patients. Hematopoietic stem and progenitor cell phenotypic characterization revealed an exhaustion of myeloid progenitors. Somatic mutations in STAG2, ASXL1 and SETBP1 genes along with cytogenetic abnormalities (monosomy 7, trisomy 8, der(1;7)) occurred frequently in patients with GATA2 germline mutations. Patients were classified into three hematopoietic spectra based on bone marrow cytomorphology. No somatic additional mutations were detected in patients with normal bone marrow (spectrum 0), whereas clonal hematopoiesis mediated by STAG2 mutations was frequent in those with a hypocellular and/or myelodysplastic bone marrow without excess blasts (spectrum 1). Finally, SETBP1, RAS pathway and RUNX1 mutations were predominantly associated with leukemic transformation stage (spectrum 2), highlighting their implications in the transformation process. Specific somatic alterations, potentially providing distinct selective advantages to affected cells, are therefore associated with the clinical/hematological evolution of GATA2 syndrome. Our study not only suggests that somatic genetic profiling will help clinicians in their management of patients, but will also clarify the mechanism of leukemogenesis in the context of germline GATA2 mutations

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015. We calculated DALYs by summing years of life lost (YLLs) and years of life lived with disability (YLDs) for each geography, age group, sex, and year. We estimated HALE using the Sullivan method, which draws from age-specific death rates and YLDs per capita. We then assessed how observed levels of DALYs and HALE differed from expected trends calculated with the Socio-demographic Index (SDI), a composite indicator constructed from measures of income per capita, average years of schooling, and total fertility rate. FINDINGS: Total global DALYs remained largely unchanged from 1990 to 2015, with decreases in communicable, neonatal, maternal, and nutritional (Group 1) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). Much of this epidemiological transition was caused by changes in population growth and ageing, but it was accelerated by widespread improvements in SDI that also correlated strongly with the increasing importance of NCDs. Both total DALYs and age-standardised DALY rates due to most Group 1 causes significantly decreased by 2015, and although total burden climbed for the majority of NCDs, age-standardised DALY rates due to NCDs declined. Nonetheless, age-standardised DALY rates due to several high-burden NCDs (including osteoarthritis, drug use disorders, depression, diabetes, congenital birth defects, and skin, oral, and sense organ diseases) either increased or remained unchanged, leading to increases in their relative ranking in many geographies. From 2005 to 2015, HALE at birth increased by an average of 2·9 years (95% uncertainty interval 2·9-3·0) for men and 3·5 years (3·4-3·7) for women, while HALE at age 65 years improved by 0·85 years (0·78-0·92) and 1·2 years (1·1-1·3), respectively. Rising SDI was associated with consistently higher HALE and a somewhat smaller proportion of life spent with functional health loss; however, rising SDI was related to increases in total disability. Many countries and territories in central America and eastern sub-Saharan Africa had increasingly lower rates of disease burden than expected given their SDI. At the same time, a subset of geographies recorded a growing gap between observed and expected levels of DALYs, a trend driven mainly by rising burden due to war, interpersonal violence, and various NCDs. INTERPRETATION: Health is improving globally, but this means more populations are spending more time with functional health loss, an absolute expansion of morbidity. The proportion of life spent in ill health decreases somewhat with increasing SDI, a relative compression of morbidity, which supports continued efforts to elevate personal income, improve education, and limit fertility. Our analysis of DALYs and HALE and their relationship to SDI represents a robust framework on which to benchmark geography-specific health performance and SDG progress. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform financial and research investments, prevention efforts, health policies, and health system improvement initiatives for all countries along the development continuum. FUNDING: Bill & Melinda Gates Foundation

Maternal exposure to pesticides and risk of childhood lymphoma in France: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Background: Few studies have assessed the relation between maternal prenatal pesticides use and childhood lymphoma risk, some reporting a positive association with non-Hodgkin lymphoma (NHL). We investigated the association between maternal exposure to pesticides during pregnancy and childhood Hodgkin (HL) and non-Hodgkin lymphoma.Methods: We pooled data from the two French national population-based case-control studies ESCALE (2003-2004) and ESTELLE (2010-2011). Data on domestic and occupational exposures to pesticides during pregnancy were obtained through standardised maternal interviews. Logistic regression models were used to compute odds ratios (OR) and 95% confidence intervals (CI) for HL and NHL, by pesticide category adjusted for potential confounders. Analyses by histological subtypes were also performed.Results: We included 328 H L, 305 non-Hodgkin NHL and 2,415 controls. Around 40% of control mothers reported having used pesticides during index pregnancy, of whom 95% reported insecticides use. Maternal use of herbicides and fungicides occurred mostly in combination with insecticides. Insecticides use was more frequently reported in cases than controls (ORNHL = 1.6 [95%CI 1.3-2.1], p = 0.0001; ORHL = 1.3 [95%CI 1.0-1.7], p = 0.03). This association appeared more marked for Burkitt lymphoma and mixed cellularity classical HL. No obvious association was observed with occupational pesticides exposure during pregnancy.Conclusion: These results suggest that maternal domestic use of insecticides during pregnancy might be related to both childhood NHL and HL. Further larger studies are urgently needed

Thrombopoietin receptor agonists as an emergency treatment for severe newly diagnosed immune thrombocytopenia in children

International audienc

First 2D and 3D interpretative models of sedimentation in the Cretaceous Hama-koussou sedimentary basin: Litho-bio-stratigraphy and palaeoenvironment records

The Hama-Koussou Basin is one of the offset structures of the eastern end of the Benue Trough in Northern Cameroon. This sedimentary basin is an asymmetrical syncline whose axis is strongly shifted towards the East, filled predominantly with Cretaceous deposits, The basin has experienced at least three (3) phases of sedimentation during its geological history: two (2) fluvial phases with one at the top and the second at the bottom consisting of conglomerate, micro-conglomerate, and sandstone, sandwiching one fluvio-lacustrine phase consisting of fossiliferous claystones and marlstones with intercalations of siltstones and carbonate cemented fine sandstone. Numerous sedimentary structures including planar, oblique, and cross stratifications, convolute bedding, desiccation cracks, ripple marks and loadcast have been recorded. The mineral assemblage is dominated by quartz, plagioclase, mica and microcline, accompagnied by diagenetic phases (iron oxide, silica and carbonate). Clay minerals consist of kaolinite, illite and chlorite/smectite. Palynofloral analysis reveals various taxa indicative of a fluvio-lacustrine environment: These include Classopollis sp., Eucommiidites sp., Concavisporites sp., Cicatricosisporites sp, Araucariacites australis, Callialasporites dampieri, Callialasporites microvelatus. The occurrence of Callialasporites microvelatus confirms the Cretaceous age whereas age determination for all other samples was uncertain due to scarcity in palynomorphs. Low numbers of bisaccate, grass, and other angiosperm pollen grains may be indicative of a Cenozoic or younger age, although contamination by modern pollens cannot be excluded.The region experienced volcanism represented by explosive and effusive phases, recorded as sills and dykes. Plutonism is characterized by the establishment of intrusive granite. The East-West elongation observed in the HSB is the same in the Mayo-Oulo-Lere and Babouri Figuil basins and can be interpreted as the result of the same tectonic event linked to the opening of the Atlantic Ocean resulting in the formation of the Benue Trough and adjoins basins