Kajian Bentuk Dan Sensitivitas Rumus Indeks Pi, Storet, Ccme Untuk Penentuan Status Mutu Perairan Sungai Tropis Di Indonesia (Assessment of the Forms and Sensitivity of the Index Formula Pi, Storet, Ccme for the Determination of Water Quality Status)

Metode-metode Pollution Index (USA), metode Storet (USA) dan metode CCME (Canada) adalah metode indeks kualitas air (IKA) untuk penentuan status mutu air. Dua yang pertama banyak digunakan praktisi lingkungan di Indonesia karena dirujuk dalam Keputusan Menteri Lingkungan Hidup No. 115/2013. Ketiganya dapat menghitung IKA dengan baku mutu kualitas air lokal sungai kajian. Mengingat negara penyusun metode tersebut berbeda kondisi lingkungannya dan masing-masing metode mempunyai faktor spesifik untuk menghitung IKA, maka perlu dikaji kesesuaian masing-masing metode untuk diterapkan di sungai tropis Indonesia. Masing-masing metode akan dikaji bentuk persamaan dan sensitivitasnya dengan menggunakan banyak parameter kualitas air dan menggunakan jumlah parameter kualitas air tertentu mengacu pada metode IKA yang dikembangkan di negara tropis lainnya. Kajian menggunakan data pemantauan “Prokasih” di sungai Gadjah Wong Yogyakarta tahun 1996/1997 - 2011/2012. Penelitian ini dilakukan dalam rangka menyusun metode IKA sungai tropis Indonesia pada umumnya dan di sungai Gadjah Wong khususnya serta program pengelolaan kualitas air untuk pengendalian pencemaran air sungai, dengan target konservasi air sungai yang multifungsi atau overall/general use(memenuhi kriteria kesehatan air baku, memenuhi kriteria estetika serta kriteria ekologi/aman bagi kehidupan di perairan). Hasil kajian menunjukkan bahwa dibandingkan 2 metode lainnya, metode CCME dinilai paling obyektif (secara statistik) menghitung IKA perairan sungai Gadjah Wong. CCME paling sensitif merespon dinamika indeks mutu air di setiap lokasi pemantauan, lebih universal untuk dapat diaplikasikan di luar negara penyusunnya. Namun untuk diaplikasikan di sungai Gadjah Wong, metode CCME perlu diadaptasi terhadap beberapa hal yaitu jumlah dan jenis parameter kualitas air yang dianggap signifikan, jumlah dan kelas mutu air. Adaptasi mempertimbangkan program pengendalian pencemaran air dan strategi operasional/manajemen aliran sungai yang ekologis dan berkelanjutan. Skor batas dan makna setiap kelas mutu air dalam IKA harus diverifikasi terhadap data lingkungan lain misal hasil biotilik ataupun bioassay sehingga status indeks kualitas air tidak bertentangan dengan kondisi biologi di sungai. Pelibatan parameter bakteriologi kualitas air (Escherichia Coli dan Total Coliform) serta Electric Conductivity/EC sebagai parameter kualitas air signifikan dalam metode IKA masih perlu dikaji lebih lanjut untuk pengembangan metode IKA khas perairan sungai di negara tropis Indonesia

Effect of Fibrinolytic Therapy on ST-Elevation Myocardial Infarction Clinical Outcomes during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis

BACKGROUND: ST-elevation myocardial infarction (STEMI) is the result of transmural ischemia of the myocardium and is associated with a high mortality rate. Primary percutaneous coronary intervention (PPCI) is the recommended first-line treatment strategy for patients with STEMI. The timely delivery of PPCI became extremely challenging for STEMI patients during the coronavirus disease 2019 (COVID-19) pandemic, leading to a projected steep rise in mortality. These delays were overcome by the shift from first-line therapy and the development of modern fibrinolytic-based reperfusion. It is unclear whether fibrinolytic-based reperfusion therapy is effective in improving STEMI endpoints. AIM: To determine the incidence of fibrinolytic therapy during the COVID-19 pandemic and its effects on STEMI clinical outcomes. METHODS: PubMed, Google Scholar, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were queried from January 2020 up to February 2022 to identify studies investigating the effect of fibrinolytic therapy on the prognostic outcome of STEMI patients during the pandemic. Primary outcomes were the incidence of fibrinolysis and the risk of all-cause mortality. Data were meta-analyzed using the random effects model to derive odds ratios (OR) and 95% confidence intervals. Quality assessment was carried out using the Newcastle-Ottawa scale. RESULTS: Fourteen studies including 50136 STEMI patients (n = 15142 in the pandemic arm; n = 34994 in the pre-pandemic arm) were included. The mean age was 61 years; 79% were male, 27% had type 2 diabetes, and 47% were smokers. Compared with the pre-pandemic period, there was a significantly increased overall incidence of fibrinolysis during the pandemic period [OR: 1.80 (1.18 to 2.75); I2= 78%; P = 0.00; GRADE: Very low]. The incidence of fibrinolysis was not associated with the risk of all-cause mortality in any setting. The countries with a low-and middle-income status reported a higher incidence of fibrinolysis [OR: 5.16 (2.18 to 12.22); I2 = 81%; P = 0.00; GRADE: Very low] and an increased risk of all-cause mortality in STEMI patients [OR: 1.16 (1.03 to 1.30); I2 = 0%; P = 0.01; GRADE: Very low]. Meta-regression analysis showed a positive correlation of hyperlipidemia (P = 0.001) and hypertension (P \u3c 0.001) with all-cause mortality. CONCLUSION: There is an increased incidence of fibrinolysis during the pandemic period, but it has no effect on the risk of all-cause mortality. The low- and middle-income status has a significant impact on the all-cause mortality rate and the incidence of fibrinolysis

Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

Production costs have been covered by ESMO from central funds

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

Early stent fractures in superficial femoral artery resulting multiple pseudoaneurysm formation within one year: a case report

Abstract Background Though fracture is known complication of stenting, pseudoaneurysm asscoiated with stent fracture is an extremely rare complication. This has previoulsy been described to occur at least one or more years following initial stent placement. Here we present a case of multi-site stent fracture leading to two separate SFA pseudoaneurysms within one year of placement, successfully treated with covered stents. Case presentation A 72-year-old male presented with severe claudication of his left lower extremity (Rutherford 3), found to have long segment SFA chronic total occlusion (CTO). Patient successfully underwent endovascular revascularization. Follow-up duplex ultrasound (US) at one year demonstrated a focus of severe in-stent restenosis (ISR). During repeat angiogram for treatment of the stenosis, stent fracture and pseudoaneurysm was seen in the distal SFA, which was treated successfully with a self-expanding covered stent. Additional stent fractures and pseudoanerusyms were subseuqently identified on follow-up, necessitating a third angiogram, and these were successfully repaired using overlapping covered stents, without further recurrence. Conclusions Superficial femoral artery stent fractures leading to pseudoaneurysms are extremely rare, particularly within first year of stent placement. Endovascular repair with covered stents has proven to be an effective treatment option with decreased procedural morbidity compared to surgical repair

Tumor therapeutic response monitored by telemetric temperature sensing, a preclinical study on immunotherapy and chemotherapy

Abstract Temperature in the body and the tumor reflects physiological and pathological conditions. A reliable, contactless, and simplistic measurement system can be used for long-term monitoring of disease progression and therapy response. In this study, miniaturized battery-free wireless chips implanted into growing tumors on small animals were used to capture both basal and tumor temperature dynamics. Three preclinical models: melanoma (B16), breast cancer (4T1), and colon cancer (MC-38), were treated with adoptive T cell transfer, AC-T chemotherapy, and anti-PD-1 immunotherapy respectively. Each model presents a distinctive pattern of temperature history dependent on the tumor characteristic and influenced by the administered therapy. Certain features are associated with positive therapeutic response, for instance the transient reduction of body and tumor temperature following adaptive T cell transfer, the elevation of tumor temperature following chemotherapy, and a steady decline of body temperature following anti-PD-1 therapy. Tracking in vivo thermal activity by cost-effective telemetric sensing has the potential of offering earlier treatment assessment to patients without requiring complex imaging or lab testing. Multi-parametric on-demand monitoring of tumor microenvironment by permanent implants and its integration into health information systems could further advance cancer management and reduce patient burden

COVID-19-associated MRSA infective endocarditis and mitral valve perforation: a case report

Abstract Background Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic, leading to significant morbidity and mortality. The interplay between COVID-19 and other medical conditions can complicate diagnosis and management, necessitating further exploration. Case presentation This case report presents a patient with COVID-19 who developed infective endocarditis (IE) and mitral valve perforation caused by methicillin-resistant Staphylococcus aureus on a native mitral valve. Notably, the patient did not exhibit typical IE risk factors, such as intravenous drug use. However, he did possess risk factors for bacteremia, including a history of diabetes mellitus and recent steroid use due to the COVID-19 infection. The diagnosis of IE was crucially facilitated by transesophageal echocardiography. Conclusions This case highlights the potential association between COVID-19 and the development of infective endocarditis. Prompt evaluation using transesophageal echocardiography is vital when there is a high suspicion of IE in COVID-19 patients. Further research is required to elucidate the precise relationship between COVID-19 and IE