Long-Term Safety of Tedizolid in a Patient With Spondilodiscitis After Switch From Linezolid Due to Toxicity

The patient is a 57-year-old man with liver cirrhosis, Bricker anastomosis after a radical cystoprostatectomy and, a history of bacteremias caused by extended-spectrum -lactamase-positive Escherichia coli, Enterococcus faecium, and Candida albicans. He presented with persistent low back pain and was diagnosed with vertebral osteomyelitis, for which he received ertapenem-linezolid treatment. However, after 20 days, linezolid had to be discontinued because of myelotoxicity and metabolic acidosis. The patient was switched to tedizolid, which, in combination with ertapenem, was successfully given for 114 days until biopsy showed no growth of gram-positive cocci. We conclude that tedizolid can be an alternative to linezolid in case of toxicity, especially in long-term treatments

Patentometric: monitoring the scientific and technological trends of Additive Manufacturing in Medical Applications

[EN] Patents are a means of protecting inventions developed by firms, institutions or individuals, and they may be interpreted as indicators of invention. Patents indicators convey information on the processes of inventive activities. Therefore, patent statistics will assess science and technology (S&T) activities. Besides, additive manufacturing (AM) has become a revolutionary technology that is changing medical science. For this reason, the patent statistics will allow us to monitor what is the state of the inventive activity of AM in medical applications. The database used in order to retrieve patent information is Patseer and the data have been analyzed through the analytics package called Quick Stats. From the data obtained, it can be concluded that, additive manufacturing in medical applications is an emerging technology with huge market potential. Undoubtedly, the core of invention is located in United States, followed by Germany, United Kingdom and China somewhat behind. Firms are the main holders of legal rights, and the firm’s market value and the knowledge diffusion of technology are ensured by the technological diversity and the number of forward citations presented by patents.Alvarez-Meaza, I.; Zarrabeitia-Bilbao, E.; Rio-Belver, R.; Martinez De Alegria, I.; Bildosola, I. (2019). Patentometric: monitoring the scientific and technological trends of Additive Manufacturing in Medical Applications. International Journal of Production Management and Engineering. 7(Número Especial):65-72. https://doi.org/10.4995/ijpme.2019.10789SWORD65727Número EspecialASTM. (2015). ISO / ASTM52900-15, standard terminology for additive manufacturing - general principles - termi-nology. West Conshohocken, PA: ASTM International.Atzeni, E., & Salmi, A. (2012). Economics of additive manufacturing for end-usable metal parts. The International Journal of Advanced Manufacturing Technology, 62(9-12), 1147-1155. https://doi.org/10.1007/s00170-011-3878-1Galati, M., & Iuliano, L. (2018). A literature review of powder-based electron beam melting focusing on numerical simulations. Additive Manufacturing, 19, 1-20. https://doi.org/10.1016/j.addma.2017.11.001Gibson, I., Rosen, D. W., & Stucker, B. (2010). Additive manufacturing technologies. NY: Springer. https://doi.org/10.1007/978-1-4419-1120-9GridLogics. (2014). 3D printing: An analysis of patenting activity around 3D-printing from 1990-current GridLogics Technologies Pvt Ltd.Hopkinson, N., & Dickens, P. (2006). Emerging rapid manufacturing processes. Rapid manufacturing (pp. 55-80) John Wiley & Sons, Ltd. https://doi.org/10.1002/0470033991.ch5Jin, Y., Ji, S., Li, X., & Yu, J. (2017). A scientometric review of hotspots and emerging trends in additive manufactur-ing. Journal of Manufacturing Technology Management, 28(1), 18-38. https://doi.org/10.1108/JMTM-12-2015-0114Lerner, J. (1994). The importance of patent scope: An empirical analysis RAND Journal of Economics, 25(2), 319-333.Mellor, S., Hao, L., & Zhang, D. (2014). Additive manufacturing: A framework for implementation. International Jour-nal of Production Economics, 149, 194-201. https://doi.org/10.1016/j.ijpe.2013.07.008OECD. (2009). OECD patent statistics manual OECD.Petrovic, V., Haro, J. V., JOrdá, O., Delgado, J., Blasco, J. R., & Portolés, L. (2011). Additive layered manufacturing: Sectors of industrial application shown through case studies. Internatinal Journal of Production Research, 49(4), 1061-1079. https://doi.org/10.1080/00207540903479786Rodriguez-Salvador, M., Rio-Belver, R. M., & Garechana-Anacabe, G. (2017). Scientometric and patentometric analyses to determine the knowledge landscape in innovative technologies: The case of 3D bioprinting PLoS ONE, 12(6), 1-22. https://doi.org/10.1371/journal.pone.0180375Sinha, M., & Pandurangi, A. (2016). Guide to practical patent searching and how to use PatSeer for patent search and analysis. India: Gridlogics Technologies Pvt. Ltd.Zarrabeitia, E., Bildosola, I., Rio-Belver, R. M., Alvarez, I., & Cilleruelo, E. (2017). Laser additive manufacturing: A patent overview. Lect. Notes in Managem. Industrial Engineering - Engineering Digital Transformation. Springer. https://doi.org/10.1007/978-3-319-96005-0_2

Evidence for a mixed mass composition at the `ankle' in the cosmic-ray spectrum

We report a first measurement for ultra-high energy cosmic rays of the correlation between the depth of shower maximum and the signal in the water Cherenkov stations of air-showers registered simultaneously by the fluorescence and the surface detectors of the Pierre Auger Observatory. Such a correlation measurement is a unique feature of a hybrid air-shower observatory with sensitivity to both the electromagnetic and muonic components. It allows an accurate determination of the spread of primary masses in the cosmic-ray flux. Up till now, constraints on the spread of primary masses have been dominated by systematic uncertainties. The present correlation measurement is not affected by systematics in the measurement of the depth of shower maximum or the signal in the water Cherenkov stations. The analysis relies on general characteristics of air showers and is thus robust also with respect to uncertainties in hadronic event generators. The observed correlation in the energy range around the `ankle' at $\lg(E/{\rm eV})=18.5-19.0$ differs significantly from expectations for pure primary cosmic-ray compositions. A light composition made up of proton and helium only is equally inconsistent with observations. The data are explained well by a mixed composition including nuclei with mass $A > 4$. Scenarios such as the proton dip model, with almost pure compositions, are thus disfavoured as the sole explanation of the ultrahigh-energy cosmic-ray flux at Earth.Comment: Published version. Added journal reference and DOI. Added Report Numbe

Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory

Data from the Pierre Auger Observatory are analyzed to search for anisotropies near the direction of the Galactic Centre at EeV energies. The exposure of the surface array in this part of the sky is already significantly larger than that of the fore-runner experiments. Our results do not support previous findings of localized excesses in the AGASA and SUGAR data. We set an upper bound on a point-like flux of cosmic rays arriving from the Galactic Centre which excludes several scenarios predicting sources of EeV neutrons from Sagittarius $A$. Also the events detected simultaneously by the surface and fluorescence detectors (the `hybrid' data set), which have better pointing accuracy but are less numerous than those of the surface array alone, do not show any significant localized excess from this direction.Comment: Matches published versio

Observation of Orbitally Excited B_s Mesons

We report the first observation of two narrow resonances consistent with states of orbitally excited (L=1) B_s mesons using 1 fb^{-1} of ppbar collisions at sqrt{s} = 1.96 TeV collected with the CDF II detector at the Fermilab Tevatron. We use two-body decays into K^- and B^+ mesons reconstructed as B^+ \to J/\psi K^+, J/\psi \to \mu^+ \mu^- or B^+ \to \bar{D}^0 \pi^+, \bar{D}^0 \to K^+ \pi^-. We deduce the masses of the two states to be m(B_{s1}) = 5829.4 +- 0.7 MeV/c^2 and m(B_{s2}^*) = 5839.7 +- 0.7 MeV/c^2.Comment: Version accepted and published by Phys. Rev. Let

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

The NEXT White (NEW) detector

Conceived to host 5 kg of xenon at a pressure of 15 bar in the fiducial volume, the NEXT-White apparatus is currently the largest high pressure xenon gas TPC using electroluminescent amplification in the world. It is also a 1:2 scale model of the NEXT-100 detector for Xe-136 beta beta 0 nu decay searches, scheduled to start operations in 2019. Both detectors measure the energy of the event using a plane of photomultipliers located behind a transparent cathode. They can also reconstruct the trajectories of charged tracks in the dense gas of the TPC with the help of a plane of silicon photomultipliers located behind the anode. A sophisticated gas system, common to both detectors, allows the high gas purity needed to guarantee a long electron lifetime. NEXT-White has been operating since October 2016 at the Laboratorio Subterraneo de Canfranc (LSC), in Spain. This paper describes the detector and associated infrastructures, as well as the main aspects of its initial operation

Trends and outcome of neoadjuvant treatment for rectal cancer: A retrospective analysis and critical assessment of a 10-year prospective national registry on behalf of the Spanish Rectal Cancer Project

Introduction: Preoperative treatment and adequate surgery increase local control in rectal cancer. However, modalities and indications for neoadjuvant treatment may be controversial. Aim of this study was to assess the trends of preoperative treatment and outcomes in patients with rectal cancer included in the Rectal Cancer Registry of the Spanish Associations of Surgeons. Method: This is a STROBE-compliant retrospective analysis of a prospective database. All patients operated on with curative intention included in the Rectal Cancer Registry were included. Analyses were performed to compare the use of neoadjuvant/adjuvant treatment in three timeframes: I)2006–2009; II)2010–2013; III)2014–2017. Survival analyses were run for 3-year survival in timeframes I-II. Results: Out of 14, 391 patients, 8871 (61.6%) received neoadjuvant treatment. Long-course chemo/radiotherapy was the most used approach (79.9%), followed by short-course radiotherapy ± chemotherapy (7.6%). The use of neoadjuvant treatment for cancer of the upper third (15-11 cm) increased over time (31.5%vs 34.5%vs 38.6%, p = 0.0018). The complete regression rate slightly increased over time (15.6% vs 16% vs 18.5%; p = 0.0093); the proportion of patients with involved circumferential resection margins (CRM) went down from 8.2% to 7.3%and 5.5% (p = 0.0004). Neoadjuvant treatment significantly decreased positive CRM in lower third tumors (OR 0.71, 0.59–0.87, Cochrane-Mantel-Haenszel P = 0.0008). Most ypN0 patients also received adjuvant therapy. In MR-defined stage III patients, preoperative treatment was associated with significantly longer local-recurrence-free survival (p < 0.0001), and cancer-specific survival (p < 0.0001). The survival benefit was smaller in upper third cancers. Conclusion: There was an increasing trend and a potential overuse of neoadjuvant treatment in cancer of the upper rectum. Most ypN0 patients received postoperative treatment. Involvement of CRM in lower third tumors was reduced after neoadjuvant treatment. Stage III and MRcN + benefited the most