Aspectele clinice ale sarcinii și nașterii la femeile cu colestază intrahepatică de sarcină

Introduction. Intrahepatic cholestasis of pregnancy (ICP) is a liver pathology that has negative impact on progression of pregnancy and childbirth in affected women. This study aims to assess the clinical characteristics of pregnancy and delivery among women diagnosed with intrahepatic cholestasis of pregnancy. Material and methods. The study was conducted as a prospective cohort study involving 142 clinical cases, divided into two groups according to the complication of pregnancy with cholestasis gravidarum. Evaluation of pregnancy and childbirth clinical aspects was performed alongside an examination of medical records. Statistical data were processed using IBM Statistics SPSS 21, MedCalc and GraphPad software. Results. It was determined that every fourth pregnant woman diagnosed with intrahepatic cholestasis of pregnancy also presented with hyperemesis gravidarum during the current pregnancy. Additionally, an elevated prevalence of iron deficiency anemia and gestational diabetes mellitus was detected among pregnant women with this condition. Meconium staining of the amniotic fluid complicated approximately one in every four pregnancies in women with intrahepatic cholestasis gravidarum. Conclusions. The study findings indicate a notable increase in hepato-biliary conditions and nephrourinary pathology among women with ICP. Hence, a high incidence of hyperemesis gravidarum, along with an elevated frequency of iron deficiency anemia and gestational diabetes mellitus, was found in women with this condition.Introducere. Colestaza intrahepatică de sarcină este o patologie hepatică, care are un impact negativ asupra evoluției sarcinii și nașterii la femeile cu patologie cercetată. Studiul a avut drept scop evaluarea particularităților clinice ale sarcinii și nașterii la femeile cu colestază intrahepatică de sarcină. Material și metode. Premisa cercetării s-a bazat pe un studiu prospectiv de cohortă a 142 de cazuri clinice, divizate în două loturi, în funcție de complicațiile în sarcină cu afecțiunea colestaza gravidarum. Cercetarea a fost realizată prin aprecierea particularităților sarcinii și nașterii la femeile cu patologia data și analizarea documentației medicale. Datele statistice au fost prelucrate prin intermediul programului IBM Statistics SPSS 21, MedCalc și GraphPad. Rezultate. S-a constatat că, fiecare a patra gravidă cu colestază intrahepatică de sarcină a fost diagnosticată cu hiperemesis gravidarum în sarcina curentă și s-a depistat o frecvență crescută a anemiei feriprive și a diabetului gestațional în rândul gravidelor cu patologie cercetată. Astfel, la femeile cu colestaza gravidarum, aproximativ fiecare a patra sarcină a prezentat complicații la nivel intrauterin, prin–colorația meconială a lichidului amniotic. Concluzii. Rezultatele studiului au demostrat că ratele afecțiunilor hepato-biliare și nefrourinare au fost semnificativ mai mari la femeile cu colestaza intrahepatică de sarcină, identificându-se o rată crescută de hyperemesis gravidarum, o frecvență crescută a anemiei feriprive și a diabetului gestațional la femeile cu patologia cercetată

The Gibraltar Corridor:Watergate of the Messinian Salinity Crisis

The existence and evolution of a Messinian salt giant in the Mediterranean Sea has caused much debate in the marine science community. Especially the suggestion that the Mediterranean was a deep desiccated basin during the Messinian Salinity Crisis (MSC, 5.97–5.33 Ma), triggered by a temporal disconnection from the global ocean, made it a well-known crisis beyond the scientific boundaries. Approximately ~50 years after this provocative statement, it remained unknown which Mediterranean–Atlantic seaway delivered the 5–6% of the global ocean's salt into the Mediterranean basin. Here, we review the changes in Mediterranean-Atlantic connectivity throughout the late Miocene in order to locate, date and quantify the missing Messinian gateway that provided the salt water inflow during the MSC. We conclude that all the known pre-MSC gateways through southern Spain and northern Morocco were closed, leaving the “Gibraltar Corridor” at its Messinian configuration as the sole candidate. We consider the possibility of longer and narrower straits existing at depth below the present Gibraltar region, and using strait dynamic theory we calculate its dimensions during the Messinian based on the salinity changes in the Mediterranean. A marine Messinian gateway through the Gibraltar Corridor is in agreement with growing evidence that Atlantic waters reached the Mediterranean Sea during all three stages of the MSC

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Designing Sustainable Urban Futures

Many 21st century cities have the potential to be sustainable and resource-saving living spaces when multifunctional structures, well-integrated transportation infrastructure, and democratic governance processes are present. Sustainable urban futures require a focus on the needs of humans and environmental best practices, as well as on the creative scope for community-driven sustainability innovations. This book is based on contributions from science and practice to the international symposium on “Sustainable Urban Development at Different Scales” organized by the Institute for Technology Assessment and Systems Analysis at the Karlsruhe Institute of Technology, Karlsruhe, Germany, in May 2014. The symposium used the global urbanization and reurbanization trend as an opportunity to examine cities as sustainable living spaces. This book identifi es concepts, analytic approaches, and practical applications for the design of sustainable urban futures among multiple disciplines and cultural backgrounds.Viele Städte des 21. Jahrhunderts haben das Potenzial, ein nachhaltiger und ressourcenschonender Lebensraum zu sein, wenn multifunktionale Strukturen, eine gut integrierte Verkehrsinfrastruktur und demokratische Stadtentwicklungsprozesse gegeben sind. Nachhaltige Stadtzukünfte erfordern einen starken Fokus auf die Berücksichtigung menschlicher Bedürfnissen an ihren Lebensraum, auf Umweltfreundlichkeit und Gesundheit sowie die gemeinsame Gestaltung kreativer Freiräume für nachhaltige Praktiken. Diese Buch basiert auf Beiträgen aus Wissenschaft und Praxis zum internationalen Symposium „Sustainable Urban Development at Different Scales“, das im Mai 2014 am Institut für Technikfolgenabschätzung und Systemanalyse am Karlsruher Institut für Technologie stattfand. Das Symposium nahm den globalen Urbanisierungsund Reurbanisierungstrend zum Anlass, um Städte auf unterschiedlichen Maßstabsebenen als nachhaltige Lebensräume zu diskutieren. Dieses Buch bietet Analysen, Konzepte und Ansätze zur Gestaltung nachhaltiger Stadtzukünfte aus der Sicht multipler Disziplinen und vor unterschiedlichen kulturellen Hintergründen

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector

A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions

Search for High-Mass Resonances Decaying to τν in pp Collisions at √s=13 TeV with the ATLAS Detector

A search for high-mass resonances decaying to τν using proton-proton collisions at √s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level