Using IoT for Accessible Tourism in Smart Cities

In the past few years, the Smart City concept became one of the main driving forces for the transition towards sustainable economy and improved mobility. Tourism, as one of the fastest growing economies worldwide, is an integrated part of the Smart City paradigm. Taking into consideration recent studies performed by the United Nations, stating that almost one third of the population is directly affected by disability, the concept of Accessible Tourism needs also to be integrated in the future vision for tourism, especially in the context of Smart Cities, environments fully benefiting from the recent technological advances. Within the combined framework of Smart Cities and Accessible Tourism, the Internet-of-Things (IoT) concept is the key technological point for the development of smart urban environments. IoT and big data are both technology-driven developments, leading to scenarios such as the Smart Cities one that has the potential to make citizen live smarter, more sustainable and more accessible. This chapter analyses the key requirements for IoT applications in a Smart City context, the state-of-the-art for the use of IoT for Accessible Tourism applications and proposes an architecture together with its practical implementation, tailored for the use-case of accessible tourism for physically impaired persons

Televisione e infanzia. La parola ai protagonisti

Terzo, e ultimo, rapporto che chiude l’indagine triennale che OssCom, Centro di ricerca sui media e la comunicazione dell’Università Cattolica, ha realizzato con il supporto di Sky Italia per conto di Focus in media – Osservatorio della Fondazione per la Sussidiarietà sul tema della Children’s Television (CT), cioè della televisione rivolta ai bambini e ai preadolescenti nel nostro Paese. Dopo l’analisi dell’offerta di televisione tematica destinata a questo target specifico (primo rapporto) e la descrizione dei discorsi sociali a carattere normativo che esprimono le aspettative nutrite dai diversi attori e stakeholder nei confronti della CT (secondo rapporto), questo report presenta una raccolta ragionata di testimonianze privilegiate maturate nel contesto dell’intero ecosistema della CT. Le domande di ricerca a cui il report risponde è “quali condizioni rendono più facile che la CT risponda efficacemente a tali aspettative” e “perché la CT non è sempre in grado di soddisfarle”. Si è trattato, dunque, di cogliere punti di forza e punti di debolezza della CT in un’ottica sistemica: cercando, cioè, di prendere in considerazione la complessità delle relazioni che legano fra di loro gli attori della filiera produttiva e distributiva, le istituzioni volte alla regolamentazione e al controllo della programmazione, i pubblici diretti e indiretti di questa forma di produzione culturale

Televisione e infanzia. Le aspettative nei confronti dell'offerta televisiva per i bambini

Secondo report dell’indagine triennale che OssCom, Centro di ricerca sui media e la comunicazione dell’Università Cattolica, sta realizzando per Focus in Media, l’osservatorio sulla comunicazione e i media della Fondazione per la Sussidiarietà. In questo report si presenta l’analisi delle aspettative che i diversi soggetti sociali interessati (mercato, istituzioni, società civile, ricercatori) nutrono nei confronti della programmazione della Children’s Television

Lung anatomy, energy load, and ventilator-induced lung injury

High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed to find the volumetric VILI threshold and see whether PEEP is protective per se or indirectly

Televisione e Infanzia. Rapporto sull’offerta televisiva per bambini in Italia

Il presente report restituisce i risultati della prima annualità (2011-2012) della ricerca denominata “Televisione e Infanzia”, realizzata da OssCom – Centro di ricerca sui media e la comunicazione dell’Università Cattolica del Sacro Cuore per conto della Fondazione per la Sussidiarietà, nel quadro delle attività di Focus in Media, al fine di ricostruire e descrivere l’offerta televisiva specificamente rivolta al pubblico dei bambini e dei preadolescenti

First line avelumab in PD-L1+ve metastatic or locally advanced urothelial cancer (aUC) patients unfit for cisplatin (cis): The ARIES trial

Background: Avelumab (ave) was approved as maintenance therapy after platinum-based first line (1L) therapy for patients (pts) with aUC based on ph. 3 Javelin Bladder 100 study (NCT02603432), showing significant overall survival (OS) improvement. Here we tested the activity of ave as 1L of therapy in cis-unfit pts with aUC and PD-L1+ve expression. Methods: ARIES is a single-arm, multi-site, open-label phase II trial. Enrolled pts had aUC, were cis-unfit (at least one of: ECOG-PS = 2, CrCl < 60 mL/min, grade ≥2 peripheral neuropathy/hearing loss, progression within 6-mos before the end of neo/adj chemo), had not previously received chemo for aUC and PD-L1≥5% (SP263) centrally assessed. Pts received ave 10 mg/Kg IV Q2W until progression, unacceptable toxicity and withdrawal, whichever occurred first. The primary endpoint was the 1-year OS. Key secondary endpoints were median-OS, -PFS, ORR and safety. Results: A total of 198 eligible cis-unfit pts have been tested for PD-L1 and 71 (35.6%) have been found positive. Among enrolled patients (N = 71), median age was 75 y, 35 (49.3%) had visceral disease, and 22 (31.0%) had ECOG-PS = 2; 50 (70.4%) had CrCl < 60 mL/min and 9 (12.7%) progressed within 6-mos from the end of neo/adj chemo. At the cut-off data (Oct 7, 2021), median follow up was 9.0 mo and 13 patients are still on treatment. The median OS was 10.0 mos (95% CI, 5.7-14.3), and 40.8% of patients were alive at 1-year. The ORR for all patients was 22.5%; complete response, 1.4% (n = 1); partial response, 21.1% (n = 15). Clinical benefit was 43.6% (n = 31). Median PFS was 2.0 mos (95% CI, 1.4-2.6). Among the 56 pts who received at least 3 cycles (29 days) of therapy the median OS was 16.0 vs 1.0 mos. Five (7.0%) grade 3 ave-related adverse events, and no treatment-related death were reported. Conclusions: Ave is active and safe in pts with cis-unfit, PD-L1+ve aUC and poor baseline characteristics

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe