Enigmas da Providência – Sofismas da Filosofia

Este texto mostra como, no primeiro volume do que atualmente chamaríamos de “trilogia”: Justine ou les Infortunes de la vertu (1787), Justine ou les Malheurs de la vertu (1791) e La Nouvelle Justine ou les Malheurs de la vertu, suivie de l'Histoire de Juliette, sa soeur (1797), Sade foi o último protagonista do grande debate filosófico e moral que percorre a Ilustração, dos primórdios ao seu final

A semântica da forma

A semântica da form

A ambivalência do riso em Rousseau e Diderot

Este artigo pretende apresentar o lugar ambivalente do riso nas teorias teatrais de Rousseau e Diderot a partir do tratamento que os dois fizeram do tema, principalmente na Carta a d’Alembert sobre os espetáculos e no Discurso sobre a poesia dramática. Demonstrado o lugar do riso e do risível na teoria de ambos o que se busca é considerar as os modos como o cômico foi tratado na obra desses dois filósofos e sua íntima relação com a moral

Margarita de Sossa, Sixteenth-Century Puebla de los Ángeles, New Spain (Mexico)

Margarita de Sossa’s freedom journey was defiant and entrepreneurial. In her early twenties, still enslaved in Portugal, she took possession of her body; after refusing to endure her owner’s sexual demands, he sold her, and she was transported to Mexico. There, she purchased her freedom with money earned as a healer and then conducted an enviable business as an innkeeper. Sossa’s biography provides striking insights into how she conceptualized freedom in terms that included – but was not limited to – legal manumission. Her transatlantic biography offers a rare insight into the life of a free black woman (and former slave) in late sixteenth-century Puebla, who sought to establish various degrees of freedom for herself. Whether she was refusing to acquiesce to an abusive owner, embracing entrepreneurship, marrying, purchasing her own slave property, or later using the courts to petition for divorce. Sossa continued to advocate on her own behalf. Her biography shows that obtaining legal manumission was not always equivalent to independence and autonomy, particularly if married to an abusive husband, or if financial successes inspired the envy of neighbors

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits