Local detection of microvessels in IDH-wildtype glioblastoma using relative cerebral blood volume: an imaging marker useful for astrocytoma grade 4 classification

[EN] Background The microvessels area (MVA), derived from microvascular proliferation, is a biomarker useful for high-grade glioma classification. Nevertheless, its measurement is costly, labor-intense, and invasive. Finding radiologic correlations with MVA could provide a complementary non-invasive approach without an extra cost and labor intensity and from the first stage. This study aims to correlate imaging markers, such as relative cerebral blood volume (rCBV), and local MVA in IDH-wildtype glioblastoma, and to propose this imaging marker as useful for astrocytoma grade 4 classification. Methods Data from 73 tissue blocks belonging to 17 IDH-wildtype glioblastomas and 7 blocks from 2 IDH-mutant astrocytomas were compiled from the Ivy GAP database. MRI processing and rCBV quantification were carried out using ONCOhabitats methodology. Histologic and MRI co-registration was done manually with experts' supervision, achieving an accuracy of 88.8% of overlay. Spearman's correlation was used to analyze the association between rCBV and microvessel area. Mann-Whitney test was used to study differences of rCBV between blocks with presence or absence of microvessels in IDH-wildtype glioblastoma, as well as to find differences with IDH-mutant astrocytoma samples. Results Significant positive correlations were found between rCBV and microvessel area in the IDH-wildtype blocks (p < 0.001), as well as significant differences in rCBV were found between blocks with microvascular proliferation and blocks without it (p < 0.0001). In addition, significant differences in rCBV were found between IDH-wildtype glioblastoma and IDH-mutant astrocytoma samples, being 2-2.5 times higher rCBV values in IDH-wildtype glioblastoma samples. Conclusions The proposed rCBV marker, calculated from diagnostic MRIs, can detect in IDH-wildtype glioblastoma those regions with microvessels from those without it, and it is significantly correlated with local microvessels area. In addition, the proposed rCBV marker can differentiate the IDH mutation status, providing a complementary non-invasive method for high-grade glioma classification.This work was funded by grants from the National Plan for Scientific and Technical Research and Innovation 2017-2020, No. PID2019-104978RB-I00) (JMGG); H2020-SC1-2016-CNECT Project (No. 727560) (JMGG), and H2020SC1-BHC-2018-2020 (No. 825750) (JMGG). M.A.T was supported by DPI201680054-R (Programa Estatal de Promocion del Talento y su Empleabilidad en I + D + i). EFG was supported by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 844646. The funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.Álvarez-Torres, MDM.; Fuster García, E.; Juan-Albarracín, J.; Reynes, G.; Aparici-Robles, F.; Ferrer Lozano, J.; Garcia-Gomez, JM. (2022). Local detection of microvessels in IDH-wildtype glioblastoma using relative cerebral blood volume: an imaging marker useful for astrocytoma grade 4 classification. BMC Cancer. 22(1):1-13. https://doi.org/10.1186/s12885-021-09117-411322

SeDeM Diagram: A New Expert System for the Formulation of Drugs in Solid Form

The SeDeM expert system is a methodology which is applied in preformulation and formulation studies of medicines specifically in solid dosage forms. This system informs on the physical profile of powdered substances (APIs and excipients) used to formulate drugs (Suñé et al, 2005; García et al, 2010; Aguilar et al, 2009). By determining whether powders (API or excipient) are suitable for direct compression, the SeDeM profile will inform about the advantages and gaps of those powdered substance to be used in direct compression, so the system informs on whether the direct compression method is appropriate (e.g.. wet granulation should be applied before compression). The characterization of powdered substances by SeDeM facilitates the identification of the characteristics that require amendment in order to obtain tablets by direct compression. This system thus provides information that will ensure the robust design of the formulation in the final product. This new method is based on the selection and application of several parameters that the formulation must fulfill to ensure a successful tablet elaborated by direct compression..

Impact of a training project for primary health-care providers (FOCO project) in the HIV screening and HIV late diagnosis

Poster [P043] OBJECTIVE Reducing HIV late diagnosis remains an epidemiological challenge . The objective of this project was to promote early HIV diagnosis through the training of primary health - care providers (PHCP) . METHODS HIV specialists conducted training sessions in 108 primary care centers (PCC) from six Spanish regions during 2016 and 2017 , and with 1804 PHCP involved . The intervention was evaluated using a pre - experimental design collecting the dependent variables both in the six months before and after the intervention . Number of requests for HIV tests from the PCC trained and clinical data of new HIV diagnosed patients were collected . Parametric and non - parametric tests were used to assess differences between pre and post - intervention data . RESULTS 3. Differences in clinical variables in pre and post intervention period

A Measurement of B Meson Production and Lifetime Using D`− Events in Z0 Decays

A study of B meson decays into D l- X final states is presented. In these events, neutral and charged D mesons originate predominantly from B+ and B0 decays, respectively. The dilution of this correlation due to D** production has been taken into account. From 263700 hadronic Z0 decays collected in 1991 with the DELPHI detector at the LEP collider, 92 D0 --> K- pi+, 35 D+ --> K- pi+ pi+ and 61 D*+ --> D0 pi+ followed by D0 --> K- pi+ or D0 --> K- pi+ pi+ pi-, are found with an associated lepton of the same charge as the kaon. From the D0 l- and D*+ l-, the probability f(d) that a b quark hadronizes into a B- (or B0BAR),meson is found to be 0.44 +/-0.08 +/-0.09, corresponding to a total (B(s) + LAMBDA(b)) hadronization fraction of 0.12(-0.12)+0.24 .By reconstructing the energy of each B meson, the b quark fragmentation is directly measured for the first time. The mean value of the B meson energy fraction is: [X(E)(B)] = 0.695+/-0.015(stat.)+/-0.029(syst.) Reconstructing D-lepton vertices, the following B life-times are measured: tau(B) = 1.27(-0.18)+0.22(stat.)+/-0.15(syst.) ps, where bBAR --> D0 l- X, tau(B) = 1.18(-0.27)+0.39(stat.)+/-0.15(syst.) ps, where BBAR --> D+ l- X, T(B) = 1.19(-0.19)+0.25(stat.)+/-0.15(syst.) ps where BBAR --> D*+ l- X, and an average tau(B) = 1.23(-0.13)+0.14(stat.)+/-0.15(syst.) ps is found. Allowing for decays into D** l- vBAR, the B+ and B0 lifetimes are: tau(B+)= 1.30(0.29)+0.33(stat.)+/-0.15(syst. exp.) +/-0.05(syst. D**) ps, tau(B0)= 1.17(-0.23)+0.29(stat.)+/-0.15(syst. exp.) +/-0.05 (syst. D**) ps, tau(B+)/tau(B0) = 1.11(0.39)+0.51(stat.)+/-0.05(syst. exp.) +/-0.10(syst. D**) ps

Measurement of the triple-gluon vertex from 4-JET events at LEP

From the combined data of 1990 and 1991 of the DELPHI experiment at LEP, 13057 4-jet events are obtained and used for determining the contribution of the triple-gluon vertex. The relevant variables are the generalized Nachtmann Reiter angle theta(NR)* and the opening angle of the two least energetic jets. A fit to their two-dimensional distribution yields C(A)/C(F)=2.12+/-0.35 and N(C)/N(A)=0.46+/-0.19, where C(A)/C(F) is the ratio of the coupling strength of the triple-gluon vertex to that of gluon bremsstrahlung from quarks, and N(C)/N(A), the ratio of the number of quark colours to the number of gluons. This constitutes a convincing model-independent proof of the existence of the triple-gluon vertex, since its contribution is directly proportional to C(A)/C(F). The results are in agreement with the values expected from QCD: C(A)/C(F)=2.25, and N(C)/N(A)=3/8

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Measurement of the top quark-pair production cross section with ATLAS in pp collisions at \sqrt{s}=7\TeV

A measurement of the production cross-section for top quark pairs(\ttbar) in $pp$ collisions at \sqrt{s}=7 \TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in two different topologies: single lepton (electron $e$ or muon $\mu$) with large missing transverse energy and at least four jets, and dilepton ($ee$, $\mu\mu$ or $e\mu$) with large missing transverse energy and at least two jets. In a data sample of 2.9 pb-1, 37 candidate events are observed in the single-lepton topology and 9 events in the dilepton topology. The corresponding expected backgrounds from non-\ttbar Standard Model processes are estimated using data-driven methods and determined to be $12.2 \pm 3.9$ events and $2.5 \pm 0.6$ events, respectively. The kinematic properties of the selected events are consistent with SM \ttbar production. The inclusive top quark pair production cross-section is measured to be \sigmattbar=145 \pm 31 ^{+42}_{-27} pb where the first uncertainty is statistical and the second systematic. The measurement agrees with perturbative QCD calculations.Comment: 30 pages plus author list (50 pages total), 9 figures, 11 tables, CERN-PH number and final journal adde