Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

25th annual computational neuroscience meeting: CNS-2016

The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong

Abregé chronologique de l'histoire générale d'Italie, depuis la chûte de l'empire romain en occident, c'est à dire depuis l'an 476 de l'ere chretiène, jusqu'au traité d'Aix-la-Chapelle en 1748

Tome premier : depuis l'an 476, jusqu'à l'an 840Tome second : depuis l'an 840, jusqu'à l'an 1027Tome troisième, première partie : depuis l'an 1027, jusqu'à l'an 1076Tome troisième, seconde partie : depuis l'an 1076, jusqu'à l'an 1137Cinquième volume : depuis l'an 1138, jusqu'à l'an 1254Sixième volume : depuis l'an 1220, jusqu'à l'an 1314par M. de Saint-Marc ...Vol. V doppelt enthalten. Vol. V* & VI in abweichender Ausgabe. Vol. VI mit abweichendem Impressum: A Paris, chez Nicholas-Augustin Delalain ..., 177

Paul von Rapin Herrn von Thoyras algemeine Geschichte von England mit Tindals und de St. Mare Anmerkungen ... Genau durchgesehen und mit einer Vorrede begleitet D. Carl Friedrich Pauli ... ; Siebenter Band

PAUL VON RAPIN HERRN VON THOYRAS ALGEMEINE GESCHICHTE VON ENGLAND MIT TINDALS UND DE ST. MARE ANMERKUNGEN ... GENAU DURCHGESEHEN UND MIT EINER VORREDE BEGLEITET D. CARL FRIEDRICH PAULI ... ; SIEBENTER BAND Paul von Rapin Herrn von Thoyras algemeine Geschichte von England mit Tindals und de St. Mare Anmerkungen ... Genau durchgesehen und mit einer Vorrede begleitet D. Carl Friedrich Pauli ... (-) Paul von Rapin Herrn von Thoyras algemeine Geschichte von England mit Tindals und de St. Mare Anmerkungen ... Genau durchgesehen und mit einer Vorrede begleitet D. Carl Friedrich Pauli ... ; Siebenter Band (Bd. 7) (1) Einband (1) Titelseite (3) Frontispiz (12) Titelblatt (13) Vorrede (15) 21. Buch, 3. Abschnitt der Regierung Carls I. (23) 22. Buch, 1. Abschnitt, Die Republik in England (375) 22. Buch, 2. Abschnitt, Olivier Cromwells Protectorat (437) 22. Buch, 3. Abschnitt, Richard Cromwells Protectorat (476) 23. Buch, Carl 2, 26. König von England seit der Eroberung (526) Register der merkwürdigsten Sachen (761) Fotodokumentation (787

Paul von Rapin Herrn von Thoyras algemeine Geschichte von England mit Tindals und de St. Mare Anmerkungen ... Genau durchgesehen und mit einer Vorrede begleitet D. Carl Friedrich Pauli ...

PAUL VON RAPIN HERRN VON THOYRAS ALGEMEINE GESCHICHTE VON ENGLAND MIT TINDALS UND DE ST. MARE ANMERKUNGEN ... GENAU DURCHGESEHEN UND MIT EINER VORREDE BEGLEITET D. CARL FRIEDRICH PAULI ... Paul von Rapin Herrn von Thoyras algemeine Geschichte von England mit Tindals und de St. Mare Anmerkungen ... Genau durchgesehen und mit einer Vorrede begleitet D. Carl Friedrich Pauli ... Paul von Rapin Herrn von Thoyras algemeine Geschichte von England mit Tindals und de St. Mare Anmerkungen ... Genau durchgesehen und mit einer Vorrede begleitet D. Carl Friedrich Pauli ... ; Siebenter Band (Bd. 7

Variations in isotope incorporation rates and trophic discrimination factors of carbon and nitrogen stable isotopes in scales from three European sea bass (Dicentrarchus labrax) populations

Carbon (δ13C) and nitrogen (δ15N) stable isotope analyses are used in marine ecology to study trophic relationships and migrations of species since they reflect dietary sources consumed which may vary geographically. However, better estimations of isotope incorporation rates and trophic discrimination factors (TDF) under controlled conditions are required. Moreover, variability of isotope incorporation rates and TDF among and within populations has been poorly described, especially in fish scales, whereas the use of non-lethal method is becoming a standard. This study aimed to experimentally assess whether carbon and nitrogen isotope incorporation rates (λC and λN, respectively) and TDF of scales vary in the European sea bass (Dicentrarchus labrax) among (1) Atlantic, West Mediterranean and East Mediterranean populations, (2) sexes and (3) individuals. Fish were reared under controlled conditions and switched from a diet 1 to a diet 2 with different δ13C and δ15N values. Scales were sampled repeatedly on 16 fish within the three populations, from the day of diet change (day 0) to the end of the experiment (day 217). Isotope incorporation rates of scales and TDF were determined using a time-dependent model. Isotopic carbon and nitrogen half-lives (t50C and t50N) were similar among the three populations but males had significantly lower t50C and t50N than females (29 ± 2 and 35 ± 2 days vs. 53 ± 7 and 80 ± 11 days, respectively). Females had higher growth rates but lower catabolic rates than males. Variability of λC and λN was large within sexes: t50C ranged from 17 to 159 days and t50N ranged from 18 to 342 days among individuals. Thus, variability between sexes and among individuals must be considered to avoid misinterpretation in field-based studies. For the 48 fish, TDF were 4.91 ± 0.03 and 2.46 ± 0.06‰ for carbon and nitrogen, respectively, and similar between sexes and among populations. Besides, TDF varied among individuals from 2.95 to 5.59‰ and from 0.93 to 3.55‰ for carbon and nitrogen, respectively. Empirical mixing models were run to estimate how different TDF influenced estimation of the contributions of food sources to diet of their consumer. The output differed considerably when using TDF from fish literature or those estimated herein, which confirms that a tissue-specific TDF must be used to avoid misinterpretation in field-based studies. Individual variation in TDF did not, however, influence estimation of the contributions of food sources, confirming that scales are a valid tissue for non-lethal sampling. Previous article in issu