The fate of high-redshift massive compact galaxies

Massive high-redshift quiescent compact galaxies (nicknamed red nuggets) have been traditionally connected to present-day elliptical galaxies, often overlooking the relationships that they may have with other galaxy types. We use large bulge–disc decomposition catalogues based on the Sloan Digital Sky Survey to check the hypothesis that red nuggets have survived as compact cores embedded inside the haloes or discs of present-day massive galaxies. In this study, we designate a compact core as the bulge component that satisfies a prescribed compactness criterion. Photometric and dynamic mass–size and mass–density relations are used to show that, in the inner regions of galaxies at z ∼ 0.1, there are abundant compact cores matching the peculiar properties of the red nuggets, an abundance comparable to that of red nuggets at z ∼ 1.5. Furthermore, the morphology distribution of the present-day galaxies hosting compact cores is used to demonstrate that, in addition to the standard channel connecting red nuggets with elliptical galaxies, a comparable fraction of red nuggets might have ended up embedded in discs. This result generalizes the inside-out formation scenario; present-day massive galaxies can begin as dense spheroidal cores (red nuggets), around which either a spheroidal halo or a disc is formed later

Agitation near the end of life with dementia: An ethnographic study of care

Background and objectives Agitation is common in people living with dementia especially at the end of life. We examined how staff interpreted agitation behavior in people with dementia nearing end of life, how this may influence their responses and its impact on the quality of care. Research design Ethnographic study. Structured and semi-structured non-participant observations (referred to subsequently in this paper as “structured observations”) of people living with dementia nearing the end of life in hospital and care homes (south-east England) and in-depth interviews with staff, conducted August 2015-March 2017. Methods Three data sources: 1) detailed field notes, 2) observations using a structured tool and checklist for behaviors classed as agitation and staff and institutional responses, 3) staff semi-structured qualitative interviews. We calculated the time participants were agitated and described staff responses. Data sources were analyzed separately, developed continuously and relationally during the study and synthesized where appropriate. Results We identified two main ‘ideal types’ of staff explanatory models for agitation: In the first, staff attribute agitated behaviors to the person’s “moral judgement”, making them prone to rejecting or punitive responses. In the second staff adopt a more “needs-based” approach in which agitation behaviors are regarded as meaningful and managed with proactive and investigative approaches. These different approaches appear to have significant consequences for the timing, frequency and quality of staff response. While these models may overlap they tend to reflect distinct organizational resources and values. Conclusions Care worker knowledge about agitation is not enough, and staff need organizational support to care better for people living with dementia towards end of life. Positional theory may help to explain much of the cultural-structural context that produces staff disengagement from people with dementia, offering insights on how agitation behavior is reframed by some staff as dangerous. Such behavior may be associated with low-resource institutions with minimal staff training where the personhood of staff may be neglected

Agitation near the end of life with dementia: An ethnographic study of care

Background and objectivesAgitation is common in people living with dementia especially at the end of life. We examined how staff interpreted agitation behavior in people with dementia nearing end of life, how this may influence their responses and its impact on the quality of care.Research designEthnographic study. Structured and semi-structured non-participant observations (referred to subsequently in this paper as "structured observations") of people living with dementia nearing the end of life in hospital and care homes (south-east England) and in-depth interviews with staff, conducted August 2015-March 2017.MethodsThree data sources: 1) detailed field notes, 2) observations using a structured tool and checklist for behaviors classed as agitation and staff and institutional responses, 3) staff semi-structured qualitative interviews. We calculated the time participants were agitated and described staff responses. Data sources were analyzed separately, developed continuously and relationally during the study and synthesized where appropriate.ResultsWe identified two main 'ideal types' of staff explanatory models for agitation: In the first, staff attribute agitated behaviors to the person's "moral judgement", making them prone to rejecting or punitive responses. In the second staff adopt a more "needs-based" approach in which agitation behaviors are regarded as meaningful and managed with proactive and investigative approaches. These different approaches appear to have significant consequences for the timing, frequency and quality of staff response. While these models may overlap they tend to reflect distinct organizational resources and values.ConclusionsCare worker knowledge about agitation is not enough, and staff need organizational support to care better for people living with dementia towards end of life. Positional theory may help to explain much of the cultural-structural context that produces staff disengagement from people with dementia, offering insights on how agitation behavior is reframed by some staff as dangerous. Such behavior may be associated with low-resource institutions with minimal staff training where the personhood of staff may be neglected

Development, feasibility, and acceptability of an intervention to improve care for agitation in people living in nursing homes with dementia nearing the end-of-life

OBJECTIVES: To develop a staff training intervention for agitation in people with severe dementia, reaching end-of-life, residing in nursing homes (NHs), test feasibility, acceptability, and whether a trial is warranted. DESIGN: Feasibility study with pre- and post-intervention data collection, qualitative interviews, and focus groups. SETTING: Three NHs in South East England with dementia units, diverse in terms of size, ownership status, and location. PARTICIPANTS: Residents with a dementia diagnosis or scoring ≥2 on the Noticeable Problems Checklist, rated as "severe" on Clinical Dementia Rating Scale, family carers, and staff (healthcare assistants and nurses). INTERVENTION: Manualized training, delivered by nonclinical psychology graduates focusing on agitation in severe dementia, underpinned by a palliative care framework. MEASUREMENTS: Main outcomes were feasibility of recruitment, data collection, follow-up, and intervention acceptability. We collected resident, family carer, and staff demographics. Staff provided data on resident's agitation, pain, quality of life, and service receipt. Staff reported their sense of competence in dementia care. Family carers reported on satisfaction with end-of-life care. In qualitative interviews, we explored staff and family carers' views on the intervention. RESULTS: The target three NHs participated: 28 (49%) residents, 53 (74%) staff, and 11 (85%) family carers who were eligible to participate consented. Eight-four percent of staff attended ≥3 sessions, and we achieved 93% follow-up. We were able to complete quantitative interviews. Staff and family carers reported the intervention and delivery were acceptable and helpful. CONCLUSIONS: The intervention was feasible and acceptable indicating a larger trial for effectiveness may be warranted

Comparison of the VIMOS-VLT Deep Survey with the Munich semi-analytical model. II. The colour-density relation up to z=1.5

[Abridged] We perform on galaxy mock catalogues the same colour-density analysis made by Cucciati et al. (2006) on a 5 Mpc/h scale using the VVDS-Deep survey, and compare the results from mocks with observed data. We use mocks with the same flux limits (I=24) as the VVDS (CMOCKS), built using the semi- analytic model by De Lucia & Blaizot (2007) applied to the Millennium Simulation. From CMOCKS, we extracted samples of galaxies mimicking the VVDS observational strategy (OMOCKS). We computed the B-band Luminosity Function LF and the colour-density relation (CDR) in the mocks. We find that the LF in mocks roughly agrees with the observed LF, but at z<0.8 the faint-end slope of the model LF is steeper than the VVDS one. Computing the LF for early and late type galaxies, we show that mocks have an excess of faint early-type and of bright late-type galaxies with respect to data. We find that the CDR in OMOCKS is in excellent agreement with the one in CMOCKS. At z~0.7, the CDR in mocks agrees with the VVDS one (red galaxies reside mainly in high densities). Yet, the strength of the CDR in mocks does not vary within 0.2<z<1.5, while the observed relation flattens with increasing z and possibly inverts at z=1.3. We argue that the lack of evolution in the CDR in mocks is not due only to inaccurate prescriptions for satellite galaxies, but that also the treatment of central galaxies has to be revised. The reversal of the CDR can be explained by wet mergers between young galaxies, producing a starburst event. This should be seen on group scales. A residual of this is found in observations at z=1.5 on larger scales, but not in the mocks, suggesting that the treatment of physical processes affecting satellites and central galaxies in models should be revised.Comment: 15 pages, 12 figures, accepted for publication in A&

Equity in ecosystem restoration

The importance of equity has been emphasized in climate change, biodiversity loss, land degradation, and ecosystem restoration. However, equity implications are rarely considered explicitly in restoration projects. Although the role of equity has been studied in the context of biodiversity conservation and environmental governance, environmental variables are often ignored in equity studies, and spatial analyses of equity are lacking. To address these gaps, we use a mixed methods approach, integrating spatially explicit ecological and social data to evaluate, through an equity lens, a restoration project in a semi-arid rangeland socioecological system in Kenya. We use questionnaires and semi-structured key informant interviews to explore four dimensions of equity: distributional, procedural, recognitional, and contextual. Our results show that restoration employment and distance to the restoration site strongly influence perceived distributional and procedural equity. Employment and distance to restoration site can interact in counterintuitive ways in their influence on aspects of perceived equity, in this case, the fairness of site selection. Our findings exemplify that equity dimensions are intimately linked, and trade-offs can occur between equity dimensions, across socio-temporal scales, and in choosing the ethical framework to apply. Our work demonstrates how restoration is influenced by different dimensions of equity and we opine that incorporating equity in project planning and implementation processes can improve restoration outcomes. We emphasize the importance of respecting plurality in the values systems and ethical frameworks that underlie what is considered equitable, while negotiating trade-offs between diverse ethical positions in the design and implementation of ecosystem restoration projects

Interpreting ambiguous ‘trace’ results in Schistosoma mansoni CCA Tests: Estimating sensitivity and specificity of ambiguous results with no gold standard

Background The development of new diagnostics is an important tool in the fight against disease. Latent Class Analysis (LCA) is used to estimate the sensitivity and specificity of tests in the absence of a gold standard. The main field diagnostic for Schistosoma mansoni infection, Kato-Katz (KK), is not very sensitive at low infection intensities. A point-of-care circulating cathodic antigen (CCA) test has been shown to be more sensitive than KK. However, CCA can return an ambiguous ‘trace’ result between ‘positive’ and ‘negative’, and much debate has focused on interpretation of traces results. Methodology/Principle findings We show how LCA can be extended to include ambiguous trace results and analyse S. mansoni studies from both Côte d’Ivoire (CdI) and Uganda. We compare the diagnostic performance of KK and CCA and the observed results by each test to the estimated infection prevalence in the population. Prevalence by KK was higher in CdI (13.4%) than in Uganda (6.1%), but prevalence by CCA was similar between countries, both when trace was assumed to be negative (CCAtn: 11.7% in CdI and 9.7% in Uganda) and positive (CCAtp: 20.1% in CdI and 22.5% in Uganda). The estimated sensitivity of CCA was more consistent between countries than the estimated sensitivity of KK, and estimated infection prevalence did not significantly differ between CdI (20.5%) and Uganda (19.1%). The prevalence by CCA with trace as positive did not differ significantly from estimates of infection prevalence in either country, whereas both KK and CCA with trace as negative significantly underestimated infection prevalence in both countries. Conclusions Incorporation of ambiguous results into an LCA enables the effect of different treatment thresholds to be directly assessed and is applicable in many fields. Our results showed that CCA with trace as positive most accurately estimated infection prevalence

Non-adherence to the single dose nevirapine regimen for the prevention of mother-to-child transmission of HIV in Bindura town, Zimbabwe: a cross-sectional analytic study

<p>Abstract</p> <p>Background</p> <p>The Prevention of Mother to Child Transmission of HIV (PMTCT) programme was introduced at Bindura Hospital in 2003. Seven additional satellite PMTCT clinics were set up in the district to increase service coverage but uptake of PMTCT interventions remained unsatisfactory. In this study we determined the prevalence of and factors associated with non-adherence to the single dose nevirapine (SD-NVP) regimen for PMTCT in Bindura town.</p> <p>Methods</p> <p>An analytic cross-sectional study was conducted in four health institutions in Bindura town. Participants were mother-baby pairs on the PMTCT programme attending routine six weeks post natal visits in the participating health institutions from March to July 2008. We interviewed 212 mothers using a structured questionnaire.</p> <p>Results</p> <p>The non-adherence rate to the maternal nevirapine dose was 30.7%, while non-adherence to the newborn nevirapine dose was 26.9%. The combined mother-baby pair nevirapine non-adherence was 42.9%. Non-adherence to the maternal dose of nevirapine was associated with lack of maternal secondary education (POR = 2.38; 95%CI: 1.05-3.39) and multi-parity (POR = 2.66; 95%CI: 1.05-6.72), while previous maternal exposure to the PMTCT programme (POR = 0.22; 95%CI: 0.08-0.57) and giving the mother a NVP tablet to take home during antenatal care (POR = 0.03; 95%CI: 0.01-0.09) were associated with improved maternal adherence to nevirapine. Non-adherence to the infant dose of nevirapine was associated with maternal non-disclosure of HIV results to sexual partner (POR = 2.75; 95%CI: 1.04-7.32) and home deliveries (POR = 48.76; 95%CI: 17.51-135.82).</p> <p>Conclusions</p> <p>Non-adherence to nevirapine prophylaxis for PMTCT was high in Bindura. Ensuring institutional deliveries, encouraging self-disclosure of HIV results by the mothers to their partners and giving HIV positive mothers nevirapine doses to take home early in pregnancy all play significant roles in improving adherence to PMTCT prophylaxis.</p

The Many Manifestations of Downsizing: Hierarchical Galaxy Formation Models confront Observations

[abridged] It has been widely claimed that several lines of observational evidence point towards a "downsizing" (DS) of the process of galaxy formation over cosmic time. This behavior is sometimes termed "anti-hierarchical", and contrasted with the "bottom-up" assembly of the dark matter structures in Cold Dark Matter models. In this paper we address three different kinds of observational evidence that have been described as DS: the stellar mass assembly, star formation rate and the ages of the stellar populations in local galaxies. We compare a broad compilation of available data-sets with the predictions of three different semi-analytic models of galaxy formation within the Lambda-CDM framework. In the data, we see only weak evidence at best of DS in stellar mass and in star formation rate. We find that, when observational errors on stellar mass and SFR are taken into account, the models acceptably reproduce the evolution of massive galaxies, over the entire redshift range that we consider. However, lower mass galaxies are formed too early in the models and are too passive at late times. Thus, the models do not correctly reproduce the DS trend in stellar mass or the archaeological DS, while they qualitatively reproduce the mass-dependent evolution of the SFR. We demonstrate that these discrepancies are not solely due to a poor treatment of satellite galaxies but are mainly connected to the excessively efficient formation of central galaxies in high-redshift haloes with circular velocities ~100-200 km/s. [abridged]Comment: MNRAS accepted, 16 pages, 10 figure

The central dark matter content of early-type galaxies: scaling relations and connections with star formation histories

We examine correlations between the masses, sizes, and star formation histories for a large sample of low-redshift early-type galaxies, using a simple suite of dynamical and stellar populations models. We confirm an anti-correlation between size and stellar age, and survey for trends with the central content of dark matter (DM). An average relation between central DM density and galaxy size of ~ Reff^-2 provides the first clear indication of cuspy DM haloes in these galaxies -- akin to standard LCDM haloes that have undergone adiabatic contraction. The DM density scales with galaxy mass as expected, deviating from suggestions of a universal halo profile for dwarf and late-type galaxies. We introduce a new fundamental constraint on galaxy formation by finding that the central DM fraction decreases with stellar age. This result is only partially explained by the size-age dependencies, and the residual trend is in the opposite direction to basic DM halo expectations. Therefore we suggest that there may be a connection between age and halo contraction, and that galaxies forming earlier had stronger baryonic feedback which expanded their haloes, or else lumpier baryonic accretion that avoided halo contraction. An alternative explanation is a lighter initial mass function for older stellar populations.Comment: 24 pages, 23 figures. MNRAS, submitted with minor modifications following referee report