Crónica de la provincia de León

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 2007Texto a dos col.H. de map.: B. Cuaranta grabr. litog\so\pLas h. de lám. son retratos de Juan de Ferreras, Sancho IV, Juan de la Encina, Juana (La Beltraneja) y Fernando de Villafañ

Data regarding active psychosis and functional outcome, among other clinical variables, during early phases of the illness in first-episode psychosis in the PAFIP 10-year follow-up program

This article describes data related to the research study entitled ?Duration of active psychosis during early phases of the illness and functional outcome: The PAFIP 10-year follow-up study.? [1]. We present data concerning the clinical and sociodemographic characteristics of a sample of drug-naïve patients with a first episode of non-affective psychosis. The dataset was obtained from a 3-year longitudinal intervention program as part of an ongoing 10-year epidemiological study. The tables and figure shown present the data from the analysis between the active psychosis (presence of positive psychotic symptoms), among other sociodemographic and clinical predictor variables, recorded during the 3-year longitudinal intervention program and the evaluation of the functional outcome (social functioning and functional recovery) present at the 10-year mark. The data explores how those early parameters could influence long-term outcome

10Kin1day: A Bottom-Up Neuroimaging Initiative.

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain

Duration of active psychosis during early phases of the illness and functional outcome: The PAFIP 10-year follow-up study

PAFIP research group.[Introduction] Longer duration of active psychosis (presence of positive psychotic symptoms) has been associated to worsening of functional and symptomatic outcome in patients with a first-episode of psychosis. There could be a “critical period” of increased brain vulnerability in the early phases of the illness when the effect of active psychosis would be exceptionally pernicious.[Objectives] We aim to explore the impact of lengthy periods of active psychosis during early phases of illness on long-term functional outcome.[Methods] This is a prospective clinical study. We assessed the effect of the duration active psychosis in patients with a first-episode of nonaffective psychosis on long-term social functioning and functional recovery. The study consisted of a 3-year clinical follow-up and a functional evaluation performed after a 10-year period.[Results] The sample consisted of 169 patients with a first-episode of non-affective psychosis. The duration of active psychosis after treatment (DAT) during the 3-year clinical follow-up acted as predictor of social functioning at the 10-year functional evaluation (Wald: 10.705; p = .001), but not of functional recovery. The duration of untreated psychosis (DUP) did not act as a predictor of any of the two long-term measures of functional outcome.[Conclusions] Active psychosis in early phases of the illness seems to be correlated to worst long-term functionality. In this study the duration of active psychosis after treatment (DAT) was a better predictor of long-term outcome than the duration of untreated psychosis (DUP). Reducing DAT should be considered an important objective for early intervention programs

Aripiprazole vs Risperidone for the acute-phase treatment of first-episode psychosis: A 6-week randomized, flexible-dose, open-label clinical trial

Selecting the first antipsychotic agent for the acute phase of a first episode of psychosis (FEP) is a critical task that may impact on the long-term outcome. Despite that, there is a lack of research comparing head-to-head different second-generation antipsychotics at this stage. The aim of this study was to compare the effectiveness of aripiprazole and risperidone in the treatment of the acute phase after a FEP. For that purpose, from February 2011 to October 2018, a prospective, randomized, open-label study was undertaken. Two hundred-sixty-six first-episode, drug-naïve patients were randomly assigned to aripiprazole (n = 136), or risperidone (n = 130) and followed-up for 6-weeks. The primary effectiveness measure was all-cause treatment discontinuation. In addition, an analysis based on intention-to-treat principle was conducted to assess clinical efficacy. The overall dropout rate at 6-week reached 19.5%. Effectiveness measures were similar between both treatment groups as treatment discontinuation rates (χ2 = 1.863; p = 0.172) and mean time until all-cause discontinuation (log rank = 1.421; p = 0.233) showed no statistically significant differences. In terms of clinical efficacy, risperidone proved a statistically significant better performance according to BPRS mean change between baseline and 6-week total score (t = 3.187; p = 0.002). Patients under risperidone treatment were significantly more likely to suffer sex-related adverse events. In conclusion, no differences regarding effectiveness were found between aripiprazole and risperidone for the acute-phase treatment of FEP. Despite the importance of efficacy during this phase of treatment, selecting the most effective treatment for the long-term outcome, requires addressing safety and patient´s preferences.This study was conducted as part of a the PAFIP-3 clinical trial “Effectiveness of Second Generation Antipsychotics in First Episode Psychosis Patients: 1-year Follow-up (PAFIP3_1Y)”. ClinicalTrials.gov Identifier: (NCT02532491). The authors wish to thank all “Programa Asistencial de las Fases Iniciales de Psicosis”(PAFIP) research team and all patients and family members who participated in the study

Active psychosis and pro-inflammatory cytokines in first-episode of psychosis

Higher levels of pro-inflammatory cytokines are consistently found in the serum of first episode psychosis (FEP) patients and this immune dysfunction could contribute to neural harm. On the other hand, lengthy periods of active psychosis during the early phases of the illness appear to be associated to worst functional outcome. We aim to explore the possible relationship between lengthy periods of active psychosis during early phases of the illness and the levels of pro-inflammatory cytokines. This is a prospective clinical study consisting of a 3-year clinical follow-up. We assessed the relation between the duration of active psychosis in patients with FEP and the serum levels of 21 cytokines at baseline and 3 months after initiating antipsychotic medication. We used the Human High Sensitivity T Cell Magnetic Bead Panel protocol from the Milliplex® Map Kit. The sample consisted of 59 patients with a FEP. The percentage of variation of the serum levels of the chemokine MIP-3α during the first 3 months of antipsychotic treatment and the score in negative psychotic symptoms 3 months after the initiation of antipsychotic medication, acted as predictors of the initial time to remission of positive psychotic symptoms. Our findings open the possibility to investigating the potential use of the variation in chemokine MIP-3α serum levels during the first months of antipsychotic treatment to identify a subtype of FEP patients that could benefit from an add-on treatment with immune modulators

Título: Historia ilustrada y descriptiva de sus provincias, sus poblaciones más importantes y posesiones de ultramar

Otros editores: Rubio : Vitturi : GriloTexto a dos colContiene lám., mapas y retr. firmados que no forman parte de la secuencia de págContiene lám., retr. firmados que no forman parte de la secuencia de pagContiene: Crónica de la provincia de Madrid / Cayetano Rossell -- Crónica de la provincia de Guadalajara / José María Escudero (66 p., [3] h. de lám.) -- Crónica de la provincia de Cuenca / Pedro Pruneda (78 p., [4] h. de lám., [1] h. de map.) -- Crónica de la provincia de Toledo / Eduardo de Mariátegui (112 p., [6] h. de lám.) -- Crónica de la provincia de Ciudad Real / Jose de Hosta (95 p., [5] h. de lám.) -- Crónica de la provincia de La Coruña / Fernando Fulgosio (128 p., [7] h. de lám., [1] h. de map.) -- Crónica de la provincia de Orense / Fernando Fulgosio (48 p., [2] h. de lám., [1] h. de map.) -- Crónica de la provincia de Lugo / José Villa-amil y Castro (80 p.) -- Crónica de la provincia de Pontevedra / Fernando Fulgosio (94 p., [5] h. de lám., [1] h. de map.) -- Crónica de la provincia de Gerona / Narciso Blanch é Illa (176 p., [10] h. de lám., [1] h. de map.) -- Crónica de la provincia Lérida / Enrique Blanch (63 p., [3] h. de lám., [1] h. de map.)-- Crónica de la provincia de Tarragona / Fernando Fulgosio (96 p., [5] h. de lám., [1] h. de map.) -- Crónica de la provincia de Barcelona / Manuel Angelón (159 p., [9] h. de lám., [1] h. de map.) -- Crónica de la provincia de León / José García de la Foz (95 p., [5] h. de lám., [1] h. de map.) -- Crónica de la provincia de Palencia / Federico Villalva (VIII, 80 p., [4] h. de lám., [1] h. de map.) -- Crónica de la provincia de Valladolid / Fernando Fulgosio (78 p., [4] h. de lám., [1] h. de map.) -- Crónica de la provincia de Zamora / Fernando Fulgosio (80 p., [4] h. de lám., [1] h. de map.) -- Crónica de la provincia de Salamanca / Manuel González de la Llana (63 p., [3] h. de lám., [2] h. de map.) -- Crónica del Principado de Asturias / Evaristo Escalera (192 p., [11] h. de lám., [1] h. de map.) -- Crónica de la provincia de Valencia / Vicente Boix (111 p., [6] h. de lám., [1] h. de map.) -- Crónica de la provincia de Alicante / Vicente Boix (62 p., [3] h. de lám., [1] h. de map.) -- Crónica de la provincia de Castellón de la Plana / Adolfo Miralles de Imperial (80 p., [2] h. de lám.) -- Crónica de la provincia de Zaragoza / José Fernando González (158 p., [9] h. de lám., [1] h. de map.) -- Crónica de la provincia de Huesca / José Fernando González (80 p., [4] h. de lám.) -- Crónica de la provincia de Teruel / Pedro Pruneda (95 p., [3] h. de lám.) -- Crónica de la provincia de Navarra / Julio Nombela, 1868 (VIII, 112 p., [6] h. de lám., [1] h. de map.) -- Crónica de la provincia de Guipúzcoa / Fernando Fulgosio (80 p., [4] h. de lám., [1] h. de map.) -- Crónica del Señorío de Vizcaya / Francisco Rodríguez García (160 p., [7] h. de lám.) -- Crónica de la provincia de Álava / José Bisso (78 p., [4] h. de lám., [1] h. de map.) -- Crónica de la provincia de Sevilla / José Bisso (94 p., [5] h. de lám., [1] h. de map.) -- Crónica de la provincia de Córdoba / Manuel González Llana (95 p., [5] h. de lám., [1] h. de map.) -- Crónica de la provincia de Cádiz / José Bisso (127 p., [7] h. de lám., [1] h. de map.) -- Crónica de la provincia de Huelva / Manuel Climent (63 p., [2] h. de lám.) -- Crónica de la provincia de Almería / Enrique Santoyo (63 p., [3] h. de lám., [1] h. de map.) -- Crónica de la provincia de Jaén / Francisco Lozano Muñoz (79 p., [3] h. de lám., [1] h. de map.) -- Crónica de la provincia de Málaga / José Bisso (99 p., [5] h. de lám., [1] h. de map.) -- Crónica de la provincia de Granada / Juan de Dios de la Rada y Delgado (191 p., [9] h. de lám.) -- Crónica de la provincia de Ávila / Fernando Fulgosio (64 p., [3] h. de lám., [1] h. de map.) -- Crónica de la provincia de Segovia / Luis Carreras (95 p., [5] h. de lám., [1] h. de map.) -- Crónica de la provincia de Burgos / Joaquín Maldonado Macanaz (112 p., [6] h. de lám., [1] h. de map.) -- Crónica de la provincia de Logroño / Waldo Gímenez Romera (63 p., [3] h. de lám., [1] h. de map.) -- Crónica de la provincia de Soria / Antonio Pérez Rioja -- Crónica de la provincia de Santander / Manuel de Assas (126 p., [7] h. de lám., [1] h. de map.) -- Crónica de la provincia de Cáceres / Juan P. de GuzmánContiene: Crónica de la provincia de Madrid / Cayetano Rossell -- Crónica de la provincia de Guadalajara / José María Escudero -- Crónica de la provincia de Cuenca / Pedro Pruneda -- Crónica de la provincia de Toledo / Eduardo de Mariátegui -- Crónica de la provincia de Ciudad Real / Jose de Hosta -- Crónica de la provincia de la Coruña / Fernando Fulgosio -- Crónica de la provincia de Orense / Fernando Fulgosio -- Crónica de la provincia de Lugo / José Villa-amil y Castro -- Crónica de la provincia de Pontevedra / Fernando Fulgosio -- Crónica de la provincia de Gerona / Narciso Blanch é Illa -- Crónica de la provincia Lérida / Enrique Blanch -- Crónica de la provincia de Tarragona / Fernando Fulgosio -- Crónica de la provincia de Barcelona / Manuel Angelón -- Crónica de la provincia de León / José García de la Foz -- Crónica de la provincia de Palencia / Federico Villalva -- Crónica de la provincia de Valladolid / Fernando Fulgosio -- Crónica de la provincia de Zamora / Fernando Fulgosio -- Crónica de la provincia de Salamanca / Manuel González de la Llana -- Crónica del Principado de Asturias / Evaristo Escalera -- Crónica de la provincia de Valencia / Vicente Boix -- Crónica de la provincia de Alicante / Vicente Boix -- Crónica de la provincia de Castellón de la Plana / Adolfo Miralles de Imperial -- Crónica de la provincia de Zaragoza / José Fernando González -- Crónica de la provincia de Huesca / José Fernando González -- Crónica de la provincia de Teruel / Pedro Pruneda -- Crónica de la provincia de Navarra / Julio Nombela -- Crónica de la provincia de Guipuzcoa / Fernando Fulgosio -- Crónica del Señorío de Vizcaya / Francisco Rodríguez García -- Crónica de la provincia de Alava / José Bisso -- Crónica de la provincia de Sevilla / José Bisso -- Crónica de la provincia de Córdoba / Manuel González Llana -- Crónica de la provincia de Cádiz / José Bisso -- Crónica de la provincia de Huelva / Manuel Climent -- Crónica de la provincia de Almeria / Enrique Santoyo -- Crónica de la provincia de Jaen / Francisco Lozano Muñoz -- Crónica de la provincia de Málaga / José Bisso -- Crónica de la provincia de Granada / Juan de Dios de la Rada y Delgado -- Crónica de la provincia de Avila / Fernando Fulgosio -- Crónica de la provincia de Segovia / Luis Carreras -- Crónica de la provincia de Burgos / Joaquín Maldonado Macanaz -- Crónica de la provincia de Logroño / Waldo Gímenez Romera -- Crónica de la provincia de Soria / Antonio Pérez Rioja -- Crónica de la provincia de Santander / Manuel de Assas -- Crónica de la provincia de Cáceres / Juan P. de Guzmán -- Crónica de la provincia de Badajoz / Manuel Henao y Muñoz -- Crónica de la provincia de Albacete / Narciso Blanch é Illa -- Crónica de la provincia de Murcia / José Bisso -- Crónica de Las Antillas / Jacobo de la Pezuela -- Crónica de las Islas Canarias / Waldo Gímenez Romera -- Crónica de las Islas Baleares / Fernando Fulgosio -- Africa : Islas de Fernando Póo, Corisco y Annobon / José Muñoz y Gaviri