54 research outputs found
By Any Other Name: Heterologous Replacement of the Escherichia coli RNase P Protein Subunit Has In Vivo Fitness Consequences
- Author
- A Babajide
- A Loria
- A Mondragón
- A Wagner
- AH Buck
- AH Buck
- Akio Kanai
- AV Kazantsev
- C Guerrier-Takada
- C Reich
- C Reidys
- C Spitzfaden
- CA Panagiotidis
- CR Woese
- D Evans
- DJ Coughlin
- DT Jones
- E Bornberg-Bauer
- E Seif
- E Westhof
- ES Haas
- F Vasi
- FG Hansen
- FJ Richards
- Jasmine L. Loveland
- JC Ellis
- JF Peden
- JJ Kim
- JW Brown
- K Peck-Miller
- K Tamura
- KA Datsenko
- KE Nelson
- L Meyer-Leon
- M Gossringer
- M Gossringer
- M Kitagawa
- MA Huynen
- N Galtier
- NJ Reiter
- O Gimple
- P Dalgaard
- Paula C. G. Turrini
- PM Sharp
- RC Edgar
- Robert L. Dorit
- S Altman
- T Aita
- T Stams
- U Bastolla
- VS Cooper
- W Fontana
- WH McClain
- X Guo
- Y Hori
- Y Li
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Bacterial RNase P is an essential ribonucleoprotein composed of a catalytic RNA component (encoded by the rnpB gene) and an associated protein moiety (encoded by rnpA). We construct a system that allows for the deletion of the essential endogenous rnpA copy and for its simultaneous replacement by a heterologous version of the gene. Using growth rate as a proxy, we explore the effects on fitness of heterologous replacement by increasingly divergent versions of the RNase P protein. All of the heterologs tested complement the loss of the endogenous rnpA gene, suggesting that all existing bacterial versions of the rnpA sequence retain the elements required for functional interaction with the RNase P RNA. All replacements, however, exact a cost on organismal fitness, and particularly on the rate of growth acceleration, defined as the time required to reach maximal growth rate. Our data suggest that the similarity of the heterolog to the endogenous version — whether defined at the sequence, structure or codon usage level — does not predict the fitness costs of the replacement. The common assumption that sequence similarity predicts functional similarity requires experimental confirmation and may prove to be an oversimplification
Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agapitos A
- Agram JL
- Ahmad A
- Ahmad M
- Ahuja S
- Akchurin N
- Akgun B
- Akin IV
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Alderweireldt S
- Aleksandrov A
- Alexander J
- Alimena J
- Alverson G
- Alves GA
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- Amsler C
- Anagnostou G
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Measurement of the Zγ production cross section in pp collisions at 8 TeV and search for anomalous triple gauge boson couplings
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agapitos A
- Agram J-L
- Ahmad A
- Ahmad M
- Ahuja S
- Akchurin N
- Akgun B
- Akin IV
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Alderweireldt S
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Ali MABM
- Alimena J
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anderson I
- Anderson J
- Andrea J
- Andreev V
- Andreev Y
- Androsov K
- Antonelli L
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
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- Arenton MW
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- Asawatangtrakuldee C
- Asin I
- Askew A
- Aslanoglou X
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- Autermann C
- Auzinger G
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- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Baber M
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- Bachmair F
- Bachtis M
- Baden A
- Baffioni S
- Bagliesi G
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Ball AH
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Barbieri R
- Bargassa P
- Barge D
- Baringer P
- Barker A
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- Battilana C
- Bauerdick LAT
- Baumgartel D
- Baus C
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- Behnamian H
- Behr J
- Behrens U
- Beirão Da Cruz E Silva C
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- Belknap DA
- Bell AJ
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- Bhattacharya S
- Bhawandeep U
- Bhowmik S
- Bialkowska H
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Open Access, Copyright CERN, for the benefit of the CMS Collaboration. Article funded by SCOAP3.Abstract: The cross section for the production of Zγ in proton-proton collisions at 8 TeV is measured based on data collected by the CMS experiment at the LHC corresponding to an integrated luminosity of 19.5 fb−1. Events with an oppositely-charged pair of muons or electrons together with an isolated photon are selected. The differential cross section as a function of the photon transverse momentum is measured inclusively and exclusively, where the exclusive selection applies a veto on central jets. The observed cross sections are compatible with the expectations of next-to-next-to-leading-order quantum chromodynamics. Limits on anomalous triple gauge couplings of ZZγ and Zγγ are set that improve on previous experimental results obtained with the charged lepton decay modes of the Z boson
Measurements of the t(t)over-bar production cross section in lepton plus jets final states in pp collisions at 8 and ratio of 8 to 7 TeV cross sections
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- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Measurements of the Upsilon(1S), Upsilon(2S), and Upsilon(3S) differential cross sections in pp collisions at root s=7 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adair A
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- Adams JR
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- Publication venue
- Publication date
- 01/01/2015
- Field of study
Peer reviewe
Search for lepton flavour violating decays of the Higgs boson to eτand eμin proton–proton collisions at √s=8TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adair A
- Adam W
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- Yilmaz Y
- Yohay R
- Yonamine R
- Yoo HD
- Yoo J
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- Yumiceva F
- Yusli MN
- Zabel J
- Zabi A
- Zaganidis N
- Zagozdzinska A
- Zakaria M
- Zalewski P
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- Zevi Della Porta G
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- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhokin A
- Zhu RY
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- Zou D
- Zsigmond AJ
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- Elsevier
- Publication date
- 01/01/2016
- Field of study
A direct search for lepton flavour violating decays of the Higgs boson (H) in the H →eτand H →eμchannels is described. The data sample used in the search was collected in proton–proton collisions at √s=8TeVwith the CMS detector at the LHC and corresponds to an integrated luminosity of 19.7fb−1. No evidence is found for lepton flavour violating decays in either final state. Upper limits on the branching fractions, B(H →eτ) <0.69%and B(H →eμ) <0.035%, are set at the 95% confidence level. The constraint set on B(H →eτ)is an order of magnitude more stringent than the existing indirect limits. The limits are used to constrain the corresponding flavour violating Yukawa couplings, absent in the standard model
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
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- Abbott T
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- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
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- Abdelhady S
- Abdelhamed R
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- Abdul-Latif S
- Abdulaziz H
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- Abdulhakeem EM
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- Abebe NS
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- Appiah EK
- Aql S
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- Aranzabal Durand SY
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- Arevalo Azmitia JR
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- Lytras D
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- Ma J
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- Macchitella Y
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- Macfarlane A
- Machaca M
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- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
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- Manchego Bautista AC
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- Manfreda S
- Mangan C
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- Manipal CE
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- Mann T
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- Mano MJB
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- Mesbah N
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- Mirza A
- Mirza S
- Mistry A
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- Mohamed F
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- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
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- Mohammad A
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- Montrimaite M
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- Nanthakumaran S
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- Samaraweera DI
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- Urbonas T
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- Wold TB
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- Yaseen TM
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- Yeang LJ
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- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
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- Zani A
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- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
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- Zilinskiene R
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- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
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- A Barbero
- A Mackay-Sim
- A Rajan
- A Shehadah
- A Taguchi
- AC Bachoud-Levi
- AF Cristante
- AJ Mathew
- AM Malek
- AM Okamura
- AR Massensini
- AU Hicks
- B Yamout
- BA Aguado
- BC Heng
- BG Ballios
- BL Guo
- BV Slaughter
- C Paul
- C Watts
- C Yan
- CR Bjarkam
- CR Freed
- CV Borlongan
- CV Borlongan
- CW Olanow
- D Kalladka
- D Karussis
- D Kondziolka
- D Kondziolka
- D Kondziolka
- D Usvald
- D Yin
- DP Lammertse
- E Bible
- E Bible
- E Bible
- EA Miljan
- EA Silva
- EM Torres
- F Asten van
- F Feron
- F Miyanji
- FJ Nicholls
- FS Veraitch
- G Nikkhah
- G Nikkhah
- G Wang
- GK Steinberg
- GT Gobbel
- GT Gobbel
- H Wang
- HJ Kong
- HP Tan
- I Mendez
- I Mendez
- J Guest
- J Gutierrez
- J Muller-Ehmsen
- J Riley
- J Riley
- JD Glass
- JH Ryu
- JP Hubschman
- JP Riley
- JS Lunn
- JT Heaton
- K Agashi
- L Mazzini
- L Mazzini
- LA Jones
- LY Qiao
- M Grellier
- M Janowski
- M Tol
- MA Laflamme
- MB Potts
- MH Amer
- MH Amer
- MJ Mahoney
- MK Mamidi
- MT Harting
- MT Silvestrini
- N Knoller
- N Zakaria
- NA Kishk
- O Lindvall
- P Brundin
- P Tabakow
- PA Walker
- PF Morrison
- PH Rosado-de-Castro
- PL Richard
- Q Zeng
- R El Khoury
- R Korenaga
- RA Pearson
- RD Myers
- RE Breeze
- RS Reneman
- S Karimi-Abdolrezaee
- S Reyes
- S Stolberg
- SB Seif-Naraghi
- SD Schwartz
- SG Schwartz
- SH Yoon
- SJ Bidarra
- SL Peterson
- SP Sutera
- SS Lee
- T Mehta
- T Rossetti
- T Tanzeglock
- TC Srijaya
- TM Bliss
- V Guarino
- V Misra
- X Chen
- Y Chen
- Y Ma
- Z Bayoussef
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2017
- Field of study
Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell-therapy interventions
Search for lepton-flavour-violating decays of the Higgs boson
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- Abbiendi G
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- Abdullah WAT Wan
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- Acosta D
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Search for resonant pair production of Higgs bosons decaying to two bottom quark-antiquark pairs in proton-proton collisions at 8TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
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- Potenza A
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- Poyraz D
- Pozdnyakov A
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- Pozzobon N
- Prado Da Silva WL
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- Prokofyev O
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- Ribeiro Cipriano PM
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- Savrin V
- Saxena P
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- Schael S
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- Stephans GSF
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- Stober FM
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- Strologas J
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- Vazquez Valencia F
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- Veeraraghavan V
- Velasco M
- Velicanu D
- Velkovska J
- Venditti R
- Venturi A
- Verdier P
- Verdini PG
- Veres GI
- Vergili M
- Vernieri C
- Verwilligen P
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- Veszpremi V
- Vesztergombi G
- Veverka J
- Vidal Marono M
- Vidal R
- Vila I
- Vilar Cortabitarte R
- Vilela Pereira A
- Villella I
- Vinogradov A
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- Vitulo P
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- Volobouev I
- Volpe R
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- Vorobyev A
- Vorobyev An
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- West C
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- Wickramage N
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- Wissing C
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- Wolf R
- Wolfe E
- Wolfe H
- Wollny H
- Womersley WJ
- Won S
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- Wood JS
- Woodard A
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- Worm SD
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- Wu Z
- Wulsin HW
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- Xiao H
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- Yumiceva F
- Zabel J
- Zabi A
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- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
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- Zenoni F
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- Zevi Della Porta G
- Zeyrek M
- Zhang J
- Zhang L
- Zhokin A
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- Zhukov V
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- Zotto P
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- Zsigmond AJ
- Zucchetta A
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- Zvada M
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Peer reviewe
- …