199 research outputs found
Sporulation, bacterial cell envelopes, and the origin of life
- Author
- A Typas
- AL Koch
- BA Dmitriev
- C Campbell
- C Gram
- C Rinke
- CR Woese
- CT Brown
- D Hillmann
- D Kay
- D Wu
- Davi R. Ortega
- DC McPherson
- E Hoiczyk
- E Sauvage
- EC Garner
- EI Tocheva
- EI Tocheva
- EJ Hayhurst
- Elitza I. Tocheva
- EN Houben
- FD Ciccarelli
- Grant J. Jensen
- H Marchandin
- H Song
- IC Sutcliffe
- IC Sutcliffe
- IS Tan
- J Dominguez-Escobar
- J Errington
- J Lombard
- J Nigou
- JA Lake
- JA Lake
- JA Lake
- JA Lake
- JP Gogarten
- K Raymann
- KH Schleifer
- KS Swithers
- L Gan
- L Gan
- LA Hug
- M Beeby
- M Niederweis
- M Remmert
- MA de Pedro
- MD Kane
- N Yutin
- P Meyer
- P Puigbo
- P Setlow
- R Gouy
- RE Valas
- RG Skophammer
- RH Senaratne
- RS Gupta
- RS Gupta
- RS Gupta
- RW Verwer
- RW Verwer
- S Foster
- SE Mergenhagen
- SM Desmarais
- T Cavalier-Smith
- T Cavalier-Smith
- TJ Silhavy
- W Martin
- W Vollmer
- W Vollmer
- W Vollmer
- W Vollmer
- WF Doolittle
- WL Nicholson
- Y Uenishi
- YI Wolf
- Publication venue
- Nature Publishing Group
- Publication date
- 29/02/2016
- Field of study
Electron cryotomography (ECT) enables the 3D reconstruction of intact cells in a near-native state. Images produced by ECT have led to the proposal that an ancient sporulation-like event gave rise to the second membrane in diderm bacteria. Tomograms of sporulating monoderm and diderm bacterial cells show how sporulation can lead to the generation of diderm cells. Tomograms of Gram-negative and Gram-positive cell walls and purified sacculi suggest that they are more closely related than previously thought and support the hypothesis that they share a common origin. Mapping the distribution of cell envelope architectures onto a recent phylogenetic tree of life indicates that the diderm cell plan, and therefore the sporulation-like event that gave rise to it, must be very ancient. One explanation for this model is that during the cataclysmic transitions of the early Earth, cellular evolution may have gone through a bottleneck in which only spores survived, which implies that the last bacterial common ancestor was a spore
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
- Author
- A Suto
- A Suto
- A Vogelzang
- A-U Rasheed
- AC Poholek
- AG Zaretsky
- AN Hotson
- B Klein
- Burton Barnett
- C King
- CDC Allen
- CG Vinuesa
- CH Kim
- Christopher Lao
- CS Ma
- D Allman
- D Breitfeld
- D Kashiwakuma
- D Yu
- D Zotos
- Danelle Eto
- Daniel DiToro
- DT Avery
- EK Deenick
- ES Vitetta
- F Eddahri
- F Rousset
- G Jego
- G Jego
- G Jego
- G Martins
- GA Martins
- H Akiba
- H Elsaesser
- H Kwon
- H Qi
- HC van Zaanen
- I GonzĂĄlez-GarcĂa
- I Yusuf
- IC MacLennan
- IL King
- Isharat Yusuf
- J Rolf
- J Zhu
- JL Fornek
- JS Yi
- K Ozaki
- K Ozaki
- L Wei
- L Zhou
- Lisa Ng Fong Poh
- M Howard
- M Kopf
- M Kopf
- M Shapiro-Shelef
- MA Linterman
- MM McCausland
- NM Haynes
- O Dienz
- O Dienz
- P Schaerli
- PC Heinrich
- R Bataille
- R Ettinger
- R Förster
- R Nurieva
- R Spolski
- RI Nurieva
- RI Nurieva
- RJ Johnston
- RL Reinhardt
- Robin Kageyama
- S Crotty
- S Crotty
- S Crotty
- S Crotty
- S Diehl
- S Hardtke
- SA Diehl
- Shane Crotty
- T Chtanova
- T Korn
- Tania C. Escobar
- VL Bryant
- Y Saito
- Y Wu
- Publication venue
- Public Library of Science
- Publication date
- 01/03/2011
- Field of study
Cytokines are important modulators of lymphocytes, and both interleukin-21 (IL-21) and IL-6 have proposed roles in T follicular helper (Tfh) differentiation, and directly act on B cells. Here we investigated the absence of IL-6 alone, IL-21 alone, or the combined lack of IL-6 and IL-21 on Tfh differentiation and the development of B cell immunity in vivo. C57BL/6 or IL-21â/â mice were treated with a neutralizing monoclonal antibody against IL-6 throughout the course of an acute viral infection (lymphocytic choriomeningitis virus, LCMV). The combined absence of IL-6 and IL-21 resulted in reduced Tfh differentiation and reduced Bcl6 protein expression. In addition, we observed that these cytokines had a large impact on antigen-specific B cell responses. IL-6 and IL-21 collaborate in the acute T-dependent antiviral antibody response (90% loss of circulating antiviral IgG in the absence of both cytokines). In contrast, we observed reduced germinal center formation only in the absence of IL-21. Absence of IL-6 had no impact on germinal centers, and combined absence of both IL-21 and IL-6 revealed no synergistic effect on germinal center B cell development. Studying CD4 T cells in vitro, we found that high IL-21 production was not associated with high Bcl6 or CXCR5 expression. TCR stimulation of purified naĂŻve CD4 T cells in the presence of IL-6 also did not result in Tfh differentiation, as determined by Bcl6 or CXCR5 protein expression. Cumulatively, our data indicates that optimal Tfh formation requires IL-21 and IL-6, and that cytokines alone are insufficient to drive Tfh differentiation
21st century well-child care
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Arrival Directions of Cosmic Rays above 32 EeV from Phase One of the Pierre Auger Observatory
- Author
- Abreu P
- Aglietta M
- Albury JM
- Allekotte I
- Almela A
- Alvarez-Muniz J
- Anastasi GA
- Anchordoqui L
- Andrada B
- Andringa S
- Aramo C
- Arbeletche LB
- Armand JP
- Arnone E
- Asorey H
- Assis P
- Avila G
- Avocone E
- Badescu AM
- Bakalova A
- Balaceanu A
- Barbato F
- Batista RA
- Bellido JA
- Berat C
- Berisso MG
- Bertaina ME
- Bertolli CP
- Bhatta G
- Biermann PL
- Binet V
- Bismark K
- Bister T
- Biteau J
- Blazek J
- Bleve C
- Blumer J
- Bohacova M
- Boncioli D
- Bonifazi C
- Borodai N
- Botti AM
- Brack J
- Bravo OM
- Bretz T
- Briechle FL
- Buchholz P
- Bueno A
- Buitink S
- Buscemi M
- Busken M
- Caballero-Mora KS
- Caccianiga L
- Canfora F
- Caracas I
- Caruso R
- Castellina A
- Catalani F
- Cataldi G
- Cazon L
- Cerda M
- Cerutti ACC
- Cheminant KA
- Chinellato JA
- Chudoba J
- Chytka L
- Clay RW
- Colalillo R
- Coleman A
- Coluccia MR
- Conceicao R
- Condorelli A
- Consolati G
- Contreras F
- Convenga F
- Covault CE
- Covilakam VVK
- D'Olivo JC
- Dasso S
- Daumiller K
- Dawson BR
- Day JA
- de Almeida RM
- de Carvalho WR
- de Jesus J
- de Jong SJ
- De Mitri I
- de Oliveira J
- de Oliveira MAL
- de Palma F
- de Souza V
- De Vito E
- Del Popolo A
- del Rio M
- Deligny O
- Deval L
- di Matteo A
- Dobre M
- Dobrigkeit C
- dos Anjos RC
- dos Santos DC
- Dova MT
- Ebr J
- Engel R
- Epicoco I
- Erdmann M
- Escobar CO
- Etchegoyen A
- Falcke H
- Farmer J
- Farrar G
- Fauth AC
- Fazzini N
- Feldbusch F
- Fenu F
- Ferreira PRA
- Fick B
- Figueira JM
- Fitoussi T
- Fodran T
- Franco DD
- Fujii T
- Fuster A
- Galea C
- Galelli C
- Galicia JFV
- Garcia B
- Gemmeke H
- Gesualdi F
- Gherghel-Lascu A
- Ghia PL
- Giaccari U
- Giammarchi M
- Glombitza J
- Gobbi F
- Gollan F
- Golup G
- Gomez JDS
- Gongora JP
- Gonzalez JM
- Gonzalez N
- Goos I
- Gora D
- Gorgi A
- Gottowik M
- Grubb TD
- Guarino F
- Guedes GP
- Guido E
- Hahn S
- Hamal P
- Hampel MR
- Hansen P
- Harari D
- Harvey VM
- Haungs A
- Hebbeker T
- Heck D
- Hill GC
- Hojvat C
- Horandel JR
- Horvath P
- Hrabovsky M
- Huege T
- Insolia A
- Isar PG
- Janecek P
- Johnsen JA
- Jurysek J
- Kaapa A
- Kampert KH
- Keilhauer B
- Khakurdikar A
- Klages HO
- Kleifges M
- Kleinfeller J
- Knapp F
- Kunka N
- Lago BL
- Langner N
- Lenok V
- Letessier-Selvon A
- Lhenry-Yvon I
- Lo Presti D
- Lopes L
- Lopez R
- Lu L
- Luce Q
- Lundquist JP
- Mancarella G
- Mandat D
- Manning BC
- Manshanden J
- Mantsch P
- Marafico S
- Mariani FM
- Mariazzi AG
- MariS IC
- Marsella G
- Martello D
- Martinelli S
- Martins EEP
- Mastrodicasa M
- Mathes HJ
- Matthews J
- Matthiae G
- Mayotte E
- Mayotte S
- Mazur PO
- Medina-Tanco G
- Melo D
- Mendes LMD
- Menshikov A
- Michal S
- Micheletti MI
- Miramonti L
- Mollerach S
- Montanet F
- Morejon L
- Morello C
- Mostafa M
- Muller AL
- Muller MA
- Mulrey K
- Mussa R
- Muzio M
- Namasaka WM
- Nasr-Esfahani A
- Nellen L
- Neto JRTD
- Nicora G
- Niculescu-Oglinzanu M
- Niechciol M
- Nitz D
- Norwood I
- Nosek D
- Novotny V
- Nozka L
- Nucita A
- Nunez LA
- Oliveira C
- Orchera PGB
- Palatka M
- Pallotta J
- Papenbreer P
- Parente G
- Parra A
- Pawlowsky J
- Payeras AM
- Pech M
- Peixoto CJT
- Pekala J
- Pelayo R
- Pena-Rodriguez J
- Perrone L
- Petrera S
- Petrucci C
- Pierog T
- Pimenta M
- Pirronello V
- Platino M
- Pont B
- Pothast M
- Privitera P
- Prouza M
- Puyleart A
- Querchfeld S
- Quispe IDV
- Rautenberg J
- Ravignani D
- Reininghaus M
- Ridky J
- Riehn F
- Risse M
- Rizi V
- Rojo JR
- Roncoroni MJ
- Rossoni S
- Roth M
- Roulet E
- Rovero AC
- Ruehl P
- Saftoiu A
- Saharan M
- Salamida F
- Salazar H
- Salina G
- Sanchez F
- Santos E
- Santos EM
- Sarazin F
- Sarmento R
- Sato R
- Savina P
- Schafer CM
- Scherini V
- Schieler H
- Schimassek M
- Schimp M
- Schluter F
- Schmidt D
- Scholten O
- Schoorlemmer H
- Schovanek P
- Schroder FG
- Schulte J
- Schulz T
- Sciutto SJ
- Scornavacche M
- Segreto A
- Sehgal S
- Shellard RC
- Sigl G
- Silli G
- Sima O
- Smau R
- Smida R
- Sommers P
- Soriano JF
- Squartini R
- Stadelmaier M
- Stanca D
- Stanic S
- Stasielak J
- Stassi P
- Straub M
- Streich A
- Suarez-Duran M
- Sudholz T
- Suomijarvi T
- Supanitsky AD
- Szadkowski Z
- Tapia A
- Taricco C
- Timmermans C
- Tkachenko O
- Tobiska P
- Tome B
- Torres Z
- Travaini A
- Travnicek P
- Trimarelli C
- Tueros M
- Ulrich R
- Unger M
- Vaclavek L
- Vacula M
- Valore L
- Varela E
- Vasquez-Ramirez A
- Veberic D
- Velazquez JCA
- Ventura C
- Verzi V
- Vicha J
- Vink J
- Vitale PFG
- Vorobiov S
- Wahlberg H
- Watanabe C
- Watson AA
- Weindl A
- Wiencke L
- Wilczynski H
- Wittkowski D
- Wundheiler B
- Yebra JA
- Yushkov A
- Zapparrata O
- Zas E
- Zavrtanik D
- Zavrtanik M
- Zehrer L
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2022
- Field of study
A promising energy range to look for angular correlations between cosmic rays of extragalactic origin and their sources is at the highest energies, above a few tens of EeV (1 EeV equivalent to 10^(18) eV). Despite the flux of these particles being extremely low, the area of similar to 3000 km^(2) covered at the Pierre Auger Observatory, and the 17 yr data-taking period of the Phase 1 of its operations, have enabled us to measure the arrival directions of more than 2600 ultra-high-energy cosmic rays above 32 EeV. We publish this data set, the largest available at such energies from an integrated exposure of 122,000 km^(2) sr yr, and search it for anisotropies over the 3.4 pi steradians covered with the Observatory. Evidence for a deviation in excess of isotropy at intermediate angular scales, with similar to 15 degrees Gaussian spread or similar to 25 degrees top-hat radius, is obtained at the 4 sigma significance level for cosmic-ray energies above similar to 40 EeV
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
- Casanova S
- Casasola V
- Casella P
- Casentini C
- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
- Cesarini E
- Chakraborty N
- Chamberlin SJ
- Chambers KC
- Chan M
- Chandra P
- Chang S-W
- Chang Z
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee D
- Chatterjee D
- Chatziioannou K
- Chaves RCG
- Chavez AG
- Chavushyan V
- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
- Chen L
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- Schroder FG
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- Zimnukhov DS
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- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Search for dark matter produced in association with bottom or top quarks in âs = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
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- Arslan Ozan
- Artamonov Andrei
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- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
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- Atkinson Markus
- Atlay Naim
- Augsten Kamil
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- Ayoub Mohamad
- Azuelos Georges
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- Bachacou Henri
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- Backes Moritz
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- Bajic Milena
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- Baldin Evgenii
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- Chan Stephen
- Chan Wing
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- Godlewski Jan
- Goldfarb Steven
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- Gonella Giulia
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- Gonski Julia
- Gonzalez-Sevilla Sergio
- GonzĂĄlez de la Hoz Santiago
- Gonçalo Ricardo
- Goossens Luc
- Gorbounov Petr
- Gordon Howard
- Gorini Benedetto
- Gorini Edoardo
- GoriĆĄek Andrej
- Goshaw Alfred
- Gostkin Mikhail
- Gottardo Carlo
- Goudet Christophe
- Goujdami Driss
- Goussiou Anna
- Govender Nicolin
- Gozani Eitan
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- Gradin Per
- Gramling Johanna
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- Gravila Paul
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- Gray Heather
- Greenwood Zeno
- Grefe Christian
- Gregersen Kristian
- Gregor Ingrid-Maria
- Grenier Philippe
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- Griffiths Justin
- Grillo Alexander
- Grimm Kathryn
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- Gris Philippe
- Grivaz Jean-Francois
- Groh Sabrina
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- Guan Wen
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- Guest Daniel
- Gueta Orel
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- Guo Jun
- Guo Wen
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- Gustavino Giuliano
- Gutelman Benjamin
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- Guyot Claude
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- Gwilliam Carl
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- Haas Andy
- Haber Carl
- Hadavand Haleh
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- Hagihara Mutsuto
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- Haleem Mahsana
- Haley Joseph
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- Hallewell Gregory
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- Hamity Guillermo
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- Hance Michael
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- Hanke Paul
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- Harenberg Torsten
- Hariri Faten
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- Harrison Paul
- Hartmann Nikolai
- Hasegawa Yoji
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- Hauser Reiner
- Hauswald Lorenz
- Havener Laura
- Havranek Miroslav
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- Hawkings Richard
- Hayakawa Daiki
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- Hays Jonathan
- Hayward Helen
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- Heelan Louise
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- Hellman Sten
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- Hervas Luis
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- Hesketh Gavin
- Hessey Nigel
- Hetherly Jeffrey
- Higashino Satoshi
- HigĂłn-Rodriguez Emilio
- Hildebrand Kevin
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- Hill John
- Hiller Karl
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- Hils Maximilian
- Hinchliffe Ian
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- Hoeferkamp Martin
- Hoenig Friedrich
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- Holzbock Michael
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- Hooberman Benjamin
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- Horii Yasuyuki
- Horton Arthur
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- Hostiuc Alexandru
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- Hoya Joaquin
- Hrabovsky Miroslav
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- Hsu Pai-hsien
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- Hyneman Rachel
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- Ito Fumiaki
- Iturbe Ponce Julia
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- Iwasaki Hiroyuki
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- Jain Vivek
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- Jakobs Karl
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- JAMIN David
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- Jones Samuel
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- Kharlamov Alexey
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- Korolkov Ilya
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- Kosek Tomas
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- Kourkoumeli-Charalampidi Athina
- Kourkoumelis Christine
- Kourlitis Evangelos
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- Kowalski Tadeusz
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- Kubota Takashi
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- Sugaya Yorihito
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- Trofymov Artur
- Troncon Clara
- Trottier-McDonald Michel
- Trovatelli Monica
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- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Ă kesson Torsten
- Ć filigoj Tina
- ĆœeniĆĄ Tibor
- ĆœivkoviÄ Lidija
- Îlvarez Piqueras DamiĂĄn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fbâ1 of protonâproton collision data recorded by the ATLAS experiment at âs = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
- Author
- Abdulhakim E
- Abraham P
- Abramov G
- Abu Hassan MR
- Adamson K
- Adawi F
- Adkins K
- Adler A
- Adler A
- Agarwal P
- Ahn KJ
- Akpunonu B
- Albota A
- Albu J
- Alexander K
- Alexandru C
- Alfonsi F
- Alt I
- Alvarisqueta AF
- Alvarsson M
- Alversson M
- Ambos A
- Ambos A
- Ambrosio G
- Ambulkar S
- Anagnostis G
- Anastasi L
- Andersone I
- Arambam P
- Aravind S
- Araz M
- Arciszewska M
- Argoud G
- Arias P
- Armaganijan L
- Armstrong PW
- Armstrong PW
- Aroda V
- Artemiuk E
- Aschner Montoya P
- Aschner P
- Athwal R
- Aziz NA
- Azizad M
- Babenko A
- Badat A
- Badenhoop K
- Bahit M
- Baker J
- Bakiner O
- Balaji V
- Balode A
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- Banerji MA
- Barbarash O
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- Bartkowiak A Jr
- Bashkin A
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- Beaven A
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- Bergenstal R
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- Vides H
- Viitas L
- Viljoen M
- Vishlitzky V
- Viswanath D
- Vizel S
- Vo A
- Vogel C
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- Voors-Pette C
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- VĂ©lez Pelaez S
- Wainstein J
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- Westerberg Maldonado BH
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- Wurziger J
- Wysham C
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- Yeung VT
- Yilmaz M
- Yoo SJ
- Yupanqui Lozno H
- Zachoval R
- Zadionchenko V
- Zak R
- Zavaroni DZ
- Zheng SX
- Ziegler O
- Zimanova J
- Zimmerman R
- Zinman B
- ĆmiaĆowski A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events
Measurement of the inclusive cross-section for the production of jets in association with a Z boson in proton-proton collisions at 8 TeV using the ATLAS detector
- Author
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- Abbott B
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- Zhemchugov A
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/10/2019
- Field of study
The inclusive cross-section for jet production in association with a Z boson decaying into an electronâpositron pair is measured as a function of the transverse momentum and the absolute rapidity of jets using 19.9 fb â1 of sâ=8 TeV protonâproton collision data collected with the ATLAS detector at the Large Hadron Collider. The measured Z + jets cross-section is unfolded to the particle level. The cross-section is compared with state-of-the-art Standard Model calculations, including the next-to-leading-order and next-to-next-to-leading-order perturbative QCD calculations, corrected for non-perturbative and QED radiation effects. The results of the measurements cover final-state jets with transverse momenta up to 1 TeV, and show good agreement with fixed-order calculations
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-ÎČ in murine brain
- Author
- AE Proudfoot
- AH Haas de
- AJ Hoogewerf
- AL Ford
- AR Simard
- B Johnston
- Bo Wang
- C Haass
- C Rummel
- CJ Henry
- CR Parish
- D Gate
- D Giulian
- D Spillmann
- D Wong
- E Sandwall
- E Solito
- E Zcharia
- EC Butcher
- ED Ponomarev
- Elina Hjertström
- EO Long
- Eyal Zcharia
- Feng Gong
- GJ Guillemin
- H Akiyama
- H Nakanishi
- HE Vries de
- I Shafat
- IC Martins
- Israel Vlodavsky
- J Hesselgesser
- J Horssen van
- J Khoury El
- J Khoury El
- J Most
- J Rogers
- JD Sedgwick
- Jin-Ping Li
- JM Austyn
- JM Ziebell
- JS Miners
- Juan Jia
- K Rezai-Zadeh
- KA Bates
- L Minghetti
- L Qin
- L Wang
- Lars Lannfelt
- Lars N. G. Nilsson
- M Fiala
- M Fiala
- M Maio
- MJ Carson
- ML Dustin
- ML Escobar Galvis
- NK Tonks
- O Goldshmidt
- P OâCallaghan
- Paul OâCallaghan
- S Massena
- SE Hickman
- SE Hickman
- T Kanekiyo
- T Town
- T Town
- TC Frank-Cannon
- TM Malm
- U Steidl
- UK Hanisch
- Ulf Lindahl
- VH Perry
- WL Thompson
- Xiao Zhang
- Z Morise
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Volume III DUNE far detector technical coordination
- Author
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- Acciarri R
- Acero MA
- Adamov G
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- Adinolfi M
- Ahmad Z
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- Alion T
- Alonso MR
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- Balasubramanian S
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- Chalifour M
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2020
- Field of study
The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decayâthese mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume III of this TDR describes how the activities required to design, construct, fabricate, install, and commission the DUNE far detector modules are organized and managed. This volume details the organizational structures that will carry out and/or oversee the planned far detector activities safely, successfully, on time, and on budget. It presents overviews of the facilities, supporting infrastructure, and detectors for context, and it outlines the project-related functions and methodologies used by the DUNE technical coordination organization, focusing on the areas of integration engineering, technical reviews, quality assurance and control, and safety oversight. Because of its more advanced stage of development, functional examples presented in this volume focus primarily on the single-phase (SP) detector module
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