Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

EXPERIMENTAL STUDY REGARDING ADHESIVE THICKNESS-DEPENDENCE OF STRENGTH FOR LIGHTWEIGHT ALLOY ADHESIVELY BONDED JOINTS

The effect of the adhesive thickness on the overall strength of single lap joints made by lightweight aluminum alloy was experimentally studied. The relation between the overall strength and the adhesive thickness is influenced by some intrinsic characteristics of adhesives,one of which is the adhesive toughness addressed by the present study. The results show that the variation of overall strength corresponding to relatively ductile adhesive is more remarkable compared to that corresponding to relatively brittle adhesive,especially in the comparatively small adhesive thickness range. When the adhesive thickness is larger than the critical thickness,the overall strength of the single lap joints appears equal to the bulk shear strength of the adhesives. The present experimental results agree with the previous model prediction

Wave velocity measurement in the through-thickness direction of the anisotropic material plate with ultrasonic polar scan

Ultrasonic polar scan (UPS) records the amplitude in transmission for a wide range of incidence angles, providing a UPS image with characteristic contours reflecting the acoustic parameters of the material. This study focused on a newly developed wave velocity measurement of the DD6 single-crystal material plate by analyzing the UPS image to realize the ultrasonic thickness measurement of the DD6 single-crystal material plate accordingly. Firstly, considering transducer contour size compensation, the UPS images are obtained by numerical simulation on the DD6 single-crystal material plates with different crystal orientations. Secondly, the fitting equations are obtained by analyzing the UPS images to calculate wave velocity in the thickness direction. Finally, a 5-joint UPS scanner is designed to validate the accuracy of wave velocity simulation results experimentally, and it indicates a good agreement with conventional ultrasonic velocity measurement. The measurement results demonstrated that the UPS method could evaluate the wave velocity in the through-thickness direction of the DD6 single-crystal material plate with high precision

An Ultra-High Frequency Vibration-Based Fatigue Test and Its Comparative Study of a Titanium Alloy in the VHCF Regime

This paper proposes an ultra-high frequency (UHF) fatigue test of a titanium alloy TA11 based on electrodynamic shaker in order to develop a feasible testing method in the VHCF regime. Firstly, a type of UHF fatigue specimen is designed to make its actual testing frequency reach as high as 1756 Hz. Then the influences of the loading frequency and loading types on the testing results are considered separately, and a series of comparative fatigue tests are hence conducted. The results show the testing data from the present UHF fatigue specimen agree well with those from the conventional vibration fatigue specimen with the loading frequency of 240 Hz. Furthermore, the present UHF testing data show good consistency with those from the axial-loading fatigue and rotating bending fatigue tests. But the obtained fatigue life from ultrasonic fatigue test with the loading frequency of 20 kHz is significantly higher than all other fatigue test results. Thus the proposed ultra-high frequency vibration-based fatigue test shows a balance of high efficiency and similarity with the conventional testing results

Integrated Metabolomic and Lipidomic Analysis Reveals the Neuroprotective Mechanisms of Bushen Tiansui Formula in an Aβ1-42-Induced Rat Model of Alzheimer’s Disease

Bushen Tiansui Formula (BSTSF) is a traditional Chinese medicine prescription. It has been widely applied to treat Alzheimer’s disease (AD) in the clinic; however, the mechanisms underlying its effects remain largely unknown. In this study, we used a rat AD model to study the effects of BSTSF on cognitive performance, and UPLC-MS/MS-based metabolomic and lipidomic analysis was further performed to identify significantly altered metabolites in the cerebral cortices of AD rats and determine the effects of BSTSF on the metabolomic and lipidomic profiles in the cerebral cortices of these animals. The results revealed that the levels of 47 metabolites and 30 lipids primarily associated with sphingolipid metabolism, glycerophospholipid metabolism, and linoleic acid metabolism were significantly changed in the cerebral cortices of AD rats. Among the altered lipids, ceramides, phosphatidylethanolamines, lysophosphatidylethanolamines, phosphatidylcholines, lysophosphatidylcholines, phosphatidylserines, sphingomyelins, and phosphatidylglycerols showed robust changes. Moreover, 34 differential endogenous metabolites and 21 lipids, of which the levels were mostly improved in the BSTSF treatment group, were identified as potential therapeutic targets of BSTSF against AD. Our results suggest that lipid metabolism is highly dysregulated in the cerebral cortices of AD rats, and BSTSF may exert its neuroprotective mechanisms by restoring metabolic balance, including that of sphingolipid metabolism, glycerophospholipid metabolism, alanine, aspartate, and glutamate metabolism, and D-glutamine and D-glutamate metabolism. Our data may lead to a deeper understanding of the AD-associated metabolic profile and shed new light on the mechanism underlying the therapeutic effects of BSTSF

Co(OH)₂ Nanoflowers Decorated α-NiMoO₄ Nanowires as a Bifunctional Electrocatalyst for Efficient Overall Water Splitting

The development of bifunctional electrocatalysts with high catalytic activity and cyclic stability is an effective method for electrocatalytic water splitting. Herein, a promising hydroxide/oxide Co(OH)2/α-NiMoO4 NWs/CC heterostructure with nanoflowers decorating the nanowires was fabricated on a carbon cloth (CC) substrate via hydrothermal and calcination methods. In contrast to one-dimensional nanomaterials, the interfaces of Co(OH)2 nanoflowers and α-NiMoO4 nanowires on CC provide more active sites for electrocatalytic reactions; therefore, they exhibit obviously enhanced electrocatalytic activities in overall water splitting. Specifically, the Co(OH)2/α-NiMoO4 NWs/CC electrodes exhibit an overpotential of 183.01 mV for hydrogen evolution reaction (HER) and of 170.26 mV for oxygen evolution reactions (OER) at the current density of 10 mA cm−2 in 1.0 M KOH. Moreover, the electrocatalytic oxygen evolution reaction (OER) activity of the Co(OH)2/α-NiMoO4 NWs/CC electrocatalyst was enhanced after long-term stability tests

Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance.

Reactive aldehydes can initiate protein oxidative damage which may contribute to heart senescence. Sirtuin 1 (SIRT1) is considered to be a potential interventional target for I/R injury management in the elderly. We hypothesized that aldehyde mediated carbonyl stress increases susceptibility of aged hearts to ischemia/reperfusion (I/R) injury, and elucidate the underlying mechanisms with a focus on SIRT1. Male C57BL/6 young (4-6 mo) and aged (22-24 mo) mice were subjected to myocardial I/R. Cardiac aldehyde dehydrogenase (ALDH2), SIRT1 activity and protein carbonyls were assessed. Our data revealed that aged heart exhibited increased endogenous aldehyde/carbonyl stress due to impaired ALDH2 activity concomitant with blunted SIRT1 activity (P<0.05). Exogenous toxic aldehydes (4-HNE) exposure in isolated cardiomyocyte verified that aldehyde-induced carbonyl modification on SIRT1 impaired SIRT1 activity leading to worse hypoxia/reoxygenation (H/R) injury, which could all be rescued by Alda-1 (ALDH2 activator) (all P<0.05). However, SIRT1 inhibitor blocked the protective effect of Alda-1 on H/R cardiomyocyte. Interestingly, myocardial I/R leads to higher carbonylation but lower activity of SIRT1 in aged hearts than that seen in young hearts (P<0.05). The application of Alda-1 significantly reduced the carbonylation on SIRT1 and markedly improved the tolerance to in vivo I/R injury in aged hearts, but failed to protect Sirt1(+/-) knockout mice against myocardial I/R injury. This was verified by Alda-1 treatment improved postischemic contractile function recovery in ex vivo perfused aged but not in Sirt1(+/-) hearts. Thus, aldehyde/carbonyl stress is accelerated in aging heart. These results provide a new insight that impaired cardiac SIRT1 activity by carbonyl stress plays a critical role in the increased susceptibility of aged heart to I/R injury. ALDH2 activation can restore this aging-related myocardial ischemic intolerance