Does PPP hold for Big Mac price or consumer price index? Evidence from panel cointegration

This paper examines the validity of purchasing power parity (PPP) using CPI and Big Mac prices. The benchmark model, i.e., the OLS method, which does not take nonstationarity into account, rejects the hypothesis of PPP regardless of prices used. We next use the panel cointegration method to consider the nonstationary nature of variables. Estimated results for CPI are mixed. The PPP is rejected when the nominal exchange rate is employed as the dependent variable but is not rejected when the price ratio is used as the dependent variable. By contrast, the PPP is overwhelmingly not rejected when the Big Mac price is used. Last, we remove the production bias and re-examine the same issue by using panel cointegration. The PPP is again decisively rejected when CPI price is used but not for Big Mac price. Accordingly, Big Mac price is more supportive to the validity of PPP than CPI price.Big Mac

Corpus-based study of L3 acquisition on Spanish past tense: evidence from learners’ oral production

[EN] This paper focuses on a corpus-based study on the acquisition of L3 Spanish past tense in oral production through a learners’ corpus. The main findings were: (1) Chinese-speaking learners in Taiwan demonstrated more accurate uses of the Spanish preterit than the imperfect in oral productions, same as the findings in their written productions and those in Englishnative speakers of Spanish; (2) These learners used telic verbs more correctly than those of activity and state in preterit form in both oral and written productions; (3) The developmental pattern of the Spanish past tense in the oral production of Chinesespeakinglearners was similar to that of English-speaking learners of Spanish.We are grateful for the grant for the project “Corpus-based study of the L3 acquisition on Spanish past tense” (MOST 101-2410-H-006-088-MY2) provided by the Ministry of Science and Technology of Taiwan.Lu, H.; Cheng, AC.; Hung, SY. (2019). Corpus-based study of L3 acquisition on Spanish past tense: evidence from learners’ oral production. Revista de Lingüística y Lenguas Aplicadas. 14:105-115. https://doi.org/10.4995/rlyla.2019.10744SWORD1051151

Algorithms and Architectures of Energy-Efficient Error-Resilient MIMO Detectors for Memory-Dominated Wireless Communication Systems

In a broadband MIMO-OFDM wireless communication system, embedded buffering memories occupy a large portion of the chip area and a significant amount of power consumption. Due to process variations of advanced CMOS technologies, it becomes both challenging and costly to maintain perfectly functioning memories under all anticipated operating conditions. Thus, Voltage over Scaling (VoS) has emerged as a means to achieve energy efficient systems resulting in a tradeoff between energy efficiency and reliability. In this paper we present the algorithm and VLSI architecture of a novel error-resilient K-Best MIMO detector based on the combined distribution of channel noise and induced errors due to VoS. The simulation results show that, compared with a conventional MIMO detector design, the proposed algorithm provides up-to 4.5 dB gain to achieve the near-optimal Packet Error Rate (PER) performance in the 4 × 4 64-QAM system. Furthermore, based on experimental results, when jointly considering the detector and memory power consumption, the proposed resilient scheme with VoS memory can achieve up to 32.64% savings compared to the conventional K-Best detector with perfect memory. © 2014 IEEE

First Total Synthesis of Protoapigenone and Its Analogues as Potent Cytotoxic Agents

Protoapigenone (1), isolated from Thelypteris torresiana, previously showed significant cytotoxic activity against five human cancer cell lines. In a continued structure-activity relationship study, the first total synthesis and modification of 1 were achieved. All synthesized compounds and related intermediates were evaluated for cytotoxic activity against five human cancer cell lines, HepG2, Hep3B, MDA-MB-231, MCF-7 and A549. Among them, 24 showed 2.2-14.2 fold greater cytotoxicity than 1 and naphthyl A-ring analogs remarkably enhanced the activity

Physicochemical, antioxidant properties and in vitro digestibility of wheat-purple rice flour mixtures

The physicochemical characteristics, antioxidant properties and in vitro digestibility of high-antioxidant content flours made from different combinations of Thai purple rice flour and refined wheat flour from 25%, 50% to 75% (w/w) were investigated and these were compared with whole flour from purple rice and refined wheat flour. The increase in substitution levels of purple rice flour affected all the functional properties of flours, at the same time the levels of dietary fibre, protein digestibility and antioxidant compositions were also changed. The purple rice flour exerted a particularly strong effect on starch digestibility as the purple rice increased to 50% in the mixture. Moreover, purple rice flour showed lower amounts of rapidly digested starch (RDS), whereas slowly digested starch (SDS) of whole flour from purple rice and 75% substitution purple rice flour was found to be the highest for all samples. The in vitro starch digestibility of all samples also showed a positive correlation between dietary fibre and antioxidant compounds. Overall, the addition of purple rice flour improved the final nutritional properties, notably a lower predicted glycaemic index, and a higher antioxidant potential, which are two important nutritional properties for human health

Broad targeting of resistance to apoptosis in cancer

Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic signaling, particularly the activation of an anti-apoptotic systems, allows cancer cells to escape this program leading to uncontrolled proliferation resulting in tumor survival, therapeutic resistance and recurrence of cancer. This resistance is a complicated phenomenon that emanates from the interactions of various molecules and signaling pathways. In this comprehensive review we discuss the various factors contributing to apoptosis resistance in cancers. The key resistance targets that are discussed include (1) Bcl-2 and Mcl-1 proteins; (2) autophagy processes; (3) necrosis and necroptosis; (4) heat shock protein signaling; (5) the proteasome pathway; (6) epigenetic mechanisms; and (7) aberrant nuclear export signaling. The shortcomings of current therapeutic modalities are highlighted and a broad spectrum strategy using approaches including (a) gossypol; (b) epigallocatechin-3-gallate; (c) UMI-77 (d) triptolide and (e) selinexor that can be used to overcome cell death resistance is presented. This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected