1,426 research outputs found
Cathode-overpotential And Electrosorption Effects Of Organic Additives
- Author
- Publication venue
- Scholarship@Western
- Publication date
- 01/01/1968
- Field of study
The Maunakea Spectroscopic Explorer Book 2018
- Author
- Anthony Andre
- Ariño Javier
- Babas Ferdinand
- Bagnoud Gregoire
- Baker Gabriella
- Barrick Gregory
- Bauman Steve
- Benedict Tom
- Berthod Christophe
- Bilbao Armando
- Bizkarguenaga Alberto
- Blin Alexandre
- Bradley Colin
- Brousseau Denis
- Brown Rebecca
- Brzeski Jurek
- Brzezik Walter
- Caillier Patrick
- Campo Ramón
- Carton Pierre-Henri
- Chu Jiaru
- Churilov Vladimir
- Crampton David
- Crofoot Lisa
- Dale Laurie
- de Bilbao Lander
- de la Maza Markel Sainz
- de Rivera Guillermo González
- Devost Daniel
- Edgar Michael
- Erickson Darren
- Farrell Tony
- Flagey Nicolas
- Fouque Pascal
- Fournier Paul
- Garrido Javier
- Gedig Mike
- Geyskens Nicolas
- Gilbert James
- Gillingham Peter
- Green Greg
- Grigel Eric
- Hall Patrick
- Hill Alexis
- Ho Kevin
- Horville David
- Hu Hongzhuan
- Irusta David
- Isani Sidik
- Jahandar Farbod
- Kaplinghat Manoj
- Kielty Collin
- Kulkarni Neelesh
- Lahidalga Leire
- Laurent Florence
- Lawrence Jon
- Laychak Mary Beth
- Lee Jooyoung
- Liu Zhigang
- Loewen Nathan
- Lorentz Thomas
- Lorgeoux Guillaume
- López Fernando
- Mahoney Billy
- Mali Slavko
- Manuel Eric
- Martínez Sofía
- Mazoukh Celine
- McConnachie Alan
- Messaddeq Younès
- Migniau Jean-Emmanuel
- Mignot Shan
- Monty Stephanie
- Morency Steeve
- Mouser Yves
- Muller Rolf
- Muller Ronny
- Murga Gaizka
- Murowinski Rick
- Nicolov Victor
- Pai Naveen
- Pawluczyk Rafal
- Pazder John
- Petric Andreea
- Prada Francisco
- Pécontal Arlette
- Rai Corinne
- Ricard Coba
- Roberts Jennifer
- Rodgers J. Michael
- Rodgers Jane
- Ruan Federico
- Russelo Tamatea
- Salmom Derrick
- Saunders Will
- Scott Case
- Sheinis Andy
- Simons Douglas
- Smedley Scott
- Szeto Kei
- Sánchez Justo
- Tang Zhen
- Teran Jose
- Thibault Simon
- Thirupathi Sivarani
- Tresse Laurence
- Troy Mitchell
- Urrutia Rafael
- van Vuuren Emile
- Venkatesan Sudharshan
- Venn Kim
- Vermeulen Tom
- Villaver Eva
- Waller Lew
- Wang Jianping
- Wang Lei
- Williams Eric
- Wilson Matt
- Withington Kanoa
- Yong David
- Yèche Christophe
- Zhai Chao
- Zhang Kai
- Zhelem Ross
- Zhou Zengxiang
- Publication venue
- Publication date
- 19/10/2018
- Field of study
(Abridged) This is the Maunakea Spectroscopic Explorer 2018 book. It is
intended as a concise reference guide to all aspects of the scientific and
technical design of MSE, for the international astronomy and engineering
communities, and related agencies. The current version is a status report of
MSE's science goals and their practical implementation, following the System
Conceptual Design Review, held in January 2018. MSE is a planned 10-m class,
wide-field, optical and near-infrared facility, designed to enable
transformative science, while filling a critical missing gap in the emerging
international network of large-scale astronomical facilities. MSE is completely
dedicated to multi-object spectroscopy of samples of between thousands and
millions of astrophysical objects. It will lead the world in this arena, due to
its unique design capabilities: it will boast a large (11.25 m) aperture and
wide (1.52 sq. degree) field of view; it will have the capabilities to observe
at a wide range of spectral resolutions, from R2500 to R40,000, with massive
multiplexing (4332 spectra per exposure, with all spectral resolutions
available at all times), and an on-target observing efficiency of more than
80%. MSE will unveil the composition and dynamics of the faint Universe and is
designed to excel at precision studies of faint astrophysical phenomena. It
will also provide critical follow-up for multi-wavelength imaging surveys, such
as those of the Large Synoptic Survey Telescope, Gaia, Euclid, the Wide Field
Infrared Survey Telescope, the Square Kilometre Array, and the Next Generation
Very Large Array.Comment: 5 chapters, 160 pages, 107 figure
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Afaq Saima
- Afzal Uzma
- Ahluwalia Tarunveer S.
- Ahmad Shafqat
- Alfred Tamuno
- Amin Najaf
- Bakker Stephan J. L.
- Baldassarre Damiano
- Balkau Beverley
- Bandinelli Stefania
- Barata Llilda
- Barroso Ines
- Bartz Traci M.
- Beilby John
- Bergman Richard N.
- Bergmann Sven
- Bielak Lawrence F.
- Bien Stephanie A.
- Biffar Reiner
- Blangero John
- Boehnke Michael
- Boerwinkle Eric
- Boger Carsten A.
- Bonnefond Amelie
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bottinger Erwin
- Bouchard Claude
- Braga Daniele
- Bragg Jennifer
- Bruinenberg Marcel
- Buckley Brendan M.
- Buyske Steve
- Cadby Gemma
- Campbell Harry
- Chambers John C.
- Chasman Daniel I.
- Chen Yii-Der Ida
- Chines Peter S.
- Chittani Martina
- Chu Audrey Y.
- Coggeshall Scott
- Collins Francis S.
- Cooper Richard S.
- Corre Tanguy
- Cucca Francesco
- Cupples L. Adrienne
- Curran Joanne E.
- Cusi Daniele
- Czajkowski Jacek
- de Borst Gert J.
- de Craen Anton J. M.
- de Faire Ulf
- de Geus Eco J. C.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panagiotis
- den Ruijter Hester M.
- Deng Xuan
- Direk Nese
- Eicher John D.
- Eiriksdottir Gudny
- Eriksson Anna L.
- Eriksson Joel
- Esko Tonu
- Faul Jessica D.
- Feitosa Mary F.
- Ferrucci Luigi
- Fischer Krista
- Fisher Virginia A.
- Ford Ian
- Forrester Terrence
- Fox Caroline S.
- Franks Paul W.
- Frayling Timothy M.
- Froguel Philippe
- Gertow Karl
- Gigante Bruna
- Glorioso Nicola
- Gong Jian
- Gordon-Larsen Penny
- Gorski Mathias
- Grabe Hans-Jorgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B.
- Grarup Niels
- Gudnason Vilmundur
- Hadley David
- Haiman Christopher A.
- Haitjema Saskia
- Hallmans Goran
- Hamsten Anders
- Hansen Torben
- Harder Marie Neergaard
- Harris Tamara B.
- Hartman Catharina A.
- Hassinen Maija
- Hastie Nicholas D.
- Hayward Caroline
- Heard-Costa Nancy L.
- Heath Andrew C.
- Heid Iris M.
- Hernandez Dena
- Hindorff Lucia
- Hirschhorn Joel N.
- Hocking Lynne J.
- Hollensted Mette
- Holmen Oddgeir L.
- Homuth Georg
- Horikoshi Momoko
- Hottenga Jouke Jan
- Huang Jie
- Huang Tao
- Huffman Jennifer E.
- Hung Joseph
- Hunter David J.
- Hutri-Kahonen Nina
- Hveem Kristian
- Ingelsson Erik
- Jackson Anne U.
- James Alan L.
- Jansson John-Olov
- Jarvelin Marjo-Riitta
- Jhun Min A.
- Johnson Andrew D.
- Jorgensen Marit E.
- Jukema Wouter
- Juonala Markus
- Justesen Johanne Marie
- Justice Anne E.
- Kahonen Mika
- Kanoni Stavroula
- Kardia Sharon L. R.
- Karlsson Magnus
- Kilpelainen Tuomas O.
- Kinnunen Leena
- Kivimaki Mika
- Kleber Marcus E.
- Koistinen Heikki A.
- Kolcic Ivana
- Kolovou Genovefa
- Komulainen Pirjo
- Kooner Jaspal S.
- Kooperberg Charles
- Kramer Bernhard K.
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuusisto Johanna
- Kvaloy Kirsti
- Laakso Markku
- Lakka Timo A.
- Langenberg Claudia
- Launer Lenore J.
- Le Marchand Loic
- Leander Karin
- Lee Nanette R.
- Lehtimaki Terho
- Lim Elise
- Lim Unhee
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Lobbens Stephane
- Loh Marie
- Loos Ruth J. F.
- Lorentzon Mattias
- Luan Jian'an
- Luben Robert
- Lubke Gitta
- Ludolph-Donislawski Anja
- Lupoli Sara
- Lyytikainen Leo-Pekka
- Madden Pamela A. F.
- Mahajan Anubha
- Mangino Massimo
- Manichaikul Ani
- Mannikko Reija
- Marchini Jonathan
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Nicholas G.
- Marz Winfried
- McCarthy Mark I.
- McKenzie Colin A.
- McKnight Barbara
- Mellstrom Dan
- Menni Cristina
- Metspalu Andres
- Middelberg Rita P. S.
- Mohlke Karen L.
- Montgomery Grant W.
- Morris Andrew P.
- Mueller-Nurasyid Martina
- Musk A. W. (Bill)
- Narisu Narisu
- Nauck Matthias
- Navarro Pau
- Ngwa Julius S.
- Nolte Ilja M.
- North Kari E.
- Ohlsson Claes
- Oldehinkel Albertine J.
- Olden Matthias
- Ong Ken K.
- Padmanabhan Sandosh
- Palmer Lyle J.
- Pasterkamp Gerard
- Pedersen Oluf
- Perez Jeremiah
- Perusse Louis
- Pervjakova Natalia
- Peters Annette
- Peters Ulrike
- Peyser Patricia A.
- Pisinger Charlotta
- Polasek Ozren
- Porteous David J.
- Psaty Bruce M.
- Qi Lu
- Qi Qibin
- Raitakari Olli T.
- Rankinen Tuomo
- Rao D. C.
- Rasmussen-Torvik Laura J.
- Rauramaa Rainer
- Rawal Rajesh
- Renstrom Frida
- Rice Treva
- Ridker Paul M.
- Rose Lynda M.
- Rudan Igor
- Sanna Serena
- Sarti Cinzia
- Sarzynski Mark A.
- Sattar Naveed
- Savonen Kai
- Schlessinger David
- Scholtens Salome
- Schurmann Claudia
- Scott Robert A.
- Sennblad Bengt
- Siemelink Marten A.
- Silbernagel Gunther
- Slagboom P. Eline
- Smith Albert Vernon
- Smith Blair H.
- Smith Jennifer A.
- Snieder Harold
- Sorensen Thorkild I. A.
- Spector Tim D.
- Staessen Jan A.
- Stancakova Alena
- Stott David J.
- Strachan David P.
- Strauch Konstantin
- Strawbridge Rona J.
- Stringham Heather M.
- Sung Yun Ju
- Swertz Morris A.
- Swift Amy J.
- Tanaka Toshiko
- Taylor Kent D.
- Tayo Bamidele O.
- Teumer Alexander
- Thorand Barbara
- Thuillier Dorothee
- Tiemeier Henning
- Tremoli Elena
- Trompet Stella
- Tuomilehto Jaakko
- Tyrrell Jessica
- Uitterlinden Andre G.
- Van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Duijn Cornelia M.
- Van Vliet-Ostaptchouk Jana V.
- Vandenput Liesbeth
- Vedantam Sailaja L.
- Verweij Niek
- Vestergaard Henrik
- Vink Jacqueline M.
- Vitart Veronique
- Vohl Marie-Claude
- Vollenweider Peter
- Volzke Henry
- Vonk Judith M.
- Waeber Gerard
- Waldenberger Melanie
- Wareham Nicholas J.
- Weir David R.
- Westendorp R. G. J.
- Whitfield John B.
- Wild Sarah
- Willemsen Gonneke
- Wilson James F.
- Winkler Thomas W.
- Wolffenbuttel Bruce H. R.
- Wong Andrew
- Wright Alan F.
- Wu Joseph
- Wu Ying
- Xue Luting
- Yengo Loic
- Young Kristin
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zillikens M. Carola
- Zimmermann Martina E.
- Zubair Niha
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.Peer reviewe
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
- Author
- Afaq Saima
- Akiyama Masato
- Amin Najaf
- Bakker Stephan JL
- Bansal Nisha
- Baptista Daniela
- Bergmann Sven
- Biggs Mary L
- Biino Ginevra
- Bochud Murielle
- Boerwinkle Eric
- Bottinger Erwin P
- Boutin Thibaud S
- Brumat Marco
- Burkhardt Ralph
- Butterworth Adam S
- Böger Carsten A
- Campana Eric
- Campbell Archie
- Campbell Harry
- Carroll Robert J
- Catamo Eulalia
- Chambers John C
- Chu Audrey Y
- Cifkova Renata
- Ciullo Marina
- Cocca Massimiliano
- Concas Maria Pina
- Coresh Josef
- Corre Tanguy
- Cusi Daniele
- de Borst Martin H
- De Grandi Alessandro
- de Mutsert Renée
- de Vries Aiko PJ
- Delgado Graciela
- Demirkan Ayşe
- Devuyst Olivier
- Dittrich Katalin
- Eckardt Kai-Uwe
- Edwards Todd L
- Ehret Georg
- Endlich Karlhans
- Evans Michele K
- Felicita Sala Cinzia
- Fuchsberger Christian
- Gansevoort Ron T
- Gasparini Paolo
- Gaziano J Michael
- German Chronic Kidney Disease Study
- Ghasemi Sahar
- Giedraitis Vilmantas
- Gieger Christian
- Giri Ayush
- Girotto Giorgia
- Gordon Scott D
- Gorski Mathias
- Gudbjartsson Daniel F
- Gudnason Vilmundur
- Gögele Martin
- Haller Toomas
- Halperin Kuhns Victoria L
- Hamet Pavel
- Harris Tamara B
- Hayward Caroline
- Heid Iris M
- Hicks Andrew A
- Ho Kevin
- Hofer Edith
- Holm Hilma
- Hoppmann Anselm
- Horn Katrin
- Huang Wei
- Hung Adriana M
- Hutri-Kähönen Nina
- Hwang Shih-Jen
- Ikram M Arfan
- Ingelsson Erik
- Jakobsdottir Johanna
- Jonsdottir Ingileif
- Jonsson Helgi
- Joshi Peter K
- Josyula Navya Shilpa
- Jung Bettina
- Kamatani Yoichiro
- Kanai Masahiro
- Kerr Shona M
- Kiess Wieland
- Kirsten Holger
- Kleber Marcus E
- Koenig Wolfgang
- Kooner Jaspal S
- Kovacs Peter
- Krajcoviechova Alena
- Kronenberg Florian
- Krämer Bernhard K
- Kubo Michiaki
- Kähönen Mika
- Körner Antje
- Köttgen Anna
- Kühnel Brigitte
- La Bianca Martina
- Lange Leslie A
- Lehne Benjamin
- Lehtimäki Terho
- Lewis Raychel M
- Li Man
- Li Yong
- Lifelines Cohort Study
- Liu Jun
- Loeffler Markus
- Loos Ruth JF
- Lyytikäinen Leo-Pekka
- Magi Reedik
- Mahajan Anubha
- Marten Jonathan
- Martin Nicholas G
- Mascalzoni Deborah
- Matsuda Koichi
- Meisinger Christa
- Meitinger Thomas
- Metspalu Andres
- Milaneschi Yuri
- Mishra Pashupati P
- Mohlke Karen L
- Mononen Nina
- Montgomery Grant W
- Mook-Kanamori Dennis O
- März Winfried
- Müller-Nurasyid Martina
- Nadkarni Girish N
- Nalls Mike A
- Nauck Matthias
- Nikus Kjell
- Ning Boting
- Noce Damia
- Nolte Ilja M
- Noordam Raymond
- Nutile Teresa
- O'Connell Jeffrey R
- O'Connor Luke J
- O'Donnell Christopher J
- Okada Yukinori
- Olafsson Isleifur
- Padmanabhan Sandosh
- Parsa Afshin
- Pattaro Cristian
- Pendergrass Sarah A
- Penninx Brenda WJH
- Perls Thomas
- Peters Annette
- Pirastu Mario
- Pirastu Nicola
- Pistis Giorgio
- Polasek Ozren
- Ponte Belen
- Porteous David J
- Poulain Tanja
- Pramstaller Peter P
- Preuss Michael H
- Prins Bram
- Psaty Bruce M
- Qiu Chengxiang
- Rabelink Ton J
- Raffield Laura M
- Raitakari Olli T
- Rettig Rainer
- Rheinberger Myriam
- Rice Kenneth M
- Rizzi Federica
- Robino Antonietta
- Rudan Igor
- Rueedi Rico
- Ruggiero Daniela
- Ryan Kathleen A
- Saba Yasaman
- Salvi Erika
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Sedaghat Sanaz
- Shaffer Christian M
- Sieber Karsten B
- Smith Albert V
- Smith Blair H
- Snieder Harold
- Spracklen Cassandra N
- Stefansson Kari
- Strauch Konstantin
- Stumvoll Michael
- Sulem Patrick
- Susztak Katalin
- Sveinbjornsson Gardar
- Tajuddin Salman M
- Teren Andrej
- Teumer Alexander
- Thiery Joachim
- Thio Chris HL
- Thorsteinsdottir Unnur
- Tin Adrienne
- Toniolo Daniela
- Tremblay Johanne
- Tönjes Anke
- Uitterlinden André G
- V. A. Million Veteran Program
- Vaccargiu Simona
- van der Harst Pim
- van der Most Peter J
- van Duijn Cornelia M
- Verweij Niek
- Vitart Veronique
- Vollenweider Peter
- Völker Uwe
- Waeber Gerard
- Waldenberger Melanie
- Whitfield John B
- Wild Sarah H
- Wilson James F
- Wilson James G
- Wilson Otis D
- Woodward Owen M
- Wuttke Matthias
- Xu Yizhe
- Yang Qiong
- Yu Zhi
- Zhang Weihua
- Zonderman Alan B
- Ärnlöv Johan
- Publication venue
- Nat Genet
- Publication date
- 01/01/2019
- Field of study
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. Variant annotation was supported by software resources provided via the Caché Campus program of the InterSystems GmbH to Alexander Teumer
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
- Author
- Abaterusso Cataldo
- Abdul Kadir Khalid
- Abrahamovych Orest
- Acharya Shamasunder
- Acosta Idalia
- Adam Noor
- Adams Luthando
- Adawi Faiad
- Adolphe Allen
- Ahmad Ghazali
- Ahmed Azazuddin
- Ahmed Ziauddin
- Ahn Kyu Jeung
- Alcantara-Gonzalez Altagracia Aurora
- Aldrete Jorge
- Ali Norhaliza Mohd
- Almirall Jaume
- Alscher Mark
- Alvarado Odilon
- Alvarez German
- Alvarisqueta Andres
- Amin Mohammad
- Amodeo Celso
- Andress Dennis L
- Annand Andrew
- Antunes Ferreira Manuel Anibal
- Anzai Jiichi
- Apostolou Theofanis
- Arauz-Pacheco Carlos
- Arciszewska Malgorzata
- Argoud Georges
- Arif Ahmed
- Aronson Ronnie
- Arrieta Lezama Javier
- Assefi Ali
- Ato Keita
- Atray Naveen
- Awua-Larbi Stella
- Aziz Nor Azizah
- Azuma Nobuyuki
- Bai Liqun
- Bailey Gordon
- Bajaj Harpreet Singh
- Bakdash Wa'El
- Baker John
- Baker Penelope
- Bako Gabriel
- Bakris George
- Bakris George
- Bansal Shweta
- Bar-Dayan Yosefa
- Bardymova Tatiana
- Barendregt Jnm
- Barengolts Elena
- Bartaskova Dagmar
- Bau Cho-Tsan
- Bayliss George
- Beddhu Srinivasan
- Bedros Fadi
- Belledonne Mario
- Belo Diogo
- Bentsianov Marie
- Bhargava Anuj
- Bhorat Qasim
- Bieler Tasso
- Birne Rita
- Blagoveshchenskaya Olga
- Bloom Scott
- Blumenthal Samuel
- Bochicchio-Ricardelli Tomasso
- Bock Andreas
- Bohm Guillermo
- Boiskin Mark
- Bonet Sol Josep
- Borges Joao Lindolfo
- Bowman-Stroud Cynthia
- Brantley Roman
- Bressler Peter
- Brown Eric
- Brunati Chiara
- Brusco Osvaldo
- Bucek Petr
- Budde Klemens
- Burga Nunez Jose
- Burgos-Calderon Rafael
- Busch Robert
- Butt Salman
- Cabrita Antonio
- Calderon Ortiz Ricardo
- Calderon Ticona Jorge
- Calero Gonzalez Francesca
- Cangiano Jose
- Capasso Giovambattista
- Carranza-Madrigal Jaime
- Castillo Alvaro
- Castro-Alonso Cristina
- Cathcart Harold
- Cercato Cintia
- Cha Dae-Ryong
- Chan Doris
- Chatha Rupi
- Chen Ching-Chu
- Chen Jung-Fu
- Chen Nan
- Cheung Siu Fai
- Chevaile-Ramos Jose
- Chew Wong Alfredo
- Chmelickova Hana
- Cho Ho Chan
- Cho Yong-Wook
- Choi Kyung Mook
- Choi Moon-Gi
- Chow Stephen
- Christofides Elena
- Chu Chih-Hsun
- Chuang Peale
- Chung Choon Hee
- Ciechanowski Kazimierz
- Cigarran Guldris Secundino
- Coetzee Kathleen
- Cohen Josef
- Combe Christian
- Comulada-Rivera Angel
- Conte Giuseppe
- Cooke Duncan
- Correa-Rotter Ricardo
- Costa e Forti Adriana
- Cournoyer Serge
- Cruz Lucita
- Cusumano Ana
- D'Avila Domingos
- Dahl Neera
- Danin Vargas Alfredo
- Daoud Deeb
- Davis Tim
- de Arteaga Javier
- De Cosmo Salvatore
- De la Calle Gilda
- de Lourdes Noronha Irene
- de Zeeuw Dick
- Deboni Luciane
- Delgado-Butron Cesar
- Dellanna Frank
- Desai Sachin
- Dextre Espinoza Augusto
- Ding Guohua
- Ding Xiaoqiang
- Distiller Larry
- Dixon Brad
- Doo-Man Kim
- Doshi Ankur
- Draibe Sergio
- Dudar Iryna
- Dulude Emily
- Duma Livia
- Dussol Bertrand
- Egido Jesus
- Egstrup Kenneth
- El-Shahawy Mohamed
- Elbert Alicia
- Elder John
- Eliaschewitz Freddy
- Ellis Graham
- Endre Zoltan
- Esnault Vincent
- Esposito Ciro
- Essaian Ashot
- Eustace Joseph
- Fang Michael
- Farfan-Aspilcueta Julio
- Farias Eduardo
- Fekete Jozef
- Felicio Joao
- Fellstrom Bengt
- Fernandez Fresnedo Gema
- Fernandez Giraldez Elvira
- Fernando Ronald
- Fitz-Patrick David
- Flores Jose
- Foo Marjorie Wai Yin
- Fraenkel Margaret
- Fraige Filho Fadlo
- Frajewicki Victor
- Frias Juan
- Fried Linda
- Fu Ping
- Fu Shuxia
- Fujii Shinya
- Fujita Akira
- Fulopova Alla
- Fung Samuel
- Fung Yin Khet
- Furuya Ryuichi
- Fushtey Ivan
- Galan Antonio
- Galfre Andrea
- Galindo Ramos Eugenia
- Gallagher Martin
- Galphin Claude
- Galushchak Olga
- Gansevoort Ronald
- Gaona Raul
- Garcia Mendez Isabel
- Gesualdo Loreto
- Gilbert John
- Gillard Pieter
- Gnudi Luigi
- Godoy Gonzalo
- Goh Bak Leong
- Goldfarb David
- Golestaneh Laden
- Goluch Richard
- Gonzalez Gonzalez Jose
- Gonzalez Fernando
- Gonzalez-Galvez Guillermo
- Goto Daisuke
- Gouge Steven
- Goumenos Dimitrios
- Graf Ronald
- Greenwood Gregory
- Greloni Gustavo
- Guadiz Ramon
- Guasch Antonio
- Gundroo Aijaz
- Guo Xiaohui
- Gutierrez Vicente
- Halimi Jean-Michel
- Hall Karen
- Hames Melanie
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- Hanson Lenita
- Hao Chuanming
- Harada Hiroyuki
- Hashiguchi Yasuhiro
- Hassan Wan Hasnul Halimi Wan
- Hasslacher Christoph
- Heerspink Hiddo J L
- Hellberg Olof
- Herman Lee
- Hernandez-Jaras Julio
- Herrada Orue Benjamin
- Herrero Calvo Jose
- Hershon Kenneth
- Hirano Fuminori
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- Horwitz Edward
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- Hussein Zanariah
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- Iitsuka Tadashi
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- Kishimoto Rui
- Kitzman Dalane W
- Kiyosue Arihiro
- Klimontov Vadim
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- Kobayashi Kunihisa
- Kohan Donald
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- Mcfadden Christopher
- Mcmurray John J V
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- Melnick Joel Z
- Menefee Judson
- Merican Nor Shaffinaz Yusuf Azmi
- Mersey James
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- Miller Alan
- Miller Michael G
- Miller Steven
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- Pergola Pablo E
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- Schenkenberger Isabelle
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- Sekikawa Takashi
- Sensenbrenner John
- Seo Ji A
- Seron Daniel
- Sezer Siren
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- Shamkhalova Minara
- Shaw Sylvia
- Sheu Wayne
- Shi Bingyin
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- Stanislavchuk Mykola
- Stefanidis Ioannis
- Stoica George
- Strand Jorma
- Stranks Stephen
- Stryzhak Vasyl
- Su Benli
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- Sun Shiren
- Suranyi Michael
- Suzuki Katsunori
- Szerlip Harold
- Tadika Takenobu
- Takeda Tetsuro
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- Tam Paul
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- Thomson Stephen
- Tien Kai-Jen
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- Tkac Ivan
- Tkach Sergii
- Tobe Sheldon
- Tobe Sheldon
- Tokui Mikiya
- Tomilina Natalia
- Topchii Ivan
- Toussaint Nigel
- Trokis Julien
- Tseng Shih-Ting
- Tsuchida Kenichi
- Tsujimoto Tetsuro
- Tsutsui Masahiro
- Tulloch Brian
- Tuta Liliana
- Tutescu Adriana
- Ueda Shinichiro
- Ujihara Makoto
- Umayahara Yutaka
- Urena Torres Pablo
- Vaithilingam Indralingam
- Valera Cortes Ildefonso
- Vallejos Augusto
- Van Vlem Bruno
- Van Zyl Louis
- Vargas-Gonzales Rolando
- Varghese Freemu
- Vazquez-Tanus Jose
- Vengadasalam V Paranthaman P
- Vercammen Chris
- Vicks Steven
- Vielhauer Volker
- Vijayasingham Shalini
- Villevalde Svetlana
- Vogel Daniel
- Vogt Liffert
- Wainstein Julio
- Wang Song
- Wanner Christoph
- Warling Xavier
- Watanabe Shuichi
- Weinstein Debra
- Weinstein Talia
- Weiss Robert
- Weng Jian
- Whaley-Connell Adam
- Wiecek Andrzej
- Wigderson Melissa
- Wise Jonathan
- Wong Hin Seng
- Woo Jeong-Taek
- Wruk Michal
- Wu Du-An
- Wu Mai-Szu
- Xiao Guanqing
- Xing Changying
- Xu Gang
- Xu Yan
- Yagil Yoram
- Yalcin Murat
- Yamada Daishiro
- Yamaguchi Yukinari
- Yamamoto Masahiro
- Yamauchi Akira
- Yambe Yuko
- Yang Jinkui
- Yavdosyuk Andrey
- Yeoh Lee Ying
- Yeung Vincent
- Yi Joo Hark
- Yi Tingting
- Yildiz Alaattin
- Yoo Soon-Jib
- Yoon Kun Ho
- Yoon Sun Ae
- Youmbissi Joseph
- Yu Shengqiang
- Yu Tae Yang
- Zahumensky Emil
- Zanella Maria
- Zaoui Philippe
- Zapata-Rincon Luis
- Zea-Nunez Carlos Antonio
- Zeig Steven
- Zhao Hongwen
- Zhao Jiajun
- Zhao Minghui
- Zieve Franklin
- Zolotaikina Viktoriia
- Zrazhevskiy Konstantin
- Zucchini Alfredo
- Zuo Li
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie
Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Jacob
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M
- Babb John
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnes Virgil E
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barth Christian
- Bartosik Nazar
- Basegmez Suzan
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Beernaert Kelly
- Behnamian Hadi
- Behr Joerg
- Behrenhoff Wolf
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W
- Bellan Riccardo
- Bellato Marco
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Bodlak Martin
- Boimska Bożena
- Bolla Gino
- Bolognesi Sara
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Boutle Sarah
- Bradmiller-Feld John
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brinson Jessica
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Brown Robert M
- Brownson Eric
- Brun Hugues
- Bruner Christopher
- Bruno Giacomo
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bucinskaite Inga
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Böser Christian
- Cabrillo Iban Jose
- Caebergs Thierry
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calamba Aristotle
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Calvert Brian
- Calvo Enrique
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Cappello Gigi
- Cardaci Marco
- Carlin Roberto
- Carlsmith Duncan
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Wagner
- Carver Matthew
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Casimiro Linares Edgar
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Caudron Adrien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Kwok Ming
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Po-Hsun
- Chen Yi
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Christopher Grant
- Chu Jennifer
- Chwalek Thorsten
- Ciangottini Diego
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- CMS Collaboration
- Cockerill David JA
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Costanza Francesco
- Couderc Fabrice
- Coughlan John A
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cripps Nicholas
- Crucy Shannon
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Curry David
- Cussans David
- Custódio Analu
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Costa Eliza Melo
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Dahmes Bryan
- Dahms Torsten
- Dalchenko Mykhailo
- Dall'Osso Martino
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Danielson Thomas
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- Dauncey Paul
- David Tinoco Mendes Andre
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
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- Hauser Jay
- Hauth Thomas
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- Heath Greg P
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- Hernandez Jose M
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- Hooberman Benjamin
- Hoorani Hafeez R
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- Neumeister Norbert
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- Newman-Holmes Catherine
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- Würthwein Frank
- Xiao Hong
- Xie Si
- Xie Wei
- Xu Lingshan
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zito Giuseppe
- Zou Wei
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akin Ilina Vasileva
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Ian
- Anderson Jacob
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
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- Barbieri Richard
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
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- Basegmez Suzan
- Battilana Carlo
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Beernaert Kelly
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- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
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- Belyaev Andrey
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- Berger Joram
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- Berryhill Jeffrey
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- Bhardwaj Ashutosh
- Bhat Pushpalatha C.
- Bhatnagar Vipin
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- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Kwok Ming
- Chan Matthew
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- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Sushil
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- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
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- Chen Mingshui
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- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Somnath
- Christopher Grant
- Chu Jennifer
- Chwalek Thorsten
- Ciangottini Diego
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clarke Christopher
- Clement Emyr
- Clerbaux Barbara
- CMS Collaboration
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
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- Costantini Silvia
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- Couderc Fabrice
- Coughlan John A.
- Cousins Robert
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- Cox Peter Timothy
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- Cumalat John Perry
- Curry David
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- Cutts David
- Cwiok Mikolaj
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- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
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- Dalchenko Mykhailo
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- Daubie Evelyne
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- David Tinoco Mendes Andre
- Davies Gavin
- de Barbaro Pawel
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- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Degano Alessandro
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Del Rocio Vargas Trevino Andrea
- Delaere Christophe
- Delannoy Andrés G.
- Delgado Peris Antonio
- Dell'Orso Roberto
- Della Negra Michel
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- Eusebi Ricardo
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- Geurts Frank J. M.
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- Gronberg Jeffrey
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- Gutay Laszlo
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- Görner Martin
- Gülmez Erhan
- Güth Andreas
- Haas Jeff
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- Haj Ahmad Wael
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- Hall Geoffrey
- Hall-Wilton Richard
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- Hammer Josef
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- Harr Robert
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- Harris Robert M.
- Hart Andrew
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- Hassan Qamar
- Hatakeyama Kenichi
- Hauk Johannes
- Hauser Jay
- Hauth Thomas
- Haytmyradov Maksat
- Heath Greg P.
- Heath Helen F.
- Hebbeker Thomas
- Hebda Philip
- Hegeman Jeroen
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- Heilman Jesse
- Heintz Ulrich
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- Heredia-de La Cruz Ivan
- Hernandez Jose M.
- Hernandez-Almada Alberto
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- Hildreth Michael
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- Hirschauer James
- Hits Dmitry
- Hobson Peter R.
- Hoepfner Kerstin
- Hoffmann Malte
- Hofman David Jonathan
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- Hong Byung-Sik
- Hooberman Benjamin
- Hoorani Hafeez R.
- Horisberger Roland
- Horvath Dezso
- Hos Ilknur
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- Hrubec Josef
- Hu Zhen
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- Hugon Justin
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- Jiang Chun-Hua
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- Jo Mihee
- Johns Willard
- Johnson Kurtis F.
- Johnson Marvin
- Jones Matthew
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- Josa Maria Isabel
- Joshi Umesh
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- Junkes Alexandra
- Juodagalvis Andrius
- Justus Christopher
- Kaadze Ketino
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- Kadastik Mario
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- Kaestli Hans-Christian
- Kalakhety Himali
- Kalinin Alexey
- Kalinowski Artur
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- Kalsi Amandeep Kaur
- Kamenev Alexey
- Kamon Teruki
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- Kaplan Steven
- Karancsi János
- Karapinar Guler
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- Karchin Paul Edmund
- Kargoll Bastian
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- Karjavin Vladimir
- Karmgard Daniel John
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- Kaur Manjit
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- Kenny III Raymond Patrick
- Kenzie Matthew
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- Kiesenhofer Wolfgang
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- Kim Dong Hee
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- Kodolova Olga
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- Konecki Marcin
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- Konigsberg Jacobo
- Konoplyanikov Viktor
- Konstantinov Dmitri
- Korjenevski Sergey
- Kornmayer Andreas
- Korol Ievgen
- Kortelainen Matti J.
- Korytov Andrey
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- Landsberg Greg
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- Nachtman Jane
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- Newbold Dave M.
- Newman Harvey B.
- Newman-Holmes Catherine
- Ngadiuba Jennifer
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- Weber Hendrik
- Weber Martin
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- Weinberg Marc
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- Weng Yao
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- West Christopher
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- Whitmore Juliana
- Wickramage Nadeesha
- Wilbur Scott
- Wilken Rachel
- Wilkinson Richard
- Williams Thomas
- Wimpenny Stephen
- Winer Brian L.
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
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- Wittmer Bruno
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- Won Steven
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- Wood Jeffrey Scott
- Wood John
- Woodard Anna
- Woods Nathaniel
- Worm Steven
- Wright Douglas
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xiao Meng
- Xie Si
- Xie Wei
- Xu Lingshan
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- York Andrew
- You Can
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Zvada Marian
- Publication venue
- American Meteorological Society
- Publication date
- 01/08/2011
- Field of study
The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe
Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adzic Petar
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behera Prafulla Kumar
- Behnamian Hadi
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Bierwagen Katharina
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bin Anuar Afiq Aizuddin
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blinov Vladimir
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bożena
- Boletti Alessio
- Bolla Gino
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Boos Edouard
- Boren Samuel
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Borzou Ahmad
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bowen James
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breto Guillermo
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brinson Jessica
- Brito Lucas
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brodski Michael
- Brom Jean-Marie
- Brondolin Erica
- Brooke James John
- Brown Robert M
- Brun Hugues
- Bruner Christopher
- Bruno Giacomo
- Buchmuller Oliver
- Bucinskaite Inga
- Bundock Aaron
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burkett Kevin
- Burns Douglas
- Burns Dustin
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Buttignol Michael
- Butz Erik
- Bylinkin Alexander
- Bylsma Ben
- Byszuk Adrian
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Call Kenneth
- Calligaris Luigi
- Calpas Betty
- Calvelli Valerio
- Calvert Brian
- Calvo Enrique
- Caminada Lea
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Caputo Claudio
- Carlin Roberto
- Carnes Andrew
- Carpinteyro Severiano
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
- Carver Matthew
- Casal Bruno
- Casarsa Massimo
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- Wickramage Nadeesha
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- Yang Yong
- Yang Yu Chul
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Geum Bong
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Sunan Kalijaga State Islamic University
- Publication date
- 01/01/2012
- Field of study
Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- Artía Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- Balaña-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- Bognár Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
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- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
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- Zhu Jiaqi
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- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
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