249 research outputs found
Thrombomodulin Regulates Keratinocyte Differentiation and Promotes Wound Healing
- Author
- Publication venue
- The Society for Investigative Dermatology, Inc.
- Publication date
- 30/06/2013
- Field of study
The membrane glycoprotein thrombomodulin (TM) has been implicated in keratinocyte differentiation and wound healing, but its specific function remains undetermined. The epidermis-specific TM knockout mice were generated to investigate the function of TM in these biological processes. Primary cultured keratinocytes obtained from TMlox/lox; K5-Cre mice, in which TM expression was abrogated, underwent abnormal differentiation in response to calcium induction. Poor epidermal differentiation, as evidenced by downregulation of the terminal differentiation markers loricrin and filaggrin, was observed in TMlox/lox; K5-Cre mice. Silencing TM expression in human epithelial cells impaired calcium-induced extracellular signal–regulated kinase pathway activation and subsequent keratinocyte differentiation. Compared with wild-type mice, the cell spreading area and wound closure rate were lower in keratinocytes from TMlox/lox; K5-Cre mice. In addition, the lower density of neovascularization and smaller area of hyperproliferative epithelium contributed to slower wound healing in TMlox/lox; K5-Cre mice than in wild-type mice. Local administration of recombinant TM (rTM) accelerated healing rates in the TM-null skin. These data suggest that TM has a critical role in skin differentiation and wound healing. Furthermore, rTM may hold therapeutic potential for the treatment of nonhealing chronic wounds
Metadata management for high content screening in OMERO
- Author
- Aleksandra Tarkowska
- Allan
- Andrews
- Balaji Ramalingam
- Breker
- Buck
- Burel
- Burman
- Chia
- Cho
- Chris Allan
- Colin Blackburn
- Collinet
- Cote
- Dominik Lindner
- Eleanor Williams
- Eliceiri
- Emil Rozbicki
- Fong
- Gabriella Rustici
- Goldberg
- Graml
- Gudjonsson
- Gustafsdottir
- Helen Flynn
- Jason R. Swedlow
- Jean-Marie Burel
- Josh Moore
- Kenneth Gillen
- Kirsanova
- Linkert
- Ljosa
- Mark Carroll
- Melissa Linkert
- Moore
- Moore
- Moudry
- Neumann
- Petr Walczysko
- Richard K. Ferguson
- Ritzerfeld
- Roger Leigh
- Rohn
- Schmidt
- Simon Li
- Simpson
- Srikumar
- Swedlow
- Sébastien Besson
- Thorpe
- Toret
- Vempati
- Warren
- William J. Moore
- Young
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2016
- Field of study
High content screening (HCS) experiments create a classic data management challenge—multiple, large sets of heterogeneous structured and unstructured data, that must be integrated and linked to produce a set of “final” results. These different data include images, reagents, protocols, analytic output, and phenotypes, all of which must be stored, linked and made accessible for users, scientists, collaborators and where appropriate the wider community. The OME Consortium has built several open source tools for managing, linking and sharing these different types of data. The OME Data Model is a metadata specification that supports the image data and metadata recorded in HCS experiments. Bio-Formats is a Java library that reads recorded image data and metadata and includes support for several HCS screening systems. OMERO is an enterprise data management application that integrates image data, experimental and analytic metadata and makes them accessible for visualization, mining, sharing and downstream analysis. We discuss how Bio-Formats and OMERO handle these different data types, and how they can be used to integrate, link and share HCS experiments in facilities and public data repositories. OME specifications and software are open source and are available at https://www.openmicroscopy.org
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
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- J. F. J.
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- Sengupta A. S.
- Sentenac D.
- Sequino V.
- Sergeev A.
- Shaddock D. A.
- Shaffer T. J.
- Shah A. A.
- Shahriar M. S.
- Shaner M. B.
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- Shapiro B.
- Shawhan P.
- Sheperd A.
- Shoemaker D. H.
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- Sonnenberg J. A.
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- Steinmeyer D.
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- Trinastic J.
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- Trozzo L.
- Tsang K. W.
- Tse M.
- Tso R.
- Tsukada L.
- Tsuna D.
- Tuyenbayev D.
- Ueno K.
- Ugolini D.
- Unnikrishnan C. S.
- Urban A. L.
- Usman S. A.
- V
- Vahlbruch H.
- VAJENTE GABRIELE
- Valdes G.
- van Bakel N.
- van Beuzekom M.
- van den Br
- Van Den Broeck C.
- van der Schaaf L.
- van Heijningen J. V.
- van Veggel A. A.
- Vardaro M.
- Varma V.
- Vass S.
- Vasuth M.
- Vecchio A.
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- Veitch J.
- Veitch P. J.
- Venkateswara K.
- Venugopalan G.
- Verkindt D.
- Vetrano F.
- Vicere A.
- Viets A. D.
- Vinciguerra S.
- Vine D. J.
- Vinet J. -.Y.
- Virgo Collaboration
- Vitale S.
- Vo T.
- Vocca H.
- Vorvick C.
- Vyatchanin S. P.
- Wade A. R.
- Wade L. E.
- Wade M.
- Walet R.
- Walker M.
- Wallace L.
- Walsh S.
- Wang G.
- Wang H.
- Wang J. Z.
- Wang W. H.
- Wang Y. F.
- Ward R. L.
- Warner J.
- Was M.
- Watchi J.
- Weaver B.
- Wei L. -.W.
- Weinert M.
- Weinstein A. J.
- Weiss R.
- Wen L.
- Wessel E. K.
- Wessels P.
- Westerweck J.
- Westphal T.
- Wette K.
- Whelan J. T.
- Whiting B. F.
- Whittle C.
- Wilken D.
- Williams D.
- Williams R. D.
- Williamson A. R.
- Willis J. L.
- Willke B.
- Wimmer M. H.
- Winkler W.
- Wipf C. C.
- Wittel H.
- Woan G.
- Woehler J.
- Wofford J.
- Wong K. W. K.
- Worden J.
- Wright J. L.
- Wu D. S.
- Wysocki D. M.
- Xiao S.
- Yamamoto H.
- Yancey C. C.
- Yang L.
- Yap M. J.
- Yazback M.
- Yu Hang
- Yu Haocun
- Yvert M.
- Zadrozny A.
- Zanolin M.
- Zelenova T.
- Zendri J. -.P.
- Zertuche L. Magana
- Zevin M.
- Zhang L.
- Zhang M.
- Zhang T.
- Zhang Y. -.H.
- Zhao C.
- Zhou M.
- Zhou Z.
- Zhu S. J.
- Zhu X. J.
- Zucker M. E.
- Zweizig J.
- Publication venue
- American Physical Society
- Publication date
- 01/01/2017
- Field of study
Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of
continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a
fully coherent search, based on matched filtering, which uses the position and rotational parameters
obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto-
noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch
between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have
been developed, allowing a fully coherent search for gravitational waves from known pulsars over a
fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of
11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial
outliers, further studies show no significant evidence for the presence of a gravitational wave signal.
Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of
the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for
the first time. For an additional 3 targets, the median upper limit across the search bands is below the
spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried
out so far
A gravitational-wave standard siren measurement of the Hubble constant
- Author
- Abbott
- Abbott
- Abbott
- Abbott
- Abdalla
- Acernese
- Ackley
- Adams
- Adams
- Addesso
- Adhikari
- Adya
- Affeldt
- Afrough
- Agarwal
- Agathos
- Agatsuma
- Aggarwal
- Aguiar
- Aiello
- Ain
- Ajith
- Alexander
- Allam
- Allen
- Allen
- Allocca
- Altin
- Amato
- Ananyeva
- Anderson
- Anderson
- Angelova
- Annis
- Antier
- Appert
- Arai
- Araya
- Arcavi Iair
- Areeda
- Arnaud
- Arun
- Ascenzi
- Ashton
- Ast
- Aston
- Astone
- Atallah
- Aufmuth
- Aulbert
- AultONeal
- Austin
- Avila-Alvarez
- Babak
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- Hreibi
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- Seidel
- Sellers
- Sengupta
- Sentenac
- Sequino
- Sergeev
- Serra-Ricart
- Sevilla-Noarbe
- Shaddock
- Shaffer
- Shah
- Shahriar
- Shaner
- Shao
- Shapiro
- Shappee
- Shawhan
- Sheperd
- Shoemaker
- Shoemaker
- Siebert
- Siellez
- Siemens
- Sieniawska
- Sigg
- Silva
- Simon
- Singer
- Singh
- Singhal
- Sintes
- Slagmolen
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Soares-Santos
- Sobreira
- Somala
- Son
- Sonnenberg
- Sorazu
- Sorrentino
- Souradeep
- Spencer
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- Staats
- Staley
- Stebbins
- Steeghs
- Steer
- Steinke
- Steinlechner
- Steinlechner
- Steinmeyer
- Stevenson
- Stone
- Stops
- Strain
- Stratta
- Strigin
- Strunk
- Sturani
- Stuver
- Suchyta
- Summerscales
- Sun
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- Worden
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- Wysocki
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- Yamamoto
- Yancey
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- Yurkov
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- Zadrozny
- Zanolin
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- Zimmerman
- Zucker
- Zweizig
- Publication venue
- Publication date
- 01/01/2017
- Field of study
On 17 August 2017, the Advanced LIGO 1 and Virgo 2 detectors observed the gravitational-wave event GW170817-a strong signal from the merger of a binary neutron-star system 3 . Less than two seconds after the merger, a γ-ray burst (GRB 170817A) was detected within a region of the sky consistent with the LIGO-Virgo-derived location of the gravitational-wave source 4-6 . This sky region was subsequently observed by optical astronomy facilities 7 , resulting in the identification 8-13 of an optical transient signal within about ten arcseconds of the galaxy NGC 4993. This detection of GW170817 in both gravitational waves and electromagnetic waves represents the first 'multi-messenger' astronomical observation. Such observations enable GW170817 to be used as a 'standard siren' 14-18 (meaning that the absolute distance to the source can be determined directly from the gravitational-wave measurements) to measure the Hubble constant. This quantity represents the local expansion rate of the Universe, sets the overall scale of the Universe and is of fundamental importance to cosmology. Here we report a measurement of the Hubble constant that combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using the electromagnetic data. In contrast to previous measurements, ours does not require the use of a cosmic 'distance ladder' 19 : the gravitational-wave analysis can be used to estimate the luminosity distance out to cosmological scales directly, without the use of intermediate astronomical distance measurements. We determine the Hubble constant to be about 70 kilometres per second per megaparsec. This value is consistent with existing measurements 20,21 , while being completely independent of them. Additional standard siren measurements from future gravitationalwave sources will enable the Hubble constant to be constrained to high precision
First measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary–Black-hole Merger GW170814
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2019
- Field of study
International audienceWe present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in , which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
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- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO’s second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h95%0=3.47×10−25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering
Multi-messenger observations of a binary neutron star merger
- Author
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- Aartsen MG
- Abbott BP
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- Moskvitin AS
- Mostaf M
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- Moulai M
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- Mow-Lowry CM
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- Mukherjee D
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- Muniz EA
- Muoz A Gonzolez
- Muoz RR
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- Murata KL
- Muratore M
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- Nagai H
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- Nakajima M
- Nakamura Y
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- Nakar E
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- Nakashima S
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- Natalucci L
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- Ohshima T
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- Ottaway DJ
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- Palamos JR
- Palashov O
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- Paliya VS
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- Pan Howard
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- Pandya H
- Paneque D
- Pang B
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- Pankova DV
- Pankow C
- Pannarale F
- Pant BC
- Panter M
- Paoletti F
- Paoletti F
- Paoli A
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- Parra A
- Parsons RD
- Pascucci D
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- Passaquieti R
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- Paul T
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- Paxman J
- Paz-Chinchn F
- Pea-Rodriguez J
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- Pedreira F
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- Pekowsky L
- Pelayo R
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- Pian E
- Piano G
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- Piccinni OJ
- Pichot M
- Picozza P
- Piel Q
- Pieloth D
- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
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- Piran T
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- Piranomonte S
- Pirello M
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- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
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- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Porowski C
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- Porter TA
- Possenti A
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- Powell J
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- Prestegard T
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- Prokhorov D
- Prokhorov LG
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- Prouza M
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- Puncken O
- Punturo M
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- Querel R
- Quetschke V
- Quimby RM
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- Quirrenbach A
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- Reimer A
- Reimer O
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- Reitze DH
- Relethford B
- Relich M
- Ren W
- Ren Z
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- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
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- Reyes SD
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- Riviere C
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- Robie R
- Robinet F
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- Rosell A Carnero
- Rosenberg M
- Rosetti S
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- Rosswog S
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- Rowlinson A
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- Rysewyk D
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- Sahakian V
- Sai N
- Saito S
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- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
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- Salamida F
- Salazar H
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- Saleem M
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- Salina G
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- Sanchez B
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- Sand DJ
- Sandberg V
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- Sarazin F
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- Sasaki M
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- Schneider A
- Schneider M
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- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
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- Schreiber E
- Schroder FG
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- Schulz A
- Schulz A
- Schulze S
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- Scott J
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- Sellers D
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- Sentenac D
- Sequino V
- Sergeev A
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- Serino M
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- Seunarine S
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- Siemens X
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- Sigg D
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- Steinmeyer D
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- Stubbs CW
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- Stuver AL
- Suarez F
- Suarez-Duran M
- Suchyta E
- Sudholz T
- Sugawara Y
- Sugita S
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- Suomijarvi T
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- Tacca M
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- Takahashi I
- Takahashi J
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- Tao C
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- Terrier R
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- Testa V
- Tewari SV
- Thayer JB
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- Torrie CI
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Erratum: "A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo" (2021, ApJ, 909, 218)
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- Publication venue
- London : Institute of Physics Publ.
- Publication date
- 01/01/2021
- Field of study
[no abstract available
- …