Singularity computations

An approach is described for singularity computations based on a numerical method for elastoplastic flow to delineate radial and angular distribution of field quantities and measure the intensity of the singularity. The method is applicable to problems in solid mechanics and lends itself to certain types of heat flow and fluid motion studies. Its use is not limited to linear, elastic, small strain, or two-dimensional situations

Development of the program SPECEL: A special element for elasto-plastic crack tip analysis

Theory is stated in terms of increments of displacement and stress, and of instantaneous or accumulated values of stress. The equilibrium equations, in the absence of body forces, are written, along with constitutive relations for plane strain

Open source bioimage informatics for cell biology

Significant technical advances in imaging, molecular biology and genomics have fueled a revolution in cell biology, in that the molecular and structural processes of the cell are now visualized and measured routinely. Driving much of this recent development has been the advent of computational tools for the acquisition, visualization, analysis and dissemination of these datasets. These tools collectively make up a new subfield of computational biology called bioimage informatics, which is facilitated by open source approaches. We discuss why open source tools for image informatics in cell biology are needed, some of the key general attributes of what make an open source imaging application successful, and point to opportunities for further operability that should greatly accelerate future cell biology discovery

Association of p60c-src with endosomal membranes in mammalian fibroblasts.

We have examined the subcellular localization of p60c-src in mammalian fibroblasts. Analysis of indirect immunofluorescence by three-dimensional optical sectioning microscopy revealed a granular cytoplasmic staining that co-localized with the microtubule organizing center. Immunofluorescence experiments with antibodies against a number of membrane markers demonstrated a striking co-localization between p60c-src and the cation-dependent mannose-6-phosphate receptor (CI-MPR), a marker that identifies endosomes. Both p60c-src and the CI-MPR were found to cluster at the spindle poles throughout mitosis. In addition, treatment of interphase and mitotic cells with brefeldin A resulted in a clustering of p60c-src and CI-MPR at a peri-centriolar position. Biochemical fractionation of cellular membranes showed that a major proportion of p60c-src co-enriched with endocytic membranes. Treatment of membranes containing HRP to alter their apparent density also altered the density of p60c-src-containing membranes. Similar density shift experiments with total cellular membranes revealed that the majority of membrane-associated p60c-src in the cell is associated with endosomes, while very little is associated with plasma membranes. These results support a role for p60c-src in the regulation of endosomal membranes and protein trafficking

Research priorities for advanced fibrous composites

Priorities for research in advanced laminated fibrous composite materials are presented. Supporting evidence is presented in two bodies, including a general literature survey and a survey of aerospace composite hardware and service experience. Both surveys were undertaken during 1977-1979. Specific results and conclusions indicate that a significant portion of contemporary published research diverges from recommended priorites

Cultural Surprises as Sources of Sudden, Big Policy Change

A major complaint against cultural theories is that they cannot explain political change (Lockhart 1997). Cultural and institutional accounts of politics are also often seen as antagonistic (Chai 1997; Grendstad and Selle 1995; Lockhart 1999). The cultural theory (CT) developed by Mary Douglas, Aaron Wildavsky, and others (see, e.g., Schwarz and Thompson 1990; Thompson, Ellis, and Wildavsky 1990), by contrast, offers a theory of culture that includes a theory of cultural change that integrates institutions into its explanation of change (Lockhart 1997, 1999; Thompson, Ellis, and Wildavsky 1990, 69–81; Wildavsky 1985). Moreover, CT can help specify the cultural conditions for sudden, big institutional and policy change, thereby, I argue, strengthening Frank Baumgartner and Bryan Jones's “punctuated equilibria” (PE) theory of change (Baumgartner and Jones 1993, 2002). The plausibility of this CT of PE change is illustrated in this article by using it to explain dramatic changes in forest and wildlife management in the Pacific Northwest (PNW) (building on Swedlow 2002a, b, 2003, 2007, 2009, and 2011a, b)

Editor's Introduction: Cultural Theory's Contributions to Political Science

Many political scientists first learned of anthropologist Mary Douglas's cultural theory (CT) through Aaron Wildavsky's APSA presidential address (Wildavsky 1987), in which he sought to explain the value of this theoretical approach for political science. Since then, much additional work has been done to develop CT as an ambitious general theory of politics