18 research outputs found
Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 11/05/2021
- Field of study
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
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- Adya VB
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- Agathos M
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- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
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- Al Samarai I
- Albert A
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- Albuquerque IFM
- Albury JM
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- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
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- Altmann D
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- Anastasi GA
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- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
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- Pavalas GE
- Pavana M
- Paxman J
- Paz-Chinchn F
- Pea-Rodriguez J
- Pearlstone BL
- Pech M
- Pedraza M
- Pedreira F
- Pedurand R
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- Peixoto CJ Todero
- Pekeur NW
- Pekowsky L
- Pelayo R
- Pele A
- Pellegrino C
- Pelletier G
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- Penacchioni AV
- Penn S
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- Perennes C
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- Perez-Perez EG
- Perley DA
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- Perri LM
- Perri M
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- Perrodin D
- Perrone L
- Pescalli A
- Pesce-Rollins M
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- Petrera S
- Petrucci P-O
- Peyaud B
- Pfeiffer HP
- Phelps M
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- Phuntsok J
- Pian E
- Piano G
- Piattelli P
- Piccinni OJ
- Pichot M
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- Piel Q
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- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
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- Poe M
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- Pollmann A Obertacke
- Poolakkil S
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- Principe G
- Principe M
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- Prodi GA
- Prokhorov D
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- Prokoph H
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- Przybylski GT
- Pulone L
- Pumo ML
- Punch M
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- Qi H
- Qi H
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- Quataert E
- Quel EJ
- Querchfeld S
- Querel R
- Quetschke V
- Quimby RM
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- Quinones C
- Quintero EA
- Quirrenbach A
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- Rabeling DS
- Rabus M
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- Ramirez-Ruiz E
- Ramos-Buades A
- Ramos-Pollan R
- Rana J
- Rando R
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- RATIR RIMAS
- Rau A
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- Rebolo R
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- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
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- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
- Reynolds T
- Rho CD
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- Ricci F
- Ricci R
- Ricciarini S
- Riccobene G
- Richman M
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- Rios-Lopez E
- Risse M
- Ristori P
- Rivera A Ramirez
- Riviere C
- Rizi V
- Rizzo M
- Roberts OJ
- Robertson NA
- Robertson S
- Robie R
- Robinet F
- Rocchi A
- Rochester LS
- Rodi J
- Rodriguez H
- Rojas D Avila
- Rojas-Bravo C
- Rojo J Rodriguez
- Rol E
- Rolland L
- Rollins JG
- Roma VJ
- Romano R
- Romel CL
- Romer AK
- Romero M Dominguez
- Romie JH
- Romoli C
- Roncoroni MJ
- Rongen M
- Roodman A
- Roques J-P
- Rosa-Gonzlez D
- Rosell A Carnero
- Rosenberg M
- Rosetti S
- Rosinska D
- Ross MP
- Rossi A
- Rosswog S
- Rosswog S
- Roth M
- Rott C
- Roulet E
- Rovero AC
- Rowan S
- Rowell G
- Rowlinson A
- Rowlinson A
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- Rudak B
- Ruehl P
- Ruggi P
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- Ruiz R Gracia
- Ruiz-Velasco E
- Rulten CB
- Rumyantsev VV
- Rusu F
- Rutins G
- Ryan K
- Rybicki KA
- Ryckbosch D
- Rykoff ES
- Rysewyk D
- Saba A
- Sachdev S
- Sadecki T
- Sadeghian L
- Sadler EM
- Sadler EM
- Saffe C
- Saffi SJ
- Saftoiu A
- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
- Sako M
- Sako S
- Salafia OS
- Salamida F
- Salazar H
- Salazar H
- Salconi L
- Saldaa M
- Saleem M
- Saleh A
- Salemi F
- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
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- Sanchez E
- Sanchez EJ
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- Sanchez LE
- Sanchez-Losa A
- Sanchez-Lucas P
- Sanchez-Ramirez R
- Sanchis-Gual N
- Sand DJ
- Sandberg V
- Sanders JR
- Sandoval A
- Sandrock A
- Sandroos J
- Sanguineti M
- Sansom EK
- Santander M
- Santangelo A
- Santos E
- Santos EM
- Sapienza P
- Sarazin F
- Sarkar S
- Sarkar S
- Sarmento R
- Sarmiento-Cano C
- Sasaki M
- Sasaki R
- Sassolas B
- Satalecka K
- Sathyaprakash BS
- Sato R
- Saulson PR
- Sauseda M
- Sauter O
- Savage RL
- Savchenko V
- Sawadsky A
- Sbarufatti B
- Scalzo RA
- Scarpine V
- Schady P
- Schale P
- Schauer M
- Scheel M
- Scherini V
- Scheuer J
- Schieler H
- Schimp M
- Schindler R
- Schipani P
- Schlegel DJ
- Schlickeiser R
- Schlunder P
- Schmalz SE
- Schmidt BP
- Schmidt D
- Schmidt J
- Schmidt P
- Schmidt T
- Schnabel R
- Schneider A
- Schneider M
- Schneiter M
- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
- Schubnell M
- Schuette D
- Schulte BW
- Schultz ASB
- Schulz A
- Schulz A
- Schulze S
- Schumacher J
- Schumacher L
- Schutz BF
- Schwalbe SG
- Schwanke U
- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
- Scott J
- Scott SM
- Secco LF
- Seckel D
- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
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- Sengupta AS
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- Sequino V
- Sergeev A
- Sergienko Yu P
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- Serrau M
- Settimo M
- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
- Sgro C
- Shaddock DA
- Shadkam A
- Shaffer TJ
- Shafi N
- Shah AA
- Shahriar MS
- Shaner MB
- Shang Z
- Shannon RM
- Shao L
- Shapiro B
- Shappee BJ
- Shara MM
- Sharma I
- Sharp RG
- Shawhan P
- Sheldon E
- Shellard RC
- Sheperd A
- Shidatsu M
- Shilon I
- Shimizu Y
- Shimomukai R
- Shingles LJ
- Shiningayamwe K
- Shoemaker DH
- Shoemaker DM
- Shulevski A
- Siebert MR
- Siegel MH
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- Siemens X
- Sieniawska M
- Sigg D
- Sigl G
- Silli G
- Silva AD
- Sim SA
- Simon JD
- Simonetti JH
- Simoni R
- Singer LP
- Singh A
- Singhal A
- Sinnis G
- Sintes AM
- Siskind EJ
- Slagmolen BJJ
- Slzer T
- Smartt SJ
- Smida R
- Smirnov OM
- Smith AJ
- Smith B
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- Smith KW
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- Sobreira F
- Sodre L
- Soedingrekso J
- Soffitta P
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- Somala S
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- Sonnenberg JA
- Sonntag S
- Sorazu B
- Soriano JF
- Sorrentino F
- Souradeep T
- Spada F
- Spandre G
- Spanier F
- Spencer AP
- Spera M
- Spiczak GM
- Spiering C
- Spir-Jacob M
- Springer RW
- Spurio M
- Squartini R
- Srivastava AK
- Staats K
- Stachurska J
- Staff J
- Stagni M
- Stalder B
- Staley A
- Stamatikos M
- Stamerra A
- Stanbro M
- Stanca D
- Stanev T
- Stanic S
- Stanway ER
- Starck M
- Starling RLC
- Stasielak J
- Stasik A
- Stassi P
- Stawarz L
- Stebbins A
- Steeghs DTH
- Steele I
- Steele K
- Steenkamp R
- Stegmann C
- Steinke M
- Steinlechner J
- Steinlechner S
- Steinmeyer D
- Stella L
- Steppa C
- Stettner J
- Steuer A
- Stevenson SP
- Stewart AJ
- Stezelberger T
- Stokstad RG
- Stolarczyk Th
- Stolpovskiy M
- Stone R
- Stops DJ
- Stosl A
- Strafella F
- Strain KA
- Stratta G
- Streich A
- Strigin SE
- Strotjohann NL
- Strunk A
- Stubbs CW
- Sturani R
- Stuttard T
- Stuver AL
- Suarez F
- Suarez-Duran M
- Suchyta E
- Sudholz T
- Sugawara Y
- Sugita S
- Sugizaki M
- Sullivan GW
- Sullivan M
- Sumi T
- Summerscales TZ
- Sun L
- Sun L
- Sun T
- Sunil S
- Suntzeff NB
- Sunyaev R
- Suomijarvi T
- Supanitsky AD
- Supik J
- Surajbali P
- Surcis G
- Suresh J
- Sushch I
- Suson DJ
- Sutherland M
- Sutton PJ
- Svinkin DS
- Swain J
- Swanson MEC
- Swinkels BL
- Szadkowski Z
- Szczepanczyk MJ
- Szegedi H
- Szomoru A
- Taboada A
- Taboada I
- Taborda OA
- Tacca M
- Tachibana Y
- Taddia F
- Tagliaferri G
- Tait SC
- Taiuti M
- Tajitsu A
- Takahashi I
- Takahashi J
- Takahashi M
- Takahashi T
- Takao Y
- Takayama M
- Talbot C
- Talukder D
- Tamura T
- Tamura Y
- Tan Y
- Tanaka I
- Tanaka M
- Tanaka Y
- Tanimoto A
- Tanner DB
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- Tao C
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- Tao WH
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- Tarle G
- Tartaglia L
- Tasson JD
- Tatar J
- Taubenberger S
- Tavani M
- Tavernet J-P
- Tavernier T
- Tayalati Y
- Taylor AM
- Taylor GB
- Taylor JA
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- Team AGILE
- Team Euro VLBI
- Team MAXI
- Team The 1M2H
- Telescope ATCA Australia
- Telescope Fermi Large Area
- Telescope Nordic Optical
- Tello JC
- Telluride AstroSat Cadmium Zinc
- Tenholt F
- Ter Veen S
- Ter-Antonyan S
- Terai T
- Terliuk A
- Terreran G
- Terrier R
- Tesic G
- Testa V
- Tewari SV
- Thayer JB
- Thayer JG
- Theeg T
- Thene CC
- Thierry P
- Thierry P
- Thies F
- Thomas EG
- Thomas M
- Thomas P
- Thomas RC
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- Thorne KA
- Thorne KS
- Thrane E
- Tibaldo L
- Tibaldo L
- Tibolla O
- Tilav S
- Timmermans C
- Tingay SJ
- Tiwari S
- Tiwari V
- Tiziani D
- Tjus J Becker
- Tjus J Becker
- Tlatov AG
- Tluczykont M
- Toale PA
- Tobin MN
- Tohuvavohu A
- Tokmakov KV
- Toland K
- Tollefson K
- Toma K
- Tomankova L
- Tomasella L
- Tome B
- Tomida H
- Tominaga N
- Tonelli M
- Tonnis C
- Tonry J
- Torii S
- Tornasi Z
- Tornatore M
- Torres DF
- Torres I
- Torres-Flores S
- Torres-Forn A
- Torresi E
- Torrie CI
- Toscano S
- Tosi D
- Towner MC
- Toyr D
- Tpai M
- Travasso F
- Travnicek P
- Traylor G
- Trichard C
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- Trinastic J
- Tringali MC
- Trini M
- Tristram PJ
- Trois A
- Troja E
- Troja E
- Trott CM
- Trovato A
- Troxel MA
- Trozzo L
- Tsai J
- Tsang KW
- Tse M
- Tselengidou M
- Tsirou M
- Tso R
- Tsuboi Y
- Tsuji N
- Tsukada L
- Tsuna D
- Tsunemi H
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- Tungalag N
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- Turpin D
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- Ty B
- Tyurina NV
- Ubertini P
- Uchiyama Y
- Ueda Y
- Uemura M
- Ueno K
- Ueno S
- Ugolini D
- Ukwatta TN
- Ulaczyk K
- Ulanov MV
- Ulloa N
- Ulrich R
- Unger E
- Unger M
- Univ Chandra Team McGill
- Univ Texas Tech
- Universe High Time Resolution
- Unnikrishnan CS
- Urban AL
- Urban M
- Ursi A
- Usman SA
- Usner M
- Utsumi Y
- Vacca V
- Vadawale SV
- Vahlbruch H
- Vaisanen P
- Vajente G
- Valdes G
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- Verrecchia F
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- Vibhute A
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- Vink J
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- Vitale PF Gomez
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- Vivolo D
- Vizzoca A
- Vladimirov VV
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- Vogel E
- Voisin F
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- Walz D
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- Wave GRAWITA GRAvitational
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- Weiland H
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- Wessel EK
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- Wiebusch CH
- Wiedenski M
- Wiencke L
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- Wierzcholska A
- Wijers RAMJ
- Wijers RAMJ
- Wilczynski H
- Wilken D
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- Worden J
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- Wrochna G
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- Wundheiler B
- Wyrzykowski L
- Wysocki DM
- Xiao GC
- Xiao S
- Xiong SL
- Xu D
- Xu DL
- Xu H
- Xu XW
- Xu Y
- Xu Y
- Xu YP
- Yamada S
- Yamaguchi MS
- Yamamoto H
- Yamaoka K
- Yamaoka K
- Yamauchi M
- Yan L
- Yan LL
- Yancey CC
- Yanez JP
- Yang J
- Yang J
- Yang JW
- Yang L
- Yang L
- Yang R
- Yang S
- Yang S
- Yang YJ
- Yanny B
- Yap MJ
- Yapici T
- Yaron O
- Yasuda N
- Yatabe F
- Yatsu Y
- Yazback M
- Yock PC
- Yodh G
- Yodh GB
- Yoneyama T
- Yoon Y
- Yoshida A
- Yoshida M
- Yoshida S
- Yoshii T
- Young DR
- Younk PW
- Yu Hang
- Yu Haocun
- Yu P-C
- Yuan T
- Yuan X
- Yurkov VV
- Yushkov A
- Yvert M
- Zaborov D
- Zacharias M
- Zadrozny A
- Zadrozny A
- Zaharijas G
- Zaltzman M
- Zanin R
- Zanolin M
- Zaremba M
- Zarnecki AF
- Zas E
- Zavrtanik D
- Zavrtanik M
- Zdziarski AA
- Zech A
- Zefi F
- Zelenova T
- Zendri J-P
- Zenko T
- Zenteno A
- Zepeda A
- Zertuche L Magaa
- Zevin M
- Zhang AM
- Zhang B-B
- Zhang C
- Zhang CL
- Zhang CM
- Zhang F
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- Zhang HM
- Zhang J
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- Zhang M
- Zhang Q
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- Zhang T
- Zhang W
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- Zhang Y
- Zhang Y
- Zhang Y
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- Zhang YF
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- Zhang Z
- Zhang ZL
- Zhao C
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- Zhao JL
- Zhao W
- Zhao XF
- Zheng SJ
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- Zhu SJ
- Zhu XJ
- Zhu Y
- Zhu YX
- Zhu Z
- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
- Zong Z
- Zorn J
- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Zimmermann CM
- Ziviani E
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- Zorzano A
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
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- Abozeid K
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- Appiah EK
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- Aranzabal Durand SY
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- Arevalo Azmitia JR
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- Khouri Ferreira SA
- Khreishi R
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- Khulu LB
- Khyrallh A
- Kiasat A
- Kidd T
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- Kim MY-H
- Kim S-H
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- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong SN
- Kong V
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- Konstantina K
- Kontos M
- Kordorwu HEK
- Korkolis D
- Kosai NR
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- Kose E
- Koskenvuo L
- Kostov E
- Kotb AHE-B
- Kotecha D
- Koto MZ
- Kotobi H
- Koumpa F
- Kouraklis G
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- Kyrou G
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- L'Heveder A
- La Brocca A
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- Labib P
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- Lam FY
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- Lam WH
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- Lap G
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- Latif A
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- Laurie K
- Lauzikas G
- Law JH
- Lawal A
- Lawal AO
- Lawal T
- Lawal TA
- Lawani I
- Lawther R
- Lazzari G
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- Lazzarini Cury AD
- Le VTH
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- Lecompte J-F
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- Leusink A
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- Macfarlane A
- Machaca M
- Machain Vega GM
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- Maciejec L
- Madiba T
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- Madrid Barrientos LA
- Maffioli A
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- Mohamed F
- Mohamed I
- Mohamed M
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- Mohamed MAEH
- Mohamed MM
- Mohamed O
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- Mohammad A
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- Mohammed MMH
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- Montrimaite M
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- Samaraweera DI
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- Sion M
- Sishuba N
- Sivaganesh S
- Skardziukaite A
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- Slapelyte E
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- Smart N
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- Smedley A
- Smith C
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
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- Solar Garcia L
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- Soldevila-Verdeguer C
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- Steccanella F
- Stefanopoulos A
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- Sundstrom SM
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- Swaroop M
- Swaroop M
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- Tabiri S
- Tabiri S
- Tabiri S
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- Yoganathan P
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- Yong CO
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- Younis A
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- Youssef H
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- Zahran D
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- Zakaria Y
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- Zapata Ponze De Leon M
- Zapata F
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- Zerihun AB
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- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
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- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
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- A Chattopadhyay
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- A Dey
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- A Gaeta
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- A Gnjec
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- A Gopalakrishnan
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
- Author
- Ç
- Ö
- Ž
- Ž
- Ž
- &apos
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- Boshnaq M
- Botero Jam
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- Burns H
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- Cadogan Dd
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- Canto Md
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- Cecilia T
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- Chachulski W
- Chai Ca
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- Cheah Aez
- Chen Cy
- Chen Jhc
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- Chenn R
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- Chibuye C
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- Choi J
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- Chu K
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- Chun T
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- Claire R
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- Clegg-Lampety Jn
- Clegg-Lamptey Jn
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- Daqeeq A
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- Darweesh M
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- De La Medina AR
- de Leó
- De Leon MZP
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- Dell A
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- Depalma N
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- Der Y
- Dervenis C
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- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
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- Di Martino N
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- Diaconescu B
- Diaconescu Ib
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- Dick L
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- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
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- Donnelly P
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- Dorismé
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- Drake Tm
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- Duffy L
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- El-Ma&apos
- El-Rabaa S
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- Elabdin Hz
- Elashmawy M
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- Elazayem Aa
- Elazoul M
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- Elfeki H
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- Elkorashy Am
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- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
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- Elshobary M
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- Elwan A
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- Elwy E
- Elzahed N
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- Emadeldin D
- Emadeldin H
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- Emile S
- Eng C
- English W
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- Fahim M
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- Fairfield C
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- Farhangmehr N
- Farinella E
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- Fattah Aa
- Fatuga A
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- Faturoti O
- Faure A
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- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
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- Fermani C
- Fermani Cg
- Ferná
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- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Freitas Av
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- Gerosa A
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- Halicioglu I
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- Hamarshi A
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- Ibrahem Aa
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- Ibrahim A
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- Ibrahim I
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- Kouraklis G
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- Kretzmann H
- Krishna K
- Kruspi S
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- Kwatiwani C
- Kwizera S
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- Kyziridis D
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- La Brocca A
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- Labib P
- Ladukas A
- Lafferty K
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- Lam Fy
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- Lap G
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- Lasek A
- Lasheen A
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- Latif A
- Laufer Lav
- Laugzemys E
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- Laurie K
- Lauzikas G
- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
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- Lawani I
- Lawther R
- Lazzari G
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- Leal A
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- Lee C
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- Lee F
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- Lee Kc
- Lee Ky
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- Leone N
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- Leppä
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- Leung Kw
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- Leusink A
- Lewis J
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- Liew I
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- Lilford R
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- Lim G
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- Loaloa Mr
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- Macchitella Y
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- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
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- Magdy A
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- Margaritis M
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- Marks E
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- Marshall Dc
- Martian Bv
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- Miranda C
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- Mironescu A
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- Mirza A
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- Mistry A
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- Modolo Mm
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- Mogan Yp
- Moghazy Me
- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
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- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
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- Mohammed H
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- Mohammed S
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- Molina G
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- Monaghan E
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- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
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- Montes I
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- Montrimaite M
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- Moodley Y
- Moore R
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- Mora Jjv
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- Moreira G
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- Mosalum O
- Mostafa Ha
- Mostafa M
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- Moustafa A
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- Mowafy B
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- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
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- Muktar U
- Mukuzunga C
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- Nanthakumaran S
- Napolitano L
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- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
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- Negida A
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- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
- Nessa A
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- Nevieraite V
- Newton T
- Ng S
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- Nikoloudis N
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
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- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
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- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
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- O&apos
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- Olaolorun A
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- Samaniego Cs
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- Senanayake Kj
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- Septiem Jg
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- Shahbaz Ar
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- Snyder E
- Sobnach S
- Sodde P
- Soeselo Da
- Sokratous A
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- Soldevila-Verdeguer C
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- Suá
- Suarez A
- Suarez Aab
- Subocius A
- Suleiman Si
- Summerour V
- Sund M
- Sund M
- Sunderland G
- Sundstrom Sm
- Suresh S
- Sutandi N
- Sutanto Epr
- Sutton P
- Sutton P
- Suyadi A
- Swann J
- Swaroop M
- Swaroop M
- Syibrah Kz
- Sykes M
- Szczap A
- Szeto Ccl
- Szeto Kj
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha Ems
- Tahboub H
- Taher Aa
- Taher M
- Taher Mm
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan Cl
- Tan Cy
- Tan Jj
- Tan Jk
- Tan Ksk
- Tan Rck
- Tan Yk
- Tan Yw
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani Si
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata Md
- Tatagiba Ls
- Tawfik Ba
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah Mm
- Tembo T
- Temoche E
- Tennakoon A
- Teo Sy
- Ter Ez
- Tessera G
- Teufelberger G
- Tew Yy
- Tew Yy
- Tewari S
- Th&apos
- Thabet W
- Thalgaspitiya Spb
- Tham Jc
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Ticona Wa
- Tierney G
- Tilston Tw
- Timothy Ok
- Ting Jrs
- To K
- To K
- Todd O
- Toeema Ag
- Tolba H
- Tolg C
- Tolonen M
- Tolotra Tec
- Tori Sa
- Torrance Hd
- Torrance Hd
- Torres Cpg
- Torres Sg
- Toto Ö
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola Sk
- Tugnoli G
- Tugnoli G
- Tun Ak
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze Rge
- Tze Rge
- Tzikos G
- Uš
- Ubhi Hk
- Ubiali P
- Ugalde P
- Ukwenya Y
- Uluş
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
- Urbonas T
- Urniež
- Urniezius Z
- Urquizu Mc
- Usaityte A
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldañ
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Vega Gmm
- Vega Gmm
- Velá
- Velá
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Alc
- Verjee A
- Vermaas M
- Veronese E
- Viš
- Vianna P
- Vicario E
- Vico Td
- Vida Lc
- Vida Lc
- Vilč
- Villa R
- Villalobos S
- Villegas Mi
- Vimalachandran D
- Vincent J
- Violi P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Vth Le
- Wael N
- Wagener M
- Wakefield R
- Walę
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward Ae
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick Am
- Waterman A
- Watson Nf
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein Ms
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini Ta
- Widmer Lw
- Wijayarathna Ls
- Wild Jrl
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson Ms
- Wilson Msj
- Wimalge Pmsn
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold Tb
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong Cs
- Wong Cy
- Wong F
- Wong Hy
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright Nj
- Xerri T
- Xerri T
- Yahaya Mt
- Yakubu M
- Yallop L
- Yam Sy
- Yang J
- Yap S
- Yaseen T
- Yaseen Tm
- Yau Jd
- Yavuz Ma
- Ye J
- Yeang Lj
- Yee J
- Yeo Ls
- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome
- Author
- A Schramm
- Brian Weiss
- DW Parsons
- Eric M. Sanford
- G Schleiermacher
- GM Frampton
- Irina Ostrovnaya
- J Zhang
- JJ Molenaar
- John M. Maris
- Kaitlyn R. Rubnitz
- Karthik Kalletla
- Katherine Janeway
- KR Bosse
- M Sausen
- Meaghan P. Granger
- MH Harris
- MS Irwin
- MS Lawrence
- NK Cheung
- Olivia M. Padovan-Merhar
- P Yael
- Pichai Raman
- RJ Mody
- Shakeel Modak
- Siraj M. Ali
- TF Eleveld
- TJ Pugh
- Vincent A. Miller
- W Chang
- Yael P. Mossé
- YP Mosse
- YP Mosse
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
The Contribution of Cdc2 in Rotenone-Induced G2/M Arrest and Caspase-3-Dependent Apoptosis
- Author
- A Colell
- A Currais
- A Florentin
- A Hartmann
- BA Larkins
- BF El-Khodor
- CH Yam
- FM Lopes
- GD Hilton
- GU Höglinger
- Hongcai Wang
- I Vincent
- J Folch
- J Huang
- J Li
- Jinsha Huang
- JM Frade
- KJ Livak
- KP Sundararaj
- L Gu
- LA Buttitta
- M Pompeiano
- Nian Xiong
- O Demir
- P Chadebech
- Ping Zhang
- PL Kuo
- R Betarbet
- R Rigolio
- S Goodyear
- S Kamada
- Tao Wang
- TB Sherer
- TF Oo
- WR Taylor
- X Zhu
- Y Cabeza-Arvelaiz
- Y Yang
- YT Cheung
- YW Yap
- Zhentao Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Surface morphological, electrical and transport properties of rapidly annealed double layers Ru/Cr Schottky structure on n-type InP
- Author
- B Akkal
- C Fontaine
- C Zhuang
- CH Han
- CW Wilmsen
- D Sri Silpa
- EH Rhoderickand
- FE Cimilli
- G Vincent
- H Cetin
- H Norde
- H Zhao
- HC Card
- J Lin
- JP Sullivan
- K. Shanthi Latha
- L Dasaradha
- LV Francesco
- M Bhaskar
- ME Aydin
- MSP Reddy
- MY Soomro
- N Ucar
- NA Papanicolaon
- O Gullu
- R Padma
- R Padma
- R Yatskiv
- S Chand
- S Karatas
- S Sridaran
- SK Cheung
- T Cakici
- T Kilicoglu
- TF Lei
- V Janardhanam
- V Lakshmi Devi
- V Rajagopal
- V Rajagopal Reddy
- V. Rajagopal Reddy
- WC Huang
- WE Spicer
- Y Munikrishna Reddy
- Y Wang
- ZJ Horwath
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Expression of antiapoptotic and proapoptotic molecules in diabetic retinas
- Author
- A M Abu El-Asrar
- A-G Wang
- AJ Barber
- AJ Barber
- AM Abu El-Asrar
- AM Schmeichel
- AM Vincent
- C Chen
- C Maihöfner
- C Zhang
- C Zhu
- DR Schultz
- DW Rickman
- E Daugas
- H Hsu
- JE Reynold
- JH Weishaupt
- JL Wilkinson-Berka
- JR Chao
- JW Russell
- K Geboes
- K Kannan
- KM Kozopas
- L Dralands
- L Missotten
- M Muranyi
- M Van Gurp
- M-T Lin
- ML Kuo
- MS Chin
- N Orike
- OC Trifan
- P Kermer
- P Zhou
- R Kowluru
- RA Kowluru
- RA Kowluru
- RM Andrews
- S-H Park
- SA Susin
- SP Cregan
- ST Chen
- T Hisatomi
- T Nakazawa
- T Nakazawa
- TF Franke
- UC Nazeako
- W-K Ju
- WE Kaufmann
- X Tang
- Y Du
- Y Isashiki
- Y Sun
- ZH Cheung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study