Clot retraction

The haemorrhagic disorders form only a small, although often most alarming part of the diseases inflicted upon mankind, and in spite of the enthusiasm of the disproportionally great number of workers investigating the problem of the coagulation of the blood, this problem until quite recently could only be looked upon as being mainly of academic physiological interest. With the advent and daily increasing use of the highly dangerous anti-coagulant therapy for thrombosis and embolism, demanding at least a general understanding of the mechanism of blood clotting, every aspect of this mechanism has become of practical clinical importance, and no serious effort to clarify the question can be considered wasted. It is peculiar that the last phase of coagulation, the contraction of the clot, which is by no means the least spectacular, has received rather scanty attention compared to the enormous amount of work that has been expended on the earlier stages. No agreement exists with regard to the mechanism or purpose of clot retraction; the factors controlling it are to a large-extent unknown, and even the fundamental question of the part played by the platelets is undecided

Thalassaemia-haemoglobin E disease in a Cape coloured family

No Abstract

The relation between the action of vitamin E and protein in the body, and the influence of various fish-liver oils in the diet upon vitamin E activity in vivo

The experiments reported here were undertaken primarily to investigate further the histological changes occurring in the enamel organ of the rat’s incisor tooth during vitamin E deficiency. These changes were originally described by Irving (1942) and have been confirmed in general by Granados, Mason & Dam (1945, 1946) and by Pindborg (7950, 1952). It was, however, found by the present writers, usinga diet based on that of Gillman, Gilbert, Gillman & Spence (1952), that extreme changes in the enamel organ, avertable by vitamin E, could be produced in 21 days or less, whereas the changes described by the other authors took much longer to develop and were less extensive. In an attempt to determine further the effects of other dietary factors upon the enamel organ, certain additional findings seemed to be of significance. The present paper is concerned chiefly with these, and an account of the histological aspect is being prepared for publication. In particular it was found that the vitamin content of the oil containing highly unsaturated fatty acids was of importance and also that the actions of protein and vitamin E, which superficially appeared similar, differed in certain fundamental respectsKIM2017https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/div-classtitlethe-relation-between-the-action-of-vitamin-e-and-protein-in-the-body-and-the-influence-of-various-fish-liver-oils-in-the-diet-upon-vitamin-e-activity-in-vivodiv/C6F1ED8366757D1725B07106117DEB6

The design of the wide field monitor for LOFT

LOFT (Large Observatory For x-ray Timing) is one of the ESA M3 missions selected within the Cosmic Vision program in 2011 to carry out an assessment phase study and compete for a launch opportunity in 2022-2024. The phase-A studies of all M3 missions were completed at the end of 2013. LOFT is designed to carry on-board two instruments with sensitivity in the 2-50 keV range: a 10 m 2 class Large Area Detector (LAD) with a <1{\deg} collimated FoV and a wide field monitor (WFM) making use of coded masks and providing an instantaneous coverage of more than 1/3 of the sky. The prime goal of the WFM will be to detect transient sources to be observed by the LAD. However, thanks to its unique combination of a wide field of view (FoV) and energy resolution (better than 500 eV), the WFM will be also an excellent monitoring instrument to study the long term variability of many classes of X-ray sources. The WFM consists of 10 independent and identical coded mask cameras arranged in 5 pairs to provide the desired sky coverage. We provide here an overview of the instrument design, configuration, and capabilities of the LOFT WFM. The compact and modular design of the WFM could easily make the instrument concept adaptable for other missions.Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91442

Efficacy of tissue brushing as measured by the prosthodontic tissue index

This study was conducted to determine the efficacy of brushing the oral mucosa supporting complete dentures with a soft brush to see if this treatment would reduce inflammation. The oral mucosa health status of 60 patients was monitored for 120 days using the PTI to measure inflammation. For comparison the patients were divided into two groups, and every effort was made to balance the groups for those variables that may effect inflammation. The patients were also compared with themselves. The experiment consisted of three phases; Phase 1 established baseline data, and Phases 2 and 3 were information-gathering sessions. Each patient received brushing instructions at the start of the brushing test period and additional brushing instruction during a reinforcement session after 30 days. Tissue brushing did reduce the inflammation index of the oral mucosa examined.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74782/1/j.1754-4505.1984.tb00150.x.pd

Risk to human health related to the presence of perfluoroalkyl substances in food

Acknowledgements: The Panel wishes to thank the following for their support provided to this scientific output as Hearing experts: Klaus Abraham, Esben Budtz-Jørgensen, Tony Fletcher, Philippe Grandjean, Hans Mielke and Hans Rumke and EFSA staff members: Davide Arcella, Marco Binaglia, Petra Gergelova, Elena Rovesti and Marijke Schutte. The Panel wishes to acknowledge all European competent institutions, Member State bodies and other organisations that provided data for this scientific output. The Panel would also like to thank the following authors and co-authors for providing additional information in relation to their respective studies: Berit Granum, Margie M Peden-Adams, Thomas Webster.Peer reviewedPublisher PD

The Large Observatory for x-ray timing

The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final down-selection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supra-nuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a WideField Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study