1,607 research outputs found
VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory
- Author
- Abeysekara A. U.
- Alfaro R.
- Alvarez C.
- Arceo R.
- Arteaga-Velázquez J. C.
- Avila-Aroche A.
- Badillo C.
- Barber A. S.
- Baughman B. M.
- Bautista-Elivar N.
- Belmont E.
- BenZvi S. Y.
- Benítez E.
- Berley D.
- Bernal A.
- Braun J.
- Caballero-Lopez R. A.
- Caballero-Mora K. S.
- Cabrera I.
- Carramiñana A.
- Castañeda-Martínez L.
- Castillo M.
- Cotti U.
- Cotzomi J.
- de la Fuente E.
- De León C.
- DeYoung T.
- Diaz-Azuara A.
- Diaz-Cruz L.
- Dingus B. L.
- Dultzin D.
- DuVernois M. A.
- Díaz-Vélez J. C.
- Ellsworth R. W.
- Fernandez A.
- Fiorino D. W.
- Fraija N.
- Galicia J. F. Valdés
- Galindo A.
- García-Torales G.
- Garfias F.
- Gonzalez J. Becerra
- González A.
- González L. X.
- González M. M.
- Goodman J. A.
- Grabski V.
- Gussert M.
- Guzmán-Cerón C.
- Hampel-Arias Z.
- Harding J. P.
- Hernandez R. Diaz
- Hernández-Cervantes L.
- Hui C. M.
- Hüntemeyer P.
- Imran A.
- Iriarte A.
- Karn P.
- Kieda D.
- Kunde G. J.
- Langarica R.
- Lara A.
- Lara G.
- Lauer R. J.
- Lee W. H.
- Lennarz D.
- Linares E. C.
- Linnemann J. T.
- Longo M.
- Luna-Garcia R.
- Marinelli A.
- Martos M.
- Martínez H.
- Martínez L. A.
- Martínez O.
- Martínez-Castro J.
- Matthews J. A. J.
- McEnery J.
- Miranda-Romagnoli P.
- Moreno E.
- Mostafá M.
- Nava J.
- Nellen L.
- Newbold M.
- Noriega-Papaqui R.
- Oceguera-Becerra T.
- Page D. P.
- Patricelli B.
- Pelayo R.
- Pretz J.
- Pérez-Pérez E. G.
- Ramírez I.
- Renter A.
- Rivière C.
- Rosa-González D.
- Rosales M. Bonilla
- Ruiz-Sala F.
- Ruiz-Velasco E. L.
- Ryan J.
- Sacahui J. R.
- Salazar H.
- Salesa F.
- Sandoval A.
- Santos E.
- Schneider M.
- Silich S.
- Sinnis G.
- Smith A. J.
- Solares H. A. Ayala
- Springer R. W.
- Suarez F.
- Taboada I.
- Tepe A.
- Tinoco S.
- Toale P. A.
- Tollefson K.
- Torres E. Mendoza
- Torres I.
- Ukwatta T. N.
- Vanegas P.
- Vargas H. León
- Villaseñor L.
- Vázquez A.
- Wall W.
- Weisgarber T.
- Westerhoff S.
- Wisher I. G.
- Wood J.
- Woodle K. Sparks
- Yodh G. B.
- Younk P. W.
- Zaborov D.
- Zepeda A.
- Zhou H.
- Álvarez J. D.
- Ángeles F.
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/08/2014
- Field of study
VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l.
in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design,
construction techniques and data acquisition system of the HAWC observatory.
HAWC is an air-shower array currently under construction at the same site of
VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water
Cherenkov detectors and two different data acquisition systems. It was in
operation between October 2011 and May 2012 with an average live time of 30%.
Besides the scientific verification purposes, the eight months of data were
used to obtain the results presented in this paper: the detector response to
the Forbush decrease of March 2012, and the analysis of possible emission, at
energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages,
10 figures). Corresponding authors: A.Marinelli and D.Zaboro
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
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- Zeng JC
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zieminska D
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- Zimmermann S
- Zinonos Z
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- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
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- Zabi A
- Zabolotny W
- Zachariadou A
- Zalewski P
- Zampieri A
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
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- Zheng Y
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- Zhokin A
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- Zhukov V
- Zhukova V
- Ziebarth EB
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Performance and Operation of the CMS Electromagnetic Calorimeter
- Author
- Abadjiev K.
- Abbaneo D.
- Abbiendi G.
- Abbrescia M.
- Abdullin S.
- Abelev B.
- Acosta D.
- Acosta J. G.
- Acosta M. Vazquez
- Actis O.
- Actis O.
- Adam N.
- Adam W.
- Adams M. R.
- Adams T.
- Adiguzel A.
- Adler V.
- Adolphi R.
- Adolphi R.
- Adzic P.
- Afaq M. A.
- Agostino L.
- Agram J. -L.
- Agram J. -L.
- Aguilar-Benitez M.
- Ahmad M.
- Ahmad W. Haj
- Ahmad W. Haj
- Ahmed I.
- Ahmed W.
- Ahuja S.
- Aisa D.
- Aisa S.
- Akchurin N.
- Akgun B.
- Akgun U.
- Akimenko S.
- Akin I. V.
- Alagoz E.
- Alampi G.
- Albajar C.
- Albayrak E. A.
- Alberdi J.
- Albergo S.
- Albert E.
- Albrow M.
- Alcaraz Maestre J.
- Alexander J.
- Alidra M.
- Aliev T.
- Allfrey P.
- Almeida N.
- Altenhoefer G.
- Altenhoefer G.
- Altsybeev I.
- Alver B.
- Alverson G.
- Alves G. A.
- Amaglobeli N.
- Amaglobeli N.
- Amapane N.
- Ambroglini F.
- Amsler C.
- Anagnostou G.
- Anagnostou G.
- Ananthan B.
- Anastassov A.
- Andelin D.
- Anderson M.
- Andrea J.
- Andreev V.
- Andreev Yu.
- Anghel I. M.
- Anguelov T.
- Anisimov A.
- Antillon E.
- Antipov P.
- Antonelli L.
- Anttila E.
- Anttila E.
- Antunes J. Rodrigues
- Antunovic Z.
- Antunovic Z.
- Apanasevich L.
- Apollinari G.
- Apresyan A.
- Arce P.
- Arcidiacono R.
- Arenton M. W.
- Arfaei H.
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- Publication date
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- Field of study
The operation and general performance of the CMS electromagnetic calorimeter
using cosmic-ray muons are described. These muons were recorded after the
closure of the CMS detector in late 2008. The calorimeter is made of lead
tungstate crystals and the overall status of the 75848 channels corresponding
to the barrel and endcap detectors is reported. The stability of crucial
operational parameters, such as high voltage, temperature and electronic noise,
is summarised and the performance of the light monitoring system is presented
Adult Circadian Behavior in Drosophila Requires Developmental Expression of cycle, But Not period
- Author
- A Claridge-Chang
- A Matsumoto
- A Sehgal
- AH Brand
- B Grima
- B Kloss
- B Kloss
- BC Lear
- C Helfrich-Forster
- C Lee
- C Lim
- CE Boothroyd
- D Stoleru
- DM Lin
- DM Zerr
- EE Zhang
- Gloribel Bonilla
- H Wijnen
- Herman Wijnen
- J Blau
- J Currie
- J Ewer
- J Ewer
- Jake Currie
- JE Rutila
- JH Park
- JL Price
- JL Price
- Joseph S. Takahashi
- JS Menet
- JS Wu
- K Bae
- Karolina Mirowska
- KD Curtin
- M Kaneko
- Min-Ho Kim
- MK Baylies
- MP Fernandez
- Neethi Varadaraja Rao
- NR Glossop
- OT Shafer
- OT Shafer
- PE Hardin
- R Allada
- R Allada
- R Allada
- R Stanewsky
- RF Smith
- RJ Konopka
- S Kadener
- S Martinek
- S Tanoue
- SA Cyran
- SC Renn
- SE McGuire
- Tadahiro Goda
- TD Schmittgen
- TK Darlington
- Y Peng
- Z Yang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Circadian clocks have evolved as internal time keeping mechanisms that allow anticipation of daily environmental changes and organization of a daily program of physiological and behavioral rhythms. To better examine the mechanisms underlying circadian clocks in animals and to ask whether clock gene expression and function during development affected subsequent daily time keeping in the adult, we used the genetic tools available in Drosophila to conditionally manipulate the function of the CYCLE component of the positive regulator CLOCK/CYCLE (CLK/CYC) or its negative feedback inhibitor PERIOD (PER). Differential manipulation of clock function during development and in adulthood indicated that there is no developmental requirement for either a running clock mechanism or expression of per. However, conditional suppression of CLK/CYC activity either via per over-expression or cyc depletion during metamorphosis resulted in persistent arrhythmic behavior in the adult. Two distinct mechanisms were identified that may contribute to this developmental function of CLK/CYC and both involve the ventral lateral clock neurons (LNvs) that are crucial to circadian control of locomotor behavior: (1) selective depletion of cyc expression in the LNvs resulted in abnormal peptidergic small-LNv dorsal projections, and (2) PER expression rhythms in the adult LNvs appeared to be affected by developmental inhibition of CLK/CYC activity. Given the conservation of clock genes and circuits among animals, this study provides a rationale for investigating a possible similar developmental role of the homologous mammalian CLOCK/BMAL1 complex
Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset
- Author
- Adarmes-Gomez A
- Aguilar M
- Alvarez I
- Alvarez V
- Bandres-Ciga S
- Barbosa IA
- Bergareche Yarza J
- Bernal-Bernal I
- Billingsley KJ
- Blauwendraat C
- Blazquez M
- Bonilla-Toribio Bernal M
- Botia JA
- Boungiorne M
- Bras J
- Brice A
- Brockmann K
- Bubb VJ
- Buiza-Rueda D
- Camara A
- Carcel M
- Carrillo F
- Carrion-Claro M
- Cerdan D
- Chelban V
- Clarimon J
- Compta Y
- Cookson M
- Danjou F
- de Munain Arregui AL
- Deshpande C
- Diez-Fairen M
- Dols-Icardo O
- Duarte J
- Duran RI
- Escamilla-Sevilla F
- Escott-Price V
- Ezquerra M
- Faghri F
- Fernandez M
- Fernandez-Santiago R
- Finkbeiner S
- Foltynie T
- Gan-Or Z
- Garcia C
- Garcia-Ruiz P
- Gasser T
- Gibbs JR
- Giri A
- Gomez Heredia M
- Gomez-Garre P
- Gonzalez-Aramburu I
- Gorostidi Pagola A
- Guerreiro R
- Hardy J
- Hernandez D
- Heutink P
- Hoenicka J
- Holmans P
- Houlden H
- Infante J
- IPDGC
- Javier Barrero F
- Jesus S
- Jimenez-Escrig A
- Jose Marti M
- Kia D
- Kinghorn K
- Koks S
- Krohan L
- Kulisevsky J
- Labrador-Espinosa M
- Leonard H
- Lesage S
- Lewis P
- Lopez-Sendon J
- Loverin R
- Lubbe S
- Lungu C
- Macias D
- Majamaa K
- Marin J
- Marinus J
- Martinez Torres I
- Martinez M
- Martinez-Castrillo J
- Mencacci N
- Mendez-del-Barrio C
- Menendez Gonzalez M
- Middlehurst B
- Minguez A
- Mir P
- Mok K
- Mondragon Rezola E
- Morris HR
- Munoz E
- Nalls MA
- Nicolas A
- Noyce A
- Ojo O
- Okubadejo N
- Pablo Tartari J
- Pagonabarraga J
- Pastor P
- Perez Errazquin F
- Perinan-Tocino T
- Pihlstrom L
- Plun-Favreau H
- Quinn JP
- R'Bibo L
- Reed X
- Reynolds RH
- Rizig M
- Rizzu P
- Robak L
- Rouleau G
- Ruiz-Martinez J
- Ruz C
- Ryten M
- Sanchez Rodriguez A
- Scholz S
- Schulte C
- Sharma M
- Shulman J
- Sierra M
- Siitonen A
- Simon-Sanchez J
- Simpson MA
- Singleton A
- Suarez-Sanmartin E
- Taba P
- Tabernero C
- Tan M
- Tejera-Parrado C
- Tolosa E
- Trabzuni D
- Tucci A
- Valldeoriola F
- van Hilten J
- Vargas-Gonzalez L
- Vela L
- Vives F
- Williams N
- Wood N
- Zhang D
- Zimprich A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson’s disease (PD). Yet the role that
mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here, we
comprehensively assessed the role of mitochondrial function-associated genes in sporadic PD by leveraging improvements in the
scale and analysis of PD GWAS data with recent advances in our understanding of the genetics of mitochondrial disease. We
calculated a mitochondrial-specific polygenic risk score (PRS) and showed that cumulative small effect variants within both our
primary and secondary gene lists are significantly associated with increased PD risk. We further reported that the PRS of the
secondary mitochondrial gene list was significantly associated with later age at onset. Finally, to identify possible functional
genomic associations we implemented Mendelian randomization, which showed that 14 of these mitochondrial functionassociated genes showed functional consequence associated with PD risk. Further analysis suggested that the 14 identified genes
are not only involved in mitophagy, but implicate new mitochondrial processes. Our data suggests that therapeutics targeting
mitochondrial bioenergetics and proteostasis pathways distinct from mitophagy could be beneficial to treating the early
stage of PD
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
- Author
- Adarmes-Gomez AD
- Aguilar M
- Alvarez I
- Alvarez V
- Anderson T
- Bandres-Ciga S
- Bentley S
- Bergareche Yarza JA
- Bernal-Bernal I
- Billingsley K
- Blauwendraat C
- Blazquez M
- Bonilla-Toribio M
- Botia J
- Bras J
- Brice A
- Brockmann K
- Buiza-Rueda D
- Camara A
- Carcel M
- Carlos Martinez-Castrillo J
- Carrillo F
- Carrion-Claro M
- Cerdan D
- Chelban V
- Clarimon J
- Compta Y
- Cookson MR
- Corvol J-C
- Dalrymple-Alford J
- Danjou F
- de Munain Arregui AL
- Diez-Fairen M
- Dis SGP
- Dols-Icardo O
- Duarte J
- Duran R
- Escamilla-Sevilla F
- Escott-Price V
- Ezquerra M
- Faghri F
- Fernandez M
- Fernandez-Santiago R
- Finkbeiner S
- Foltynie T
- Fowdar J
- Gan-Or Z
- Garcia C
- Garcia-Ruiz P
- Gasser T
- Genomics IPD
- Gibbs JR
- Giri A
- Gomez Heredia MJ
- Gomez-Garre P
- Gonzalez-Aramburu I
- Gorostidi Pagola A
- Gratten J
- Guerreiro R
- Halliday G
- Hardy J
- Henders AK
- Hernandez DG
- Heutink P
- Hickie I
- Hoenicka J
- Holmans P
- Houlden H
- Infante J
- Javier Barrero F
- Jesus S
- Jimenez-Escrig A
- Jose Marti M
- Kassam I
- Kennedy M
- Kia DA
- Kinghorn KJ
- Koks S
- Krohan L
- Kulisevsky J
- Kwok J
- Labrador-Espinosa MA
- Leonard H
- Lesage S
- Lewis P
- Lewis S
- Lovering R
- Lubbe S
- Luis Lopez-Sendon J
- Lungu C
- Macias D
- Majamaa K
- Marin J
- Marinus J
- Martinez Torres I
- Martinez M
- Mellick G
- Mencacci NE
- Mendez-del-Barrio C
- Menendez Gonzalez M
- Middlehurst B
- Minguez A
- Mir P
- Mok KY
- Mondragon Rezola E
- Montgomery G
- Morris HR
- Munoz E
- Nalls MA
- Nicolas A
- Noyce AJ
- Ojo OO
- Okubadejo NU
- Pablo Tartari J
- Pagonabarraga J
- Pastor P
- Pearson J
- Perez Errazquin F
- Perinan-Tocino T
- Pihlstrom L
- Pitcher T
- Plun-Favreau H
- Quinn J
- R'Bibo L
- Reed X
- Reynolds RH
- Rizig M
- Rizzu P
- Robak L
- Rouleau GA
- Ruiz-Martinez J
- Ruz C
- Ryten M
- Sanchez Rodriguez A
- Scholz SW
- Schulte C
- Sharma M
- Shulman JM
- Sidorenko J
- Sierra M
- Siitonen A
- Silburn PA
- Simon-Sanchez J
- Singleton AB
- Suarez-Sanmartin E
- Taba P
- Tabernero C
- Taliun SAG
- Tan M
- Tejera-Parrado C
- Teresa Boungiorno M
- Tolosa E
- Trabzuni D
- Tucci A
- Valldeoriola F
- Vallerga CL
- van Hilten JJ
- Vargas-Gonzalez L
- Vela L
- Visscher PM
- Vives F
- Wallace L
- Williams N
- Wood NW
- Wray NR
- Xue A
- Yang J
- Zhang F
- Zimprich A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomic PD findings to specific brain cell types. We found that PD heritability attributable to common variation does not enrich in global and regional brain annotations or brain-related cell-type-specific annotations. Likewise, we found no enrichment of PD susceptibility genes in brain-related cell types. In contrast, we demonstrated a significant enrichment of PD heritability in a curated lysosomal gene set highly expressed in astrocytic, microglial, and oligodendrocyte subtypes, and in LoF-intolerant genes, which were found highly expressed in almost all tested cellular subtypes. Our results suggest that PD risk loci do not lie in specific cell types or individual brain regions, but rather in global cellular processes detectable across several cell types
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