Host Preference between Symbiotic and Aposymbiotic Aphis fabae, by the Aphid Parasitoid, Lysiphlebus ambiguus

Few empirical studies have directly explored the association between Buchnera aphidicola (Enterobacteriales: Enterobacteriaceae), the primary endosymbiont of aphids, and the life history strategies of aphid parasitoids. A series of paired-choice experiments were conducted to explore the preference of the parasitoid Lysiphlebus ambiguus Halliday (Hymenoptera: Aphididae) for symbiotic and aposymbiotic Aphis fabae Scopoli (Hemiptera: Aphididae) and the suitability of these hosts for parasitoid development. When given a choice between symbiotic and aposymbiotic aphids of the same instar, the parasitoid significantly preferred symbiotic over aposymbiotic aphids only during the later instars (L4 and adult). The suitability of aposymbiotic aphids for parasitoid development was equal to that of symbiotic aphids in terms of survivorship and sex ratio, but was significantly lower than that of symbiotic aphids for L4 and adult instars in development rate and/or female adult size. When given a choice between similar-sized symbiotic L2 and aposymbiotic L4 aphids, the parasitoid preferred the former. No significant differences in preference or host suitability were demonstrated when the parasitoid was given a choice between different instars of aposymbiotic aphids. While parasitoid lifetime fecundity increased with aphid instar at the time of oviposition, there was no significant influence of previous development from symbiotic versus aposymbiotic aphids. These results suggest that while L. ambiguus can discriminate between symbiotic and aposymbiotic A. fabae during later instars and when the aphids are of a similar size, the primary endosymbiont is not needed for successful parasitoid development; and its absence only compromises parasitoid growth reared from later instar aposymbiotic host

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Preparation and Application of Electrodes in Capacitive Deionization (CDI): a State-of-Art Review

As a promising desalination technology, capacitive deionization (CDI) have shown practicality and cost-effectiveness in brackish water treatment. Developing more efficient electrode materials is the key to improving salt removal performance. This work reviewed current progress on electrode fabrication in application of CDI. Fundamental principal (e.g. EDL theory and adsorption isotherms) and process factors (e.g. pore distribution, potential, salt type and concentration) of CDI performance were presented first. It was then followed by in-depth discussion and comparison on properties and fabrication technique of different electrodes, including carbon aerogel, activated carbon, carbon nanotubes, graphene and ordered mesoporous carbon. Finally, polyaniline as conductive polymer and its potential application as CDI electrode-enhancing materials were also discussed

Defensive behaviors of the Oriental armyworm Mythimna separata in response to different parasitoid species (Hymenoptera: Braconidae)

This study examined defensive behaviors of Mythimna separata (Lepidoptera: Noctuidae) larvae varying in body size in response to two parasitoids varying in oviposition behavior; Microplitis mediator females sting the host with the ovipositor after climbing onto it while Meteorus pulchricornis females make the sting by standing at a close distance from the host. Mythimna separata larvae exhibited evasive (escaping and dropping) and aggressive (thrashing) behaviors to defend themselves against parasitoids M. mediator and M. pulchricornis. Escaping and dropping did not change in probability with host body size or parasitoid species. Thrashing did not vary in frequency with host body size, yet performed more frequently in response to M. mediator than to M. pulchricornis. Parasitoid handling time and stinging likelihood varied depending not only on host body size but also on parasitoid species. Parasitoid handling time increased with host thrashing frequency, similar in slope for both parasitoids yet on a higher intercept for M. mediator than for M. pulchricornis. Handling time decreased with host size for M. pulchricornis but not for M. mediator. The likelihood of realizing an ovipositor sting decreased with thrashing frequency of both small and large hosts for M. pulchricornis, while this was true only for large hosts for M. mediator. Our results suggest that the thrashing behavior of M. separata larvae has a defensive effect on parasitism, depending on host body size and parasitoid species with different oviposition behaviors

Brood size and sex ratio in response to host quality and wasp traits in the gregarious parasitoid Oomyzus sokolowskii (Hymenoptera: Eulophidae)

This laboratory study investigated whether the larval-pupal parasitoid Oomyzus sokolowskii females adjust their brood size and sex ratio in response to body size and stage of Plutella xylostella larval hosts, as well as to their own body size and the order of oviposition. These factors were analyzed using multiple regression with simultaneous entry of them and their two-way interactions. Parasitoids brood size tended to increase with host body size at parasitism when the 4th instar larval host was attacked, but did not change when the 2nd and 3rd instar larvae were attacked. Parasitoids did not vary in brood size according to their body size, but decreased with their bouts of oviposition on a linear trend from 10 offspring adults emerged per host in the first bout of oviposition down to eight in the third. Parasitoid offspring sex ratio did not change with host instar, host body weight, wasp body size, and oviposition bout. Proportions of male offspring per brood were from 11% to 13% from attacking the 2nd to 4th instar larvae and from 13% to 16% across three successive bouts of oviposition, with a large variation for smaller host larvae and wasps. When fewer than 12 offspring were emerged from a host, one male was most frequently produced; when more than 12 offspring were emerged, two or more males were produced. Our study suggests that O. sokolowskii females may optimize their clutch size in response to body size of mature P. xylostella larvae, and their sex allocation in response to clutch size

Petrogenesis and Tectonic Implications of the Early Cretaceous Granitic Pluton in the Sulu Orogenic Belt: The Caochang Granitic Pluton as an Example

The Sulu orogenic belt is the source of information on important magmatic events associated with the collision of the Yangtze craton and North China craton (NCC) and the destruction of the NCC during the Mesozoic in eastern China. In this study, we have, for the first time, identified a monzonitic granitic pluton. We hereby present petrological, geochemical, and zircon U-Pb-Hf-O isotopic data, shedding new light on the petrogenesis and tectonic implications for the granitic pluton in the Sulu belt. LA-ICP-MS and SHRIMP II analyses of zircon grains suggest that the monzonitic granitic pluton was crystallized in the Early Cretaceous (ca. 120 Ma). Geochemically, the granitic pluton shows sub-alkaline, high-K calc-alkaline, and metaluminous signatures, and is genetically of I-type granite, excluding the possibility of S-type granite, as evidenced by mantle-like zircon oxygen isotopic features. In addition, the pluton is enriched in light REE and large-ion lithophile elements (LILE) (e.g., La, Cs, Ba, K, and Pb), but depleted in high-field-strength elements (HFSE) (e.g., Nb, Ta, P, and Ti), suggesting an arc-related affinity. Zircon Hf isotopes (εHf(t) = −27.51~−32.35; TDM2 = 2979~3175 Ma) and mantle-like δ18O values (5.12–6.24‰) together indicate that the identified granitic pluton is derived from the partial melting (reworking) of the ancient mafic lower crustal material, with no supra-crustal material participation. Moreover, high Magnesium number (Mg# = 42–49) values and mafic micro-granular enclaves suggest that mantle-derived magma participated in the evolution of the granitic pluton in this study. Integrating the findings of this study and previous work, we propose that the Caochang granitic pluton is derived from the partial melting of the deep Yangtze basaltic lower crust during the Early Cretaceous, and that the large-scale thinning of the lithospheric mantle was the main factor that led to Early Cretaceous magmatic flare-up in the Sulu orogenic belt

Observer-based SMC for stochastic systems with disturbance driven by fractional Brownian motion

This paper investigates the problem of disturbance-observer-based sliding mode control for stabilization of stochastic systems driven by frac-tional Brownian motion (fBm). By proposing a novel disturbance observer, an integral-typ e sliding surface is put forward with the estimated disturbance error confined within a certain value. Meanwhile, by virtue of fractional infin-itesimal operator and linear matrix inequality, a sufficient criterion is derived to guarantee the asymptotic stability of obtained sliding mode dynamics. Fur-ther, an observer-based sliding mode controller is designed to ensure finite-time reachability of state trajectories onto the predefined sliding surface. Lastly, an illustrative example is utilized to verify the reliability and applicability of the proposed control strategy