A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Corporate Responses in an Emerging Climate Regime: The Institutionalization and Commensuration of Carbon Disclosure

This paper examines corporate responses to climate change in relation to the development of reporting mechanisms for greenhouse gases, more specifically carbon disclosure. It first presents some background and context on the evolution of carbon trading and disclosure, and then develops a conceptual framework using theories of global governance, institutional theory and commensuration to understand the role of carbon disclosure in the emerging climate regime. Subsequently, a closer look is taken at carbon disclosure and reporting mechanisms, with a particular focus on the Carbon Disclosure Project (CDP). Our analysis of responses shows that CDP has been successfully using institutional investors to urge firms to disclose extensive information about their climate change activities. However, although response rates in terms of numbers of disclosing firms are impressive and growing, neither the level of carbon disclosure that CDP promotes nor the more detailed carbon accounting provide information that is particularly valuable for investors, NGOs or policy makers at this stage. As a project of commensuration, carbon disclosure has achieved some progress in technical terms, but much less with regard to the cognitive and value dimensions.