391 research outputs found
Etablierung von SNaPshot-Assays zur Charakterisierung Y-chromosomaler Haplogruppen – ein Teilprojekt zur Bestimmung der Ursprungspopulation unbekannter Tatortspuren
- Author
- Publication venue
- Publication date
- 17/04/2018
- Field of study
Get PDFEine der wichtigsten Methoden in der internationalen Verbrechensbekämpfung ist die Erstellung individualspezifischer Desoxyribonukleinsäure-Profile (engl. deoxyribonucleic acid (DNA)), anhand derer Tatortspuren einem Tatverdächtigen zugeordnet werden können. Gibt es keine Hinweise auf mögliche Tatverdächtige, so kann die Ursprungspopulation einer unbekannten DNA-Spur des Tatortes für die polizeilichen Ermittlungsarbeiten von großer Bedeutung sein. Bei männlichen Spuren liefert, neben autosomalen Einzelnukleotid-Polymorphismen (engl. single nucleotide polymorphisms (SNPs)) und Polymorphismen mitochondrialer DNA (mtDNA), die Y-chromosomale Haplogruppe einen wichtigen Hinweis auf die ursprüngliche Herkunft des Spurenlegers. Sie ist über die Allelausprägung bestimmter Einzelnukleotid-Polymorphismen auf dem Y-Chromosom definiert. Das Vorkommen sowie die Verteilung solcher Haplogruppen kann in unterschiedlichen Populationen stark variieren.
In dieser Studie wurden drei Minisequencing-Assays mit insgesamt 45 SNPs des Y-Chromosoms zusammengestellt und etabliert. Der Prozess der Etablierung beinhaltete das Erstellen zuverlässiger Multiplex-Polymerasekettenreaktionen-Assays (engl. polymerase chain reaction (PCR)) und SNaPshot-Multiplex-PCR-Assays, die auch geringe DNA-Mengen sowie degradierte DNA zuverlässig analysieren können. Die Kombination der Y-SNPs in den Minisequencing-Assays erlaubt eine eindeutige Zuordnung zu bestimmten, im Vorfeld ausgesuchten Y-Haplogruppen. Anschließend wurden die erstellten Minisequencing-Assays verifiziert, indem die Verteilung der Y-chromosomalen Haplogruppen in insgesamt 385 Personen aus Nordeuropa, vom Balkan, aus der Türkei, dem Nahen Osten, sowie aus Nord- und Westafrika bestimmt wurde.
Dabei konnten metapopulationsspezifische Haplogruppen (Hg), wie beispielsweise Hg E1b1a für Westafrika, ermittelt werden. Es zeigte sich allerdings auch, dass andere Haplogruppen in mehreren Metapopulationen in etwa gleichen Anteilen vorkommen, wie zum Beispiel Haplogruppe J1e in Nordafrika, dem Nahen Osten und der Türkei. Anhand einiger Beispiele konnte nachgewiesen werden, dass die Y-chromosomalen Haplogruppen eine wichtige Ergänzung zur Analyse autosomaler SNPs sind
Pion-Xi correlations in Au-Au collisions at STAR
- Author
- A. Derevschikov A.
- A. Kuznetsov A.
- A. Lisa M.
- A. Matulenko Yu.
- A. Nikitin V.
- A. P. Suaide A.
- A. Petrov V.
- A. Zolnierczuk P.
- Adams J.
- Adler C.
- Ahammed Z.
- Amonett J.
- Anderson M.,
- Arkhipkin D.
- B. Dunin V.
- B. Nurushev S.
- B. Roberts J.
- B. Tonjes M.
- Balewski J.
- Barannikova O.
- Baudot J.
- Bekele S.
- Bellwied R.
- Berger J.
- Bhardwaj S.
- Bhaskar P.
- Bichsel H.
- Billmeier A.
- Botje M.
- Boucham A.
- Brandin A.
- Bravar A.
- C. Bland L.
- C. Dunlop J.
- C. Phatak S.
- Caines H.
- Calderón De La Barca Sánchez M.
- Carroll J.
- Castillo J.
- Castro M.
- Cebra D.
- Chaloupka P.
- Chattopadhyay S.
- Chen Y.
- Cherney M.
- Chikanian A.
- Choi B.
- Christie W.
- Coffin J.P.
- D. Anderson B.
- D. Gutierrez T.
- D. Koetke D.
- D. Kovalenko A.
- D. Trivedi M.
- D. Westfall G.
- Das D.
- Das S.
- Didenko L.
- Dietel T.
- Dong X.
- Du F.
- E. Bonner B.
- E. Draper J.
- E. Gonzalez J.
- E. Shestermanov K.
- E. Tribble R.
- E. Vigdor S.
- Eckardt V.
- Emelianov V.
- Engelage J.
- Eppley G.
- Erazmus B.
- Estienne Magali
- F. Chen H.
- F. Moore C.
- Fachini P.
- Faine V.
- Faivre J.
- Fatemi R.
- Filimonov K.
- Filip P.
- Finch E.
- Fisyak Y.
- Flierl D.
- Fu J.
- G. Cramer J.
- G. Efimov L.
- G. Jones P.
- G. Judd E.
- G. Ma Y.
- G. Minaev N.
- G. Munhoz M.
- G. Reid J.
- G. Ritter H.
- G. Underwood D.
- Gagliardi C.A.
- Gagunashvili N.
- Gans J.
- Gaudichet L.
- Germain Marie
- Geurts F.
- Ghazikhanian V.
- Ghosh P.
- Grachov O.
- Grigoriev V.
- Gronstal S.
- Grosnick D.
- Guedon M.
- Gupta Anupam
- Gushin E.
- H. Tang A.
- H. Thomas J.
- Hardtke D.
- Heinz M.
- Heppelmann S.
- Herston T.
- Hippolyte B.
- Hirsch A.
- Hjort E.
- Horsley M.
- I. Bezverkhny B.
- I. Kravtsov V.
- I. Kulikov A.
- I. Pavlinov A.
- I. Yurevich V.
- Igo G.
- Ishihara A.
- J. Crawford H.
- J. Dong W.
- J. Foley K.
- J. Hallman T.
- J. Humanic T.
- J. Kunde G.
- J. Levine M.
- J. Lindenbaum S.
- J. Liu Q.
- J. Llope W.
- J. M. Symons T.
- J. Mora-Corral M.
- J. Ruan L.
- Jacobs P.
- Jacobs W.W.
- Janik M.
- Jiang H.
- Johnson I.
- K. Badyal S.
- K. Bhati A.
- K. Dubey A.
- K. Mangotra L.
- K. Nandi B.
- K. Nayak S.
- K. Nayak T.
- K. Pal S.
- Kabana S.
- Kaneta M.
- Kaplan M.
- Keane D.
- Kh. Kutuev R.
- Kiryluk J.
- Kisiel A.
- Klay J.
- Klyachko A.
- Kollegger T.
- Kopytine M.
- Kotchenda L.
- Kramer M.
- Kravtsov P.
- Krueger K.
- Kuhn C.
- Kumar A.
- L. Huang S.
- L. Kunz C.
- L. Miller M.
- L. Ray R.
- L. Romero J.
- L. Wang X.
- Lamont M.A. C.
- Lange S.
- Lasiuk B.
- Laue F.
- Lauret J.
- Lebedev A.,
- Lednický R.
- Li C.
- Li Q.
- Liu F.
- Liu L.
- Liu Z.
- Ljubicic T.
- Long H.
- Lopez-Noriega M.
- Love W.A.
- Ludlam T.
- Lynn D.
- M. Aggarwal M.
- M. Cormier T.
- M. De Moura M.
- M. Guertin S.
- M. Landgraf J.
- M. Nelson J.
- M. Poskanzer A.
- M. Spinka H.
- M. Vandermolen A.
- M. Wang Z.
- M. Zhang W.
- Ma J.
- Magestro D.
- Mahajan S.
- Majka R.
- Manweiler R.
- Margetis S.
- Markert C.
- Martin Lilian
- Marx J.
- Meissner F.
- Melnick Yu.
- Meschanin A.
- Messer M.
- Milosevich Z.
- Mironov C.
- Mishra D.
- Mitchell J.
- Mohanty B.
- Molnar L.
- Morozov D.A.
- Morozov V.
- N. Singaraju R.
- N. Vasiliev A.
- N. Zubarev A.
- Nevski P.
- Norman B.
- O. Blyth C.
- Odyniec G.
- Ogawa A.
- Okorokov V.
- Oldenburg M.
- Olson D.
- P. Chernenko S.
- P. Lansdell C.
- P. Mahapatra D.
- P. Scharenberg R.
- P. Viyogi Y.
- P. Zhang Z.
- Paic G.
- Panebratsev Y.
- Pawlak T.
- Perevoztchikov V.
- Perkins C.
- Peryt W.
- Picha R.
- Planinic M.
- Pluta J.
- Porile N.
- Porter J.
- Potekhin M.
- Potrebenikova E.
- Prindle D.
- Pruneau C.
- Putschke J.
- R. Dutta Majumdar M.
- R. Klein S.
- Rai G.
- Rakness G.
- Raniwala R.
- Raniwala S.
- Ravel O.
- Reichhold D.
- Renault G.
- Retiere F.
- Ridiger A.
- Rose A.
- Roy C.
- S. Averichev G.
- S. Barnby L.
- S. Ganti M.
- S. Longacre R.
- S. Matis H.
- S. Mcshane T.
- S. Schroeder L.
- Sahoo R.
- Sakrejda I.
- Salur S.
- Sandweiss J.
- Savin I.
- Schambach J.
- Schmitz N.
- Schweda K.
- Seger J.
- Seliverstov D.
- Seyboth P.
- Shahaliev E.
- Shao M.
- Sharma M.
- Shimanskii S.S.
- Simon F.
- Skoro G.
- Smirnov N.
- Snellings R.
- Sood G.
- Sorensen P.
- Sowinski J.
- Srivastava B.
- Stanislaus S.
- Stock R.
- Stolpovsky A.
- Strikhanov M.
- Stringfellow B.
- Struck C.
- Sugarbaker E.
- Suire C.
- Sumbera M.
- Surrow B.
- Szanto De Toledo A.
- Szarwas P.
- Tai A.
- Takahashi J.
- Thein D.
- Tikhomirov V.
- Tokarev M.
- Trainor T.A.
- Trentalange S.
- Trofimov V.
- Tsai O.
- U. Pandey S.
- Ullrich T.
- V. Belaga V.
- V. Cadman R.
- V. K. S. Potukuchi B.
- V. Nogach L.
- V. Razin S.
- V. Rogachevski O.
- V. Zanevski Y.
- Van Buren G.
- Vasiliev M.
- Voloshin S.A.
- W. Harris J.
- W. Henry T.
- W. Hoffmann G.
- W. Watson J.
- W. Wissink S.
- Waggoner W.
- Wang F.
- Wang Gang
- Ward H.
- Wells R.
- Whitten C.
- Wieman H.
- Willson R.
- Witt R.
- Wood J.
- Wu J.
- Xu N.
- Xu Z.
- Y. Panitkin S.
- Yamamoto E.
- Yepes P.
- Yu. Khodyrev V.
- Z. Cai X.
- Z. Huang H.
- Z. Xu Z.
- Zborovský I.
- Zhang H.
- Zoulkarneev R.
- Zoulkarneeva J.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2004
- Field of study
Full text linkWe present pion-Xi correlation analysis in Au-Au collisions at sqrt(s_NN)=
200 GeV and sqrt(s_NN) = 62.4 GeV, performed using the STAR detector at RHIC. A
Xi*(1530) resonance signal is observed for the first time in Au-Au collisions.
Experimental data are compared with theoretical predictions. The strength of
the Xi* peak is reproduced in the correlation function assuming that pions and
Xis emerge from a system in collective expansion.Comment: To appear in the proceedings of 18th Nuclear Physics Division
Conference of the EPS (NPDC18),Prague, 23.8.-29.8. 200
Inclusive pi0 spectra at high transverse momentum in d-Au collisions at RHIC
- Author
- A. Derevschikov A.
- A. Kuznetsov A.
- A. Lisa M.
- A. Matulenko Yu.
- A. Nikitin V.
- A. O Nierczuk P.
- A. P. Suaide A.
- A. Petrov V.
- Adams J.
- Adler C.
- Ahammed Z.
- Amonett J.
- Anderson M.,
- Arkhipkin D.
- B. Dunin V.
- B. Nurushev S.
- B. Roberts J.
- B. Tonjes M.
- Balewski J.
- Barannikova O.
- Baudot J.
- Bekele S.
- Bellwied R.
- Berger J.
- Bhardwaj S.
- Bhaskar P.
- Bichsel H.
- Billmeier A.
- Botje M.
- Boucham A.
- Brandin A.
- Bravar A.
- C. Bland L.
- C. Dunlop J.
- C. Phatak S.
- Caines H.
- Calderón De La Barca Sánchez M.
- Carroll J.
- Castillo J.
- Castro M.
- Cebra D.
- Chaloupka P.
- Chattopadhyay S.
- Chen Y.
- Cherney M.
- Chikanian A.
- Choi B.
- Christie W.
- Coffin J.P.
- D. Anderson B.
- D. Gutierrez T.
- D. Koetke D.
- D. Kovalenko A.
- D. Trivedi M.
- D. Westfall G.
- Das D.
- Das S.
- Didenko L.
- Dietel T.
- Dong X.
- Du F.
- E. Bonner B.
- E. Draper J.
- E. Gonzalez J.
- E. Shestermanov K.
- E. Tribble R.
- E. Vigdor S.
- Eckardt V.
- Emelianov V.
- Engelage J.
- Eppley G.
- Erazmus B.
- Estienne Magali
- F. Chen H.
- F. Moore C.
- Fachini P.
- Faine V.
- Faivre J.
- Fatemi R.
- Filimonov K.
- Filip P.
- Finch E.
- Fisyak Y.
- Flierl D.
- Fu J.
- G. Cramer J.
- G. Efimov L.
- G. Jones P.
- G. Judd E.
- G. Ma Y.
- G. Minaev N.
- G. Munhoz M.
- G. Reid J.
- G. Ritter H.
- G. Underwood D.
- Gagliardi C.A.
- Gagunashvili N.
- Gans J.
- Gaudichet L.
- Germain Marie
- Geurts F.
- Ghazikhanian V.
- Ghosh P.
- Grachov O.
- Grigoriev V.
- Gronstal S.
- Grosnick D.
- Guedon M.
- Gupta Anupam
- Gushin E.
- H. Tang A.
- H. Thomas J.
- Hardtke D.
- Heinz M.
- Heppelmann S.
- Herston T.
- Hippolyte B.
- Hirsch A.
- Hjort E.
- Horsley M.
- I. Bezverkhny B.
- I. Kravtsov V.
- I. Kulikov A.
- I. Pavlinov A.
- I. Yurevich V.
- Igo G.
- Ishihara A.
- J. Crawford H.
- J. Dong W.
- J. Foley K.
- J. Hallman T.
- J. Humanic T.
- J. Kunde G.
- J. Levine M.
- J. Lindenbaum S.
- J. Liu Q.
- J. Llope W.
- J. M. Symons T.
- J. Mora-Corral M.
- J. Ruan L.
- Jacobs P.
- Jacobs W.W.
- Janik M.
- Jiang H.
- Johnson I.
- K. Badyal S.
- K. Bhati A.
- K. Dubey A.
- K. Mangotra L.
- K. Nandi B.
- K. Nayak S.
- K. Nayak T.
- K. Pal S.
- Kabana S.
- Kaneta M.
- Kaplan M.
- Keane D.
- Kh. Kutuev R.
- Kiryluk J.
- Kisiel A.
- Klay J.
- Klyachko A.
- Kollegger T.
- Kopytine M.
- Kotchenda L.
- Kramer M.
- Kravtsov P.
- Krueger K.
- Kuhn C.
- Kumar A.
- L. Huang S.
- L. Kunz C.
- L. Miller M.
- L. Ray R.
- L. Romero J.
- L. Wang X.
- Lamont M.A. C.
- Lange S.
- Lasiuk B.
- Laue F.
- Lauret J.
- Lebedev A.,
- Lednický R.
- Li C.
- Li Q.
- Liu F.
- Liu L.
- Liu Z.
- Ljubicic T.
- Long H.
- Lopez-Noriega M.
- Love W.A.
- Ludlam T.
- Lynn D.
- M. Aggarwal M.
- M. Cormier T.
- M. De Moura M.
- M. Guertin S.
- M. Landgraf J.
- M. Nelson J.
- M. Poskanzer A.
- M. Spinka H.
- M. Vandermolen A.
- M. Wang Z.
- M. Zhang W.
- Ma J.
- Magestro D.
- Mahajan S.
- Majka R.
- Manweiler R.
- Margetis S.
- Markert C.
- Martin Lilian
- Marx J.
- Meissner F.
- Melnick Yu.
- Meschanin A.
- Messer M.
- Milosevich Z.
- Mironov C.
- Mishra D.
- Mitchell J.
- Mohanty B.
- Molnar L.
- Morozov D.A.
- Morozov V.
- N. Singaraju R.
- N. Vasiliev A.
- Nevski P.
- Norman B.
- O. Blyth C.
- Odyniec G.
- Ogawa A.
- Okorokov V.
- Oldenburg M.
- Olson D.
- P. Chernenko S.
- P. Lansdell C.
- P. Mahapatra D.
- P. Scharenberg R.
- P. Viyogi Y.
- P. Zhang Z.
- Paic G.
- Panebratsev Y.
- Pawlak T.
- Perevoztchikov V.
- Perkins C.
- Peryt W.
- Picha R.
- Planinic M.
- Pluta J.
- Porile N.
- Porter J.
- Potekhin M.
- Potrebenikova E.
- Prindle D.
- Pruneau C.
- Putschke J.
- R. Dutta Majumdar M.
- R. Klein S.
- Rai G.
- Rakness G.
- Raniwala R.
- Raniwala S.
- Ravel O.
- Reichhold D.
- Renault G.
- Retiere F.
- Ridiger A.
- Rose A.
- Roy C.
- S. Averichev G.
- S. Barnby L.
- S. Ganti M.
- S. Longacre R.
- S. Matis H.
- S. Mcshane T.
- S. Schroeder L.
- Sahoo R.
- Sakrejda I.
- Salur S.
- Sandweiss J.
- Savin I.
- Schambach J.
- Schmitz N.
- Schweda K.
- Seger J.
- Seliverstov D.
- Seyboth P.
- Shahaliev E.
- Shao M.
- Sharma M.
- Shimanskii S.S.
- Simon F.
- Skoro G.
- Smirnov N.
- Snellings R.
- Sood G.
- Sorensen P.
- Sowinski J.
- Srivastava B.
- Stanislaus S.
- Stock R.
- Stolpovsky A.
- Strikhanov M.
- Stringfellow B.
- Struck C.
- Sugarbaker E.
- Suire C.
- Surrow B.
- Szanto De Toledo A.
- Szarwas P.
- Tai A.
- Takahashi J.
- Thein D.
- Tikhomirov V.
- Tokarev M.
- Trainor T.A.
- Trentalange S.
- Trofimov V.
- Tsai O.
- U. Pandey S.
- Ullrich T.
- Umbera M.
- V. Belaga V.
- V. Cadman R.
- V. K. S. Potukuchi B.
- V. Nogach L.
- V. Razin S.
- V. Rogachevski O.
- V. Zanevski Y.
- Van Buren G.
- Vasiliev M.
- Voloshin S.A.
- W. Harris J.
- W. Henry T.
- W. Hoffmann G.
- W. Watson J.
- W. Wissink S.
- Waggoner W.
- Wang F.
- Wang Gang
- Ward H.
- Wells R.
- Whitten C.
- Wieman H.
- Willson R.
- Witt R.
- Wood J.
- Wu J.
- Xu N.
- Xu Z.
- Y. Panitkin S.
- Yamamoto E.
- Yepes P.
- Yu. Khodyrev V.
- Z. Cai X.
- Z. Huang H.
- Z. Xu Z.
- Zborovský I.
- Zhang H.
- Zoulkarneev R.
- Zoulkarneeva J.
- Zubarev A. N.
- Publication venue
- 'Elsevier BV'
- Publication date
- 23/08/2004
- Field of study
Full text linkPreliminary results on inclusive neutral pion production in d-Au collisions
at sqrt(s_NN) = 200 GeV in the pseudo-rapidity range 0<eta<1 are presented. The
measurement is performed using the STAR Barrel Electromagnetic calorimeter
(BEMC). In this paper, the analysis of the first BEMC hadron measurement is
described and the results are compared with earlier RHIC findings. The pi0
invariant differential cross sections show good agreement with next-to-leading
order (NLO) perturbative QCD calculations.Comment: 4 pages, 5 figures, 18th Nuclear Physics Division Conference of the
EPS, Prague, submitted to Nucl. Phys.
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
- Author
- Adams Mark James
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Alda Martin
- Alfredsson Lars
- Andreassen Ole a.
- Appadurai Vivek
- Artigas María soler
- Ashley-Koch Allison e.
- Awasthi Swapnil
- Azevedo M. helena
- Bakian Amanda v.
- Bass Nicholas
- Bau Claiton h.d.
- Baune Bernhard t.
- Beckham Jean c.
- Behera Chittaranjan
- Bellivier Frank
- Berger Klaus
- Berrettini Wade h.
- Biernacka Joanna m.
- Bigdeli Tim b.
- Binder Elisabeth b.
- Boehnke Michael
- Bohus Martin
- Boks Marco p.
- Braff David l.
- Breen Gerome
- Bryant Richard
- Budde Monika
- Bulik Cynthia m.
- Byrne Enda m.
- Børglum Anders d.
- Cahn Wiepke
- Campos Adrian i.
- Castelao Enrique
- Cervilla Jorge a.
- Chang Xiao
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei j.
- Christensen Erik d.
- Coleman Jonathan r.i.
- Coon Hilary
- Corvin Aiden
- Craddock Nicholas
- Crow Scott
- Demontis Ditte
- Dennis Michelle
- Diblasi Emily
- Djurovic Srdjan
- Docherty Anna r.
- Duriez Philibert
- Edenberg Howard j.
- Edwards Alexis c.
- Erlangsen Annette
- Fernández-Aranda Fernando
- Foo Jerome c.
- Forstner Andreas j.
- Frye Mark
- Fullerton Janice m.
- Galfalvy Hanga
- Gandal Michael
- Garrett Melanie
- Gatt Justine m.
- Gelernter Joel
- Giegling Ina
- Glatt Stephen j.
- Gorwood Philip
- Grabe Hans j.
- Green Melissa j.
- Grevet Eugenio h.
- Grigoroiu-Serbanescu Maria
- Guo Yiran
- Gutierrez Blanca
- Guzman-Parra Jose
- Hafferty Jonathan d.
- Hair Lauren
- Hakonarson Hakon
- Halmi Katherine a.
- Hamshere Marian l.
- Hartmann Annette m.
- Harvey Philip
- Hauser Elizabeth r.
- Hauser Joanna
- Hauser Michael a.
- Heilmann-Heimbach Stefanie
- Hishimoto Akitoyo
- Hoffmann Per
- Hougaard David m.
- Huffman Jennifer
- Hwu Hai-Gwo
- Ising Marcus
- Jacobson Daniel
- Jain Sonia
- Jamain Stéphane
- Jiménez-Murcia Susana
- Johnson Craig
- Jones Ian
- Jones Lisa a.
- Jonsson Lina
- Kahn René s.
- Kang Jooeun
- Kaplan Allan s.
- Kaye Walter h.
- Keel Pamela k.
- Kelsoe John r.
- Kendler Kenneth s.
- Kennedy James l.
- Kessler Ronald c.
- Kim Minsoo
- Kimbrel Nathan a.
- Kloiber Stefan
- Klump Kelly l.
- Koenen Karestan c.
- Kogevinas Manolis
- Kranzler Henry r.
- Krebs Marie-Odile
- Kuo Po-Hsiu
- Landén Mikael
- Leboyer Marion
- Lee Phil h.
- Levey Daniel f.
- Levinson Douglas f.
- Lewis Cathryn m.
- Li Dong
- Li Qingqin s.
- Liao Calwing
- Liao Shih-Cheng
- Lieb Klaus
- Lilenfeld Lisa
- Lissowska Jolanta
- Liu Chih-Min
- Madduri Ravi
- Mann J. john
- Marshall Christian r.
- Martin Nicholas g.
- Mayoral Fermin
- Mcelroy Susan l.
- Mcgrath Patrick
- Mcguffin Peter
- Mcintosh Andrew m.
- Mcmahon Benjamin
- Mcquillin Andrew
- Medland Sarah e.
- Mehta Divya
- Melle Ingrid
- Mitchell James e.
- Mitchell Philip b.
- Molina Esther
- Monson Eric t.
- Morken Gunnar
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- Mullins Niamh
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- Nordentoft Merete
- Nurnberger John i.
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- Okazaki Satoshi
- Olsen Catherine m.
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- Owen Michael j.
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- Penninx Brenda w.j.h.
- Pinto Dalila
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- Powers Abigail
- Preisig Martin
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- Ribasés Marta
- Richarte Vanesa
- Rietschel Marcella
- Ripke Stephan
- Rivera Margarita
- Roberts Andrea
- Roberts Gloria
- Roepke Stefan
- Rouleau Guy a.
- Rovaris Diego l.
- Rozanov Vsevolod
- Ruderfer Douglas m.
- Sanders Alan r.
- Scherer Stephen w.
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- Schofield Peter r.
- Schulze Thomas g.
- Scott Laura j.
- Serretti Alessandro
- Shabalin Andrey
- Shi Jianxin
- Sirignano Lea
- Sklar Pamela
- Smeland Olav b.
- Smith Daniel j.
- Smoller Jordan w.
- Sokolowski Marcus
- Sonuga-Barke Edmund j.s.
- Stahl Eli a.
- Starnawska Anna
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- Streit Fabian
- Strober Michael
- Su Mei-Hsin
- Thornton Laura m.
- Trafton Jodie
- Treasure Janet
- Trzaskowski Maciej
- Tsuang Ming t.
- Turecki Gustavo
- Ursano Robert j.
- Van der auwera Sandra
- Vilar-Ribó Laura
- Vincent John b.
- Völzke Henry
- Walss-Bass Consuelo
- Walters James t.r.
- Ware Erin b.
- Wasserman Danuta
- Watson Hunna j.
- Weickert Cynthia shannon
- Weickert Thomas w.
- Weissman Myrna m.
- Wendt Frank
- Werge Thomas
- Whiteman David c.
- Williams Leanne m.
- Willour Virginia
- Witt Stephanie h.
- Woodside D. blake
- Wray Naomi r.
- Yilmaz Zeynep
- Zai Clement c.
- Zillich Lea
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Get PDFObjective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and crossvalidated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS metaanalysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. Methods: This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. Results: Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values <5×10-8. These loci were mostly intergenic and implicated DRD2, SLC6A9, FURIN, NLGN1, SOX5, PDE4B, and CACNG2. The multi-ancestry SNP-based heritability estimate of SA was 5.7% on the liability scale (SE=0.003, p=5.7×10-80). Significant brain tissue gene expression and drug set enrichment were observed. There was shared genetic variation of SA with attention deficit hyperactivity disorder, smoking, and risk tolerance after conditioning SA on both major depressive disorder and posttraumatic stress disorder. Genetic causal proportion analyses implicated shared genetic risk for specific health factors. Conclusions: This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated with suicide attempt across ancestry admixture populations, in veteran and civilian populations, and in attempt versus death.</p
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
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- Woodside D. Blake
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- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
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- Yang Jian
- Yao Shuyang
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- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Get PDFBackground Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Finishing the euchromatic sequence of the human genome
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- . Magner
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- Golinveaux Kristen
- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
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- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
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- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
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- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
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- Gustafson Erik
- Guthrie Ian
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- Ha Chi
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- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
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- Hashimoto Wakako
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- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
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- Homsi Farah J.
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- Idlebird Devincent G.
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- Imo Kelvin C.
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Jia Jia
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
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- Lu Yongxiang
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- Lucier Raymond L.
- Ludeman Thom
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- MacLean Christine
- Madabhushi Ramki
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- Mareth David
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- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
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- Meidi Patrick
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- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
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- Mesirov Jill P.
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- Munidasa Mala
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- Murayama Yuji
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- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
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- Nandkeshwar Richard
- Nankervis Colin E.
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- Nazareth Lynne V.
- Neal Dearl D.
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- Nwokenkwo Stanley
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- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
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- Olson Maynard V.
- Omotosho Bamidele
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- Ow David
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- Pasternak Shiran
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- Patel Ritesh
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- Paul Shelia
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
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- Qin Xiang
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- Radionenko Maxim
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- Ridler Kerry
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- Thorpe Karen
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- Tu Yuefeng
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- Wycoff-Montenegro Melissa
- Wylie Kris
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- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
Get PDFThe sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies
- Author
- Adams Mark J.
- Adan Roger A.H.
- Adkins Amy E.
- Adkins Daniel E.
- Agrawal Arpana
- Alfredsson Lars
- Aliev Fazil
- Ando Tetsuya
- Andreassen Ole A.
- Bacanu Silviu-Alin
- Baker Jessica H.
- Batzler Anthony
- Bergen Andrew W.
- Berrettini Wade H.
- Bertelsen Sarah
- Biernacka Joanna M.
- Bierut Laura J.
- Bigdeli Tim B.
- Birgegård Andreas
- Boardman Jason D.
- Boden Joseph M.
- Boehm Ilka
- Boni Claudette
- Boomsma Dorret I.
- Brandt Harry
- Breen Gerome
- Brown Sandra A.
- Bryois Julien
- Bucholz Kathleen K.
- Buehren Katharina
- Bulik Cynthia M.
- Burghardt Roland
- Cassina Matgteo
- Chen Danfeng
- Chen Li-Shiun
- Choi Doo-Sup
- Chou Yi-Ling
- Cichon Sven
- Clarke Toni-Kim
- Clementi Maurizio
- Coleman Jonathan R.I.
- Cone Roger D.
- Copeland William E.
- Costello E. Jane
- Courtet Philippe
- Crawford Steven
- Crow Scott
- Crowley James J.
- Culverhouse Robert C.
- Dahmen Norbert
- Danner Unna N.
- Davis Oliver S.P.
- de Wit Harriet
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Louisa
- Degortes Daniela
- DeSocio Janiece E.
- Diazgranados Nancy
- Dick Danielle M.
- Dikeos Dimitris
- Dina Christian
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Docherty Anna R.
- Domingue Benjamin W.
- Duncan Laramie E.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eriksson Johan G.
- Escaramís Geòrgia
- Esko Tõnu
- Estivill Xavier
- Farmer Anne
- Farrer Lindsay A.
- Favaro Angela
- Fernández-Aranda Fernando
- Fichter Manfred M.
- Fischer Krista
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forzan Monica
- Fox Louis
- Frank Josef
- Franklin Christopher S.
- Frye Mark A.
- Föcker Manuel
- Gallinger Steven
- Gaspar Héléna A.
- Gelernter Joel
- Giegling Ina
- Gillespie Nathan A.
- Giuranna Johanna
- Giusti-Rodríguez Paola
- Goate Alison M.
- Goldman David
- Gonidakis Fragiskos
- Gordon Scott
- Gorwood Philip
- Grove Jakob
- Grucza Richard A.
- Guillaume Sébastien
- Guo Yiran
- Gäbel Wolfgang
- Hack Laura M.
- Hakonarson Hakon
- Halmi Katherine A.
- Hancock Dana B.
- Hanscombe Ken B.
- Harris Kathleen Mullan
- Hartmann Annette M.
- Hartz Sarah M.
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Henders Anjali K.
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hesselbrock Victor
- Hewitt John K.
- Hinney Anke
- Hodgkinson Colin
- Hoffmann Per
- Hopfer Christian
- Horwood L. John
- Hottenga Jouke-Jan
- Huckins Laura M.
- Hudson James I.
- Hübel Christopher
- Iacono William G.
- Imgart Hartmut
- Inoko Hidetoshi
- Ising Marcus
- Janout Vladimir
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Emma C.
- Johnson Eric O.
- Jordan Jennifer
- Julià Antonio
- Kalsi Gursharan
- Kaminská Deborah
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karpyak Victor M.
- Karwautz Andreas
- Kas Martien J.H.
- Kaye Walter H.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Keyes Margaret
- Kiefer Falk
- Kiezebrink Kirsty
- Kim Youl-Ri
- Klump Kelly L.
- Knudsen Gun Peggy S.
- Koller Gabrielle
- Konte Bettina
- Kramer John
- Kranzler Henry R.
- Krauter Kenneth
- Kuperman Samuel
- La Via Maria C.
- Lahti Jari
- Lahti-Pulkkinen Marius
- Lai Dongbing
- Landén Mikael
- Larsen Janne T.
- Le Hellard Stephanie
- Leppä Virpi M.
- Levitan Robert D.
- Li Dong
- Lichtenstein Paul
- Ligthart Lannie
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lissowska Jolanta
- Loukola Anu
- Lucae Susanne
- Luykx Jurjen
- Lynskey Michael T.
- MacKillop James
- Madden Pamela A.F.
- Maes Hermine H.
- Magistretti Pierre J.
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Maj Mario
- Mann Karl
- Mannik Katrin
- Marsal Sara
- Marshall Christian R.
- Martin Nicholas G.
- Mattheisen Manuel
- Mattingsdal Morten
- Mayora Monica Gratacos
- Mbarek Hamdi
- McClintick Jeanette N.
- McDevitt Sara
- McGue Matt
- McGuffin Peter
- McIntosh Andrew M.
- McQueen Matthew B.
- Medland Sarah E.
- Metspalu Andres
- Meulenbelt Ingrid
- Meyers Jacquelyn L.
- Micali Nadia
- Milaneschi Yuri
- Mitchell James
- Mitchell Karen
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W.
- Mortensen Preben Bo
- Munn-Chernoff Melissa A.
- Murray Alison D.
- Männistö Satu
- Müller-Myhsok Bertram
- Nacmias Benedetta
- Navratilova Marie
- Neale Benjamin M.
- Nelson Elliot C.
- Norring Claes
- Ntalla Ioanna
- Nurnberger John I.
- Nöthen Markus M.
- Olsen Catherine M.
- Ophoff Roel A.
- O’Toole Julie K.
- Padyukov Leonid
- Palmer Abraham A.
- Palotie Aarno
- Palviainen Teemu
- Pantel Jacques
- Papezova Hana
- Parker Richard
- Pearson John F.
- Pedersen Nancy L.
- Penninx Brenda W.J.H.
- Perica Vesna Boraska
- Petersen Liselotte V.
- Peterson Roseann E.
- Pinto Dalila
- Polimanti Renato
- Porjesz Bernice
- Preuss Ulrich
- Rabionet Raquel
- Raevuori Anu
- Ramoz Nicolas
- Reichborn-Kjennerud Ted
- Reynolds Maureen D.
- Ricca Valdo
- Rice John P.
- Ridinger Monika
- Rietschel Marcella
- Riley Brien P.
- Ripatti Samuli
- Ripke Stephan
- Ritschel Franziska
- Roberts Marion
- Rose Richard J.
- Rotondo Alessandro
- Rujescu Dan
- Rybakowski Filip
- Ryu Euijung
- Räikkönen Katri
- Saccone Nancy L.
- Salvatore Jessica E.
- Sanchez-Roige Sandra
- Santonastaso Paolo
- Scherag André
- Scherbaum Norbert
- Scherer Stephen W.
- Schmidt Ulrike
- Schork Nicholas J.
- Schosser Alexandra
- Schuckit Marc A.
- Schwandt Melanie
- Seitz Jochen
- Shen Pei-Hong
- Sherva Richard
- Silberg Judy
- Slachtova Lenka
- Slagboom P. Eline
- Slof-Op’t Landt Margarita C.T.
- Slopien Agnieszka
- Sorbi Sandro
- Soyka Michael
- Stallings Michael C.
- Streit Fabian
- Strober Michael
- Strohmaier Jana
- Stuber Garret D.
- Sullivan Patrick F.
- Szatkiewicz Jin P.
- Tachmazidou Ioanna
- Tarter Ralph E.
- Tenconi Elena
- Thomas Nathaniel
- Thornton Laura M.
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Treutlein Jens
- Tsitsika Artemis
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- van Elburg Annemarie A.
- van Furth Eric F.
- Vanyukov Michael M.
- Vrieze Scott
- Wade Tracey D.
- Wagner Gudrun
- Wall Tamara L.
- Walters Raymond K.
- Walton Esther
- Wang Jen-Chyong
- Watson Hunna J.
- Webb Bradley T.
- Wedow Robbee
- Werge Thomas
- Wetherill Leah
- Whiteman David C.
- Whitfield John B.
- Widen Elisabeth
- Wills Amanda G.
- Witt Stephanie H.
- Wodarz Norbert
- Woodside D. Blake
- Yao Shuyang
- Yilmaz Zeynep
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhao Hongyu
- Zhou Hang
- Zill Peter
- Zipfel Stephan
- Świątkowska Beata
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Get PDFFirst published: 16 February 202
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
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- Chakravarty Mallar
- Chalker Alison
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- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
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- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
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- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
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- Deary Ian J
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- Hauser Robert
- Hawkins Keith A
- Hefti Franz
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- Heindel Walter
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- Henskens Frans A
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- Herring Scott
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- Hu Shu-Ching
- Hulshoff Pol Hilleke E
- Hunter Christine
- Hynes Mary L
- Häusler Alexander N
- Håberg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
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- Ing Alex
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- Isaacson Stuart
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- Ittermann Bernd
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- Jankovic Joseph
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E
- Jennings Danna
- Jernigan Terry L
- Jia Tianye
- Jia Tianye
- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
- Johnson Keith A
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
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- Jönsson Erik G
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- Marshall Gad A
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- Martinot Jean-Luc
- Martinot Jean-Luc
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- Mathalon Daniel H
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- Mather Karen A
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- Mathis Chet
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- Matthews Brandy R
- Matthews Sarah
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- McEwen Sarah C
- McMahon Katie L
- McMahon Mary Agnes B
- Medland Sarah E
- Melle Ingrid
- Melzer Tracy R
- Mendick Susan
- Mesulam M Marcel
- Mesulam Marek-Marsel
- Meyer Javier Villanueva
- Meyer-Lindenberg Andreas
- Michie Patricia T
- Milaneschi Yuri
- Millenet Sabina
- Miller Bruce L
- Miller Delwyn D
- Miller Sarah
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- Orfanos Dimitri Papadopoulos
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- Ottmann Ruth
- Oyonumo Ntekim E
- Pacini Nathaniel
- Paillere Marie-Laure
- Painter Jodie N
- Panizzon Matthew S
- Pantelis Christos
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- Reinbold Céline S
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- Repple Jonathan
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- Richard Irene
- Richer Louis
- Riedel Brandalyn C
- Rietschel Marcella
- Riordan Cheryl
- Risacher Shannon L
- Robbins Trevor
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- Rocha Cristiane S
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- Sachdev Perminder S
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- Satizabal Claudia L
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- Schofield Peter R
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- Shim Hyungsub
- Shin Jean
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- Silbert Lisa C
- Silverman Daniel H S
- Silverstein Rebecca
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- Simpson Donna M
- Simuni Tanya
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- Singleton-Garvin Jamika
- Sink Kaycee M
- Sirrel Sherye A
- Sisodiya Sanjay M
- Smith Amanda
- Smith Charles D
- Smith Karen Ekstam
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- Smoller Jordan W
- Snyder Peter
- Snyder Peter J
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- Sorensen Greg
- Sosa Elizabeth
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- Spann Bryan M
- Sperling Reisa A
- Spicer Kenneth
- Sprenger Fabienne
- Sprooten Emma
- St Pourcain Beate
- Standaert David
- Steen Vidar M
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- Stein Dan J
- Stein Jason L
- Stern Matthew
- Stern Yaakov
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- Stringaris Argyris
- Swerdlow Russell H
- Sämann Philipp G
- Sønderby Ida E
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- Tansey Katherine E
- Tarawneh Rawan
- Tariot Pierre
- Tatsuoka Curtis
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- Taylor Peggy
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- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
- Tingus Kathleen
- Tinklenberg Jared
- Todd Gretchen
- Toga Arthur
- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
- Tran Baochan
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
- Tzourio Christophe
- Uhlmann Anne
- Uitterlinden André G
- Ulysse Anaztasia
- Umek Robert
- Uribe Liz
- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
- van 't Ent Dennis
- van der Brug Marcel
- van der Lee Sven J
- van der Meer Dennis
- Van der Wee Nic J A
- van Donkelaar Marjolein M J
- van Duijn Cornelia M
- van Dyck Christopher H
- van Eijk Liza
- van Erp Theo G M
- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
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- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Get PDFThe cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
- Author
- Adams Mark J
- Adan Roger A H
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Alda Martin
- Alexander Madeline
- Alfredsson Lars
- Als Thomas D
- Andlauer Till F M
- Ando Tetsuya
- Andreassen Ole A
- Androutsos Christos
- Anjorin Adebayo
- Anney Richard J L
- Anttila Verneri
- Arking Dan E
- Arnold Paul D
- Arranz M. J.
- Artigas Maria Soler
- Aschauer Harald
- Asherson Philip
- Backlund Lena
- Baker Jessica H
- Baldursson Gísli
- Banaschewski Tobias
- Barr Cathy L
- Barta Csaba
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia
- Bellgrove Mark
- Belliveau Richard A
- Bellivier Frank
- Bencko Vladimir
- Bergen Andrew W
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Bettella Francesco
- Bey Katharina
- Bienvenu O Joseph
- Biernacka Joanna M
- Binder Elisabeth B
- Birgegård Andreas
- Black Donald W
- Blackwood Douglas H R
- Boomsma Dorret I
- Bramon Elvira
- Brandt Harry
- Breen Gerome
- Brown Lawrence W
- Buccola Nancy G
- Budde Monika
- Budman Cathy
- Buitelaar Jan
- Bulik Cynthia M
- Bunney William
- Burghardt Roland
- Burmeister Margit
- Burton Christie L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Cairns Murray J
- Campion Dominique
- Carlberg Laura
- Carr Vaughan J
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Cath Danielle
- Cerrato Felecia
- Chambert Kimberly
- Cheon Keun-Ah
- Christensen Jane H
- Churchhouse Claire
- Cichon Sven
- Ciullo Valentina
- Clarke Toni-Kim
- Clementi Maurizio
- Cloninger C Robert
- Coffey Barbara J
- Cohen David
- Coleman Jonathan R I
- Collier David A
- Collins Ryan L
- Colodro-Conde Lucía
- Cook Edwin H
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- Tucker-Drob Elliot M
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- Tübing Jennifer
- Uher Rudolf
- Vaaler Arne E
- van der Auwera Sandra
- van Elburg Annemarie A
- van Os Jim
- Vawter Marquis P
- Vieta Eduard
- Vincent John B
- Visscher Frank
- Vulink Nienke
- Wade Tracey D
- Wagner Gudrun
- Wagner Michael
- Walitza Susanne
- Walsh Dermot
- Walters G Bragi
- Walters James T R
- Walters Raymond K
- Walton Esther
- Wanderer Sina
- Wang Meg M-J
- Wang Yunpeng
- Watson Hunna J
- Weiser Mark
- Weiss Lauren A
- Weissman Myrna M
- Werge Thomas
- Wichmann H-Erich
- Wildenauer Dieter B
- Williams Nigel M
- Willsey A Jeremy
- Witt Stephanie H
- Won Hyejung
- Woods Martin
- Woodside D Blake
- Worbe Yulia
- Wormley Brandon K
- Wray Naomi R
- Yu Dongmei
- Zai Clement C
- Zai Gwyneth
- Zandi Peter
- Zayats Tetyana
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Fuquan
- Zheutlin Amanda
- Zhu Zhaozhong
- Zinner Samuel H
- Zipfel Stephan
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Get PDFGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe
Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC
- Author
- Acharya Shreyasi
- Adamova Dagmar
- Adolfsson Jonatan
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aiola Salvatore
- Akindinov Alexander
- Al-turany Mohammad
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfaro Molina Jose Ruben
- Ali Yasir
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altenkamper Lucas
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andreou Dimitra
- Andrews Harry Arthur
- Andronic Anton
- Anguelov Venelin
- Anson Christopher Daniel
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Arnaldi Roberta
- Arnold Oliver Werner
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
- Ball Markus
- Baral Rama Chandra
- Barbano Anastasia Maria
- Barbera Roberto
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- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
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- Basu Sumit
- Batigne Guillaume
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- Batzing Paul Christoph
- Bautista Guzman Irais
- Bazo Alba Jose Luis
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
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- Belyaev Vladimir
- Bencedi Gyula
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- Bercuci Alexandru
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- Kushpil Svetlana
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- Publication venue
- Publication date
- 01/01/2017
- Field of study
Get PDFResults on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe
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