Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Frequency and type of red flags in patients with Covid‐19 and headache: a series of 104 hospitalized patients

Objective In this study we aimed to evaluate the frequency of the main red flags in patients with headache who do have Covid‐19. Background Headache is one of the most frequent neurologic symptoms of Coronavirus disease 2019 (Covid‐19). Diagnosis of secondary headache disorders is still based on the presence of red flags. Design and methods Cross‐sectional study of hospitalized patients with confirmed Covid‐19 disease. We interrogated every patient about the presence of headache and if so, a headache expert conducted a structured interview assessing the presence and type of the main red flags. We evaluated the presence of laboratory abnormalities on admission. Results We screened 576 consecutive patients, 130/576 (22.6%) described headache, and 104 were included in the study. Mean age of patients was 56.7 (standard deviation: 11.2) and 66/104 (63.4%) were female. Red flags concerning prior medical history were present in 79/104 (76.0%) cases, and those related to the headache itself were observed in 99/104 (95.2%) patients. All patients 104/104 (100%) described systemic symptoms and 86/104 (82.7%) some neurologic symptoms. Laboratory results were abnormal in 98/104 (94.2%) cases. The most frequent red flags were fever, in 93/104 (89.4%) patients, cough, in 89/104 (85.6% cases), and increased C‐reactive protein in 84/100 (84.0%) cases. Conclusion In patients with Covid‐19 that described headache red flags were present in most cases. There was not any universal red flag, being necessary the comprehensive evaluation of all of them.Peer reviewe

Efecto de la acumulación de factores de riesgo en el riesgo de carcinoma de células escamosas bucal: Acumulación de riesgos de cáncer bucal

Fil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Lazos, Jerónimo Pablo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Belardinelli, Paola. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Clínica Estomatológica; Argentina.Fil: Talavera, Ángel Daniel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Introducción: los factores de riesgo de carcinoma de células escamosas bucal son causas no necesarias y no suficientes, incluso los más aceptados, como tabaco y alcohol. Poco se conoce sobre el efecto acumulativo de todos los factores de riesgo de cáncer bucal. El objetivo de este trabajo fue analizar si la sumatoria de factores de riesgo de cáncer bucal se asocia con un aumento de su riesgo.Métodos: se realizó un estudio de casos y controles para determinar los factores de riesgo de cáncer bucal en la población bajo estudio, para luego correlacionar el número de factores de riesgo en cada individuo, con el riesgo de cáncer bucal.Resultados: la acumulación de factores de riesgo de cáncer bucal, analizada mediante diferentes estrategias, estuvo siempre asociada con un aumento significativo del riesgo de cáncer bucal. Tener 3 o más factores de riesgo estuvo asociado con mayor riesgo de cáncer bucal (OR 110, p<0,0001)Conclusión: el principal factor de riesgo de cáncer bucal es la acumulación de sus factores de riesgo. La acumulación de factores de riesgo podría considerarse una causa necesaria para el desarrollo de cáncer bucal.Introduction: the risk factors of oral squamous cell carcinoma are not necessary and not sufficient causes, even the most accepted ones, such as tobacco and alcohol. Little is known about the cumulative effect of all risk factors for oral cancer. The objective of this work was to analyze whether the sum of oral cancer risk factors is associated with an increase in its risk. Methods: a case-control study was carried out to determine the risk factors for oral cancer in the population under study, and then correlate the number of risk factors in each individual with the risk of oral cancer. Results: the accumulation of oral cancer risk factors, analyzed using different strategies, was always associated with a significant increase in the risk of oral cancer. Having 3 or more risk factors was associated with an increased risk of oral cancer (OR 110, p <0.0001) Conclusion: the main risk factor for oral cancer is the accumulation of its risk factors. The accumulation of risk factors could be considered a necessary cause for the evelopment of oral cancer.Introdução: os fatores causais do carcinoma epidermóide oral não são causas necessárias e nem suficientes, mesmo os mais aceitos, como o fumo e o álcool. Pouco se sabe sobre o efeito cumulativo de todos os fatores de risco para câncer oral. O objetivo deste trabalho foi analisar se a soma dos fatores de risco do câncer bucal está associada a um aumento do seu risco. Métodos: foi realizado um estudo caso-controle para determinar os fatores de risco para câncer bucal na população em estudo e, em seguida, correlacionar o número de fatores de risco em cada indivíduo com o risco de câncer bucal. Resultados: o acúmulo de fatores de risco para câncer bucal, analisados por meio de diferentes estratégias, sempre esteve associado a um aumento significativo no risco de câncer bucal. Ter 3 ou mais fatores de risco foi associado a um risco aumentado de câncer oral (OR 110, p <0,0001). Conclusão: o principal fator de risco para o câncer bucal é o acúmulo de seus fatores de risco. O acúm ulo de fatores de risco pode ser considerado uma causa necessária para o desenvolvimento do câncer bucal.info:eu-repo/semantics/publishedVersionFil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Lazos, Jerónimo Pablo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Belardinelli, Paola. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Clínica Estomatológica; Argentina.Fil: Talavera, Ángel Daniel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología “A"; Argentina.Otras Ciencias de la Salu

Phenolic compounds in mango fruit: a review

Mangifera indica fruit (mango) is one of the most commercialized fruits around the world occupying the 2nd position as a tropical crop, due to the great variety of existing cultivars from which different food products such as drinks, juices, concentrates, and jams are prepared. The wastes generated during the processing of this fruit (20 million tons), which represent up to 60% of the weight of the fruit and consist mainly of peels (12%) and kernels seeds (20%), cause a series of environmental and economic problems for entrepreneurs in the sector. This is because there are no clear policies for its disposal and reuse. Nevertheless, the development of biotechnological tools has led to these wastes becoming subject of interest for their use in multiple industries such as food and pharmaceuticals, since it has been shown that they can be used as raw material to obtain phenolic compounds with biological activities (antioxidant, antimicrobial, anticancer, etc.). This review compiles the most relevant works from 2016 to 2021 about extraction, quantification, identification, biological activities, and applications of phenolic compounds obtained from the mango tree, with special focus on the fruit, with the objective to promote the use of mango from a sustainable perspective, and with a biorefinery approach.CONACYT: 723724, FORDECYT: 2017-10. Ministerio de Ciencia e Innovación de España: CTQ2017-86170-R, RTI2018-095291-B-I00. Generalitat Valenciana: PROMETEOII/2018/076 (AEP045). Consejo De Ciencia, Innovación Y Tecnología Del Estado De Chiapas

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Introduction: Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality. Methods: Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis. Results: During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17–0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer. Conclusion: Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.Peer reviewe

Anosmia is associated with lower in-hospital mortality in COVID-19

[Background] Anosmia is common in Coronavirus disease 2019, but its impact on prognosis is unknown. We analysed whether anosmia predicts in-hospital mortality; and if patients with anosmia have a different clinical presentation, inflammatory response, or disease severity.[Methods] Retrospective cohort study including all consecutive hospitalized patients with confirmed Covid-19 from March 8th to April 11th, 2020. We determined all-cause mortality and need of intensive care unit (ICU) admission. We registered the first and worst laboratory parameters. Statistical analysis was done by multivariate logistic and linear regression.[Results] We included 576 patients, 43.3% female, and aged 67.2 years in mean. Anosmia was present in 146 (25.3%) patients. Patients with anosmia were more frequently females, younger and less disabled and had less frequently hypertension, diabetes, smoking habit, cardiac and neurological comorbidities. Anosmia was independently associated with lower mortality (OR: 0.180, 95% CI: 0.069–0.472) and ICU admission (OR: 0.438, 95% CI: 0.229–0.838, p = 0.013). In the multivariate analysis, patients with anosmia had a higher frequency of cough (OR: 1.96, 95%CI: 1.18–3.28), headache (OR: 2.58, 95% CI: 1.66–4.03), and myalgia (OR: 1.74, 95% CI: 1.12–2.71). They had higher adjusted values of hemoglobin (+0.87, 95% CI: 0.40–1.34), lymphocytes (+849.24, 95% CI: 157.45–1541.04), glomerular filtration rate (+6.42, 95% CI: 2.14–10.71), and lower D-dimer (−4886.52, 95% CI: −8655.29-(−1117.75)), and C-reactive protein (−24.92, 95% CI: −47.35-(−2.48)).[Conclusions] Hospitalized Covid-19 patients with anosmia had a lower adjusted mortality rate and less severe course of the disease. This could be related to a distinct clinical presentation and a different inflammatory response.Peer reviewe

Campaña nacional "Sacale la Lengua al Cáncer": año 2018

Como todos los años, se desarrolló en agosto de 2018 una nueva edición de la Campaña Nacional “Sacale la lengua al Cáncer”, organizada y ejecutada en Córdoba por las Cátedras de Estomatología “A” y ”B” de la U.N.C, en forma conjunta con distintas asociaciones profesionales e instituciones de salud pública municipal y provincial.https://www.odo.unc.edu.ar/media/attachments/2018/11/12/segunda-jeo-2018-libro-de-resumenes-digital-con-isbn.pdfFil: Bachmeier, Evelin. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Caciva, Ricardo Crhistian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Brusa, Martín Eduardo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Moine, Lorena. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Carrica, Victoriano Andrés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Talavera, Angel Daniel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Lazos, Jerónimo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Robledo, Graciela Marta. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Liandro, María Fernanda. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Allende, Adrian Alberto. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Bolesina, Nicolás. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Zapata, Marcelo Javier. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Criscuolo, María Inés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Belardinelli, Paola Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Panico, René Luis. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: López de Blanc, Silvia. Hospital Rawson. Servicio de Estomatología. Consultorio de Odontología; Argentina.Salud Pública y Medioambienta

. 32. Arqueología

Estimados colegas: en este número les ofrecemos una serie de contribuciones que ejemplifican los avances de las investigaciones sobre problemas de la arqueología mesoamericana, a escala suprarregional, regional y de sitio. Tres trabajos aportan información e interpretaciones sobre la costa del Golfo y la Huasteca, desde el Preclásico hasta el Posclásico tardío. El primero es una revisión de la secuencia cronológica del Formativo en la parte baja del río Pánuco, de García Cook y Leonor Merino —a quien recordamos de manera muy afectuosa. Por su parte, Ladrón de Guevara y Hernández proponen una interesante colaboración al reinterpretar la deidad principal de El Tajín, a quien identifican como Quetzalcóatl, por iconografía y correlación con eventos climáticos. El tercer trabajo, “Vecinos cercanos”, de Diana Zaragoza, explora la posibilidad de interacciones a gran escala en la Huasteca, integrando información sobre la porción sur del Sureste de Estados Unidos. El artículo de Francisco Beristáin recupera la información sobre la secuencia de ocupación del sitio de Tepetipac en Tlaxcala. Ma. Elena Salas y sus colaboradores estudian una colección de artefactos de hueso humano procedentes de Tikal y, para contrastar la validez de su propuesta clasificatoria, realizan experimentos tecnológicos y funcionales que redundan en un interesante ejercicio multidisciplinario. Continúan las colaboraciones de otros especialistas, como la contribución de Maldonado, Arias y Repetto sobre la recuperación y el análisis de contextos funerarios de la colonia temprana en Dzibilchaltún, en donde se proponen interpretaciones de las condiciones de vida de la población-muestra. Cierra Alberto Cravioto, en una de sus frecuentes incursiones en las fuentes utilizadas por los arqueólogos, para ofrecernos una reinterpretación sobre la identificación de los popoloca y sus constantes movimientos. En esta ocasión nos complace incluir la primera aportación de “Comentarios y debates”, en la que Blas Román Castellón discute el artículo de Francisco Rivas sobre la región de Los Reyes Metzontla, publicado en el número 29 de Arqueología. Para el avance de la disciplina es esencial la expresión abierta de opiniones y comentarios fundamentados sobre los trabajos de nuestros colegas, en un ámbito de discusión clara y mesurada, aportando información y fomentando el desarrollo de una vida académica más intensa e interactiva. Mandamos nuestra sincera felicitación al doctor Castellón y reiteramos la invitación a todos nuestros lectores para que colaboren, en especial con esta sección y con la revista en general. Es necesario aclarar que el “Índice General 1987-2003” que aparece en Arqueología 31, aparenta no tener un autor específico; sin embargo dicho índice fue realizado por Ana María Álvarez Palma.</p

A Coffee Berry Borer (Coleoptera: Curculionidae: Scolytinae) Bibliography

Native to Africa, the coffee berry borer, Hypothenemus hampei (Ferrari) (Coleoptera: Curculionidae: Scolytinae), has gradually invaded most coffee-growing areas worldwide. Adult females colonize the coffee berry and oviposit within galleries in the coffee seeds. Larvae and adults consume the seeds, resulting in drastic reductions in yields and quality, negatively affecting the income of approximately 20 million coffee-growing families (~100 million people) in ~80 countries, with losses surpassing more than $500 million annually (Vega et al. 2015). It has become evident that the coffee berry borer scientific community could greatly benefit from having access to a bibliography of the literature related to the insect. Such an information source would allow scientists to find out what research areas have been explored throughout the many coffee berry borer-infested countries after more than 100 years of research on the topic. It could also help to direct lead future research efforts into novel areas, and away from topics and ideas that have been thoroughly investigated in the past