More on Boundary Conditions for Warped AdS3 in GMG

In this paper, we study the Aggrawal, Ciambelli, Detournay, and Somerhausen (ACDS) boundary conditions ref[42] for Warped AdS$_3$ (WAdS$_3$) in the framework of General Massive Gravity (GMG) in the quadratic ensemble. We construct the phase space, the asymptotic structure, and the asymptotic symmetry algebra. We know that the global surface charges are finite, but not integrable, and also we find the conditions to make them integrable. In addition, to confirm that the phase space has the same symmetry as that of Warped Conformal Field Theory (WCFT), we compare the bulk entropy of Warped BTZ (WBTZ) black holes with the number of states belonging to a WCFT.Comment: 15 pages, general discussion extended; typos corrected; references added, accepted for publication in European Physical Journal C (EPJC

Small and Medium-sized Business Growth in Agricultural Sector (Case Study: Guilan Province)

Agriculture is one of the pillars of economics whose development requires a particular attention to all production factors. This paper aims to provide a systematic and conceptual model that is based on a conceptualization of the field. For this purpose, the theory and methodology were extracted on the basis of data derived from field observations and interviews drawn from a systematic conceptual model of key informants. The current model shows that original category of the agriculture business, i.e. business growth, is originated from causal conditions including personal features, supportive roles, and production factors and, based on evaluation strategies and the exploitation of opportunities, leads to a new value based on business growth as a result of the process. Underlying conditions, such as individual factors, and geographical conditions, as well as environmental conditions, including the government, the legislature, and banks, are effective in this process. Understanding the aspects of business growth is effective in developing policies to support and promote entrepreneurship. Moreover, it is essential to design a growth model to help business owners select a definition for firm growth. It is noteworthy that so far, the majority of the proposed models have been ineffective in some aspects and more attention should be paid to future growth modeling in the research context

A sustainability approach to vehicle modular platform design: A mathematical model

Today, sustainability and its economic, social, and environmental pillars are the main elements of new product market development. Therefore, manufacturers, considering all stages of a product life-cycle, consider it necessary to have a framework for producing sustainable products. Moreover, new product design and development processes especially sub-process of product definition and detailed design processes can play a very critical role in developing product sustainability. This paper considers the role that the car platform can play in creating a family of products and with regard to various data related to the environmental, economic, and social pillars of each of the 15 modules of a car platform and also, using the best–worst method technique and multi-objective mathematical programming with the augmented epsilon constraint method, we were able to achieve a set of platforms with maximum sustainability. The present study explores the possibility of determining the most efficient combinations of modules for every one of the 23 cars’ platforms to produce a collection of products. Through these methods, the 54 efficient solutions in the Pareto front were achieved, and out of this number, after considering all the factors and weights of the objective functions, solution no. 51 was selected as the most efficient. Subsequently, all the 15 module variants of the 23 platforms were determined for solution no. 51. Finally, these variants were ranked on the basis of the SAW technique, and finally, sensitivity analysis is done

Assessment of Mental and Spiritual Health Among Iranian Dental Students: A Cross-Sectional Study

Objective: To investigate the relationship between mental health and spiritual well-being among general and post-graduate dental students. Material and Methods: This is a cross-sectional, descriptive-analytical study conducted on 268 general and post-graduate dental students. Data collection tools included the Mental Health Questionnaire (GHQ-28: General Health Questionnaire) and the Spiritual Health Questionnaire. The data were analyzed by the SPSS version 25 using Independent Samples t-test, One-way ANOVA, Pearson correlation coefficient, Multiple linear regression with a significant level at 0.05. Results: The total score of the Spiritual Health Questionnaire was 71.48 ± 0.507 and the Mental Health Questionnaire was 40.31±0.65. There was a significant difference in the spiritual health status between the general and post-graduate students (p=0.009). Overall, there was a significant positive relationship between the students' spiritual health and mental health (p=0.045), although a significant relationship was evident between mental health and age of the students (p=0.019). Conclusion: The spiritual health was high in the dental students and Kerman University of medical sciences residents. Also, there was a positive significant relationship between spiritual and mental health

Effect of a functional food (vegetable soup) on blood rheology in patients with polycythemia

Objective: Key hemorheological variables are associated with several life-threatening diseases including cardio-cerebro-vascular diseases. A diet can influence the blood rheological variables. To compare the effectiveness of a vegetable soup on blood viscosity (BV), hematocrit (Hct), plasma fibrinogen, lipid profile, fasting blood sugar (FBS), and blood osmolarity in patients with polycythemia in comparison to a control group. Materials and Methods: This randomized controlled trial study was conducted at Isar health clinics in Mashhad, Iran, during a 7-month period. Forty male participants (35 to 60 years old) with polycythemia, but without underlying diseases, were included. They randomly assigned to two groups and either received diet/phlebotomy or phlebotomy alone, for 6 weeks. The data were analyzed by SPSS version 16 using parametric tests. Results: A significant reduction in BV at 30s (p 0.001), BV at 40s (p 0.001), BV at 50s (p 0.001), Hct (p 0.001), plasma fibrinogen (

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019

Background: Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10–24 years during the past three decades. Methods: Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10–14, 15–19, and 20–24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings: In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31·1 million DALYs (of which 16·2 million [52%] were transport related) among adolescents aged 10–24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34·4% (from 17·5 to 11·5 per 100 000) for transport injuries, and by 47·7% (from 15·9 to 8·3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80·5% to 42 774 for transport injuries and by 39·4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010–19, the rate per 100 000 of transport injury DALYs was reduced by 16·7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48·5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0·2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010–19. Interpretation: As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low–middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Funding: Bill &amp; Melinda Gates Foundation

Global injury morbidity and mortality from 1990 to 2017 : results from the Global Burden of Disease Study 2017

Correction:Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.Peer reviewe