8 research outputs found
Raskmetallide fütoremediatsiooni rakendamine reoveesette humifitseerimisväljakul
- Author
- Publication venue
- Tartu Ülikool
- Publication date
- 01/01/2018
- Field of study
Käesolevas töös uuriti raskmetallide ärastamise võimalikkust fütoremediatsiooni teel Türi reoveepuhastusjaama näitel. Analüüsiti raskmetallide sisaldust reoveesttes ja sellel kasvavas taimekultuuris. Metallide sisaldus määrati aatomabsorbtsioonspektromeetriaga. Töö tulemused näitasid, et humifitseerimisväljakul kasvav taimekultuur omandab settes olevaid metalle ja fütoremediatsiooni teel on võimalik raskmetallide kontsentratsiooni settes vähendada, kui kasvav taimekultuur niita ning perioodiliselt sette pealt eemaldada
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
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- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
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- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
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- Brown Morris J
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- Steinthorsdottir Valgerdur
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- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
- Author
- Aaron Folsom
- Aaron Isaacs
- Abbas Dehghan
- Adebowale Adeyemo
- Adrienne Tin
- Afshin Parsa
- Aida Karina Dieffenbach
- Alan B. Weder
- Alan B. Zonderman
- Alan F. Wright
- Alan Go
- Alan R. Shuldiner
- Alanna C. Morrison
- Albert Hofman
- Albert V. Smith
- Albert W. Dreisbach
- Alena Stancakova
- Alex N. Parker
- Alexander Teumer
- Alexandre F. R. Stewart
- Alistair Hall
- Amy J. Swift
- Anders Hamsten
- Andre Franke
- Andre G. Uitterlinden
- Andreas Meinitzer
- Andreas Tomaschitz
- Andreas Ziegler
- Andres Metspalu
- Andrew A. Hicks
- Andrew D. Johnson
- Andrew Plump
- Andrew Singleton
- Andrew Taylor
- Andrew Wong
- Angela Doering
- Angelo Scuteri
- Anika Grosshennig
- Anja Medack
- Anke Tonjes
- Anna F. Dominiczak
- Anna Köttgen
- Anna Maria Corsi
- Anna-Liisa Hartikainen
- Anne U. Jackson
- Annette Peters
- Annika Rosengren
- Anthony J. Balmforth
- Antonietta Robino
- Antonio Lupo
- Anuj Goel
- Aravinda Chakravarti
- Arne Schillert
- Arnika K. Wagner
- Aroon D. Hingorani
- Asif Rasheed
- Atsushi Takahashi
- Aude Saint-Pierre
- Audrey Y. Chu
- Augustine Kong
- Augusto D. Pichard
- Ayo Doumatey
- Ayse Demirkan
- Bamidele Tayo
- Barbara Kollerits
- Barbara Ludwig
- Barry I. Freedman
- Belen Ponte
- Ben A. Oostra
- Benedicte Stengel
- Benjamin F. Voight
- Benjamin J. Wright
- Bernhard K. Krämer
- Bernhard O. Böhm
- Bernhard Paulweber
- Bernhard R. Winkelmann
- Bo Hedblad
- Bok-Ghee Han
- Braxton D. Mitchell
- Brenda W. Penninx
- Brendan M. Buckley
- Bruce M. Psaty
- Bruno H. Stricker
- Candace Guiducci
- Carl D. Langefeld
- Carl G. P. Platou
- Carlos Iribarren
- Carmen A. Peralta
- Carole Proust
- Caroline Hayward
- Caroline S. Fox
- Carsten A. Böger
- Catherine Helmer
- Charles N. Rotimi
- Charles S. Janipalli
- Chien-Hsiun Chen
- Chittaranjan S. Yajnik
- Christa Meisinger
- Christian Fuchsberger
- Christian Gieger
- Christian Hengstenberg
- Christian M. Shaffer
- Christian Müller
- Christina Loley
- Christina Willenborg
- Christoph Bickel
- Christoph Sinning
- Christopher J. O’Donnell
- Christopher Newton-Cheh
- Christopher P. Nelson
- Christopher W. Knouff
- Cinzia Sala
- Claire Perret
- Colin A. McKenzie
- Cornelia M. van Duijn
- Cristian Pattaro
- Cristiano Fava
- Cuno S. P. M. Uiterwaal
- D. G. Vinay
- Dabeeru C. Rao
- Daehee Kang
- Dag S. Thelle
- Dan E. Arking
- Daniel Ackermann
- Daniel I. Chasman
- Daniel J. Rader
- Daniel Levy
- Daniel Shriner
- Daniel Taliun
- Daniela Ruggiero
- Daniela Toniolo
- Daniele Cusi
- Danish Saleheen
- Darina Czamara
- David Altshuler
- David Couper
- David Ellinghaus
- David Hadley
- David P. Strachan
- David S. Siscovick
- Dawn M. Waterworth
- Debbie A. Lawlor
- Dena Hernandez
- Devin Absher
- Diana Kuh
- Diana Zelenika
- Diederick E. Grobbee
- Dongfeng Gu
- Donna K. Arnett
- Dorairajan Prabhakaran
- Douglas Ruderfer
- E-Shyong Tai
- Edward G. Lakatta
- Elena Rochtchina
- Elin Org
- Elizabeth G. Holliday
- Elizabeth J. Atkinson
- Emelia Benjamin
- Eran Halperin
- Eric Boerwinkle
- Eric J. G. Sijbrands
- Erik Ingelsson
- Erika Salvi
- Erkki Vartiainen
- Ervin R. Fox
- Erwin P. Bottinger
- Eva Albrecht
- Eva Brand
- Ewa Zukowska-Szczechowska
- F. Gerald R. Fowkes
- Fadi J. Charchar
- Federico Murgia
- Feng Zhang
- Fernando Rivadeneira
- Florian Ernst
- Florian Kronenberg
- Francesco U. S. Mattace-Raso
- Francis S. Collins
- Francois Cambien
- Frank B. Hu
- Fredrik Nyberg
- Fulvio Ricceri
- Fumihiko Takeuchi
- Fuu-Jen Tsai
- Gang Shi
- Gary C. Curhan
- Gary F. Mitchell
- Gavin Lucas
- Georg Homuth
- George A. Wells
- George B. Ehret
- George Davey Smith
- Gerjan J. Navis
- Germaine C. Verwoert
- Gian-Andri Thun
- Gina Hilton
- Giorgio Pistis
- Giovanni Gambaro
- Giovanni Malerba
- Giriraj R. Chandak
- Giuseppe Matullo
- Goncalo R. Abecasis
- Grant W. Montgomery
- Guangju Zhai
- Gudmar Thorleifsson
- Gudmundur Thorgeirsson
- Gudny Eiriksdottir
- Gudrun Veldre
- Gunnar Jacobs
- Guo Li
- H-Erich Wichmann
- Haidong Zhu
- Hakon H. Hakonarson
- Halit Ongen
- Hans J. Rupprecht
- Hao Mei
- Harald Dobnig
- Harald Grallert
- Harold Snieder
- Harry Campbell
- Heather M. Stringham
- Helena Schmidt
- Henri Wallaschofski
- Henry Völzke
- Heribert Schunkert
- Hermann Brenner
- Heyo K. Kroemer
- Hilma Holm
- Hirotsugu Ueshima
- Holly Kramer
- Honghuang Lin
- Hua Tang
- Hubert Scharnagl
- Hugh Watkins
- Hyung-Lae Kim
- I. Mateo Leach
- Ian Ford
- Ian H. de Boer
- Ian N. M. Day
- Ida Yii-Der Chen
- Idris Guessous
- Iftikhar Kullo
- Igor Rudan
- Ilja M. Nolte
- Ines Barroso
- Inga Prokopenko
- Ingrid Borecki
- Inke R. König
- Ioanna Tzoulaki
- Iris M. Heid
- Ivana Kolcic
- Ivana Persico
- J. H. Young
- J. Wouter Jukema
- Jaakko Tuomilehto
- Jaana Laitinen
- Jaap W. Deckers
- Jackie A. Cooper
- Jacqueline C. M. Witteman
- Jacques S. Beckmann
- James E. Hixson
- James F. Meschia
- James F. Wilson
- James Scott
- James T. Willerson
- Jan A. Staessen
- Jan Stritzke
- Janine F. Felix
- Janja Nahrstedt
- Janos Terzic
- Jasmin Divers
- Jaspal S. Kooner
- Jayashri Aragam
- Jean-Charles Lambert
- Jean-Michel Gaspoz
- Jeanette Erdmann
- Jeanette M. Stafford
- Jeffrey R. Gulcher
- Jeffrey R. O’Connell
- Jemma C. Hopewell
- Jennifer A. Smith
- Jennifer L. Bragg-Gresham
- Jer-Yuarn Wu
- Jerome I. Rotter
- Jessica D. Faul
- Jiang He
- Jianjun Liu
- Jian’an Luan
- Jie Jin Wang
- Jie Yao
- Jing Hua Zhao
- Jingzhong Ding
- Joanne Murabito
- Joban S. Sehmi
- Joe Devaney
- Joel N. Hirschhorn
- Johanna Kuusisto
- Johanne Tremblay
- Johannes H. Smit
- Johannes Haerting
- John Attia
- John B. Whitfield
- John C. Chambers
- John Chalmers
- John Danesh
- John F. Peden
- John M. Connell
- John P. Beilby
- John R. Thompson
- John S. Gottdiener
- Jong-Young Lee
- Jorma Viikari
- Josef Coresh
- Joseph M. Lindsay
- Joshua C. Bis
- Joshua C. Denny
- Joshua Knowles
- Juan P. Casas
- Judith A Hoffman Bolton
- Juha Karjalainen
- Jutta Palmen
- Jyotika K. Fernandes
- Jürgen Grässler
- K. Radha Mani
- Karen L. Mohlke
- Kari Stefansson
- Karin Halina Greiser
- Karl Andersen
- Karl J. Lackner
- Karl Werdan
- Karl Winkler
- Karlhans Endlich
- Katalin Susztak
- Katja Butterbach
- Kay-Tee Khaw
- Kazuhiko Yamamoto
- Keith L. Keene
- Kelly Volcik
- Kenneth M. Kent
- Kenneth M. Rice
- Kent D. Taylor
- Kerri L. Wiggins
- Khanh-Dung Hoang Nguyen
- Kiran Musunuru
- Klaus Stark
- Kristian Hveem
- Kristin Marciante
- Kurt Lohman
- L. Adrienne Cupples
- Lars Lind
- Laura J. Scott
- Laura Portas
- Laura R. Loehr
- Laurence Tiret
- Leena Peltonen
- Leif Groop
- Lenore J. Launer
- Leo-Pekka Lyytikäinen
- Leslie J. Raffel
- Li Chen
- Li-Ching Chang
- Liming Qu
- Linda S. Adair
- Loic Yengo
- Lori L. Bonnycastle
- Louise V. Wain
- Lowell Satler
- Lude Franke
- Luigi Ferrucci
- Lyle J. Palmer
- Lynda M. Rose
- Lynne E. Wagenknecht
- Lyudmyla Kedenko
- M. Arfan Ikram
- M. J. Kranthi Kumar
- Maciej Tomaszewski
- Madhumathi Rao
- Maija Garnaas
- Maja Barbalic
- Maksim Struchalin
- Man Li
- Manuela Uda
- Marco Orru
- Marcus Dörr
- Marcus E. Kleber
- Marcus Fischer
- Margaret M. Redfield
- Margherita Cavalieri
- Margot Haun
- Margus Viigimaa
- Maria Blettner
- Maria Soler Artigas
- Marie Metzger
- Marilyn C. Cornelis
- Marina Ciullo
- Mario A. Morken
- Mario Pirastu
- Maris Laan
- Mariza de Andrade
- Marjo-Riitta Jarvelin
- Mark A. McEvoy
- Mark Hlatky
- Mark J. Caulfield
- Mark Lathrop
- Mark Seielstad
- Mark Woodward
- Marketa Sjögren
- Markku Laakso
- Markus Perola
- Martin Adam
- Martin D. Tobin
- Martin Farrall
- Martin G. Larson
- Mary F. Feitosa
- Mary Susan Burnett
- Masato Isono
- Massimiliano Cocca
- Massimo Mangino
- Mathias Gorski
- Matthew Denniff
- Matthew N. Cooper
- Matthias Nauck
- Matthias Olden
- Max C. Walker
- Medea Imboden
- Meena Kumari
- Megan E. Rudock
- Melanie Waldenberger
- Melissa Garcia
- Menno Pruijm
- Meredith Foster
- Michael Boehnke
- Michael G. Marmot
- Michael M. Hoffmann
- Michael Nalls
- Michael Preuss
- Michael Stumvoll
- Michele K. Evans
- Michele M. Sale
- Michiaki Kubo
- Michiel L. Bots
- Mika Kivimaki
- Mika Kähönen
- Min Jin Go
- Ming-Huei Chen
- Mingyao Li
- Mladen Boban
- Morris J. Brown
- Muhammad Islam
- Muredach P Reilly
- Murielle Bochud
- Myriam Alexander
- Myriam Rheinberger
- N. Charlotte Onland-Moret
- Nabila Bouatia-Naji
- Najaf Amin
- Nanette I. Steinle
- Nanette R. Lee
- Naoharu Iwai
- Naoyuki Kamatani
- Narisu Narisu
- Neil Risch
- Nele Friedrich
- Nicholas G. Martin
- Nicholas J. Wareham
- Nicholas L. Smith
- Nicholette D. Palmer
- Nick Hastie
- Nick R. G. Shrine
- Nicole L. Glazer
- Nicole Probst-Hensch
- Nicole Soranzo
- Niek Verweij
- Nilesh J. Samani
- Nish Chaturvedi
- Noel Burtt
- Norbert Watzinger
- Norihiro Kato
- Norman Klopp
- null null
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- null null
- Olga Jarinova
- Olivier Devuyst
- Olle Melander
- Olli Raitakari
- Omri Gottesman
- Oscar H. Franco
- Ozren Polasek
- Paavo Zitting
- Pankaj Arora
- Pankaj Sharma
- Panos Deloukas
- Paolo Gasparini
- Paolo Vineis
- Patricia B. Munroe
- Patricia P. Chang
- Patrick Diemert
- Patrick Linsel-Nitschke
- Paul Elliott
- Paul F. O’Reilly
- Paul M. Ridker
- Paul Mitchell
- Paul Muntner
- Paul R. Burton
- Pavel Hamet
- Peng Chen
- Peter E. H. Schwarz
- Peter H. Whincup
- Peter J. van der Most
- Peter Kovacs
- Peter Nilsson
- Peter P. Pramstaller
- Peter S. Braund
- Peter Vollenweider
- Petra Bruse
- Philip Howard
- Philipp S. Wild
- Philippa J. Talmud
- Philippe Froguel
- Pierre Meneton
- Pilar Galan
- Pim van der Harst
- Pio d’Adamo
- Qiong Yang
- Rainer Rettig
- Ramachandran S. Vasan
- Rebecca Hardy
- Reedik Mägi
- Reijo Laaksonen
- Reiner Biffar
- Reinhold Schmidt
- Renate Schnabel
- Richard J. Rodeheffer
- Richard Myers
- Richard N. Bergman
- Richard S. Cooper
- Richard W. Morris
- RickTwee-Hee Ong
- Rita P. S. Middelberg
- Robert Clarke
- Robert J. Carroll
- Robert Roberts
- Robert W. Lawrence
- Robert Wilensky
- Robert Zweiker
- Roberto Elosua
- Rodney J. Scott
- Ron Waksman
- Ronit Katz
- Rory Collins
- Rossella Sorice
- Ruth J. F. Loos
- Ruth McPherson
- S. -J. Cathy Fann
- Samer Najjar
- Sanaz Sedaghat
- Sanjay Kinra
- Santhi K. Ganesh
- Santosh Dahgam
- Sarah H. Wild
- Satoshi Umemura
- Sekar Kathiresan
- Serge Hercberg
- Serkalem Demissie-Banjaw
- Sharon L. R. Kardia
- Sheila Ulivi
- Shih-Jen Hwang
- Shiro Maeda
- Shufeng Chen
- Siim Sõber
- Simon Heath
- Simonetta Guarrera
- Smita R. Kulkarni
- Solveig Gretarsdottir
- Sonny Dandona
- Stacey B. Gabriel
- Stefan Blankenberg
- Stefan Coassin
- Stefan Enroth
- Stefan Kloiber
- Stefan Pilz
- Stefan R. Bornstein
- Stefan Schreiber
- Stefan-Martin Brand
- Stefania Bandinelli
- Stella Trompet
- Stephan B. Felix
- Stephan J. L. Bakker
- Stephen E. Epstein
- Stephen Fortmann
- Stephen G. Ball
- Stephen J. Hancock
- Stephen T. Turner
- Steve E. Humphries
- Steven C. Hunt
- Steven M. Schwartz
- Steven Sidney
- Su-Chi Lim
- Sudha Seshadri
- Sue Shaw-Hawkins
- Susan R. Heckbert
- Susana Eyheramendy
- Sven Bergmann
- Sylvia E. Rosas
- Sylvia Stracke
- Takayoshi Ohkubo
- Talin Haritunians
- Tamara B. Harris
- Tanja B. Grammer
- Tanja Zeller
- Tatiana Kuznetsova
- Tatijana Zemunik
- Tatjana Stojakovic
- Tatsuhiko Tsunoda
- Tazeen H. Jafar
- Terho Lehtimäki
- Terrence Forrester
- Terri L. Young
- Tetsuro Miki
- Themistocles L. Assimes
- Thomas F. Münzel
- Thomas H. Mosley
- Thomas Illig
- Thomas J. Wang
- Thomas Lumley
- Thomas Meitinger
- Thomas Quertermous
- Thor Aspelund
- Thorsten Reffelmann
- Tien-Yin Wong
- Tiit Nikopensius
- Tim D. Spector
- Timothy M. Frayling
- Tin Aung
- Toby Johnson
- Tom R. Gaunt
- Tomohiro Katsuya
- Tomonori Okamura
- Tonu Esko
- Toshihiro Tanaka
- Toshiko Tanaka
- Toshio Ogihara
- Tunde Salako
- Tune H. Pers
- Ulf Gyllensten
- Unnur Thorsteinsdottir
- Uwe Völker
- Valur Emilsson
- Vasyl Pihur
- Veikko Salomaa
- Veronique Vitart
- Vikal Tripathy
- Ville Aalto
- Vilmundur Gudnason
- Vincent Chouraki
- Vincent Mooser
- Viviane Nicaud
- Vladan Mijatovic
- W. H. Linda Kao
- Walter Palmas
- Wayne D. Rosamond
- Wei-Min Chen
- Weihua Zhang
- Wendy L. McArdle
- Wiek H. van Gilst
- Wilfried Renner
- Will T. Longstreth
- William Matthai
- Wilmar Igl
- Winfried März
- Wolfgang Koenig
- Wolfgang Lieb
- Wolfram Goessling
- Xiaofeng Zhu
- Xiaoling Wang
- Xiuqing Guo
- Xueling Sim
- Yali Li
- Yan V. Sun
- Yanbin Dong
- Yasuharu Tabara
- Yen-Pei C. Chang
- Yi-An Ko
- Yik-Ying Teo
- Ying A. Wang
- Ying Wu
- Yingchang Lu
- Yong Li
- Yongmei Liu
- Yoon Shin Cho
- Yoshikuni Kita
- Young Jin Kim
- Yuan-Tsong Chen
- Yukinori Okada
- Yuri Milaneschi
- Yurii Aulchenko
- Yusuke Nakamura
- Yvonne T. van der Schouw
- Zouhair Aherrahrou
- Åsa Johansson
- Publication venue
- Springer Nature America, Inc
- Publication date
- 27/10/2015
- Field of study
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
- Author
- A.Mesut Erzurumluoglu
- Adam S Butterworth
- Adriana M Hung
- Ahmad Vaez
- Aki S Havulinna
- Alan F Wright
- Alan J Gow
- Alan James
- Alanna C Morrison
- Albert Hofman
- Albert V Smith
- Albertine J Oldehinkel
- Alex SF Doney
- Alexander Teumer
- Alice Stanton
- Alison Pattie
- Anders Hamsten
- Andres Metspalu
- Andrew A Hicks
- Andrew D Johnson
- Andrew D Morris
- Andrew P Morris
- André G Uitterlinden
- Anna Morgan
- Anne U Jackson
- Anne-Claire Vergnaud
- Annette Peters
- Antonietta Robino
- Antti Jula
- Antti-Pekka Sarin
- Anubha Mahajan
- Anuj Goel
- Aravinda Chakravarti
- Archie Campbell
- Arno Palotie
- Ayush Giri
- Ben A Oostra
- Benjamin C Lehne
- Bernard D Keavney
- Borbala Mifsud
- Bram Prins
- Brenda WJH Penninx
- Bruce M. Psaty
- Caroline Hayward
- Caterina M Barbieri
- Catharina A Hartman
- Cecilia M Lindgren
- Chiara Batini
- Christian Gieger
- Christophe Tzourio
- Christopher J O'Donnell
- Christopher Newton-Cheh
- Christopher Oldmeadow
- Christopher P Nelson
- Chrysovalanto Mamasoula
- Cinzia F Sala
- Claudia Langenberg
- Claudia P Cabrera
- Colin NA Palmer
- Cornelia M van Duijn
- Cristina Menni
- Csaba P Kovesdy
- Cumhur Yusuf Demirkale
- Dan Chasman
- Dan E Arking
- Daniel Levy
- Daniela Toniolo
- Daniella Ruggiero
- David CM Liewald
- David Conen
- David J Stott
- David Mosen-Ansorena
- David P Strachan
- David Siscovick
- Denis C Shields
- Dennis O Mook-Kanamori
- Digna R Velez Edwards
- Dorret I Boomsma
- Dragana Vuckovic
- Eco J de Geus
- Edith Hofer
- Edward G Lakatta
- Eleftheria Zeggini
- Elin Org
- Elizabeth G Holliday
- Eric Boerwinkle
- Erik Ingelsson
- Erwin P Bottinger
- Evan Tzanis
- Evangelos Evangelou
- Fabiola M Del Greco
- Francesco Cucca
- Francis Collins
- Franco Giulianini
- Fu Liang Ng
- Gail Davies
- Ganesh Chauhan
- Georg B Ehret
- Georgios Ntritsos
- Germaine C Verwoert
- Giorgia Girotto
- Gonneke Willemsen
- Gonçalo Abecasis
- Guillaume Paré
- Harold Schneider
- Harriëtte Riese
- Harry Campbell
- He Gao
- Heather J Cordell
- Helen R Warren
- Helena Schmidt
- Hugh Watkins
- Ian J Deary
- Ibrahim Karaman
- Igor Rudan
- Ilaria Gandin
- Ilja M Nolte
- Ioanna Tzoulaki
- Ivana Kolcic
- J Wouter Jukema
- J.Michael Gaziano
- Jaakko Tuomilehto
- Jacklyn N Hellwege
- James F Wilson
- Janina S Reid
- Jaspal S Kooner
- Jaume Marrugat
- Jennifer E Huffman
- Jerome I Rotter
- Jian'an Luan
- Jie Yao
- Jing-Hua Zhao
- Joanna MM Howson
- Joanne Knight
- Johan Sundström
- John C Chambers
- John Connell
- John Danesh
- John M Starr
- John R Attia
- Jonathan Marten
- Joris Deelen
- Joshua C Bis
- Jouke-Jan Hottenga
- Jun Ding
- Katarzyna Witkowska
- Kati Kristiansson
- Kay-Tee Khaw
- Kelly Cho
- Kenneth Rice
- Kent D Taylor
- Kristin L Ayers
- Lars Lind
- Lenore J Launer
- Leo-Pekka Lyytikäinen
- Li Lin
- Lili Milani
- Lingchan Lu
- Lorenz Risch
- Lorna M Lopez
- Louise V Wain
- Lynda M Rose
- Marco Brumat
- Marcus Dörr
- Marina Ciullo
- Marina Evangelou
- Maris Laan
- Marjo-Riitta Jarvelin
- Mark J Caulfield
- Markku Laakso
- Markus Perola
- Martin D Tobin
- Martin Farrall
- Martin H de Borst
- Marty Larson
- Massimiliano Cocca
- Massimo Mangino
- Mattias Frånberg
- Meixia Ren
- Michael Boehnke
- Michael R Barnes
- Michela Traglia
- Mika Kähönen
- Mike A Nalls
- Morris A Swertz
- Morris J Brown
- Muralidharan Sargurupremraj
- Murielle Bochud
- Nabi Shah
- Najaf Amin
- Neil R Poulter
- Nguyen Quang Tri
- Nicholas J Wareham
- Nick Shrine
- Niek Verweij
- Niki Dimou
- Nilesh J Samani
- null null
- Olli T Raitakari
- Ollie Melander
- Oscar H Franco
- Ozren Polasek
- Paolo Gasparini
- Patricia B Munroe
- Paul Elliott
- Paul F O'Reilly
- Paul Knekt
- Paul M Ridker
- Pekka Jousilahti
- Peter Almgren
- Peter J Munson
- Peter J van der Most
- Peter K Joshi
- Peter P Pramstaller
- Peter S Braund
- Peter Sever
- Peter Vollenweider
- Peter WF Wilson
- Philip S Tsao
- Philippe Amouyel
- Pim van der Harst
- Praveen Surendran
- Priyanka Nandakumar
- Raha Pazoki
- Rainer Rettig
- Raymond Noordam
- Reedik Mägi
- Renée de Mutsert
- Rheinhold Schmidt
- Rick Jansen
- Robert A Scott
- Roberto Elosua
- Roby Joehanes
- Rodney J Scott
- Rona J Strawbridge
- Rossella Sorice
- Ruifang Li-Gao
- Ruth JF Loos
- Samuli Ripatti
- Sandosh Padmanabhan
- Sara M Willems
- Sarah E Harris
- Sarah H Wild
- Sekar Kathiresan
- Seppo Koskinen
- Shih-Jen Hwang
- Siim Sõber
- Simon Thom
- Stefan Enroth
- Stella Trompet
- Stéphanie Debette
- Sébastien Thériault
- Tamara B Harris
- Tatijana Zemunik
- Teemu Niiranen
- Teresa Ferreira
- Teresa Nutile
- Terho Lehtimäki
- Thibaud Boutin
- Tim D Spector
- Tineka Blake
- Todd L Edwards
- Tonu Esko
- Ulf Gyllensten
- Uwe Völker
- Veikko Salomaa
- Veronique Vitart
- Vilmantas Giedraitis
- Vilmundur Gudnason
- Walter Palmas
- Wei-Yu Lin
- Weihua Zhang
- Xiuqing Guo
- Yan V Sun
- Yasaman Saba
- Yong Qian
- Yongmei Liu
- Yuri Milaneschi
- Zoltan Kutalik
- Åsa Johansson
- Publication venue
- Publication date
- 01/01/2017
- Field of study
High blood pressure is the foremost heritable global risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits to date (systolic,
diastolic, pulse pressure) in over one million people of European ancestry. We identify 535
novel blood pressure loci that not only offer new biological insights into blood pressure
regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the
potential for a precision medicine strategy for future cardiovascular disease prevention
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
- Author
- Abboud Shérine
- Abecasis Gonçalo
- Abraham Gad
- Adams Hieab H. H.
- Akiyama Masato
- Alg Varinder S.
- Almgren Peter
- Amin Najaf
- Amort Margareth
- Amouyel Philippe
- Anttila Verneri
- Arfan Ikram M.
- Arking Dan E.
- Arnold Marie-Luise
- Aromaa Arpo J.
- Artto Ville
- Attia John R.
- Ayers Kristin L.
- Bakker Mark K.
- Barbieri Caterina M.
- Batini Chiara
- Belin Andrea C.
- Beretta Simone
- Berrandou Takiy
- Bersano Anna
- Bijlenga Philippe
- Bis Joshua C.
- Blake Tineka
- Bochud Murielle
- Bodenant Marie
- Boehnke Michael
- Boerwinkle Eric
- Bonati Leo
- Boomsma Dorret I.
- Boomsma Dorret I.
- Borck Guntram
- Bottinger Erwin P.
- Bouatia-Naji Nabila
- Bourcier Romain
- Boutin Thibaud
- Bown Matthew
- Brandt Tobias
- Braund Peter S.
- Broderick Joseph P.
- Brown Morris J.
- Brumat Marco
- Brumpton Ben M.
- Brumpton Ben M.
- Buring Julie E.
- Butterworth Adam S.
- Byrnes Andrea E.
- Béjot Yannick
- Børte Sigrid
- Børte Sigrid
- Cader Zameel
- Campbell Archie
- Campbell Harry
- Canaple Sandrine
- Caria Filomena
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chasman Daniel I.
- Chasman Daniel I.
- Chauhan Ganesh
- Cherkas Lynn
- Ciullo Marina
- Cocca Massimiliano
- Cole John
- Collins Francis
- Conen David
- Connell John
- Cordell Heather J.
- Crozier Sophie
- Cucca Francesco
- Cuenca-Leon Ester
- Dallongeville Jean
- Daly Mark J.
- Danesh John
- Dauvillier J. rôme
- Davey Smith George
- Davies Gail
- de Borst Martin H.
- de Geus Eco J.
- de Giuli Valeria
- de Mutsert Renée
- Deary Ian J.
- Debette Stéphanie
- Decavel Pierre
- Deelen Joris
- del Greco M Fabiola
- Deltour Sandrine
- Desal Hubert
- Dichgans Martin
- Dichgans Martin
- Dimou Niki
- Dina Christian
- Ding Jun
- Doney Alex S. F.
- Dos Santos Michael
- Dörr Marcus
- Ehret Georg B.
- Ellekjær Hanne
- Elliott Paul
- Elosua Roberto
- Engelter Stefan
- Enroth Stefan
- Eriksson Johan G.
- Eriksson Nicholas
- Esko Tonu
- Esko Tonu
- Esserlind Ann-Louise
- Evangelou Evangelos
- Farh Kai-How
- Farrall Martin
- Ferrarese Carlo
- Ferrari Michel D.
- Ferreira Teresa
- Fluri Felix
- Folkmann Hansen Thomas
- Francke Christensen Anne
- Franco Oscar H.
- Franke Lude
- Freilinger Tobias M.
- Friedrich Christoph M.
- Fritsche Lars G.
- Frånberg Mattias
- Furlotte Nicholas A.
- Färkkilä Markus
- Gabrielsen Maiken E.
- Gandin Ilaria
- Ganesh Santhi K.
- Gao He
- Gasparini Paolo
- Gaál-Paavola Emília I.
- Gensicke Henrik
- Gentric Jean-Christophe
- Giacolone Giacomo
- Giedraitis Vilmantas
- Gieger Christian
- Girotto Giorgia
- Giroud Maurice
- Gisler Dominique
- Giulianini Franco
- Godefroy Olivier
- Goel Anuj
- Gordon Scott G.
- Gormley Padhraig
- Gow Alan J.
- Grau Armin
- Grond-Ginsbach Caspar
- Gudlaug Hrafnsdottir Maria
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf
- Göbel Hartmut
- Hagen Knut
- Hamsten Anders
- Harris Sarah E.
- Harris Tamara B.
- Hartman Catharina A.
- Hatz Florian
- Havulinna Aki S.
- Hayward Caroline
- Heath Andrew C.
- Hege Aamodt Anne
- Heidi Skogholt Anne
- Heikkilä Kauko
- Heuch Ingrid
- Hicks Andrew A.
- Hinds David A.
- Hirsch Sven
- Hofer Edith
- Hofman Albert
- Hofman Albert
- Holliday Elizabeth G.
- Holmen Oddgeir L.
- Hostettler Isabel C.
- Hottenga Jouke-Jan
- Hottenga Jouke-Jan
- Houlden Henry
- Howson Joanna M. M.
- Huang Hailiang
- Huang Jie
- Huffman Jennifer E.
- Hveem Kristian
- Hveem Kristian
- Hwang Shih-Jen
- Hämäläinen Eija
- Ingason Andres
- Ingelsson Erik
- Jackson Anne U.
- James Alan
- Jansen Rick
- Jarvelin Marjo-Riitta
- Joehanes Roby
- Johansson Åsa
- Johnsen Marianne Bakke
- Johnson Andrew D.
- Jones Gregory
- Joshi Peter K.
- Jousilahti Pekka
- Jula Antti
- Järvelin Marjo-Riitta
- Jääskeläinen Juha E.
- Kallela Mikko
- Kals Mart
- Kamatani Yoichiro
- Kanning Jos P.
- Kaprio Jaakko
- Kathiresan Sekar
- Kaunisto Mari
- Keavney Bernard D.
- Khaw Kay-Tee
- Kittner Steven
- Kloss Manja
- Knekt Paul
- Knight Joanne
- Koido Masaru
- Koiranen Markku
- Kolcic Ivana
- Kooner Jaspal S.
- Koskinen Seppo
- Kristiansson Kati
- Kristoffersen Espen S.
- Kubisch Christian
- Kurki Mitja I.
- Kurth Tobias
- Kutalik Zoltan
- Kähönen Mika
- Laakso Markku
- Laan Maris
- Lakatta Edward G.
- Lanfranconi Silvia
- Langenberg Claudia
- Larson Marty
- Launer Lenore J.
- Leder Sara
- Lee Phil H.
- Lehne Benjamin
- Lehtimäki Terho
- Lehtimäki Terho
- Levy Daniel
- Leys Didier
- Li Liming
- Li-Gao Ruifang
- Lichy Christoph
- Liewald David C. M.
- Ligthart Lannie
- Lin Kuang
- Lin Li
- Lin Wei-Yu
- Lind Lars
- Lindgren Antti
- Lindgren Cecilia M.
- Liu YongMei
- Loehrer Elizabeth
- Loos Ruth J. F.
- Lopez Lorna M.
- Louillet Fabien
- Lu Yingchang
- Luan Jian'an
- Lyrer Philippe
- Lyytikäinen Leo-Pekka
- Léger Anne
- Madden Pamela A. F.
- Mahajan Anubha
- Majersik Jennifer
- Malik Rainer
- Mamasoula Chrysovalanto
- Mangino Massimo
- Markus Hugh
- Marrugat Jaume
- Marten Jonathan
- Martin Nicholas G.
- Martin Olivier
- Martinsen Amy E.
- Mas Jean-Louis
- Matsuda Koichi
- Mcmahon George
- Medeiros Elizabeth
- Meitinger Thomas
- Melander Olle
- Menni Cristina
- Mesut Erzurumluoglu A.
- Metso Antti J.
- Metso Tiina
- Metspalu Andres
- Metspalu Andres
- Mihailov Evelin
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Millwood Iona Y.
- Montgomery Grant W.
- Montiel Paola
- Mook-Kanamori Dennis O.
- Morel Sandrine
- Morgan Anna
- Morris Andrew D.
- Morris Andrew P.
- Morrison Alanna C.
- Moulin Thierry
- Muller-Myhsok Bertram
- Munroe Patricia B.
- Munson Peter J.
- Muona Mikko
- Mägi Reedik
- Mägi Reedik
- Männikkö Minna
- Méresse Isabelle
- Naggara Olivier
- Nalls Mike A.
- Nandakumar Priyanka
- Neale Benjamin M.
- Nelson Christopher P.
- Newton-Cheh Christopher
- Nielsen Christopher S.
- Nielsen Jonas B.
- Niemelä Mika
- Niiranen Teemu
- Nolte Ilja M.
- Noordam Raymond
- Ntritsos Georgios
- Nutile Teresa
- Nyholt Dale R.
- O'reilly Paul F.
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Olesen Jes
- Oostra Ben A.
- Org Elin
- Padmanabhan Sandosh
- Padovani Alessandro
- Palmas Walter
- Palmer Colin N. A.
- Palotie Aarno
- Palotie Aarno
- Palta Priit
- Pandolfo Massimo
- Paolucci Stefano
- Paré Guillaume
- Pattie Alison
- Pedersen Linda M.
- Pedersen Linda M.
- Penninx Brenda W. J. H.
- Pera Joanna
- Perola Markus
- Pers Tune H.
- Peter Prins Bram
- Peters Annette
- Pezzini Alessandro
- Polasek Ozren
- Poli Loris
- Poulter Neil R.
- Pramstaller Peter P.
- Psaty Bruce M.
- Pärn Kalle
- Qian Yong
- Quaye Lydia
- Raitakari Olli
- Raitakari Olli T.
- Ran Caroline
- Redon Richard
- Rettig Rainer
- Rice Kenneth
- Ridker Paul M.
- Ridker Paul M.
- Ried Janina S.
- Riese Harriëtte
- Ring Susan M.
- Rinkel Gabriel J. E.
- Ripatti Samuli
- Risch Lorenz
- Robino Antonietta
- Rose Lynda M.
- Rotter Jerome I.
- Rouleau Guy A.
- Rudan Igor
- Ruggiero Daniela
- Ruigrok Ynte M.
- Saba Yasaman
- Sala Cinzia F.
- Salomaa Veikko
- Salomaa Veikko
- Samani Nilesh J.
- Samson Yves
- Sandor Cynthia
- Sandset Else C.
- Sandvei Marie S. fteland
- Sargurupremraj Muralidharan
- Sarin Antti-Pekka
- Sarin Antti-Pekka
- Sawada Tomonobu
- Schilling Sabine
- Schmidt Helena
- Schmidt Reinhold
- Schreiber Stefan
- Schürks Markus
- Scott Robert A.
- Scott Rodney J.
- Sever Peter
- Shah Nabi
- Shields Denis C.
- Shotar Eimad
- Shrine Nick
- Siscovick David
- Slowik Agnieszka
- Smith Albert V.
- Snieder Harold
- Sorice Rossella
- Southerland Andrew
- Spector Tim
- Spector Tim D.
- Stam Anine H.
- Stanton Alice
- Starr John M.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stergiakouli Evie
- Stott David J.
- Strachan David P.
- Strachan David P.
- Strawbridge Rona J.
- Stubhaug Audun
- Sundström Johan
- Surendran Praveen
- Swertz Morris A.
- Sõber Siim
- Tatlisumak Turgut
- Taylor Kent D.
- Terao Chikashi
- Terwindt Gisela M.
- Teumer Alexander
- Thijs Vincent
- Thom Simon
- Thomas Laurent F.
- Thomas-Feles Constanze
- Thériault S. bastien
- Tobin Martin D.
- Tomaszewski Maciej
- Toniolo Daniela
- Touzé Emmanuel
- Traglia Michela
- Tri Nguyen Quang
- Trompet Stella
- Tuomilehto Jaakko
- Tzourio Christophe
- Uitterlinden Andre G.
- Uitterlinden André G.
- Vaez Ahmad
- van den Maagdenberg Arn M. J. M.
- van der Harst Pim
- van der Most Peter J.
- van Duijn Cornelia M.
- van Duijn Cornelia M.
- Veldink Jan H.
- Vepsäläinen Salli
- Verschuren W. M. Monique
- Verweij Niek
- Verwoert Germaine C.
- Vitart Veronique
- Vollenweider Peter
- Vuckovic Dragana
- Vuillier Fabrice
- Völker Uwe
- Wain Louise V.
- Walters Robin G.
- Wareham Nicholas J.
- Warren Helen R.
- Watkins Hugh
- Webber Caleb
- Weber Ralf
- Wedenoja Juho
- Werge Thomas
- Werner Inge
- Werring David J.
- Wessman Maija
- Wild Sarah H.
- Willems Sara M.
- Willemsen Gonneke
- Willer Cristen J.
- Willer Cristen J.
- Wilson James F.
- Winsvold Bendik S.
- Wjh Penninx Brenda
- Woo Daniel
- Worrall Bradford
- Worrall Bradford B.
- Wouter Jukema J.
- Wright Alan F.
- Yao Jie
- Yusuf Demirkale Cumhur
- Zeggini Eleftheria
- Zemunik Tatijana
- Zhang Weihua
- Zhao Jing-Hua
- Zhou Sirui
- Zhou Wei
- Zwart John-Anker
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2023
- Field of study
Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics. Methods: A genetic risk score incorporating genetic association data for IA and 17 traits related to IA (so-called metaGRS) was created using 1161 IA cases and 407 392 controls from the UK Biobank population study. The metaGRS was validated in combination with risk factors blood pressure, sex, and smoking in 828 IA cases and 68 568 controls from the Nordic HUNT population study. Furthermore, we assessed association between the metaGRS and patient characteristics in a cohort of 5560 IA patients. Results: Per SD increase of metaGRS, the hazard ratio for ASAH incidence was 1.34 (95% CI, 1.20-1.51) and the odds ratio for IA presence 1.09 (95% CI, 1.01-1.18). Upon including the metaGRS on top of clinical risk factors, the concordance index to predict ASAH hazard increased from 0.63 (95% CI, 0.59-0.67) to 0.65 (95% CI, 0.62-0.69), while prediction of IA presence did not improve. The metaGRS was statistically significantly associated with age at ASAH (β=-4.82×10-3per year [95% CI, -6.49×10-3to -3.14×10-3]; P=1.82×10-8), and location of IA at the internal carotid artery (odds ratio=0.92 [95% CI, 0.86-0.98]; P=0.0041). Conclusions: The metaGRS was predictive of ASAH incidence, although with limited added value over clinical risk factors. The metaGRS was not predictive of IA presence. Therefore, we do not recommend using this metaGRS in daily clinical care. Genetic risk does partly explain the clinical heterogeneity of IA warranting prioritization of clinical heterogeneity in future genetic prediction studies of IA and ASAH
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- Author
- 1000 Genomes Project Consortium
- A El Wakil
- A. Mesut Erzurumluoglu
- Aarno Palotie
- AD Schmitt
- Adam S. Butterworth
- Adriana M. Hung
- AE Teo
- Ahmad Vaez
- Aki S. Havulinna
- Alan F. Wright
- Alan J. Gow
- Alan James
- Alanna C. Morrison
- Albert Hofman
- Albert V. Smith
- Albertine J. Oldehinkel
- Alex S. F. Doney
- Alexander Teumer
- Alice Stanton
- Alison Pattie
- Anders Hamsten
- Andres Metspalu
- Andrew A. Hicks
- Andrew D. Johnson
- Andrew D. Morris
- Andrew P. Morris
- André G. Uitterlinden
- Anna Morgan
- Anne U. Jackson
- Anne-Claire Vergnaud
- Annette Peters
- Antonietta Robino
- Antti Jula
- Antti-Pekka Sarin
- Anubha Mahajan
- Anuj Goel
- Aravinda Chakravarti
- Archie Campbell
- Ayush Giri
- Ben A. Oostra
- Benjamin Lehne
- Bernard D. Keavney
- BF Voight
- BK Bulik-Sullivan
- Blood Pressure Lowering Treatment Trialists’ Collaboration.
- Borbala Mifsud
- Bram Peter Prins
- Brenda W. J. H. Penninx
- Bruce M. Psaty
- C Drelon
- C Liu
- C Sudlow
- Caroline Hayward
- Caterina M. Barbieri
- Catharina A. Hartman
- Cecilia M. Lindgren
- Chiara Batini
- Christian Gieger
- Christophe Tzourio
- Christopher J. O’Donnell
- Christopher Newton-Cheh
- Christopher Oldmeadow
- Christopher P. Nelson
- Chrysovalanto Mamasoula
- Cinzia F. Sala
- CJ Willer
- Claudia Langenberg
- Claudia P. Cabrera
- Colin N. A. Palmer
- Cornelia M. van Duijn
- CP Cabrera
- Cristina Menni
- Csaba P. Kovesdy
- Cumhur Yusuf Demirkale
- DA Calhoun
- Dan E. Arking
- Daniel I. Chasman
- Daniel Levy
- Daniela Ruggiero
- Daniela Toniolo
- David C. M. Liewald
- David Conen
- David J. Stott
- David Mosen-Ansorena
- David P. Strachan
- David Siscovick
- Denis C. Shields
- Dennis O. Mook-Kanamori
- Digna R. Velez Edwards
- Dorret I. Boomsma
- Dragana Vuckovic
- E Evangelou
- E Marouli
- E Nakao
- EA Boyle
- Eco J. de Geus
- Edith Hofer
- Edward G. Lakatta
- Eleftheria Zeggini
- Elin Org
- Elizabeth G. Holliday
- Eric Boerwinkle
- Erik Ingelsson
- Erwin P. Bottinger
- Evan Tzanis
- Evangelos Evangelou
- F Tissier
- Fabiola Del Greco M.
- Francesco Cucca
- Francis Collins
- Franco Giulianini
- Fu Liang Ng
- Gail Davies
- Ganesh Chauhan
- GB Ehret
- GB Ehret
- GB Ehret
- GBD 2015 Risk Factors Collaborators.
- Georg B. Ehret
- Georgios Ntritsos
- Germaine C. Verwoert
- GH Oliveira-Paula
- Giorgia Girotto
- Gonneke Willemsen
- Gonçalo Abecasis
- GP Rossi
- Guillaume Paré
- H Ohtsu
- Harold Snieder
- Harriëtte Riese
- Harry Campbell
- He Gao
- Heather J. Cordell
- Helen R. Warren
- Helena Schmidt
- HJ Sun
- HR Warren
- Hugh Watkins
- I Tzoulaki
- Ian J. Deary
- Ibrahim Karaman
- Igor Rudan
- IK Dunham
- Ilaria Gandin
- Ilja M. Nolte
- Ioanna Tzoulaki
- Ivana Kolcic
- J MacArthur
- J Piñero
- J Piñero
- J Wang
- J Yang
- J Zhou
- J. Michael Gaziano
- J. Wouter Jukema
- Jaakko Tuomilehto
- Jacklyn N. Hellwege
- James F. Wilson
- Janina S. Ried
- Jaspal S. Kooner
- Jaume Marrugat
- JB Pawlak
- Jennifer E. Huffman
- Jerome I. Rotter
- Jian’an Luan
- Jie Yao
- Jing-Hua Zhao
- JM Gaziano
- Joanna M. M. Howson
- Joanne Knight
- Johan Sundström
- John C. Chambers
- John Connell
- John Danesh
- John M. Starr
- John R. Attia
- Jonathan Marten
- Joris Deelen
- Joshua C. Bis
- Jouke-Jan Hottenga
- JP Ioannidis
- JR Staley
- Jun Ding
- Katarzyna Witkowska
- Kati Kristiansson
- Kay-Tee Khaw
- KB Lane
- Kelly Cho
- Kenneth Rice
- Kent D. Taylor
- KP Conrad
- Kristin L. Ayers
- L Leitsalu
- Lars Lind
- Lenore J. Launer
- Leo-Pekka Lyytikäinen
- Li Lin
- Lili Milani
- Lorenz Risch
- Lorna M. Lopez
- Louise V. Wain
- LV Wain
- LV Wain
- LV Wain
- Lynda M. Rose
- M Feinleib
- M Muñoz
- Maciej Tomaszewski
- Marco Brumat
- Marcus Dörr
- Marina Ciullo
- Marina Evangelou
- Maris Laan
- Marjo-Riitta Jarvelin
- Mark J. Caulfield
- Markku Laakso
- Markus Perola
- Martin D. Tobin
- Martin Farrall
- Martin H. de Borst
- Marty Larson
- Massimiliano Cocca
- Massimo Mangino
- Mattias Frånberg
- MD Tobin
- Meixia Ren
- MH Forouzanfar
- Michael Boehnke
- Michael R. Barnes
- Michela Traglia
- Mika Kähönen
- Mike A. Nalls
- Morris A. Swertz
- Morris J. Brown
- MR Munafò
- Muralidharan Sargurupremraj
- Murielle Bochud
- Nabi Shah
- Najaf Amin
- Neil R. Poulter
- Nicholas J. Wareham
- Nick Shrine
- Niek Verweij
- Niki Dimou
- Nilesh J. Samani
- NR Poulter
- Olle Melander
- Olli T. Raitakari
- Oscar H. Franco
- Ozren Polasek
- P Elliott
- P Surendran
- Paolo Gasparini
- Patricia B. Munroe
- Paul Elliott
- Paul F. O’Reilly
- Paul Knekt
- Paul M. Ridker
- Pekka Jousilahti
- Peter Almgren
- Peter J. Munson
- Peter J. van der Most
- Peter K. Joshi
- Peter P. Pramstaller
- Peter S. Braund
- Peter Sever
- Peter Vollenweider
- Peter W. F. Wilson
- Philip S. Tsao
- Philippe Amouyel
- Pim van der Harst
- PR Loh
- Praveen Surendran
- Priyanka Nandakumar
- Quang Tri Nguyen
- R Pazoki
- R Sofat
- R Yang
- Raha Pazoki
- Rainer Rettig
- Raymond Noordam
- Reedik Mägi
- Reinhold Schmidt
- Renée de Mutsert
- Rick Jansen
- Robert A. Scott
- Roberto Elosua
- Roby Joehanes
- Rodney J. Scott
- Rona J. Strawbridge
- Rossella Sorice
- Ruifang Li-Gao
- Ruth J. F. Loos
- S Douma
- S McCarthy
- S Purcell
- Samuli Ripatti
- Sandosh Padmanabhan
- Sara M. Willems
- Sarah E. Harris
- Sarah H. Wild
- Sekar Kathiresan
- Seppo Koskinen
- Shih-Jen Hwang
- Siim Sõber
- Simon Thom
- SL Pulit
- SS Rao
- Stefan Enroth
- Stella Trompet
- Stéphanie Debette
- Sébastien Thériault
- Tamara B. Harris
- Tatijana Zemunik
- Teemu Niiranen
- Teresa Ferreira
- Teresa Nutile
- Terho Lehtimäki
- TH Pers
- Thibaud Boutin
- Tim D. Spector
- Tineka Blake
- TJ Hoffmann
- Todd L. Edwards
- Tonu Esko
- Ulf Gyllensten
- Uwe Völker
- Veikko Salomaa
- Veronique Vitart
- Vilmantas Giedraitis
- Vilmundur Gudnason
- W Feng
- Walter Palmas
- Wei-Yu Lin
- Weihua Zhang
- Xiuqing Guo
- Y Miyamoto
- Yan V. Sun
- Yasaman Saba
- Yingchang Lu
- Yong Qian
- YongMei Liu
- Yuri Milaneschi
- Zoltan Kutalik
- Åsa Johansson
- Publication venue
- Nature Research
- Publication date
- 01/01/2018
- Field of study
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic
association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European
ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but
also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological
pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- Author
- Abecasis G. (Gonçalo)
- Almgren P. (Peter)
- Amin N. (Najaf)
- Amouyel P. (Philippe)
- Arking D.E. (Dan)
- Attia J. (John)
- Ayers K.L. (Kristin)
- Barbieri C.M. (Caterina M.)
- Barnes M.J. (Michael)
- Batini C. (Chiara)
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- Blake T. (Tineka)
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- Boehnke M. (Michael)
- Boerwinkle E. (Eric)
- Boomsma D.I. (Dorret I.)
- Bottinger E.P. (Erwin P.)
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- Braund P.S. (Peter)
- Brown M.J. (Morris)
- Brumat M. (Marco)
- Butterworth A.S. (Adam S.)
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- Chambers J.C. (John C.)
- Chasman D.I. (Daniel)
- Chauhan G. (Ganesh)
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- Publication date
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- Field of study
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML.
The error has now been corrected in the HTML version of the paper
Genetic studies of body mass index yield new insights for obesity biology
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- Aasarød K
- Abecasis G
- Abecasis GR
- Abecasis GR
- Abecasis Gonçalo R.
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- Ahlqvist E
- Ahmadi KR
- Ahola A
- Ainali C
- Akylbekova E
- Ala-Korpela M
- Alavere H
- Albrecht E
- Albrecht E
- Albrecht Eva
- Alexander M
- Alhenc-Gelas F
- Alizadeh BZ
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- Altshuler D
- Altshuler D
- Altshuler D
- Altshuler D
- Ambite JL
- Amin N
- Amin N
- Amin Najaf
- Amouyel P
- Amouyel Philippe
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- Antonella M
- Antti J
- Ardissino D
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- Arking DE
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- Arnold A
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- Artigas MS
- Arveiler D
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- Assimes TL
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- Assimes Themistocles L.
- Atalay M
- Atkinson EJ
- Atkinson EJ
- Attwood Antony P.
- Aulchenko Y
- Aulchenko YS
- Avery C
- Bain SC
- Bakker SJ
- Bakker SJ
- Bakker SJ
- Bakker Stephan J.L.
- Balkau B
- Ball SG
- Balmforth AJ
- Balmforth AJ
- Bandinelli S
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- Bandinelli Stefania
- Barbalic M
- Barrett A
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- Barroso I
- Barroso Inɥs
- Bas Isabelita N.
- Basart H
- Basart HV
- Bataille V
- Baumert J
- Beckmann JS
- Beckmann JS
- Beckmann JS
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- Beckmann Jacques S.
- Beekman Marian
- Been LF
- Beilby JP
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- Beilby John
- Bell JT
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- Bennett F
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- Berenson GS
- Berger K
- Berglund G
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- Bergman Richard N.
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- Bierut LJ
- Biffar R
- Biffar R
- Bis JC
- Blackburn H
- Blagieva Roza
- Blangero John
- Blankenberg SS
- Blüher Matthias
- Boban M
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- Bochud M
- Bochud Murielle
- Boehm BO
- Boehm BO
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- Boehm Bernhard O.
- Boehnke M
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- Boehnke M
- Boehnke M
- Boehnke Michael
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- Zelenika D
- Zemunik T
- Zemunik T
- Zemunik T
- Zerbini G
- Zgaga L
- Zgaga L
- Zhai G
- Zhai G
- Zhai G
- Zhang F
- Zhang W
- Zhang W
- Zhang W
- Zhang Qunyuan
- Zhang Weihua
- Zhao JH
- Zhao JH
- Zhao JH
- Zhao JH
- Zhao W
- Zhao Jing Hua
- Zhao Wei
- Zheng W
- Zheng Wei
- Zhu H
- Zhu X
- Zhuang WV
- Zhuang WV
- Ziegler A
- Ziegler A
- Ziegler A
- Zillikens MC
- Zillikens M. Carola
- Zimmermann ME
- Zitting P
- Zondervan KT
- Zondervan KT
- Zondervan Krina T.
- Zonzin P
- Zukowska-Szczechowska E
- Zygmunt M
- Ärnlöv J
- Ärnlöv Johan
- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p