47 research outputs found

    Narrativas de la ausencia, cartografías de la memoria : tres diseños para tres narrativas

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    El treball Final de MĂ ster recull tres relats lligats a tres obres d'arquitectura i disseny, de diferents graus de desconeixement i per tant inĂšdites. El fet de donar a conĂšixer aquestes obres ha de servir per a completar aspectes de la recent histĂČria del disseny a Barcelona en dues d'elles i de descobrir una de nova en la tercera. Les tres narracions es lliguen per una narraciĂł superior identificada en la biografia d'una persona. AixĂČ dĂłna coartada per a explicar el disseny, l'art i l'arquitectura de manera diferenciada, mitjançant la subjectivitzaciĂł del relat que, paradoxalment, ha d'ajudar a interpretar el sentit de qualsevol producciĂł creativa

    Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

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    Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≄1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≀6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

    Measurement of the Top Pair Production Cross Section in the Dilepton Decay Channel in ppbar Collisions at sqrt s = 1.96 TeV

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    Submitted to Phys. Rev. DA measurement of the \ttbar production cross section in \ppbar collisions at s\sqrt{{\rm s}} = 1.96 TeV using events with two leptons, missing transverse energy, and jets is reported. The data were collected with the CDF II Detector. The result in a data sample corresponding to an integrated luminosity 2.8 fb−1^{-1} is: \sigma_{\ttbar} = 6.27 ±\pm 0.73(stat) ±\pm 0.63(syst) ±\pm 0.39(lum) pb. for an assumed top mass of 175 GeV/c2c^{2}.A measurement of the tt̅ production cross section in pp̅ collisions at √s=1.96  TeV using events with two leptons, missing transverse energy, and jets is reported. The data were collected with the CDF II detector. The result in a data sample corresponding to an integrated luminosity 2.8  fb-1 is σtt̅ =6.27±0.73(stat)±0.63(syst)±0.39(lum)  pb. for an assumed top mass of 175  GeV/c2.Peer reviewe

    Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

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    BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

    COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

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    Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≀ 18 years: 69, 48, 23; 85%), older adults (≄ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

    Narrativas de la ausencia, cartografías de la memoria : tres diseños para tres narrativas

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    El treball Final de MĂ ster recull tres relats lligats a tres obres d'arquitectura i disseny, de diferents graus de desconeixement i per tant inĂšdites. El fet de donar a conĂšixer aquestes obres ha de servir per a completar aspectes de la recent histĂČria del disseny a Barcelona en dues d'elles i de descobrir una de nova en la tercera. Les tres narracions es lliguen per una narraciĂł superior identificada en la biografia d'una persona. AixĂČ dĂłna coartada per a explicar el disseny, l'art i l’arquitectura de manera diferenciada, mitjançant la subjectivitzaciĂł del relat que, paradoxalment, ha d'ajudar a interpretar el sentit de qualsevol producciĂł creativa

    Plec : informatiu d'EINA. NĂșm. 61

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    NĂșm. 61 (feb. 2009)En defensa del disseny / Oriol Pibernat, Octavi Rofes. Contra el vedetisme mal entĂšs / Pep Bonet. Intra capsam Projectes interiors d’Ășs col·lectiu: Mostra de Projectes Final de Carrera del curs 2007-08 / Santi Ferrer-Vidal

    Narrativas de la ausencia, cartografías de la memoria : tres diseños para tres narrativas

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    El treball Final de MĂ ster recull tres relats lligats a tres obres d'arquitectura i disseny, de diferents graus de desconeixement i per tant inĂšdites. El fet de donar a conĂšixer aquestes obres ha de servir per a completar aspectes de la recent histĂČria del disseny a Barcelona en dues d'elles i de descobrir una de nova en la tercera. Les tres narracions es lliguen per una narraciĂł superior identificada en la biografia d'una persona. AixĂČ dĂłna coartada per a explicar el disseny, l'art i l'arquitectura de manera diferenciada, mitjançant la subjectivitzaciĂł del relat que, paradoxalment, ha d'ajudar a interpretar el sentit de qualsevol producciĂł creativa

    Plec : informatiu d'EINA. NĂșm. 56

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    NĂșm. 56 (feb./març 2007)Editorial: Un nou disseny per a La Masia. Converses al Vivanda: L’aportaciĂł argentina al disseny catalĂ  2.0 / Frankie de Leonardis, Mich Micenmacher i SebastiĂĄn Seifert. Fet a Eina: Bcn Degusta 2007 / Santi Ferrer-Vidal, Amaia Lizarraga, Esther MĂ rquez i Abraham Rocha

    Signal molecules and cell-surface components involved in early stages of the legume–rhizobium interactions

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