344 research outputs found
Epstein-Barr Virus Mucocutaneous Colonic Ulcer in an Immunocompetent Patient.
- Publication venue
- LVHN Scholarly Works
- Publication date
- 13/10/2017
- Field of study
None Shall Pass: Migrated Surgical Mesh Causing Gastric Outlet Obstruction with Endoscopic Extraction
- Publication venue
- LVHN Scholarly Works
- Publication date
- 01/10/2018
- Field of study
Attempted Salvage Therapy Through Initiation of Vedolizumab as an Inpatient in Two Patients with Refractory Active Ulcerative Colitis
- Publication venue
- LVHN Scholarly Works
- Publication date
- 16/10/2015
- Field of study
Initial Experience of a Community Gastroenterology Practice With Ultra-Slim Colonoscopy: A Case Series.
- Publication venue
- LVHN Scholarly Works
- Publication date
- 17/10/2017
- Field of study
The Non-Healing lleocecal Ulcer.
- Publication venue
- LVHN Scholarly Works
- Publication date
- 01/05/2018
- Field of study
Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection
- Author
- A Gilsdorf
- A Nicoll
- A Otte
- AC Boon
- Alberto J. Leόn
- Alyson A. Kelvin
- AM Kumar
- Ana Loza
- AS Headley
- B Srivastava
- Barry B. Rubin
- Bianche Shum
- BM Saunders
- BT Rouse
- C Gabay
- CA Feghali
- CH Ladel
- D Gentile
- D Huang
- DA Steinhauer
- Dat Tran
- David Andaluz
- David Banner
- David J. Kelvin
- Derek C. K. Ng
- DP Skoner
- DW Huang
- GB Ryan
- Giovanni Delogu
- Giovanni Fadda
- H Tilg
- Ignacio Martin-Loeches
- J Arcaroli
- Jesus Blanco
- Jesús F. Bermejo-Martin
- JF Bermejo-Martin
- JL Ferrara
- JM Bland
- Jordi Rello
- JSM Peiris
- KJ Huang
- Lorenzo Socias
- LR Leon
- M Kopf
- MCW Chan
- MD de Jong
- MJ Cameron
- P Damas
- Paola Sansonetti
- Paula Ramirez
- R Perez-Padilla
- Raquel Almansa
- Raul Ortiz de Lejarazu
- RS Fritz
- Salvatore Rubino
- Sigmund Krajden
- Stefan Poehlmann
- Stephen S. H. Huang
- Stéphane G. Paquette
- TC Theoharides
- TMM Uyeki
- WC Lin
- Y Zhang
- Yuan Fang
- Z Kmietowicz
- Z Xing
- Zhen Zhao
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Pandemic H1N1 influenza A (H1N1pdm) is currently a dominant circulating influenza strain worldwide. Severe cases of H1N1pdm infection are characterized by prolonged activation of the immune response, yet the specific role of inflammatory mediators in disease is poorly understood. The inflammatory cytokine IL-6 has been implicated in both seasonal and severe pandemic H1N1 influenza A (H1N1pdm) infection. Here, we investigated the role of IL-6 in severe H1N1pdm infection. We found IL-6 to be an important feature of the host response in both humans and mice infected with H1N1pdm. Elevated levels of IL-6 were associated with severe disease in patients hospitalized with H1N1pdm infection. Notably, serum IL-6 levels associated strongly with the requirement of critical care admission and were predictive of fatal outcome. In C57BL/6J, BALB/cJ, and B6129SF2/J mice, infection with A/Mexico/4108/2009 (H1N1pdm) consistently triggered severe disease and increased IL-6 levels in both lung and serum. Furthermore, in our lethal C57BL/6J mouse model of H1N1pdm infection, global gene expression analysis indicated a pronounced IL-6 associated inflammatory response. Subsequently, we examined disease and outcome in IL-6 deficient mice infected with H1N1pdm. No significant differences in survival, weight loss, viral load, or pathology were observed between IL-6 deficient and wild-type mice following infection. Taken together, our findings suggest IL-6 may be a potential disease severity biomarker, but may not be a suitable therapeutic target in cases of severe H1N1pdm infection due to our mouse data
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo Musicò
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- Annaïg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila Oláh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- Aurélie Ledreux
- Avital A Rodal
- Ayesha Saleem
- Ákos M Lőrincz
- Áurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E Benediktsdóttir
- Bernadett R Bodnár
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
- Beth Holder
- Bianca C Pachane
- Biao Lu
- Bingdong Sui
- Birke J Benedikter
- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
- Bong Hwan Sung
- Bonita H Powell
- Brachyahu M Kestecher
- Bradley Whitehead
- Brian Dobosh
- Bridges Esther M.
- Brucale Marco
- Bruce A Stanton
- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
- Camille V Trinidad
- Cansu Gorgun
- Carla Mazzeo
- Carlos Salomon
- Carmen Campos-Silva
- Carmen Carceller
- Carmen Fernandez-Becerra
- Carmen Jerónimo
- Carney Randy P.
- Carolina Balbi
- Carolina Soekmadji
- Caroline Gilbert
- Caroline J Reddel
- Catherine A Sánchez
- Catherine Martel
- Cecilia Bucci
- Cecilia Lässer
- Celine Elie-Caille
- Cécile E Malnou
- Changhai Tian
- Changjin Lee
- Chantal M Boulanger
- Charisse N Winston
- Charles J Blijdorp
- Charles P Lai
- Charlotte Lawson
- Chaya Brodie
- Chelsea N Davis
- Cherie Blenkiron
- Chiew Yong Ng
- Chihchen Chen
- Chitranshi Nitin
- Christian Neri
- Christian P Pallasch
- Christian Preußer
- Christina Nedeva
- Christopher Fernandez-Prada
- Chungmin Han
- Claudia M Radu
- Cláudio Pinheiro
- Clémence Belleannée
- Clotilde Billottet
- Clotilde Théry
- Cocucci Emanuele
- Colin L Hisey
- Cora L Alvarez
- Coralie L Guerin
- Crescitelli Rossella
- Crislyn D'Souza-Schorey
- Cristina Fornaguera
- Cristina Pr Xavier
- Cristóbal Cerda-Troncoso
- D Craig Hooper
- D Michiel Pegtel
- Daan Paget
- Dakota Gustafson
- Dalila Iannotta
- Daniel Bachurski
- Daniel H Kim
- Daniel J MacPhee
- Daniel S Lark
- Daniel W Hagey
- Daniela Boselli
- Daniela Freitas
- Daniela L Papademetrio
- Daniele D'Arrigo
- Daniele Noël
- Danielle J Beetler
- Danilo Mladenović
- David A Armstrong
- David A Routenberg
- David C Lyden
- David D Roberts
- David J Lundy
- David Juncker
- David Laurin
- David Otaegui
- David P Al-Adra
- David R Brigstock
- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
- Delaram Khamari
- Denis Corbeil
- Dennis K Jeppesen
- Di Vizio Dolores
- Diego Kyburz
- Dilara C Ozkocak
- Dimitri Aubert
- Dina Ak Ahmed
- Dinesh Upadhya
- Dionysios C Watson
- Dirk P Dittmer
- Dirk Strunk
- Dmitry Ter-Ovanesyan
- Dolores Di Vizio
- Dominic Guanzon
- Donald G Phinney
- Dong Jun Park
- Dong-Gyu Jo
- Dong-Sup Lee
- Dongin Kim
- Dorian Forte
- Dorival M Rodrigues-Junior
- Doste R Mamand
- Driedonks Tom A. P.
- Dylan Burger
- Edina Gyukity-Sebestyén
- Edison Salas-Huenuleo
- Edit I Buzas
- Eduardo Marbán
- Eduardo Martínez-Martínez
- Eduardo Reategui
- Edveena Hanser
- Edwin van der Pol
- Efrat Levy
- Eisuke Dohi
- Elena Aikawa
- Elena Izquierdo
- Elena Khomyakova
- Elena S Martens-Uzunova
- Elena Vacchi
- Elham Hosseini-Beheshti
- Elias Sulaiman
- Elisa Lázaro-Ibáñez
- Elisa Tonoli
- Elise Madec
- Elizabeth R Dellar
- Elke Pogge von Strandmann
- Ellis K Fok
- Elżbieta Karnas
- Emanuele Cocucci
- Emilia Scharrig
- Emilio Di Ianni
- Emma Kc Symonds
- Enis Kostallari
- Eqbal Mohamadi
- Erdbrügger Uta
- Erez Eitan
- Eric Boilard
- Erica Bazzan
- Ernesto Gargiulo
- Esmahan Durmaz
- Estefanía Lozano-Andrés
- Esther M Bridges
- Esther Nm Nolte-'t Hoen
- Eszter Á Tóth
- Etienne Doré
- Etienne Moussay
- Eva Rohde
- Eva-Maria Krämer-Albers
- Evan A Gizzie
- Ewa K Zuba-Surma
- Ewa Ł Stępień
- Émilie Velot
- Fabian Braun
- Fabiana Geraci
- Fabienne Archer
- Fabrice Lucien
- Faezeh Shekari
- Faisal J Alibhai
- Falcon‐Perez Juan M.
- Farah Fatima
- Farrukh Aqil
- Fatah Kashanchi
- Fatemeh Momen-Heravi
- Fausto Almeida
- Federica Collino
- Federico Cocozza
- Federico Colombo
- Ferdinando Pucci
- Fernanda Jadue
- Fernando Souza-Fonseca-Guimaraes
- Flora Guerra
- Florian Puhm
- Fons Aj van de Loo
- Francesc E Borràs
- Francesca Perut
- Francesco Valle
- Francois Mullier
- Frank Rm Stassen
- Franz L Ricklefs
- Fred H Hochberg
- Frederic St-Denis-Bissonnette
- Frederik J Verweij
- Fu Qing‐Ling
- Fumihiko Urabe
- Gabrielis Kundrotas
- Gabriella Dobra
- Gabriella Pocsfalvi
- Gagan Deep
- Ganesh V Shelke
- Ganesha Poojary
- Ganna Stepanova
- Geneviève Bart
- Georges E Grau
- Georgia K Atkin-Smith
- Georgios Giamas
- Géraldine C Genard
- Ghasem Hosseini Salekdeh
- Gi-Hoon Nam
- Giorgia Melli
- Giovanni Camussi
- Giuseppina Poppa
- Gloria Alvarez-Llamas
- Goberdhan Deborah C. I.
- Gorjana Rackov
- Graca Raposo
- Gregory E Rice
- Gregory Lavieu
- Guanshu Liu
- Guido Jenster
- Guillaume van Niel
- Guoku Hu
- Guoping Li
- Hadi Valadi
- Hafiza Padinharayil
- Hakho Lee
- Han Sang Kim
- Hang Yin
- Hannah K Jackson
- Hanser Edveena
- Hao Chen
- Hao Zhang
- Hargita Hegyesi
- Harmeet Malhi
- Harris Adrian L.
- Harry Holthofer
- Harry Vm Spiers
- Haseeb Zubair
- Haughey Norman J.
- Heather H Pua
- Hendrix An
- Henrique Girão
- Heon-Jin Lee
- Hernando A Del Portillo
- Hernán González-King Garibotti
- Héctor Peinado
- Hidetoshi Tahara
- Hilal A Rather
- Hill Andrew F.
- Hiroaki Komuro
- Honami Naora
- Hongkuan Fan
- Houjian Cai
- Huaqi Su
- Hugo R Caires
- Hyo Jung An
- Hyungsoon Im
- Igea D'Agnano
- Igor V Kurochkin
- Ilaria Giusti
- Ilaria Prada
- Iliya Lefterov
- Imola Cs Szigyártó
- In-San Kim
- Indira Prasadam
- Inge Nelissen
- Ioannis Azoidis
- Irene Bertolini
- Irina Nazarenko
- Irma Schabussova
- Isabel Barranco
- Ivan J Vechetti
- Ivan Kh Poon
- Ivanov Alexander R.
- Ivica Marić
- J Brian Byrd
- Jacky G Goetz
- Jacob A Cleary
- Jamal Ghanam
- Jameel M Inal
- James G Patton
- Jan Lötvall
- Jan Van Deun
- Jana Zarubova
- Jane Howard
- Janine Stam
- Janis A Müller
- Janne Leivo
- Janos Zempleni
- Janusz Rak
- Jascinta P Santavanond
- Jason P Webber
- Javier Ramirez-Ricardo
- Javier Sotillo
- Jean-Marie Bach
- Jeff Bouffard
- Jeff Wm Bulte
- Jeffrey L Franklin
- Jeffrey S Schorey
- Jen Alexander-Brett
- Jenifer Pendiuk Goncalves
- Jennifer C Jones
- Jens C Luoto
- Jens Gruber
- Jerome Paggetti
- Jessica Gobbo
- Jessica Schiavi-Tritz
- Jessie Santoro
- Jiao Jiao Li
- Jing Jin
- Jiri Hrdy
- Jisook Moon
- Joanne Lannigan
- Joao N Ferreira
- Joaquin Seras-Franzoso
- Joel Ej Beaumont
- Johan Skog
- Johann M Gudbergsson
- Johanna Mm Puutio
- Johannes Oesterreicher
- John J Bissler
- John J Miklavcic
- John J Tomes
- John P Nolan
- Johnathon D Anderson
- Jonathan Degosserie
- Jonathan Leor
- Joost Pg Sluijter
- Jordi Roca
- Joseph Whitley
- Joshua A Welsh
- Joshua D Spitzberg
- Jovanovic‐Talisman Tijana
- Joy Wolfram
- Juan M Falcon-Perez
- Juan P Tosar
- Juhee Park
- Julia C Gross
- Julia Kuligowski
- Julia V Burnier
- Julian Swatler
- Julie A Saugstad
- Julie Constanzo
- Julien Saint-Pol
- Juntaro Matsuzaki
- Justus C Ndukaife
- Júlia Costa
- Kaiping Burrows
- Kaloyan Takov
- Kanchana K Ayyar
- Karen Forbes
- Karin Ekström
- Karolina Soroczyńska
- Kasper M Rouschop
- Kasra Khalaj
- Katelyn A Bruno
- Katherine E White
- Kathleen M Lennon
- Kathrin Gärtner
- Kathryn L Howe
- Katrin S Reiners
- Kazunari Akiyoshi
- Kelly Coutant
- Kelly Cs Roballo
- Kendall R Van Keuren-Jensen
- Kenneth W Witwer
- Kenny Man
- Kentaro Jingushi
- Kerstin Menck
- Kevin Leandro
- Khairul I Ansari
- Kieran Brennan
- Kimberley L Alexander
- Kirsi Rilla
- Kirsty M Danielson
- Kiyotaka Shiba
- Koen Breyne
- Koji Ueda
- Konxhe Kulaj
- Krishna P Maremanda
- Krishnan Anand
- Kristyna Turkova
- Krisztina Buzas
- Krisztina Németh
- Krisztina Pálóczi
- Krisztina V Vukman
- Kruh‐Garcia Nicole A.
- Ku'ulei‐Lyn Faustino Vroniqa
- Kyburz Diego
- Kyle I Mentkowski
- Kyle P Bramich
- Kyungmoo Yea
- Laura Bongiovanni
- Laura Grech
- Laura J Vella
- Laura Yedigaryan
- Lauren A Newman
- Lausonia Ramaswamy
- Lawrence W Chamley
- Lässer Cecilia
- Leandra K Figueroa-Hall
- Lei Zheng
- Lenassi Metka
- Lennon Kathleen M.
- Leon G Coleman Jr
- Leonardo Nimrichter
- Leonid Margolis
- Leonidas A Phylactou
- Leonora Balaj
- Lesley Cheng
- Liang Dong
- Liang Wu
- Lien Lippens
- Lifang Yang
- Lila Drittanti
- Liliia Paniushkina
- Lim Sai Kiang
- Ling-Qing Yuan
- Linglei Jiang
- Lissette Retana Moreira
- Loes Teeuwen
- Loïc Steiner
- Lorena Martin-Jaular
- Lorena Urbanelli
- Lorraine O'Driscoll
- Lothar C Dieterich
- Louise C Laurent
- Lötvall Jan
- Luca Musante
- Lucas Walther
- Lucia Paolini
- Lucia R Languino
- Lucienne Tritten
- Lucio Barile
- Ludovic Vinay
- Ludwig Ermann Lundberg
- Luis A Ortiz
- Luis Arteaga-Blanco
- Luis Mariñas-Pardo
- Luis Pereira de Almeida
- Luisa Weiss
- Luke C McIlvenna
- Luke van der Koog
- Lynn Pulliam
- M Helena Vasconcelos
- M Madhy Garcia Garcia
- M. AlbaneseMembro del Collaboration Group
- Maarten P Bebelman
- Maddox Adam L.
- Magdalena E Wysmołek
- Magdalena J Lorenowicz
- Mahlegha Ghavami
- Mahoney Mỹ G.
- Maiken Mellergaard
- Maimonah E Al-Masawa
- Maja Kosanović
- Makon-Sébastien Njock
- Malene Møller Jørgensen
- Malgorzata Czystowska-Kuzmicz
- Mangesh D Hade
- Manuel Gomez-Florit
- Manuel Varas-Godoy
- Manuela Basso
- Marc-André Langlois
- Marca Hm Wauben
- Marcel I Ramirez
- Marcela A Cucher
- Marcelo A Mori
- Marcin Jurga
- Marcio L Rodrigues
- Marco Brucale
- Marco Falasca
- Margaret M Mc Gee
- Margarida Viola
- Maria D Mayan
- Maria Eldh
- Maria Elena Cicardi
- Maria Harmati
- Maria I Guillén
- Maria Kaparakis-Liaskos
- Maria Noé Garcia
- Mariama Mbengue
- Marianne S Joerger-Messerli
- Marieke T Roefs
- Marija Holcar
- Marije E Kuipers
- Marina Cretich
- Mario Gimona
- Mariola J Ferraro
- Marit Inngjerdingen
- María Fernández-Rhodes
- María José Alcaraz
- María Yáñez-Mó
- Mark C Allenby
- Mark D Hulett
- Mark J McCann
- Mark J McVey
- Mark L Weiss
- Mark Samuels
- Mark Santos
- Marni D Boppart
- Marta Garcia-Contreras
- Marta Monguió-Tortajada
- Martens‐Uzunova Elena S.
- Martijn Jc van Herwijnen
- Martin E van Royen
- Martin Olivier
- Martin Wolf
- Martina Gabrielli
- Marvin Droste
- Mary Bebawy
- Maryam Azlan
- Marzena Kurzawa-Akanbi
- Masaharu Somiya
- Masahiko Kuroda
- Masahiro Morimoto
- Masako Harada
- Masamitsu Kanada
- Masood Kamali-Moghaddam
- Massimo Bottini
- Massimo Dominici
- Mateja E Kreft
- Mathilde Bergamelli
- Mathilde Mosser
- Matias Ostrowski
- Mats Van Delen
- Mattia I Morandi
- Maurizio Muraca
- Mauro Manno
- Max Piffoux
- Mátyás Bukva
- Md Matiur Rahman
- Md Mostafizur Rahman
- Meadhbh Á Brennan
- Meena Kumari
- Megan I Mitchell
- Mehdi Kabani
- Mehdi Mirzaei
- Mei He
- Meike J Saul
- Melissa K Jones
- Meta J Kuehn
- Metka Lenassi
- Michael P Rimmer
- Michael W Graner
- Michael W Pfaffl
- Michele Zanoni
- Michelle L Pleet
- Migara K Jayasinghe
- Migmar Tsamchoe
- Miguel Flores-Bellver
- Mikael Klingeborn
- Mikhail Skliar
- Miriam Romano
- Miroslava Katsur
- Miroslaw T Kornek
- Mizenko Rachel R.
- Modeline N Longjohn
- Mohammad Rahbari
- Mohanty Sujata
- Mona Batish
- Monika Baj-Krzyworzeka
- Monika Pietrowska
- Möller Andreas
- Muhammad Nawaz
- Muller Fabbri
- Muthuvel Jayachandran
- Myltykbay S Rysmakhanov
- Mỹ G Mahoney
- Nadezhda Nikiforova
- Nadim Tawil
- Namita N Kashyap
- Nandini Asokan
- Naohiro Seo
- Natalia J Krawczynska
- Natalie R Bauer
- Natasa Zarovni
- Natasha S Barteneva
- Nataša Resnik
- Nathaniel Eb Saidu
- Naureen Javeed
- Naveed Akbar
- Navneet Dogra
- Neslihan P Taşlı
- Neta Regev-Rudzki
- Newman Lauren A.
- Nicholas J Peake
- Nicholas R Hoyle
- Nico G Menjivar
- Nicole A Kruh-Garcia
- Nicole Meisner-Kober
- Nicole Noren Hooten
- Nieuwland Rienk
- Nihal Altan-Bonnet
- Nihar Godbole
- Nilufar Ali
- Norman J Haughey
- O'Driscoll Lorraine
- Ochiya Takahiro
- Oksana Kehoe
- Ole Østergaard
- Oleg S Tutanov
- Olesia Gololobova
- Olga Shatnyeva
- Olivier Blanc-Brude
- Olivier Burgy
- Olivier de Wever
- Olivier G de Jong
- Olivier Loudig
- Omar A Osorio
- Onno J Arntz
- Orazio Fortunato
- Orman L Snyder
- Ornella Urzì
- Osamu Takikawa
- Oscar Boyadjian
- Oscar Pb Wiklander
- Oskar Staufer
- Oumaima Stambouli
- Owen G Davies
- Pamali Fonseka
- Paola A Martinez-Murillo
- Paola C Loreto Palacio
- Paola de Candia
- Paolo Bergese
- Paolo Neviani
- Paolo V Fioretti
- Partha K Chandra
- Pascal Colosetti
- Pascale Zimmermann
- Paschalia Pantazi
- Pasquale D'Acunzo
- Patricia M M Ozawa
- Patricia Xander
- Patrick Hölker
- Paul A Haynes
- Paul C Boutros
- Paul D Robbins
- Paul Harrison
- Paula Pincela Lins
- Per Svenningsen
- Peter E Kima
- Peter Nejsum
- Philip D Stahl
- Philippa K Wade
- Pia R-M Siljander
- Pierre Arsène
- Pierre-Yves Mantel
- Pieter Vader
- Pietro Parisse
- Pilar Martin-Duque
- Pingping Han
- Piul S Rabbani
- Qi Hui Poh
- Qiang Chen
- Qin Zhang
- Qing-Ling Fu
- Qiubai Li
- Quan Lu
- Quentin Lemaire
- Quentin Lubart
- Quentin Roux
- Rachel C Quilang
- Rachel E Crossland
- Rachel R Mizenko
- Rafaela F Ferreira
- Raghu Kalluri
- Raghubendra S Dagur
- Rahul Sanwlani
- Ralph Weissleder
- Raluca E Ghebosu
- Ram Sagar
- Ramaroson Andriantsitohaina
- Ramin Khanabdali
- Ramkumar Menon
- Ramon M Eichenberger
- Randy P Carney
- Randy Schekman
- Rane A Harrison
- Raphael Schneider
- Raymond M Schiffelers
- Rebecca A Dragovic
- Rebecca L Davies
- Rebecca Lim
- Reem Bagabas
- Reihaneh Safavi-Sohi
- Renata Chalupská
- René Weiss
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- van Herwijnen Martijn J. C.
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- Vivek Kumar Gupta
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- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Multi-messenger observations of a binary neutron star merger
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- Moskalenko IV
- Moskvitin AS
- Mostaf M
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- Moulai M
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- Mow-Lowry CM
- Mrka S
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- Mukherjee D
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- Muniz EA
- Muoz A Gonzolez
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- Muratore M
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- Nakahira S
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- Nakamura Y
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- Nguyen P
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- Nie JY
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- Nielsen AB
- Niemiec J
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- Observat Toros Transient Robotic
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- Palamos JR
- Palashov O
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- Palczewski T
- Paliya VS
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- Palmerio JT
- Palmese A
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- Pan Howard
- Pan Huang-Wei
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- Pan-STARRS
- Pandey SB
- Pandya H
- Paneque D
- Pang B
- Pang PTH
- Pankova DV
- Pankow C
- Pannarale F
- Pant BC
- Panter M
- Paoletti F
- Paoletti F
- Paoli A
- Papa MA
- Papenbreer P
- Paragi Z
- Parente G
- Parida A
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- Parmiggiani N
- Parra A
- Parsons RD
- Pascucci D
- Pasqualetti A
- Passaquieti R
- Passuello D
- Pastorello A
- Patat F
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- Pavalas GE
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- Pea-Rodriguez J
- Pearlstone BL
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- Peixoto CJ Todero
- Pekeur NW
- Pekowsky L
- Pelayo R
- Pele A
- Pellegrino C
- Pelletier G
- Pellizzoni A
- Penacchioni AV
- Penn S
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- Piano G
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- Piccinni OJ
- Pichot M
- Picozza P
- Piel Q
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- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
- Placco VM
- Platino M
- Plazas AA
- Plum M
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- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
- Poon H
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- Popolizio P
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- Porter EK
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- Possenti A
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- Pozanenko AS
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- Prado RR
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- Principe G
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- Prodi GA
- Prokhorov D
- Prokhorov LG
- Prokoph H
- Prouza M
- Prrer M
- Przybylski GT
- Pulone L
- Pumo ML
- Punch M
- Puncken O
- Punturo M
- Puppo P
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- Quataert E
- Quel EJ
- Querchfeld S
- Querel R
- Quetschke V
- Quimby RM
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- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
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- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
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- Riviere C
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- Robie R
- Robinet F
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- Rojo J Rodriguez
- Rol E
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- Roncoroni MJ
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- Rosa-Gonzlez D
- Rosell A Carnero
- Rosenberg M
- Rosetti S
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- Rosswog S
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- Rowlinson A
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- Rulten CB
- Rumyantsev VV
- Rusu F
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- Ryckbosch D
- Rykoff ES
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- Sadler EM
- Sadler EM
- Saffe C
- Saffi SJ
- Saftoiu A
- Sahakian V
- Sai N
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- Sakamaki A
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- Sakellariadou M
- Sako M
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- Salafia OS
- Salamida F
- Salazar H
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- Saleem M
- Saleh A
- Salemi F
- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
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- Sampson LM
- Samtleben DFE
- Sanchez B
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- Sanchez LE
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- Santangelo A
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- Sathyaprakash BS
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- Schonbeck A
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- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
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- Schulz A
- Schulz A
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- Schumacher J
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- Schwalbe SG
- Schwanke U
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- Sciutto SJ
- Scolnic D
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- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
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- Sengupta AS
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- Sergeev A
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- Serino M
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- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
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- Shaffer TJ
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- Shaner MB
- Shang Z
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- Shappee BJ
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- Sharma I
- Sharp RG
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- Shellard RC
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- Shilon I
- Shimizu Y
- Shimomukai R
- Shingles LJ
- Shiningayamwe K
- Shoemaker DH
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- Siebert MR
- Siegel MH
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- Siemens X
- Sieniawska M
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- Sim SA
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- Simoni R
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- Singh A
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- Sinnis G
- Sintes AM
- Siskind EJ
- Slagmolen BJJ
- Slzer T
- Smartt SJ
- Smida R
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- Smith KW
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- Snow GR
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- Sobreira F
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- Soedingrekso J
- Soffitta P
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- Spiering C
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- Srivastava AK
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- Starck M
- Starling RLC
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- Stassi P
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- Stolarczyk Th
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- Stone R
- Stops DJ
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- Strafella F
- Strain KA
- Stratta G
- Streich A
- Strigin SE
- Strotjohann NL
- Strunk A
- Stubbs CW
- Sturani R
- Stuttard T
- Stuver AL
- Suarez F
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- Suchyta E
- Sudholz T
- Sugawara Y
- Sugita S
- Sugizaki M
- Sullivan GW
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- Sumi T
- Summerscales TZ
- Sun L
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- Sunyaev R
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- Supanitsky AD
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- Taboada I
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- Tao C
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- Tao WH
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- Tenholt F
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- Terai T
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- Terrier R
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- Testa V
- Tewari SV
- Thayer JB
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- Tokmakov KV
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- Torresi E
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- Troxel MA
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- Tsuna D
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- Tuffs R
- Tung CF
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- Tuo YL
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- Turley CF
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- Ty B
- Tyurina NV
- Ubertini P
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- Ugolini D
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- Ulrich R
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
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- Abdellatif M
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- Zafer F
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- Çetin B
- Ölmez M
- Özbalcı GS
- Özen D
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- Öztürk OU
- Čustović S
- Štefanová H
- Ευσταθίου Η
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
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