Correction to: Does transcranial direct current stimulation improve functional locomotion in people with Parkinson’s disease? A systematic review and meta-analysis

In the original article [1], we mentioned that some study characteristics of the article by Dagan and colleagues [2] were unavailable. However, we realized that the authors provided the relevant information in their supplementary file. As such, we added participant characteristics (i.e., age = 68.8 ± 6.8, gender = 17 M, 3 F, PD duration = 9.0 ± 5.7, and UPDRS Part III at baseline = Total 39.7 ± 14.6) to Table 1, stimulation parameters (i.e., intensity = 3 mA, duration = 20 min, areas = 3 cm2) to Table 2, and methodological quality assessments (i.e., allocation concealment = 1 and Total score = 9) to Table 3. Based on the new information, we updated Fig. 2 with the corrected selection bias and performance bias results. Finally, we confirmed that these corrections did not change the meta-analytic findings in the original article

A comparison of twin birthweight data from Australia, the Netherlands, the United States, Japan and South Korea: are genetic and environmental variations in birthweight similar in Caucasians and East Asians?

Birthweight has implications for physical and mental health in later life. Using data from Caucasian twins collected in Australia, the Netherlands and the United States, and from East Asian twins collected in Japan and South Korea, we compared the total phenotypic, genetic and environmental variances of birthweight between Caucasians and East Asians. Model-fitting analyses yielded four major findings. First, for both males and females, the total phenotypic variances of birthweight were about 45% larger in Caucasians than in East Asians. The larger phenotypic variances were mainly attributable to a greater shared environmental variance of birthweight in Caucasians (ranging from 62% to 67% of variance) than Asians (48% to 53%). Second, the genetic variance of birthweight was equal in Caucasians and East Asians for both males and females, explaining a maximum of 17% of variance. Third, small variations in total phenotypic variances of birthweight within Caucasians and within East Asians were mainly due to differences in nonshared environmental variances. We speculate that maternal effects (both genetic and environmental) explain the large shared environmental variance in birthweight and may account for the differences in phenotypic variance in birthweight between Caucasians and East Asians. Recent molecular findings and specific environmental factors that are subsumed by maternal effects are discussed

Hydrodynamical analysis of hadronic spectra in the 130 GeV/nucleon Au+Au collisions

We study one-particle spectra and a two-particle correlation function in the 130 GeV/nucleon Au+Au collisions at RHIC by making use of a hydrodynamical model. We calculate the one-particle hadronic spectra and present the first analysis of Bose-Einstein correlation functions based on the numerical solution of the hydrodynamical equations which takes both longitudinal and transverse expansion into account appropriately. The hydrodynamical model provides excellent agreement with the experimental data in the pseudorapidity and the transverse momentum spectra of charged hadrons, the rapidity dependence of anti-proton to proton ratio, and almost consistent result for the pion Bose-Einstein correlation functions. Our numerical solution with simple freeze-out picture suggests the formation of the quark-gluon plasma with large volume and low net-baryon density.Comment: 7 pages, 8 figures, REVTeX4. Numerical results and figures are correcte

Measurement of the Xi-p Scattering Cross Sections at Low Energy

In this paper we report cross-section measurements for $\Xi^-p$ elastic and inelastic scatterings at low energy using a scintillating fiber active target. Upper limit on the total cross-section for the elastic scattering was found to be 24 mb at 90% confidence level, and the total cross section for the $\Xi^-p\to\Lambda\Lambda$ reaction was found to be $4.3^{+6.3}_{-2.7}$ mb. We compare the results with currently competing theoretical estimates.Comment: 9 page

Development, intercomparison, and evaluation of an improved mechanism for the oxidation of dimethyl sulfide in the UKCA model

Dimethyl sulfide (DMS) is an important trace gas emitted from the ocean. The oxidation of DMS has long been recognised as being important for global climate through the role DMS plays in setting the sulfate aerosol background in the troposphere. However, the mechanisms in which DMS is oxidised are very complex and have proved elusive to accurately determine in spite of decades of research. As a result the representation of DMS oxidation in global chemistry–climate models is often greatly simplified. Recent field observations and laboratory and ab initio studies have prompted renewed efforts in understanding the DMS oxidation mechanism, with implications for constraining the uncertainty in the oxidation mechanism of DMS as incorporated in global chemistry–climate models. Here we build on recent evidence and develop a new DMS mechanism for inclusion in the UK Chemistry Aerosol (UKCA) chemistry–climate model. We compare our new mechanism (CS2-HPMTF) to a number of existing mechanisms used in UKCA (including the highly simplified three-reactions–two-species mechanism used in CMIP6 studies with the model) and to a range of recently developed mechanisms reported in the literature through a series of global and box model experiments. Global model runs with the new mechanism enable us to simulate the global distribution of hydroperoxylmethyl thioformate (HPMTF), which we calculate to have a burden of 2.6–26 Gg S (in good agreement with the literature range of 0.7–18 Gg S). We show that the sinks of HPMTF dominate uncertainty in the budget, not the rate of the isomerisation reaction forming it and that, based on the observed DMS / HPMTF ratio from the global surveys during the NASA Atmospheric Tomography mission (ATom), rapid cloud uptake of HPMTF worsens the model–observation comparison. Our box model experiments highlight that there is significant variance in simulated secondary oxidation products from DMS across mechanisms used in the literature, with significant divergence in the sensitivity of the rates of formation of these products to temperature exhibited; especially for methane sulfonic acid (MSA). Our global model studies show that our updated DMS scheme performs better than the current scheme used in UKCA when compared against a suite of surface and aircraft observations. However, sensitivity studies underscore the need for further laboratory and observational constraints. In particular our results suggest that as a priority long-term DMS observations be made to better constrain the highly uncertain inputs into the system and that laboratory studies be performed that address (1) the uptake of HPMTF onto aerosol surfaces and the products of this reaction and (2) the kinetics and products of the following reactions: CH3SO3 decomposition, CH3S + O2, CH3SOO decomposition, and CH3SO + O3

Special Libraries, April 1933

Volume 24, Issue 3https://scholarworks.sjsu.edu/sla_sl_1933/1002/thumbnail.jp

Prunella vulgaris: A comprehensive review of chemical constituents, pharmacological effects and clinical applications.

Prunella vulgaris (PV) is a perennial herb belonging to the Labiate family and is widely distributed in northeastern Asian countries such as Korea, Japan, and China. It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. So far, about 200 compounds have been isolated from PV plant and majority of these have been characterized mainly as triterpenoids, sterols and flavonoids, followed by coumarins, phenylpropanoids, polysaccharides and volatile oils. This review summarizes and analyzes the current knowledge on the chemical constituents, pharmacological activities, mechanisms of action and clinical applications of the PV plant including its potential as a future medicinal plant. Although some of the chemical constituents of the PV plant and their mechanism of action have been investigated the biological activities of many of these remain unknown and further clinical trials are required to further enhance its reputation as a medicinal plant

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems

BackgroundHuman immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. This paucity is partially due to incomplete vital registration (VR) systems and statistical challenges related to estimating mortality rates in areas with low numbers of HIV deaths. In this analysis, we address this gap and provide novel estimates of the HIV mortality rate and the number of HIV deaths by age group, sex, and municipality in Brazil, Colombia, Costa Rica, Ecuador, Guatemala, and Mexico.MethodsWe performed an ecological study using VR data ranging from 2000 to 2017, dependent on individual country data availability. We modeled HIV mortality using a Bayesian spatially explicit mixed-effects regression model that incorporates prior information on VR completeness. We calibrated our results to the Global Burden of Disease Study 2017.ResultsAll countries displayed over a 40-fold difference in HIV mortality between municipalities with the highest and lowest age-standardized HIV mortality rate in the last year of study for men, and over a 20-fold difference for women. Despite decreases in national HIV mortality in all countries-apart from Ecuador-across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. In all six countries included in this analysis, 50% or more HIV deaths were concentrated in fewer than 10% of municipalities in the latest year of study. In addition, national age patterns reflected shifts in mortality to older age groups-the median age group among decedents ranged from 30 to 45years of age at the municipality level in Brazil, Colombia, and Mexico in 2017.ConclusionsOur subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. This analysis provides a framework for incorporating data and uncertainty from incomplete VR systems and can help guide more geographically precise public health intervention to support HIV-related care and reduce HIV-related deaths.Peer reviewe

Search for leptophobic Z ' bosons decaying into four-lepton final states in proton-proton collisions at root s=8 TeV

Peer reviewe

Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV

Peer reviewe