Un AVC ischémique a IRM cérébrale normale: à propos d’un cas

L'IRM cérébrale reste un examen de référence pour diagnostiquer un accident vasculaire cérébrale. La sensibilité au cours d'un accident vasculaire cérébrale à la phase aigüe n'atteint pas toujours 100%. Nous rapportons un cas d'un accident vasculaire cérébral ischémique à IRM cérébrale initiale normale. L'IRM cérébrale normale à la phase précoce d'un accident vasculaire cérébrale pose un doute sur l'indication de la thrombolyse qui est le traitement de référence en cas d'embole cérébrale. La répétition d'un examen avec coupe fine, en séquence de diffusion B2000 permettrait de mettre en évidence l'infarctus de très petit volume non visualisé par IRM cérébrale conventionnelle

Profil Tensionnel des Patients Parkinsoniens Idiopathiques vus au Service de Neurologie de Pontarlier

Introduction: Idiopathic Parkinson's disease is a neurodegenerative disorder characterized by motor disorders, akinesia or bradykinesia, rigidity, resting tremor and impaired posture reflexes or even frequent falls. In daily practice, an abnormal blood pressure profile is often observed in parkinsonian patients. In this study, we described the 24h blood pressure profile in our patients with idiopathic Parkinson's disease. Methodology: This is a prospective and descriptive observational study of patients hospitalized from May to October 2016 for idiopathic Parkinson's disease at the Department of Neurology at Pontarlier Hospital. We included all patients with an UPDRS (Unified Parkinson's Disease Rating Scale) score greater than 12 who made a holter TA record for 24 hours. Results: We selected 50 patients, 15 women and 35 men (a sex ratio between men and women of 2.33), aged 45 to 84, average 65.24 and standard deviation 3.04. The blood pressure profile was normal for 24h in 10 patients (20%). The remainder, 40 patients (80%), showed during the 24 hours of recording an alternation of arterial hypotension and normotension. Peaks of onset of arterial hypotension were 9h and 15h. The signs associated with this low blood pressure were falls with loss of consciousness (20%), isolated falls (12%), vertigo (11%), visual blur (8%), and other signs (25%). Conclusion: The particular clinical manifestations related to hypotension deserve more attention from us based on the interest of a systematic research in all the parkinsonian and related patients.Introduction : La maladie de Parkinson idiopathique est une affection neurodégénérative caractérisée par des troubles moteurs, l’akinésie ou bradykinésie, la rigidité, le tremblement de repos et altération des réflexes de posture voire des chutes fréquentes. Dans la pratique quotidienne, une anomalie du profil tensionnel est souvent observée chez les malades parkinsoniens. Notre objectif est de décrire le profil tensionnel pendant 24h chez nos patients atteints de la maladie de Parkinson idiopathique. Méthode : Il s'agit d'une étude d’observation prospective et descriptive portant sur des patients hospitalisés de mai à octobre 2016 pour une maladie de Parkinson idiopathique au service de Neurologie à l’hôpital de Pontarlier. Nous avons inclus tous les patients ayant un score UPDRS (Unified Parkinson’s Disease Rating Scale) supérieur à 12 ayant effectués un enregistrement holter TA pendant 24h. Résultats : Nous avons retenu 50 patients, 15 femmes et 35 hommes (soit un sex-ratio homme-femme de 2,33), âgés de 45 à 84 ans, moyenne 65,24 et ecart type 3,04. Le profil tensionnel était normal chez 10 patients soit 20%. Chez 40 patients soit 80% de cas a été retrouvée une hypotension artérielle et/ou une normotension. Les pics d'apparition de l'hypotension artérielle se situaient entre 9h et 15h. Les signes associés à cette hypotension artérielle étaient soit des chutes avec perte de connaissance brève chez 20%, des chutes sans perte de connaissance chez 12%, des vertiges chez 11%, un flou visuel chez 8% et d'autres signes chez 25%. Conclusion : Les manifestations cliniques particulières liées à l'hypotension artérielle méritent plus d'attention de notre part d’où l’intérêt d’une recherche systématique chez tout les malades parkinsoniens et apparenté

Use of twitter data for waste minimisation in beef supply chain

Approximately one third of the food produced is discarded or lost, which accounts for 1.3 billion tons per annum. The waste is being generated throughout the supply chain viz. farmers, wholesalers/processors, logistics, retailers and consumers. The majority of waste occurs at the interface of retailers and consumers. Many global retailers are making efforts to extract intelligence from customer’s complaints left at retail store to backtrack their supply chain to mitigate the waste. However, majority of the customers don’t leave the complaints in the store because of various reasons like inconvenience, lack of time, distance, ignorance etc. In current digital world, consumers are active on social media and express their sentiments, thoughts, and opinions about a particular product freely. For example, on an average, 45,000 tweets are tweeted daily related to beef products to express their likes and dislikes. These tweets are large in volume, scattered and unstructured in nature. In this study, twitter data is utilised to develop waste minimization strategies by backtracking the supply chain. The execution process of proposed framework is demonstrated for beef supply chain. The proposed model is generic enough and can be applied to other domains as well

Dasatinib as a Bone-Modifying Agent: Anabolic and Anti-Resorptive Effects

This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: Bone loss, in malignant or non-malignant diseases, is caused by increased osteoclast resorption and/or reduced osteoblast bone formation, and is commonly associated with skeletal complications. Thus, there is a need to identify new agents capable of influencing bone remodeling. We aimed to further pre-clinically evaluate the effects of dasatinib (BMS-354825), a multitargeted tyrosine kinase inhibitor, on osteoblast and osteoclast differentiation and function. [Methods]: For studies on osteoblasts, primary human bone marrow mensenchymal stem cells (hMSCs) together with the hMSC-TERT and the MG-63 cell lines were employed. Osteoclasts were generated from peripheral blood mononuclear cells (PBMC) of healthy volunteers. Skeletally-immature CD1 mice were used in the in vivo model. [Results]: Dasatinib inhibited the platelet derived growth factor receptor-β (PDGFR-β), c-Src and c-Kit phosphorylation in hMSC-TERT and MG-63 cell lines, which was associated with decreased cell proliferation and activation of canonical Wnt signaling. Treatment of MSCs from healthy donors, but also from multiple myeloma patients with low doses of dasatinib (2-5 nM), promoted its osteogenic differentiation and matrix mineralization. The bone anabolic effect of dasatinib was also observed in vivo by targeting endogenous osteoprogenitors, as assessed by elevated serum levels of bone formation markers, and increased trabecular microarchitecture and number of osteoblast-like cells. By in vitro exposure of hemopoietic progenitors to a similar range of dasatinib concentrations (1-2 nM), novel biological sequelae relative to inhibition of osteoclast formation and resorptive function were identified, including F-actin ring disruption, reduced levels of c-Fos and of nuclear factor of activated T cells 1 (NFATc1) in the nucleus, together with lowered cathepsin K, αVβ3 integrin and CCR1 expression. [Conclusions]: Low dasatinib concentrations show convergent bone anabolic and reduced bone resorption effects, which suggests its potential use for the treatment of bone diseases such as osteoporosis, osteolytic bone metastasis and myeloma bone disease. © 2012 Garcia-Gomez et al.This work was supported by grants from the Spanish Ministry of Science and Innovation – ISCIII (PI081825); Mutua Madrileña Medical Research Foundation (AP27262008); Centro en Red of Regenerative Medicine and Cellular Therapy from Castilla y León, Consejería de Sanidad JCyL – ISCIII; the Cooperative Research Thematic Network in Cancer (RTICC; RD06/0020/0006 and RD03/0020/0041); and Spanish FIS (PS09/01897). AG-G and CS are supported by the Centro en Red of Regenerative Medicine and Cellular Therapy from Castilla y León Project.Peer Reviewe

Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma

Objectives The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were >50 copies/mL in both compartments and bulk genotypic tests were realized. Results On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P = 0.0455) and T215Y (P = 0.0455). Conclusions In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performe

Chapter 19 Noise pollution and its impact on human health and the environment

This chapter deals with (1) the basic theory of sound propagation; (2) an overview of noise pollution problem in view of policy and standards by the World Health Organization, the United States, and the European Union; (3) noise exposure sources from aircraft, road traffic and railways, in-vehicle, work, and construction sites, and occupations, and households; (4) the noise pollution impact on human health and the biological environment; (5) modeling of regional noise-affected habitats in protected and unprotected land areas and the marine environment; (6) noise control measures and sustainability in view of sustainable building design, noise mapping, and control measures such as barriers and berms along roadsides, acoustic building materials, roadway vehicle noise source control, road surface, and pavement materials; and (7) environmental noise pollution management measures and their impact on human health

Glossaire illustré sur les formes d’altération de la pierre

The ICOMOS International Scientific Committee for Stone (ISCS) is providing a forum for the interchange of experience, ideas, and knowledge in the field of stone conservation. ISCS aims at facilitating the publication, dissemination and presentation of state of the art reviews on pre-identified issues. Simplification and demystification of scientific information for practitioners are also part of the main goals of the group. In studies on stone deterioration and conservation, terminological confusions lead to major communication problems between scientists, conservators and practitioners. In this context, it is of primary importance to set up a common language; if degradation patterns can be shown, named and described, then they can be recognised and compared with similar ones in a more accurate way in further investigations. The ISCS glossary constitutes an important tool for scientific discussions on decay phenomena and processes. It is also an excellent basis for tutorials on stone deterioration. It is based on the careful examination of pre-existing glossaries of English terms. It does not aim at replacing these glossaries, often set up originally in a language other than English, and for most of them done to a high standard. As President of ICOMOS I would like to congratulate the International Scientific Committee for Stone and its President Véronique Verges-Belmin for the results of years of research presented in this publication. Stone conservation is a crucial topic in monument conservation and many of our National Committees all over the world hope for advice and help from the specialists familiar with traditional and modern methods of conservation. The Illustrated Glossary on Stone Deterioration Patterns offers a wide range of suggestions and practical advice. Probably, after the English-French version becomes available the Glossary will also be translated into other languages. In view of the accelerating decay of our stone monuments worldwide this is an exemplary contribution which will promote the international cooperation so important in this field.peer-reviewe

Environmental geochemistry of radioactive contamination.

This report attempts to describe the geochemical foundations of the behavior of radionuclides in the environment. The information is obtained and applied in three interacting spheres of inquiry and analysis: (1) experimental studies and theoretical calculations, (2) field studies of contaminated and natural analog sites and (3) model predictions of radionuclide behavior in remediation and waste disposal. Analyses of the risks from radioactive contamination require estimation of the rates of release and dispersion of the radionuclides through potential exposure pathways. These processes are controlled by solubility, speciation, sorption, and colloidal transport, which are strong functions of the compositions of the groundwater and geomedia as well as the atomic structure of the radionuclides. The chemistry of the fission products is relatively simple compared to the actinides. Because of their relatively short half-lives, fission products account for a large fraction of the radioactivity in nuclear waste for the first several hundred years but do not represent a long-term hazard in the environment. The chemistry of the longer-lived actinides is complex; however, some trends in their behavior can be described. Actinide elements of a given oxidation state have either similar or systematically varying chemical properties due to similarities in ionic size, coordination number, valence, and electron structure. In dilute aqueous systems at neutral to basic pH, the dominant actinide species are hydroxy- and carbonato-complexes, and the solubility-limiting solid phases are commonly oxides, hydroxides or carbonates. In general, actinide sorption will decrease in the presence of ligands that complex with the radionuclide; sorption of the (IV) species of actinides (Np, Pu, U) is generally greater than of the (V) species. The geochemistry of key radionuclides in three different environments is described in this report. These include: (1) low ionic strength reducing waters from crystalline rocks at nuclear waste research sites in Sweden; (2) oxic water from the J-13 well at Yucca Mountain, Nevada, the site of a proposed repository for high level nuclear waste (HLW) in tuffaceous rocks; and (3) reference brines associated with the Waste Isolation Pilot Plant (WIPP). The transport behaviors of radionuclides associated with the Chernobyl reactor accident and the Oklo Natural Reactor are described. These examples span wide temporal and spatial scales and include the rapid geochemical and physical processes important to nuclear reactor accidents or industrial discharges as well as the slower processes important to the geologic disposal of nuclear waste. Application of geochemical information to remediating or assessing the risk posed by radioactive contamination is the final subject of this report. After radioactive source terms have been removed, large volumes of soil and water with low but potentially hazardous levels of contamination may remain. For poorly-sorbing radionuclides, capture of contaminated water and removal of radionuclides may be possible using permeable reactive barriers and bioremediation. For strongly sorbing radionuclides, contaminant plumes will move very slowly. Through a combination of monitoring, regulations and modeling, it may be possible to have confidence that they will not be a hazard to current or future populations. Abstraction of the hydrogeochemical properties of real systems into simple models is required for probabilistic risk assessment. Simplifications in solubility and sorption models used in performance assessment calculations for the WIPP and the proposed HLW repository at Yucca Mountain are briefly described