2,308 research outputs found

    Business or third sector? What are the dimensions and implications of researching and conceptualising the overlap between business and third sector?

    Get PDF
    This paper is designed to ‘problematise’ the business/third sector boundary in order to inform future research into third sector theorising or policy development. It sets out some of the reasons behind the development of the concepts of the ‘third sector’ and ‘social enterprise’ in the UK, and briefly shows the scope and limits of the different theories underpinning European and US-influenced research and practice. It also illustrates some of the many dimensions, motivations and values of the kinds of organisations to be found in this cross-over space, as well as the challenges and opportunities which this diversity creates for any future research or policy creation

    Widespread democratic change could trigger meaningful action on climate change

    Get PDF
    Meaningful multilateral action on climate change has been hard to come by, with objections from several countries – most notably the United States – often derailing attempts to bring carbon emissions down and thus global temperatures at a more manageable level. Here, Andrea Westall argues that democratic innovation and change could create a political context in which action on climate change becomes more likely

    Ginkgo biloba

    Get PDF

    Innovation Inside

    Get PDF
    When it comes to successful product and service innovation, the marketing team might have done a good job in developing a winning proposition, but unless they pay as much attention to organizational innovation to enable delivery, they may not get it off the ground

    Evidence of microbial activity from a shallow water whale fall (Voghera, northern Italy)

    Get PDF
    The fossil bones, associated carbonate cements and enclosing concretion of a Miocene mysticete from inner shelf deposits (Monte Vallassa Formation, northern Italy) were analyzed for evidence of microbial activity. Optical and scanning electron microscopy, Raman spectroscopy, and stable C and O isotope geochemistry were used for high spatial resolution microfacies and biosedimentological analyses. Whale cancellous bones were filled by different carbonate cements including microcrystalline dolomite, rhombohedral dolomite and sparry calcite. Biofabric and biominerals such as microbial peloids, clotted textures and pyrite framboids were associated with the dolomite cements. Dolomite inside cancellous bones and in the enclosing concretion showed similar isotopic values (avg δ 13C: -7.12‰; avg δ 18O: +3.81‰), depleted with respect to the (late) sparry calcite cement (avg δ 13C: -0.55‰; avg δ 18O: -0.98‰). Microcrystalline barite (BaSO 4) was observed on the external surface of the bones. In addition, two different types of microborings were recognized, distinguished by their size and morphology and were ascribed respectively to prokaryote and fungal trace makers. Our results testify for the development of a diverse microbial ecosystem during the decay of a shallow water whale carcass, which could be detected in the fossil record. However, none of the observed biosignatures (e.g., microbial peloids, clotted textures) can be used alone as a positive fossil evidence of the general development of a sulfophilic stage of whale fall ecological succession. The occurrence of the hard parts of chemosynthetic invertebrates associated with fossil whale bones is still the more convincing proof of the development of a sulfide-base chemoautotrophic ecosystem. © 2011 Elsevier B.V

    The Effect of Color Overlays on Oral Reading Performance

    Get PDF
    A study was performed on adults taken from the Need to Read and General Education Degree programs administered by Midland College. This study utilized color overlays to ascertain the effect of the overlays on oral reading performance of subjects ascertained to have symptoms indicative of scotopic sensitivity syndrome, SSS. Adults were randomly assigned to control and experimental groups and pre-tested and post-tested with the Slosson Oral Reading Test. The experimental group received the treatment of color overlays in the post-test. Results of the study showed the null hypothesis was rejected and color overlays do affect oral reading performance of probable scotopic sensitivity syndrome subjects

    Characterisation of actin probe microenvironments using spectral phasor analysis

    Get PDF
    Actin plays a crucial role in cellular processes ranging from the maintenance of cell structure, motility, signal transduction, and intracellular transport. The advances in structural biology, molecular genetics, and fluorescence microscopy techniques over the last eight decades have enabled scientists to investigate actin extensively. Although a great deal of understanding has been acquired regarding the structure, function, and regulation of actin, further characterisation of actin microenvironments is required, particularly for the elucidation of actin isoforms, their localisation, and differential functions. The use of fluorescent probes in conjunction with advanced microscopy techniques has been instrumental in expanding the knowledge of actin within cellular landscapes. Spectral Phasor analysis is a technique that is capable of the hyperspectral characterisation of the spectral properties of individual fluorescent probes. Shifts in the spectral properties of probes can be linked to changes in the probes local microenvironment. Therefore, the further development of Spectral Phasor analysis for spectral characterisation is expected to lead to greater understanding of actin in cellular processes. This study investigates the use of Spectral Phasor analysis as a hyperspectral tool and its applicability to characterise the microenvironments of actin probes in actin filaments. This approach was applied to fluorescent actin probes, ActinGreen and ACTA1-488, in a fixed cell model where the spectral properties of the probes were characterised and compared in their discrete binding domains on actin in various cellular regions and when influenced by the actin disruptor, Latrunculin A. The application of Spectral Phasor analysis for the characterisation of actin probe microenvironments revealed that ActinGreen and ACTA1-488 exhibit characteristic spectral properties when bound in their respective domains in filament and nuclei regions. Further, distinct spectral properties were revealed for ActinGreen and ACTA1-488 when compared across the plasma membrane, cytoplasm, and nuclear membrane regions of fixed cells. Finally, shifts in spectral properties were observed in ActinGreen and ACTA1-488 microenvironments post treatment with Latrunculin A in both region of interest sets described above. The work conducted here demonstrates that Spectral Phasor analysis can be applied to characterise distinct spectral properties of fluorescent actin probe microenvironments in a fixed cell model based on differences in their binding domains, cellular environment, and in response to an actin disrupting compound. With ongoing development and optimisation, Spectral Phasor analysis can be applied to further hyperspectral characterisation of actin isoform microenvironments in fixed cell models, with the possibility of advancing to live cell characterisation in the future

    Childhood Obesity in the Spanish Press

    Get PDF
    La investigación se centra en el fenómeno de sobrepeso y obesidad infantil y su representación en 120 noticias recogidas de las ediciones digitales de tres periódicos españoles (ABC, El Mundo, El País) y publicadas entre el 1 de enero y el 30 de junio del año 2008. El análisis del contenido proporcionó datos relevantes sobre 1) la distribución de las noticias por fuente y fecha, y 2) el contenido presentado durante este tiempo. Predominaron las noticias sobre la alimentación y hábitos alimenticios (n=22; 18,3%) y los estudios de prevalencia (n=18; 15%). Los temas comunes a los tres diarios fueron los relacionados con la salud mental de los españoles en marzo, la muerte de un niño obeso de cinco años en Murcia en abril, y las dietas “milagro” en mayo.This study aims to examine how the Spanish press reports on the topic of childhood overweight and obesity in a 120-item sample complied from the online editions of three major Spanish newspapers (ABC, El Mundo, El País) between 1 January and 30 June 2008. A content analysis provided valuable data related to 1) the frequency and distribution of news regarding childhood overweight and obesity, and 2) the contents presented during the six-month period. The topics of foods and eating habits (n=22; 18.3%) and the incidence of childhood overweight and obesity (n=18; 15%) were prevalent throughout the study period. All three daily papers published articles related to Spaniards’ mental health, the death of an obese 5-year old in Murcia and “miracle” diets in the months of March, April and May, respectively
    corecore