24 research outputs found
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
- Author
- Baker Alexander T.
- Bates Emily
- Borad Mitesh J.
- Boyd Ryan J.
- Chan Chun Kit
- Chiu Po-Lin
- Cohen Taylor S.
- Coughlan Lynda
- Fromme Petra
- Heurich Meike
- Lipka-Lloyd Magdalena
- Machiesky LeeAnn
- Nagalo Bolni M.
- Parker Alan L.
- Rizkallah Pierre J.
- Sarkar Daipayan
- Singharoy Abhishek
- Teijeira-Crespo Alicia
- Truong Chloe D.
- Umlauf Scott
- Vant John
- Vermaas Josh
- Waraich Kasim
- Williams Dewight
- Wilson Eric
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/12/2021
- Field of study
Get PDFVaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. As part of the largest vaccination campaign in history, ultrarare side effects not seen in phase 3 trials, including thrombosis with thrombocytopenia syndrome (TTS), a rare condition resembling heparin-induced thrombocytopenia (HIT), have been observed. This study demonstrates that all three adenoviruses deployed as vaccination vectors versus SARS-CoV-2 bind to platelet factor 4 (PF4), a protein implicated in the pathogenesis of HIT. We have determined the structure of the ChAdOx1 viral vector and used it in state-of-the-art computational simulations to demonstrate an electrostatic interaction mechanism with PF4, which was confirmed experimentally by surface plasmon resonance. These data confirm that PF4 is capable of forming stable complexes with clinically relevant adenoviruses, an important step in unraveling the mechanisms underlying TTS.
Abstract
INTRODUCTION
RESULTS
DISCUSSION
MATERIALS AND METHODS
Acknowledgments
Supplementary Materials
REFERENCES AND NOTES
0eLetters
Abstract
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. As part of the largest vaccination campaign in history, ultrarare side effects not seen in phase 3 trials, including thrombosis with thrombocytopenia syndrome (TTS), a rare condition resembling heparin-induced thrombocytopenia (HIT), have been observed. This study demonstrates that all three adenoviruses deployed as vaccination vectors versus SARS-CoV-2 bind to platelet factor 4 (PF4), a protein implicated in the pathogenesis of HIT. We have determined the structure of the ChAdOx1 viral vector and used it in state-of-the-art computational simulations to demonstrate an electrostatic interaction mechanism with PF4, which was confirmed experimentally by surface plasmon resonance. These data confirm that PF4 is capable of forming stable complexes with clinically relevant adenoviruses, an important step in unraveling the mechanisms underlying TTS
Measurement of the inclusive isolated-photon cross section in pp collisions at √s = 13 TeV using 36 fb−1 of ATLAS data
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- Yexley M. R.
- Yigitbasi E.
- Yorita K.
- Yoshihara K.
- Young C.
- Young C. J. S.
- Yu J.
- Yuan R.
- Yue X.
- Yuen S. P. Y.
- Zabinski B.
- Zacharis G.
- Zaffaroni E.
- Zahreddine J.
- Zaitsev A. M.
- Zakareishvili T.
- Zakharchuk N.
- Zambito S.
- Zanzi D.
- Zaripovas Donatas
- Zeitnitz C.
- Zeißner S. V.
- Zemaityte G.
- Zeng J. C.
- Zenin O.
- Zerwas D.
- Zgubič M.
- Zhang D. F.
- Zhang F.
- Zhang G.
- Zhang G.
- Zhang H.
- Zhang J.
- Zhang L.
- Zhang L.
- Zhang M.
- Zhang R.
- Zhang R.
- Zhang X.
- Zhang Y.
- Zhang Z.
- Zhang Z.
- Zhao P.
- Zhao Y.
- Zhao Z.
- Zhemchugov A.
- Zheng Z.
- Zhong D.
- Zhou B.
- Zhou C.
- Zhou M.
- Zhou M. S.
- Zhou N.
- Zhou Y.
- Zhu C. G.
- Zhu H.
- Zhu H. L.
- Zhu J.
- Zhu Y.
- Zhuang X.
- Zhukov K.
- Zhulanov V.
- Zieminska D.
- Zimine N. I.
- Zimmermann S.
- Zinonos Z.
- Ziolkowski M.
- Zobernig G.
- Zoccoli A.
- Zoch K.
- Zorbas T. G.
- Zou R.
- Zwalinski L.
- Álvarez Piqueras D.
- Åkesson T. P. A.
- Šforza F.
- Ženiš T.
- Živković L.
- Publication venue
- Institute of Physics Publishing
- Publication date
- 01/01/2019
- Field of study
Get PDFThe differential cross section for isolated-photon production in pp collisions is measured at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC using an integrated luminosity of 36.1 fb. The differential cross section is presented as a function of the photon transverse energy in different regions of photon pseudorapidity. The differential cross section as a function of the absolute value of the photon pseudorapidity is also presented in different regions of photon transverse energy. Next-to-leading-order QCD calculations from Jetphox and Sherpa as well as next-to-next-to-leading-order QCD calculations from Nnlojet are compared with the measurement, using several parameterisations of the proton parton distribution functions. The predictions provide a good description of the data within the experimental and theoretical uncertainties. [Figure not available: see fulltext.
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
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- Alimonti Gianluca
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- Anders Christoph
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- Angerami Aaron
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- Yamaguchi Yohei
- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
- Yoshihara Keisuke
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- Young Christopher
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- Yu Jie
- Yuen Stephanie
- Yusuff Imran
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- Zacharis Georgios
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Get PDFA search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Measurement of jet fragmentation in Pb+Pb and pp collisions at sNN=2.76 TeV with the ATLAS detector at the LHC
- Author
- Aad Georges
- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed Haide
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan Anton
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Alconada Verzini Maria Jose
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven Pat
- Allbrooke Benedict
- Allen Benjamin W
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah Aziz
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazi
- Amadio Brian Thom
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Pat
- Amorim Antonio
- Amoroso Simone
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Ste
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John Kenne
- Anderson Kelby
- Andreazza Attilio
- Andrei George Vic
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anghinolfi Francis
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel Jos
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan Pedro
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose Elisa
- Arduh Francisco
- Arguin Jean-Franc
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron Jame
- Armitage Lewis Jame
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim Bora
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad Ka
- Azuelos Georges
- Baas Alessandra
- Baca Matthew Jo
- Bachacou Henri
- Bachas Konstantin
- Backes Moritz
- Backhaus Malte
- Bagiacchi Paolo
- Bagnaia Paolo
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver Kei
- Baldin Evgenii
- Balek Petr
- Balestri Thomas
- Balli Fabrice
- Balunas William Ke
- Banas Elzbieta
- Banerjee Swagato
- Bannoura Arwa A E
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Ste
- Barklow Timothy
- Barlow Nick
- Barnes Sarah Loui
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros do Vale Maria Alin
- Bartoldus Rainer
- Barton Adam Edwar
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago J
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder S
- Beacham James
- Beattie Michael Da
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- Bossio Sola Jonathan D
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- Carlino Gianpaolo
- Carlson Benjamin T
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German D
- Carvalho João
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- Casado Maria Pila
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- Chomont Arthur Ren
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- Clark Brian Lee
- Clark Michael
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- Clarke Robert
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- D'amen Gabriele
- D'Auria Saverio
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- Da Cunha Sargedas De Sousa Mario Jose
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- Dado Tomas
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
- Dandoy Jeffrey
- Dang Nguyen Phu
- Daniells Andrew Chr
- Dann Nicholas S
- Danninger Matthias
- Dano Hoffmann Maria
- Dao Valerio
- Darbo Giovanni
- Darmora Smita
- Dassoulas James
- Dattagupta Aparajita
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- de Asmundis Riccardo
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- De Vasconcelos Corga Kevin
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- De Kaushik
- Dearnaley William Ja
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- Dedovich Dmitri
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- Dührssen Michael
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- Fisher Wade Camer
- Flaschel Nils
- Fleck Ivor
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- Fletcher Rob Roy Ma
- Flick Tobias
- Flierl Bernhard M
- Flores Castillo Luis
- Flowerdew Michael
- Foerster Fabian Ale
- Forcolin Giulio Tiz
- Formica Andrea
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- Foster Andrew Geo
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- Freund Benjamin
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- Fuster Juan
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- Gach Grzegorz
- Gadatsch Stefan
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- Galster Gorm Aske
- Gan KK
- Ganguly Sanmay
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- Gao Yongsheng
- Garay Walls Francisca
- Garcia-Sciveres Maurice
- García Navarro José Enri
- García Carmen
- Gardner Robert
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- Gaudio Gabriella
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- Gay Colin
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- Gee Norman
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- Gellerstedt Karl
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- Gilles Geoffrey
- Gingrich Douglas
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- Giordani MarioPaolo
- Giorgi Filippo Ma
- Giraud Pierre-Fra
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- Giugni Danilo
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- Giuliani Claudia
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- Gjelsten Børge Kil
- Gkaitatzis Stamatios
- Gkialas Ioannis
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- Glaysher Paul
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- Godlewski Jan
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- Golling Tobias
- Golubkov Dmitry
- Gomes Agostinho
- Goncalves Gama Rafael
- Goncalves Pinto Firmino Da Costa Joao
- Gonella Giulia
- Gonella Laura
- Gongadze Alexi
- Gonzalez-Sevilla Sergio
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- Gonçalo Ricardo
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- Gorini Edoardo
- Gorišek Andrej
- Goshaw Alfred
- Gostkin Mikhail Iv
- Goudet Christophe
- Goujdami Driss
- Goussiou Anna
- Govender Nicolin
- Gozani Eitan
- Graber Lars
- Grabowska-Bold Iwona
- Gradin Per Olov J
- Gramling Johanna
- Gramstad Eirik
- Grancagnolo Sergio
- Gratchev Vadim
- Gravila Paul Mirce
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- Greenwood Zeno Dixon
- Grefe Christian
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- Gregor Ingrid-Mar
- Grenier Philippe
- Grevtsov Kirill
- Griffiths Justin
- Grillo Alexander
- Grimm Kathryn
- Grinstein Sebastian
- Gris Philippe L
- Grivaz Jean-Franc
- Groh Sabrina
- Gross Eilam
- Grosse-Knetter Joern
- Grossi Giulio Cor
- Grout Zara Jane
- Grummer Aidan
- Guan Liang
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- Gul Umar
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- Gutierrez Ortiz Nicolas Gi
- Gutierrez Phillip
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- Guyot Claude
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- Gwenlan Claire
- Gwilliam Carl
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- Haddad Nacim
- Hadef Asma
- Hageböck Stephan
- Hagihara Mutsuto
- Hakobyan Hrachya
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- Hamity Guillermo
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- Hanawa Keita
- Hance Michael
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- Hansen Maike Chri
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- Hara Kazuhiko
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- Hasegawa Makoto
- Hasegawa Yoji
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- Havener Laura Brit
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- Hawkes Christophe
- Hawkings Richard Jo
- Hayakawa Daiki
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- Hays Chris
- Hays Jonathan M
- Hayward Helen
- Haywood Stephen
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- Heck Tobias
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- Helsens Clement
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- Henkelmann Steffen
- Henriques Correia Ana Maria
- Henrot-Versille Sophie
- Herbert Geoffrey H
- Herde Hannah
- Herget Verena
- Hernández Jiménez Yesenia
- Herten Gregor
- Hertenberger Ralf
- Hervas Luis
- Herwig Theodor Ch
- Hesketh Gavin Gran
- Hessey Nigel
- Hetherly Jeffrey Wa
- Higashino Satoshi
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- Hill Ewan
- Hill John
- Hiller Karl Heinz
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- Hobbs John
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- Hodgkinson Mark
- Hodgson Paul
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- Hoenig Friedrich
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- Holmes Tova Ray
- Homann Michael
- Honda Shunsuke
- Honda Takuya
- Hong Tae Min
- Hooberman Benjamin H
- Hopkins Walter
- Horii Yasuyuki
- Horton Arthur Jam
- Hostachy Jean-Yves
- Hou Suen
- Hoummada Abdeslam
- Howarth James
- Hoya Joaquin
- Hrabovsky Miroslav
- Hristova Ivana
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- Hryn'ova Tetiana
- Hrynevich Aliaksei
- Hsu Pai-hsien
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- Hubaut Fabrice
- Huegging Fabian
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- Iakovidis Georgios
- Ibragimov Iskander
- Iconomidou-Fayard Lydia
- Idrissi Zineb
- Iengo Paolo
- Igonkina Olga
- Iizawa Tomoya
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- Ikeno Masahiro
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- Introzzi Gianluca
- Ioannou Pavlos
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- Ishino Masaya
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- Iturbe Ponce Julia Mari
- Iuppa Roberto
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- Jamin David Oliv
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- Jarlskog Göran
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- Jinnouchi Osamu
- Jivan Harshna
- Johansson Per
- Johns Kenneth
- Johnson Christian
- Johnson William Jo
- Jon-And Kerstin
- Jones Roger
- Jones Samuel Dav
- Jones Sarah
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- Jovicevic Jelena
- Ju Xiangyang
- Juste Rozas Aurelio
- Jézéquel Stéphane
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- Kagan Michael
- Kahn Sebastien
- Kaji Toshiaki
- Kajomovitz Enrique
- Kalderon Charles Wi
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- Kamenshchikov Andrey
- Kanaya Naoko
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- Kanjir Luka
- Kantserov Vadim
- Kanzaki Junichi
- Kaplan Benjamin
- Kaplan Laser Seym
- Kar Deepak
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- Zimmermann Stephanie
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- Zobernig Georg
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- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/06/2017
- Field of study
Get PDFPregnancy and Thyroid Cancer
- Author
- B Weisz
- C Bal
- CL Harmer
- D Glinoer
- D.G Neale Burrow
- DA Fisher
- EK Alexander
- F Raue
- G Morreale de Escobar
- GE Krassas
- GH Tan
- GN Burrow
- I Hay
- IB Rosen
- J Dussault
- JE Haddow
- JH Lazarus
- JH Mestman
- K Kobayashi
- KH Nam
- L Vini
- LH Smith
- M Hod
- M Moosa
- M Schlumberger
- MA Rossing
- ME Dottorini
- MJ Obregon
- MS Shah
- O Gimm
- P Zhang
- PJ Bradley
- S Blazer
- S Yasmeen
- T Kondo
- T Rago
- T Takano
- T Thomas
- T Truong
- TB O’Connell
- TT Lao
- TW Furlanetto
- VJ Pop
- W Chloe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
No full textMake EU trade with Brazil sustainable
- Author
- Aalders Inge
- Aavik Tsipe
- Addison Prue
- af Segerstad Louise Hard
- Aguilee Robin
- Aguilera Eduardo
- Albanito Fabrizio
- Alexanderson Helena
- Alonso Juan C.
- Alonso-Alvarez Carlos
- Altringham John
- Alvarez Matheus Rodriguez
- Ammer Christian
- Amo Luisa
- Andresen Louise C.
- Ange Olivia
- Antal Miklos
- Antonelli Alexandre
- Antwis Rachael
- Aragon Pedro
- Arlidge William
- Arlt Debora
- Ascensao Fernando
- Ascoli Davide
- Bacon Christine D.
- Bager Simon L.
- Bagneres Anne-Genevieve
- Balmford Andrew
- Balmford Andrew
- Banks-Leite Cristina
- Barlow Jos
- Barrientos Rafael
- Bastos Araujo Miguel
- Batsleer Femke
- Battisti Corrado
- Battiston Roberto
- Bauer Barbara
- Baumann Matthias
- Benavides Lucia
- Bennett Dominic J.
- Benyei Petra
- Berenguer Erika
- Bernardo-Madrid Ruben
- Bhan Manan
- Biedermann Peter
- Billen Gilles
- Bjoersne Anna-Karin
- Bjorck Svante
- Bjorklund Heidi
- Blanco Moreno Jose M.
- Bleyhl Benjamin
- Bocquillon Pierre
- Boehnert Tim
- Bongalov Boris
- Boonstra Wiebren
- Booth Hollie
- Borges Paulo A. V.
- Borregaard Michael Krabbe
- Borrell Asuncion
- Boto Luis
- Brambach Fabian
- Briens Francois
- Brown Calum
- Brumelis Guntis
- Bruna Josef
- Buckley David
- Buckley Yvonne
- Buzzetti Filippo Maria
- Cabello Javier
- Cabeza Mar
- Cabral Juliano Sarmento
- Cahen-Fourot Louison
- Caillon Sophie
- Canals Oriol
- Canteri Elisabetta
- Caprio Enrico
- Cardoso Pedro
- Carmenta Rachel
- Carnicer Jofre
- Carrillo Juan D.
- Carvalho Joana
- Casazza Marco
- Cassar Louis F.
- Cathy Vet Gibault
- Cattaneo Claudio
- Celine Bellard
- Cesarz Simone
- Challender Dan
- Chenet Hugues
- Chobanov Dragan Petrov
- Christie Alec Philip
- Christophe Piquet Julien
- Chuine Isabelle
- Chvatalova Veronika
- Clark Mike
- Coenen Johanna
- Colino Rabanal Victor
- Collalti Alessio
- Comandulli Carolina
- Conde Marta
- Conrad Elisabeth
- Cooke Sophia
- Cooper Conor
- Corbera Esteve
- Cordero Ana Maria Araujo
- Cornell Sarah
- Cotta Benedetta
- Cottyn Hanne
- Crona Beatrice
- Csergo Anna Maria
- Curtis David
- D'Amico Marcello
- da Fonte Luis Fernando Marin
- da Silva Jessica Fonseca
- da Silva Sven
- Danet Alain
- Daniel-Ferreira Juliana
- Dara Andrey
- Darras Kevin
- Dauriach Alice
- Davoli Marco
- Daw Tim
- de Agua Luis Borda
- de Castro Fabio
- de Castro Paula Drummond
- de Freitas Flavio Luiz Mazzaro
- de Frutos Angel
- De Knijf Geert
- de la Pena Eduardo
- De la Riva Ignacio
- De Marzo Teresa
- De Smedt Pallieter
- De Smedt Sebastian
- de Waroux Yann le Polain
- Deguines Nicolas
- Dengler Juergen
- Di Gregorio Monica
- Diaz Mario
- Doherty Anya
- Domingos Tiago
- Duran Paz
- Durieux Laurent
- Edler Daniel
- Eiro Flavio
- Eisenhauer Nico
- Elias Marianne
- Emperaire Laure
- Engel Thore
- Engert Manuela
- Engl Tobias
- Engler Jan Oliver
- Englund Oskar
- Enqvist Johan
- Enseroth Tanja
- Erb Karlheinz
- Eriksson K. Martin
- Ernst Stefan
- Escobar Neus
- Esculier Fabien
- Essl Franz
- Evans Amy Louise
- Faberova Tamara
- Fandos Guillermo
- Fargallo Juan A.
- Farrell Katharine N.
- Felipe-Lucia Maria
- Felix Rob
- Fernandez-Llamazares Alvaro
- Figueiredo Ludmilla
- Fischer Joern
- Fischer-Kowalski Marina
- Fitton Nuala
- Fleischer Katrin
- Florencio Margarita
- Florez Laura V.
- Fraixedas Sara
- Franco Aldina
- Frantz David
- Friis Cecilie
- Frossard Carolina M.
- Fuchs Richard
- Gambin Belinda
- Garcia del Amo David
- Garcia Maria Mancilla
- Garnett Emma
- Garnett Tara
- Garnier Josette
- Gebara Maria Fernanda
- Geldmann Jonas
- Gerlach Justin
- Geschke Jonas
- Ghazoul Jaboury
- Gherghel Iulian
- Ghoddousi Arash
- Gil Diego
- Gledhill John
- Godde Cecile
- Goepel Jan
- Goerg Christoph
- Golland Ami
- Gollnow Florian
- Gomes Carmen Bessa
- Gonzalez Adriana Trompetero
- Goula Marta
- Granda Elena
- Grass Ingo
- Greenfield Michael
- Gremillet David
- Grieco Elisa
- Grilo Clara
- Gruychev Gradimir Valentinov
- Guedes Thais
- Gueldner Dino
- Guerrero Mayra Daniela Pena
- Guth Miriam Karen
- Haberl Helmut
- Hacket-Pain Andrew
- Hadjichambis Andreas
- Hahn Thomas
- Haklay Muki
- Hankerson Brett
- Heikkinen Anna
- Heikkurinen Pasi
- Heinen Julia Helena
- Heller Klaus-Gerhard
- Helm Aveliina
- Henders Sabine
- Henriksson Patrik J. G.
- Henrique Faria Sergio
- Henriques Sergio
- Hernandez Miguel
- Heylen Brigitte
- Hide Geoff
- Hinsley Amy
- Hinton Jennifer
- Hissa Leticia B. V.
- Hochkirch Axel
- Holzschuh Andrea
- Hortal Joaquin
- Hosner Peter A.
- Hurtado Fernando
- Infante-Amate Juan
- Islar Mine
- Ivkovic Slobodan
- Jacobs Sander
- Janke Rebekka
- Jarcuska Benjamin
- Johanisova Nadia
- Johansson Maria
- Johnson Mark D.
- Jones Julia Patricia Gordon
- Jucker Tommaso
- Juergensen Jonathan
- Jung Martin
- Junginger Martin
- Kallis Giorgos
- Kaltenpoth Martin
- Kanka Robert
- Karagouni Niki
- Kasimir Asa
- Kastner Thomas
- Kati Vassiliki
- Kechev Mihail Ognianov
- Kehoe Laura
- Kehoe Laura
- Keil Petr
- Keller Alexander
- Kerner Janika
- Kessner-Beierlein Daniela
- Kipson Marina
- Knohl Alexander
- Koh Niak
- Koster Martijn
- Kovar Pavel
- Krause Torsten
- Kreft Holger
- Kristin Anton
- Krofel Miha
- Krueger Tobias
- Kuemmerle Tobias
- Kuemmerle Tobias
- Kurdikova Vendula
- Langerwisch Fanny
- Lapka Miloslav
- Larson Sven Ake
- Lassaletta Luis
- Latella Leonardo
- Lavorel Sandra
- Lehikoinen Aleksi
- Leidinger Ludwig
- Leijten Floris
- Leitao Pedro J.
- Lena Philippe
- Lens Luc
- Leonhardt Sara Diana
- Leroy Boris
- Leve Marine
- Levers Christian
- Lewerentz Anne
- Lewis Jerome
- Libbrecht Romain
- Lindkvist Emilie
- Lipsky Zdenek
- Ljubomirov Toshko
- Llusia Diego
- Lobmann Michael
- Lobo Jorge M.
- Loetters Stefan
- Londo Marc
- Lopez Baucells Adria
- Lopez Bosch David
- Lopez Hernandez Heriberto D.
- Lopez-Marquez Violeta
- Lorrilliere Romain
- Louis Deharveng
- Lukic Marko
- Lutter Stephan
- Macdiarmid Jennie
- Mace Georgina
- Machordom Annie
- Macia Manuel J.
- Mairota Paola
- Malecore Eva
- Marescaux Audrey
- Marselle Melissa
- Martin Arnaud
- Martin Jean-Louis
- Martin Philip
- Martins Andrea Damacena
- Marull Joan
- Mas Navarro Maria
- Mascarenhas Andre
- Massa Bruno
- Masterson Vanessa Anne
- Matenaar Daniela
- Mateos David Moreno
- Matos-Maravi Pavel
- Maurel Noelie
- Mayer Andreas
- Mayer Martin
- McKay David Armstrong
- Mckeon Caroline
- McPhearson Timon
- Medvedovic Jasna
- Mehrabi Zia
- Mempel Finn
- Menzel Florian
- Mertz Ole
- Meseguer Andrea S.
- Meyer Carsten
- Meyer Christoph
- Meyfroidt Patrick
- Milchev Boyan Petrov
- Monserand Antoine
- Montade Vincent
- Morales Manuel B.
- Moreira Francisco
- Morelli Federico
- Moreta Lys Sanz
- Morin Xavier
- Motivans Elena
- Motta Renzo
- Moyano Fernando Esteban
- Mueller Daniel
- Mueller Joerg
- Mumby Hannah S.
- Munteanu Catalina
- Murtough Katie L.
- Mutke Jens
- Newig Jens
- Nielsen Jonas O.
- Nieto Roman Alejandra
- Nikolov Boris Petrov
- Noe Julia Le
- Noguera Jose C.
- Noll Domink
- Novoa Ana
- Nuernberger Fabian
- Nuissl Henning
- Nunes Matheus Henrique
- Nygren Michelle
- Ochu Erinma
- Oddie Melissa
- Ohrling Christian
- Oliveira Eduardo
- Olsson Gunilla Almered
- Olsson Urban
- Oppel Steffen
- Orach Kirill
- Orland Chloe
- Ostapowicz Katarzyna
- Ostermann Ole
- Oyanedel Rodrigo
- Padro Caminal Roc
- Paitan Claudia Parra
- Palm Celinda
- Palmeirim Jorge
- Panferov Oleg
- Partel Meelis
- Pascual Unai
- Pe'er Guy
- Peco Begona
- Pedersen Anna Frohn
- Pendrill Florence
- Penone Caterina
- Pereira Laura
- Peres Carlos A.
- Perez-Ortega Sergio
- Pergl Jan
- Perrigo Allison
- Persson Joel
- Persson Martin
- Peters Marcell K.
- Peterson Garry
- Peterson Gustaf
- Petridis Panos
- Petrik Petr
- Petrovan Silviu
- Petter Gunnar
- Phalan Ben
- Pichler Melanie
- Piemontese Luigi
- Pienkowski Thomas
- Pilo Francesca
- Piotrowski Jan A.
- Piquer-Rodriguez Maria
- Polaina Ester
- Pollet Marc
- Prat Narcis
- Presa Asencio Juan Jose
- Prevel Leonie
- Prince Karine
- Pucetaite Milda
- Pueyo Salvador
- Pynegar Edwin L.
- Pysek Petr
- Qin Siyu
- Rammig Anja
- Rands Mike
- Razanajatovo Mialy
- Rebelo Hugo
- Redlich Sarah
- Reis Tiago
- Renaud Pierre-Cyril
- Revilla Eloy
- Reyes-Garcia Victoria
- Rhee Howon
- Richardson Vanessa A.
- Riede Klaus
- Riggi Laura
- Rilovic Andro
- Ringsmuth Andrew
- Ritter Camila Duarte
- Robillard Tony
- Rocha Juan Carlos
- Rocha Ricardo
- Rodrigues Ana
- Rodriguez-Labajos Beatriz
- Roeder Achim
- Roemer Charlotte
- Roessler Daniela C.
- Romero-Munoz Alfredo
- Rosalino Luis Miguel
- Rothhaupt Karl-Otto
- Roturier Samuel
- Rounsevell Mark
- Roux Nicolas
- Rozylowicz Laurentiu
- Ruedenauer Fabian
- Rufin Philippe
- Rugani Benedetto
- Rust Niki
- Rutschmann Benjamin
- Rutting Tobias
- Salaseviciene Alvija
- Salek Martin
- Sanchez-Fernandez David
- Santagata Remo
- Santos Ana M. C.
- Sanz-Cobena Alberto
- Savaget Paulo
- Sayol Ferran
- Schilthuizen Menno
- Schindler Stefan
- Schleicher Judith
- Schlerf Martin
- Schmelzer Stefan
- Schmoll Tim
- Schneider Christoph
- Schnitzler Jan
- Schroeder Heike
- Schuenzel Julia
- Schug Franz
- Schumacher Kim
- Schwieder Marcel
- Seebens Hanno
- Sekerka Lukas
- Selva Nuria
- Semper-Pascual Asuncion
- Seppelt Ralf
- Seufert Verena
- Sieger Charlotte Sophie
- Silvestro Daniele
- Simaika John P.
- Simon Judy
- Sinare Hanna
- Sindicic Magda
- Singh Chandrakant
- Sjoberg Sissel
- Skejo Josip
- Smetschka Barbara
- Smith Annabel
- Smith Pete
- Smith Rebecca
- Snell Katherine
- Sober Virve
- Somma Francesca
- Souza Queiroz Allan
- Sovova Lucie
- Sperfeld Erik
- Staal Arie
- Stajerova Katerina
- Stanek Nicola
- Staude Ingmar
- Stein Anke
- Steinberger Julia K.
- Stenseke Marie
- Stibral Karel
- Strubbe Diederik
- Strugariu Alexandru
- Suarez Manuela Gonzalez
- Sullivan Martin
- Sutherland William J.
- Swinfield Tom
- Taiti Stefano
- Tatin Laurent
- Taylor Astrid
- Tello Enric
- Tengo Maria
- Teplitsky Celine
- Theurl Michaela C.
- Thieu Vincent
- Thonicke Kirsten
- Tiralla Nina
- Toledo-Hernandez Manuel
- Torre Ignasi
- Torres Aurora
- Traba Diaz Juan
- Trogisch Stefan
- Truong Minh-Xuan A.
- Tscharntke Teja
- Uddling Johan
- Ulgiati Sergio
- Vacchiano Giorgio
- Vaclavik Tomas
- Vajda Vivi
- Valdecasas Antonio G.
- Valentini Riccardo
- Valladares Fernando
- van den Burg Matthijs P.
- van der Ent Ruud J.
- van der Linden Sebastian
- van Kleunen Mark
- Vasconcelos Sasha
- Vavra Jan
- Verburg Peter
- Vieites David
- Vighi Morgana
- Vila Traver Jaime
- Villen-Perez Sara
- Vira Bhaskar
- Virah-Sawmy Malika
- Vlahos George
- Voigt Christian C.
- Voigt Maria
- Volaire Florence
- von Doehren Peer
- Wagner Norman
- Wandl Marie-Theres
- Wang-Erlandsson Lan
- Wanger Thomas Cherico
- Wassen M. J.
- Weigelt Patrick
- Weigend Maximilian
- Whittaker Robert J.
- Wiegand Kerstin
- Wieringa Jan J.
- Willemse Luc
- Winiwarter Verena
- Winter Marten
- Wong Grace
- Wordley Claire
- Worthington Thomas
- Yates Katherine
- Yin Fang
- Zafra-Calvo Noelia
- Zang Christian
- Zemp Delphine Clara
- Zhang Zhijie
- Zirion Maria
- Zobel Martin
- zu Ermgassen Erasmus
- Zucaro A.
- Zurell Damaris
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2019
- Field of study
Get PDFBrazil, home to one of the planet's last great forests, is currently in trade negotiations with its second largest trading partner, the European Union (EU). We urge the EU to seize this critical opportunity to ensure that Brazil protects human rights and the environment
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandra Coelho
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Alif Adlan Thabit
- Alison M. Meynert
- Alistair Nichol
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Attanyake
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amélie Valran
- Ana Freitas Ribeiro
- Ana L Rios
- Ana Martins
- Ana Silva Filipe
- Anant Kataria
- Anca Streinu-Cercel
- Andrea Angheben
- Andrea Rossanese
- Andrew Dagens
- Andrew Udy
- Andrey Svistunov
- André Cabié
- André Dias
- Andy Law
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonio Lalueza
- António Mesquita
- Arabella Fahy
- Ardiyan Apriyana
- Arfan Ikram
- Aria Kekalih
- Arianne Joy Corpuz
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsene Kpangon
- Ary Serpa Neto
- Asgar Rishu
- Ashraf Sheharyar
- Asma Moin
- Astarini Hidayah
- Attaur Rehman
- Audrey Barrelet
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Azlan Mat Soom
- B. P Edouard Soum
- Barbara Wanjiru Citarella
- Basri Mat Nor
- Beatrice Alex
- Benedict Sim Heng
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Thill
- Benoit Visseaux
- Benoît Roze
- Bernard Cholley
- Bernardo Ferreira
- Bertrand Dussol
- Bharath Kumar Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Blandine Rammaert
- Bouchra Loufti
- Brenda Reeve
- Brigitte Elharrar
- Bronner P Gonçalves
- Bronner P. Gonçalves
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Calum Semple
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlo Giaquinto
- Carlos Alexandre Brito
- Carlos Lumbreras Bermejo
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Catarina Espírito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Cecile Azoulay
- Cecile Yelnik
- Cedric Laouenan
- Ceila Sant'Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Simona Cardellino
- Chloe Donohue
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Claire Andrejak
- Claire Lévy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D. Russell
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Clotilde Allavena
- Clément Le Bihan
- Colin McArthur
- Coline Jaud-Fischer
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cédric Joseph
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Dafsah Juzar
- Damien Bouhour
- Daniel Glikman
- Daniel Haber
- Daniel Marino
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- David L. Robertson
- David Maslove
- David Richardson
- David S.Y. Ong
- David Stuart
- David Thomson
- David Zucman
- Debby Bogaert
- Deepashankari Suppiah
- Dehbia Benkerrou
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Dewi Guellec
- Diana Adrião
- Diana Hernández
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Fernando Rincon
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dyah Kanya Wati
- Dzawani Muhamad
- Eder Caceres
- Edmund Manning
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elise Artaud-Macari
- Ellen Shadowitz
- Elodie Curlier
- Elsa Nyamankolly
- Ema Leal
- Eman Al Qasim
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'ortenzio
- Eric Delaveuve
- Eric Oziol
- Eric Senneville
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L'her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewa Talarek
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fakhir Haidri
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernando Augusto Bozza
- Fernando Maltez
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
- François Goehringer
- François Lellouche
- François Martin Carrier
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Félix Djossou
- Gabriel Macheda
- Gail Carson
- Gamage Dona Priyadarshani
- Gan Ee Xian
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- Gary Leeming
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Gilles Peytavin
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- Giulia Bertoli
- Graham S. Cooke
- Grazielle Viana Ramos
- Gry Kloumann Bekken
- Grégory Corvaisier
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
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- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
- Gwenaël Le Moal
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- Ha Sha Lene
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- Hanan Fateena
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- Hans Martin Bosse
- Harald Vonkeman
- Hashmi Madiha
- Hayley Hardwick
- Heidi Dalton
- Heidi Gruner
- Heidi Jean Dalton
- Heng Gee Lee
- Hervé Le Nagard
- Hiba Zayyad
- Hikombo Hitoto
- Himasha Muvindi
- Himed Musaab
- Hiu Jian Chua
- Hodane Yonis
- Hon Shen Png
- Hongru Ren
- Hubert Tessier-Grenier
- Huda Alfoudri
- Hugo Inácio
- Hugo Mouquet Ben Morton
- Hugues Aumaître
- Hugues Cordel
- Husna Begum
- Hwa Jin Cho
- Hélène Espérou
- Hélène Salvator
- Ikram Houas
- Ilka Engelmann
- Ilonka van Veen
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- Irfan Khan
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
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- Isabelle Pironneau
- Ithan D. Peltan
- Ivy Cerelia Valerie
- J. Kenneth Baillie
- Jacky Y. Suen
- Jade Ghosn
- Jaganathan Selvanayagam
- Jaime Cruz Rojo
- Jake Dunning
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jananee Thirumanickam
- Janet Harrison
- Janet T. Scott
- Jaques Sztajnbok
- Jarne Van Hattem
- Jason Bouziotis
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean-Benoît Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-Sébastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jee Yan Ong
- Jennifer Lee
- Jenny Lennon
- Jeremie Guedj
- Jess Gibson
- Jia Shyi Loy
- Jia Wei
- Jillian Deacon
- Jimmy Ming-Yang Hsu
- Jimmy Mullaert
- Jin Yi Goh
- Jo Dalton
- Joana Alves Cabrita
- Joana Ferrão
- Joaquín Baruch
- Job van der Palen
- Johann Auchabie
- John F Fraser
- John Marshall
- Jolanta Popielska
- Jonathan Bitton
- Jonathan Chua
- Jonathan Remppis
- Jordan Zhien Toh
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Jose Andres Calvache
- Jose M. Mandei
- Joshua Solomon
- José Casimiro
- José Ernesto Vidal
- José Luis Sobrino
- José Ramalho
- João Estevão
- João Teixeira
- Juan Luis Bermúdez
- Jules Bauer
- Julian Chica
- Juliana Damas
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Juliette Patrier
- Juliette Romaru
- Justine Pages Maïder Pagadoy
- Jérémie Pasquier
- Jérôme Dimet
- Kah Chuan Lim
- Kalaiarasu Peariasamy
- Kalynn Kennon
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karisha Sivam
- Karl Erik Müller
- Karolina Nowicka
- Katharina Weil
- Kathy Brickell
- Katie O'Hearn
- Kazali Enagnon Alidjnou
- Kenneth A McLean
- Ker Hong Bee
- Kevin Katz
- Khor How Kiat
- Kim Keat Tan
- Kok Wei Hao
- Kong Yeow Kang
- Konrad Zawadka
- Krishna Bhavsar
- Kuan Pei Xuan
- Kusum Menon
- Kévin Alexandre
- Kévin Bouiller
- Kévin Didier
- Laetitia Bodenes
- Lai Hui Pang
- Lance C.W. Turtle
- Lara Absil
- Lars Heggelund
- Laura Marsh
- Laura Merson
- Laure Goubert
- Lauren Deconninck
- Laurence Bouillet
- Laurence Maulin
- Laurent Abel
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
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- Lee Lee Low
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- Liem Luong
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- M Azhari Taufik
- Mageswari Selvarajoo
- Mahdad Noursadeghi
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- Malte Kohns Vasconcelos
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- Manuel Rosa-Calatrava
- Maram Zahran
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- Maria Zambon
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- Marie-Christine Carret
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- Marieke Haalboom
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- Merce Jourdain
- Mical Paul
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- Michele Petrovic
- Michelle Girvan
- Miguel Pedrera Jiménez
- Minerva Cervantes-Gonzalez
- Minh Le
- Mirjam Evers
- Mohammad Shamsah
- Mohammed El Sanharawi
- Mohammed Quraishi
- Mohan Dass Pathmanathan
- Mohanaprasanth Balakrishnan
- Mohd Nazlin Kamarudin
- Mohiuddin Shiekh
- Morgane Gilg
- Morgane Snacken
- Moshe Matan
- Moïse Machado
- Muhammad Aisar Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Basri
- Muhammad Rayhan
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mylène Maillet
- Mário Ferraz
- Mélanie Roriz
- Nadia Ettalhaoui
- Nadia Malik
- Nadia Ouamara
- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nadège Neant
- Nagarajan Ramakrishnan
- Nassima Si Mohammed
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gault
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Navy Lolong
- Nazreen Abu Bakar
- Neerusha Kaisbain
- Neurinda Permata Kusumastuti
- Ng Yong Muh
- Ng Yong Siang
- Nicholas Sedillot
- Nicholas Yee Hing
- Nick Daneman
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Mohamed
- Nikita Nekliudov
- Nina Jamieson
- Noelia García Barrio
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Zaidan
- Nowneet Kumar Bhat
- NoéMie Mercier
- Noémie Tissot
- Noémie Vanel
- Nuno Germano
- Nur Amira
- Nurnaningsih Nurnaningsih
- Nurul Amani Noordin
- Nurul Faten Norharizam
- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sândulescu
- Obada Yousif
- Odile Launay
- Ogechukwu Menkiti
- Oleksa Rewa
- Olivia V Swann
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Ong Yiaw Joe
- Oriane Puechal
- Oryane Mabiala
- Ouifiya Kafif
- Pablo Serrano Balazote
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Parthena Savvidou
- Pascal Granier
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patricia Lizotte
- Patrick Archambault
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul Tierney
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Peter de Vries
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Philippe Jouvet
- Philippine Eloy
- Phoebe Ampaw
- Piero L Olliaro
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marie Roger
- Pieter Depuydt
- Polina Bugaeva
- Prasan Kumar Panda
- Pratap Karpayah
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain Khan
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas França
- Rafael Mahieu
- Raphael Favory
- Raphaël Borie
- Raquel Pinto
- Rashan Haniffa
- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Renata Barbalho
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rob Klont
- Robert A Fowler
- Robert A. Fowler
- Roberta Cavalin
- Robin Kobbe
- Rodrigo Díaz
- Romain Basmaci
- Romain Decours
- Romain Guery
- Romans Matulevics
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano Garcês
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saijad Orakzai
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samira Laribi
- Samreen Ijaz
- Samuel Hinton
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sanka Sri Darshana
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Machado
- Sarah E McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Sebastien Preau
- Segolène Greffe
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Sia Loong Tonnii
- Sim Choon Ean
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Siri Goepel
- Siti Nurul Ridzuan
- Siti Rohani Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sobia Masood
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stella Rousset
- Stephanie Roberts
- Stephanie Yerkovich
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- Séverine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- Véronique Lemee
- Víctor Quirós González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
No full textBackground The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities
The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
- Aasiyah Rashan
- Aasmine Kaur
- Abdulrahman Al-Fares
- Abhijit Duggal
- Adam Betz
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agamemnon Bakakos
- Agn??s Meybeck
- Agn??s Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Aidan Burrell
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisha Kalsoom Mufti
- Aisling Gavin
- Aisling Murphy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Alberto Cucino
- Alberto Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martin-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Martinelli
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J. Mentzer
- Alexander King
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Abbas
- Ali Ait Hssain
- Ali Hachemi
- Ali Liaquat
- Ali Raza
- Ali Rehan
- Alice Bogaarts
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Alison M. Meynert
- Alistair Nichol
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Lakshan Attanyake
- Am??lie Valran
- Amanda Corley
- Amanda Palacios
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Aroca
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Luiza Valle
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anant Kataria
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Tveita
- Andr?? Cabie
- Andr?? Dias
- Andr?? Roberto
- Andr??s Orquera
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Udy
- Andrey A Svistunov
- Andriy Bal
- Andy Dong
- Andy Law
- Aneela Altaf
- Angel Asensio
- Angel Sanchez-Miralles
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-H??l??ne Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Ant??nio Mesquita
- Anthony Gordon
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
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- Aoife Driscoll
- Aoife Kelly
- Aquiles Henriquez
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- Diego Bastos
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- Dinesh Kuriakose
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Domenico Luca Grieco
- Dominic So
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- Ithan D. Peltan
- Ivo Castro
- J Kevin Baird
- J. Kenneth Baillie
- J. Perren Cobb
- J??r??me Dimet
- J??r??mie Guedj
- J??r??mie Pasquier
- Jack Song Chia
- Jacky Y. Suen
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- Jade Ghosn
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- Jean-Beno??t Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
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- Jean-S??bastien Hulot
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- Jo??o Melo Alves
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- Jo??o Teixeira
- Joan G??mez-Junyent
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- Joanne Downey
- Joao Joao Mendes
- Joaqu??n Baruch
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- Jodat Saleem
- Johann Auchabie
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- Tanvir Alam
- Tarek Elshazly
- Tatiana Fonseca
- Tatsuya Kawasaki
- Tawnya Ogston
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- Terese Hammond
- Tessa Broadley
- Th??o Treoux
- Thalha Rashan
- Tharmini Ravi
- Tharwat Aisa
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
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- Tiago Reyes
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- Timo Tolppa
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- Todd Karsies
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- Tomoyuki Endo
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- Tony Trapani
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- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- V??ctor Quir??s Gonz??lez
- V??ronique Lemee
- Vadim Tieroshyn
- Val??rie Gaborieau
- Val??rie Garrait
- Val??rie Gissot
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- van der Palen Job
- Vanessa Sancho-Shimizu
- Vanessa Teotonio
- Vanina Meysonnier
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Manda
- Victoria McEneany
- Victoria Shaw
- Vieri Parrini
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Volkan Korten
- Waasila Jassat
- Wai Ching Sin
- Walter Picard
- Wan Fadzlina Wan Muhd Shukeri
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xavier S??nchez Choez
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zubair Umer
- Zul Amali Che Kamaruddin
- Zul Fakar
- Zulfiqar Sandhu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
No full textInternational audienc
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
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- Scott-Brown James
- Sedillot Nicholas
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- Senneville Eric
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- Sequeira Tânia
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- Shah Naseem Ali
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- Shaw Victoria
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- Shi Haixia
- Shiekh Mohiuddin
- Shimizu Keiki
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- Shrestha Pramesh Sundar
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- Smyth Michelle
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- Stabler Sarah
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Stolz Eva
- Stone Amy
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Stuart Ami
- Stuart David
- Suen Gabriel
- Suen Jacky Y.
- Sultana Asfia
- Summers Charlotte
- Supic Dubravka
- Surovcová Magdalena
- Svistunov Andrey
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tanaka Hiroyuki
- Taqdees Huda
- Taqi Arshad
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari
- Tawfik Hassan
- Tedder Richard S.
- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thakur Anand
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
- Tonby Kristian
- Torre Marta
- Torres Antoni
- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Treoux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/09/2022
- Field of study
No full textBackground: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).
Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.
Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).
Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre K. vin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart S. verine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Argin G.
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-H. lène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller K. vin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- de Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- de Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier K. vin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet J. rôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou F. lix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival C. line
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
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- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
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- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
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- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
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- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz M. rio
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira S. lvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Ferrão Joana
- Ficko C. line
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião S. rgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
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- Giani Marco
- Gibson Jess
- Gigante Tristan
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- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González V. ctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
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- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj J. rémie
- Guego Martin
- Guellec Dewi
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- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
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- Habraken Hannah
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- Harrison Janet
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- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-S. bastien
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- Joseph C. dric
- Joseph Mark
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- Khanal Sushil
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- Khawaja Amin
- Kho Michelle E.
- Khoo Saye
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- Olliaro Piero L.
- Ong David S. Y.
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- Payen Jean-François
- Peelman Florent
- Peiffer-Smadja Nathan
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- Peltan Ithan D.
- Pereira Rui
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- Petrovic Michele
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- Postma Douwe F.
- Povoa Pedro
- Powis Jeff
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- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
- Pudota Sravya
- Pulicken Mathew
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
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- Quraishi Mohammed
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- Real Andre
- Rebaudet Stanislas
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- Reikvam Dag Henrik
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- Tagherset Lysa
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- Thomson Emma C.
- Thwaites Ryan S.
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- Tieroshyn Vadim
- Timashev Peter S.
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- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- van der Vekens Nicky
- van der Voort Peter
- van der Werf Sylvie
- van Gulik Laura
- van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira C. sar
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik C. cile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
No full textBackground: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
