La recherche en partenariat : entre fiction et friction

Our paper deals with the issues and practices at stake in the interdisciplinary partnership research field. Taking as a starting point the observation of three on-going research projects confronting agriculture with environmental or sanitary issues, the authors analyse the effects produced, in terms of scientific results, by the relationships established among researchers and development partners. The hypothesis is that the partnership is based on a two-sided reality: fiction, on the one hand, goes with the assumption that while researchers and partners do consider each other as allies, they consistently avoid confrontation in order to let things run their course. Friction, on the other hand, may arise with disagreement and thus alter the course of events. As revealed by the results of the study, this two-sided reality is held in tension within each project. Their comparison brings out three key points required in the management of such projects: the degree of solidarity between the groups concerned, the kingpin role of mediators, and the manner in which the research is conducted to meet changes in the partnership.L'article explore les enjeux et les pratiques de recherches interdisciplinaires en partenariat. À partir d'une lecture du déroulement de trois projets de recherche, portant sur l'agriculture face à des enjeux sanitaires ou environnementaux, les auteurs analysent l'effet sur la production scientifique des relations établies avec des acteurs du développement. L'hypothèse est que ce partenariat s'inscrit dans une double réalité : l'une, "fictionnelle", qui postule que chercheurs et partenaires s'allient tout en évitant de se confronter vraiment, ce, afin de maintenir le cours des choses ; l'autre, "frictionnelle", qui surgit lorsque, dans une phase d'investissement plus poussé des acteurs, des désaccords apparaissent, ce qui réoriente le cours des événements. Les résultats révèlent la mise en tension de cette double réalité dans chacun des projets. Leur comparaison fait ressortir trois points-clés de la conduite de ces recherches : le degré de constitution et la force du "projet" propre des acteurs impliqués, le rôle pivot d'individus médiateurs et l'attention qu'il convient de porter aux reconfigurations éventuelles du partenariat qu'impliquent les évolutions mêmes du projet

Mountain building in Taiwan: A thermokinematic model

The Taiwan mountain belt is classically viewed as a case example of a critical wedge growing essentially by frontal accretion and therefore submitted to distributed shortening. However, a number of observations call for a significant contribution of underplating to the growth of the orogenic wedge. We propose here a new thermokinematic model of the Taiwan mountain belt reconciling existing kinematic, thermometric and thermochronological constraints. In this model, shortening across the orogen is absorbed by slip on the most frontal faults of the foothills. Crustal thickening and exhumation are sustained by underplating beneath the easternmost portion of the wedge (Tananao Complex, TC), where the uplift rate is estimated to ~6.3 mm a^(−1), and beneath the westernmost internal region of the orogen (Hsueshan Range units, HR), where the uplift rate is estimated to ~4.2 mm a^(−1). Our model suggests that the TC units experienced a synchronous evolution along strike despite the southward propagation of the collision. It also indicates that they have reached a steady state in terms of cooling ages but not in terms of peak metamorphic temperatures. Exhumation of the HR units increases northward but has not yet reached an exhumational steady state. Presently, frontal accretion accounts for less than ~10% of the incoming flux of material into the orogen, although there is indication that it was contributing substantially more (~80%) before 4 Ma. The incoming flux of material accreted beneath the TC significantly increased 1.5 Ma ago. Our results also suggest that the flux of material accreted to the orogen corresponds to the top ~7 km of the upper crust of the underthrust Chinese margin. This indicates that a significant amount (~76%) of the underthrust material has been subducted into the mantle, probably because of the increase in density associated with metamorphism. We also show that the density distribution resulting from metamorphism within the orogenic wedge explains well the topography and the gravity field. By combining available geological data on the thermal and kinematic evolution of the wedge, our study sheds new light onto mountain building processes in Taiwan and allows for reappraising the initial structural architecture of the passive margin

Functional diversity and redundancy of freshwater fish communities across biogeographic and environmental gradients

AimFunctional redundancy occurs when species share overlapping ecological functions and is considered an important component of ecosystem resilience. However, much of what we know about functional redundancy comes from relatively species‐rich terrestrial and marine environments. Here, we examined patterns of functional redundancy among Ontario freshwater fish communities with species richness levels ranging from 4 to 30 species across lakes of differing size, depth, productivities and thermal characteristics.LocationSix thousand nine hundred and seventy‐seven lakes in Ontario, Canada.MethodsWe examined functional redundancy by quantifying the relationship between functional diversity and species richness in lakes across Ontario and within smaller biogeographic regions. We used null models to test whether fish communities had greater redundancy than expected from random assemblages. We then used generalized additive models (GAMs) to predict how patterns of redundancy vary across environmental variables. At last, we compared species‐level functional rarity metrics across fish thermal preference groups, body sizes and species occurrence rates.ResultsThe functional diversity and species richness relationship were saturating among fish communities at the provincial scale but varied between smaller regions with differing biogeographic histories. Most communities fell within expectations from weighted null models of the functional diversity and species richness relationship. The GAMs indicated that fish communities in the largest, deepest and warmest lakes showed the greatest overall functional redundancy. No differences were observed in functional rarity measures between thermal preference groups, across body sizes or across species occurrence rates.Main conclusionsAlthough lakes in this study were relatively depauperate of fish species, Ontario fish communities exhibited functional redundancy at the provincial scale, with variation regionally. North‐eastern communities showed the least saturating relationship overall as predicted by historical biogeographic patterns of freshwater fish colonization. Overall, this study provides a broad perspective of freshwater fish diversity patterns and highlights the importance of investigating redundancy from different perspectives and multiple spatial scales.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146304/1/ddi12812_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146304/2/ddi12812.pd

Relationship between subscapularis tears and injuries to the biceps pulley

The purpose of this study was to analyse the relationship between long head of the biceps brachii (LHBT) lesions and subscapularis tears. The hypothesis was that a bicipital pulley might remain intact, even in the case of a subscapularis tear

Monthly variation in the probability of presence of adult Culicoides populations in nine European countries and the implications for targeted surveillance

Background: Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) are small hematophagous insects responsible for the transmission of bluetongue virus, Schmallenberg virus and African horse sickness virus to wild and domestic ruminants and equids. Outbreaks of these viruses have caused economic damage within the European Union. The spatio-temporal distribution of biting midges is a key factor in identifying areas with the potential for disease spread. The aim of this study was to identify and map areas of neglectable adult activity for each month in an average year. Average monthly risk maps can be used as a tool when allocating resources for surveillance and control programs within Europe. Methods : We modelled the occurrence of C. imicola and the Obsoletus and Pulicaris ensembles using existing entomological surveillance data from Spain, France, Germany, Switzerland, Austria, Denmark, Sweden, Norway and Poland. The monthly probability of each vector species and ensembles being present in Europe based on climatic and environmental input variables was estimated with the machine learning technique Random Forest. Subsequently, the monthly probability was classified into three classes: Absence, Presence and Uncertain status. These three classes are useful for mapping areas of no risk, areas of high-risk targeted for animal movement restrictions, and areas with an uncertain status that need active entomological surveillance to determine whether or not vectors are present. Results: The distribution of Culicoides species ensembles were in agreement with their previously reported distribution in Europe. The Random Forest models were very accurate in predicting the probability of presence for C. imicola (mean AUC = 0.95), less accurate for the Obsoletus ensemble (mean AUC = 0.84), while the lowest accuracy was found for the Pulicaris ensemble (mean AUC = 0.71). The most important environmental variables in the models were related to temperature and precipitation for all three groups. Conclusions: The duration periods with low or null adult activity can be derived from the associated monthly distribution maps, and it was also possible to identify and map areas with uncertain predictions. In the absence of ongoing vector surveillance, these maps can be used by veterinary authorities to classify areas as likely vector-free or as likely risk areas from southern Spain to northern Sweden with acceptable precision. The maps can also focus costly entomological surveillance to seasons and areas where the predictions and vector-free status remain uncertain

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Interpretative and predictive modelling of Joint European Torus collisionality scans

Transport modelling of Joint European Torus (JET) dimensionless collisionality scaling experiments in various operational scenarios is presented. Interpretative simulations at a fixed radial position are combined with predictive JETTO simulations of temperatures and densities, using the TGLF transport model. The model includes electromagnetic effects and collisions as well as □(→┬E ) X □(→┬B ) shear in Miller geometry. Focus is on particle transport and the role of the neutral beam injection (NBI) particle source for the density peaking. The experimental 3-point collisionality scans include L-mode, and H-mode (D and H and higher beta D plasma) plasmas in a total of 12 discharges. Experimental results presented in (Tala et al 2017 44th EPS Conf.) indicate that for the H-mode scans, the NBI particle source plays an important role for the density peaking, whereas for the L-mode scan, the influence of the particle source is small. In general, both the interpretative and predictive transport simulations support the experimental conclusions on the role of the NBI particle source for the 12 JET discharges

Conceptual and empirical advances in Neotropical biodiversity research

The unparalleled biodiversity found in the American tropics (the Neotropics) has attracted the attention of naturalists for centuries. Despite major advances in recent years in our understanding of the origin and diversification of many Neotropical taxa and biotic regions, many questions remain to be answered. Additional biological and geological data are still needed, as well as methodological advances that are capable of bridging these research fields. In this review, aimed primarily at advanced students and early-career scientists, we introduce the concept of "trans-disciplinary biogeography," which refers to the integration of data from multiple areas of research in biology (e.g., community ecology, phylogeography, systematics, historical biogeography) and Earth and the physical sciences (e.g., geology, climatology, palaeontology), as a means to reconstruct the giant puzzle of Neotropical biodiversity and evolution in space and time. We caution against extrapolating results derived from the study of one or a few taxa to convey general scenarios of Neotropical evolution and landscape formation. We urge more coordination and integration of data and ideas among disciplines, transcending their traditional boundaries, as a basis for advancing tomorrow\u27s ground-breaking research. Our review highlights the great opportunities for studying the Neotropical biota to understand the evolution of life