Search for a dileptonic edge with CMS

We present a search for a kinematic edge in the invariant mass distribution of two opposite-sign same-flavor leptons, in final states with jets and missing transverse energy. The analysis makes use of $19.4$ fb$^{-1}$ proton-proton collision data at $\sqrt{s} = 8$ TeV. The data have been recorded with the CMS experiment. Complementary methods have been used for the background estimation, which when combined achieve a total uncertainty of $5\%$ ($10\%$) for leptons in the central (forward) rapidity of the detector. We do not observe a statistically significant signal and the results are consistent with the background-only hypothesis.Comment: ICNFP2014 conference proceedings, presented in August 2014, prepared for submission in EP

The terascale tutorial

This note summarizes the lectures given in the tutorial session of the Introduction to the Terascale school at DESY on March 2023. The target audience are advanced bachelor and master physics students. The tutorial aims to best prepare the students for starting an LHC experimental physics thesis. The cross section of the top quark pair production is detailed alongside with the reconstruction of the invariant masses of the top quark as well as of the $W$ and $Z$ bosons. The tutorial uses ideas and CMS open data files from the CMS HEP Tutorial written by C. Sander and A. Schmidt, but is entirely rewritten so that it can be run in Google Colab Cloud in a columnar style of analysis with python. In addition, a minimal C/C++ version of a simple event-loop analysis relying on ROOT is exampled. The code is kept as short as possible with emphasis on the transparency of the analysis steps, rather than the elegance of the software, having in mind that the students will in any case need to rewrite their own custom analysis framework

Forecasting US unemployment with radial basis neural networks, kalman filters and support vector regressions

This study investigates the efficiency of the radial basis function neural networks in forecasting the US unemployment and explores the utility of Kalman filter and support vector regression as forecast combination techniques. On one hand, an autoregressive moving average model, a smooth transition autoregressive model and three different neural networks architectures, namely a multi-layer perceptron, recurrent neural network and a psi sigma network are used as benchmarks for our radial basis function neural network. On the other hand, our forecast combination methods are benchmarked with a simple average and a least absolute shrinkage and selection operator. The statistical performance of our models is estimated throughout the period of 1972–2012, using the last 7 years for out-of-sample testing. The results show that the radial basis function neural network statistically outperforms all models’ individual performances. The forecast combinations are successful, since both Kalman filter and support vector regression techniques improve the statistical accuracy. Finally, support vector regression is found to be the superior model of the forecasting competition. The empirical evidence of this application are further validated by the use of the modified Diebold–Mariano test

Inflation and unemployment forecasting with genetic support vector regression

In this paper a hybrid genetic algorithm–support vector regression (GA-SVR) model in economic forecasting and macroeconomic variable selection is introduced. The proposed algorithm is applied to the task of forecasting US inflation and unemployment. GA-SVR genetically optimizes the SVR parameters and adapts to the optimal feature subset from a feature space of potential inputs. The feature space includes a wide pool of macroeconomic variables that might affect the two series under study. The forecasting performance of GA-SVR is benchmarked with a random walk model, an autoregressive moving average model, a moving average convergence/divergence model, a multi-layer perceptron, a recurrent neural network and a genetic programming algorithm. In terms of our results, GA-SVR outperforms all benchmark models and provides evidence on which macroeconomic variables can be relevant predictors of US inflation and unemployment in the specific period under study

Optimisation Models for Pathway Activity Inference in Cancer

BACKGROUND: With advances in high-throughput technologies, there has been an enormous increase in data related to profiling the activity of molecules in disease. While such data provide more comprehensive information on cellular actions, their large volume and complexity pose difficulty in accurate classification of disease phenotypes. Therefore, novel modelling methods that can improve accuracy while offering interpretable means of analysis are required. Biological pathways can be used to incorporate a priori knowledge of biological interactions to decrease data dimensionality and increase the biological interpretability of machine learning models. METHODOLOGY: A mathematical optimisation model is proposed for pathway activity inference towards precise disease phenotype prediction and is applied to RNA-Seq datasets. The model is based on mixed-integer linear programming (MILP) mathematical optimisation principles and infers pathway activity as the linear combination of pathway member gene expression, multiplying expression values with model-determined gene weights that are optimised to maximise discrimination of phenotype classes and minimise incorrect sample allocation. RESULTS: The model is evaluated on the transcriptome of breast and colorectal cancer, and exhibits solution results of good optimality as well as good prediction performance on related cancer subtypes. Two baseline pathway activity inference methods and three advanced methods are used for comparison. Sample prediction accuracy, robustness against noise expression data, and survival analysis suggest competitive prediction performance of our model while providing interpretability and insight on key pathways and genes. Overall, our work demonstrates that the flexible nature of mathematical programming lends itself well to developing efficient computational strategies for pathway activity inference and disease subtype prediction

Multilingual Name Entity Recognition and Intent Classification Employing Deep Learning Architectures

Named Entity Recognition and Intent Classification are among the most important subfields of the field of Natural Language Processing. Recent research has lead to the development of faster, more sophisticated and efficient models to tackle the problems posed by those two tasks. In this work we explore the effectiveness of two separate families of Deep Learning networks for those tasks: Bidirectional Long Short-Term networks and Transformer-based networks. The models were trained and tested on the ATIS benchmark dataset for both English and Greek languages. The purpose of this paper is to present a comparative study of the two groups of networks for both languages and showcase the results of our experiments. The models, being the current state-of-the-art, yielded impressive results and achieved high performance.Comment: 24 pages, 5 figures, 11 tables, dataset availabl

Inflation and Unemployment Forecasting with Genetic Support Vector Regression

In this paper a hybrid genetic algorithm–support vector regression (GA-SVR) model in economic forecasting and macroeconomic variable selection is introduced. The proposed algorithm is applied to the task of forecasting US inflation and unemployment. GA-SVR genetically optimizes the SVR parameters and adapts to the optimal feature subset from a feature space of potential inputs. The feature space includes a wide pool of macroeconomic variables that might affect the two series under study. The forecasting performance of GA-SVR is benchmarked with a random walk model, an autoregressive moving average model, a moving average convergence/divergence model, a multi-layer perceptron, a recurrent neural network and a genetic programming algorithm. In terms of our results, GA-SVR outperforms all benchmark models and provides evidence on which macroeconomic variables can be relevant predictors of US inflation and unemployment in the specific period under study

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe

Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia