Modeling of an Elastocaloric Cooling System for Determining Efficiency

When it comes to covering the growing demand for cooling power worldwide, elastocalorics offer an environmentally friendly alternative to compressor-based cooling technology. The absence of harmful and flammable coolants makes elastocalorics suitable for energy applications such as battery cooling. Initial prototypes of elastocaloric systems, which transport heat by means of thermal conduction or convection, have already been developed. A particularly promising solution is the active elastocaloric heat pipe (AEH), which works with latent heat transfer by the evaporation and condensation of a fluid. This enables a fast and efficient heat transfer in a compression-based elastocaloric cooling system. In this publication, we present a simulation model of the AEH based on MATLAB-Simulink. The model showed very good agreement with the experimental data pertaining to the maximum temperature span and maximum cooling power. Hereby, non-measurable variables such as efficiency and heat fluxes in the cooling system are accessible, which allows the analysis of individual losses including the dissipation effects of the material, non-ideal isolation, losses in heat transfer from the elastocaloric material to the fluid, and other parasitic heat flux losses. In total, it can be shown that using this AEH-approach, an optimized system can achieve up to 67% of the material efficiency

Phenomenological model for first-order elastocaloric materials [Modèle phénoménologique pour les matériaux élastocaloriques de premier ordre]

Elastocaloric cooling systems may offer a potentially more efficient as well as environmentally friendly alternative to compressor-based cooling technology. These cooling systems use stress-induced phase transformation in elastocaloric materials to pump heat. Thermodynamically consistent material models can be used to design and quantify the efficiency of these cooling systems. In this paper, we present a phenomenological material model that depicts the behavior of first-order materials during stress-induced phase transformation. This model is based on a phenomenological heat capacity equation, from which the parameters adiabatic temperature change and isothermal entropy can be derived. Hysteresis of the materials, which determines it dissipative effects, is also taken into account. Based on this model, these parameters can be calculated as a function of stress and temperature. The performance coefficients derived from the model can be used to evaluate the materials efficiency. Furthermore, the data obtained using this model coincided very closely with experimental data

Diffractive Photoproduction of Eta_c

Diffractive photoproduction of $\eta_c$ is an important process to study the effect of Odderon, whose existence is still not confirmed in experiment. A detailed interpretation of Odderon in QCD, i.e., in terms of gluons is also unclear.Taking charm quarks as heavy quarks, we can use NRQCD and take $\eta_c$ as a $c\bar c$ bound state. Hence, in the production of $\eta_c$a free $c\bar c$ pair is first produced and this pair is transformed into $\eta_c$ subsequently.In the forward region of the kinematics, the $c\bar c$ pair interacts with initial hadron through exchanges of soft gluons. This interaction can be studied with HQET, which provides a systematic expansion in the inverse of the $c$-quark mass $m_c$. We find that the calculation of the $S$-matrix element in the forward region can be formulated as the problem of solving a wave function of a $c$-quark propagating in a background field of soft gluons. At leading order we find that the differential cross-section can be expressed with four functions, which are defined with a twist-3 operator of gluons. The effect of exchanging a Odderon can be identified with this operator in our case. We discuss our results in detail and compare them with those obtained in previous studies. Our results and those from other studies show that the differential cross-section is very small in the forward region. We also show that the production through photon exchange is dominant in the extremely forward region, hence the effect of Odderon exchange can not be identified in this region.For completeness we also give results for diffractive photoproduction of $J/\Psi$.Comment: 20 pages with 3 figures. Text improve

Antiskyrmions and their electrical footprint in crystalline mesoscale structures of Mn1.4PtSn

Skyrmionic materials hold the potential for future information technologies, such as racetrack memories. Key to that advancement are systems that exhibit high tunability and scalability, with stored information being easy to read and write by means of all-electrical techniques. Topological magnetic excitations such as skyrmions and antiskyrmions, give rise to a characteristic topological Hall effect. However, the electrical detection of antiskyrmions, in both thin films and bulk samples has been challenging to date. Here, we apply magneto-optical microscopy combined with electrical transport to explore the antiskyrmion phase as it emerges in crystalline mesoscale structures of the Heusler magnet Mn1.4PtSn. We reveal the Hall signature of antiskyrmions in line with our theoretical model, comprising anomalous and topological components. We examine its dependence on the vertical device thickness, field orientation, and temperature. Our atomistic simulations and experimental anisotropy studies demonstrate the link between antiskyrmions and a complex magnetism that consists of competing ferromagnetic, antiferromagnetic, and chiral exchange interactions, not captured by micromagnetic simulations

Scalable high-repetition-rate sub-half-cycle terahertz pulses from spatially indirect interband transitions

Intense phase-locked terahertz (THz) pulses are the bedrock of THz lightwave electronics, where the carrier field creates a transient bias to control electrons on sub-cycle time scales. Key applications such as THz scanning tunnelling microscopy or electronic devices operating at optical clock rates call for ultimately short, almost unipolar waveforms, at megahertz (MHz) repetition rates. Here, we present a flexible and scalable scheme for the generation of strong phase-locked THz pulses based on shift currents in type-II-aligned epitaxial semiconductor heterostructures. The measured THz waveforms exhibit only 0.45 optical cycles at their centre frequency within the full width at half maximum of the intensity envelope, peak fields above 1.1 kV cm−1 and spectral components up to the mid-infrared, at a repetition rate of 4 MHz. The only positive half-cycle of this waveform exceeds all negative half-cycles by almost four times, which is unexpected from shift currents alone. Our detailed analysis reveals that local charging dynamics induces the pronounced positive THz-emission peak as electrons and holes approach charge neutrality after separation by the optical pump pulse, also enabling ultrabroadband operation. Our unipolar emitters mark a milestone for flexibly scalable, next-generation high-repetition-rate sources of intense and strongly asymmetric electric field transients

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don't respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models and analyses of human melanoma patients, we show that the cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion of T cells to activated endothelial cells, which is a pre-requisite of T cell extravasation. In melanoma patients, GDF-15 serum levels strongly correlate with failure of PD-1-based immune checkpoint blockade therapy. Neutralization of GDF-15 improves both T cell trafficking and therapy efficiency in murine tumor models. Thus GDF-15, beside its known role in cancer-related anorexia and cachexia, emerges as a regulator of T cell extravasation into the tumor microenvironment, which provides an even stronger rationale for therapeutic anti-GDF-15 antibody development

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362