Etest® versus broth microdilution for ceftaroline MIC determination with Staphylococcus aureus: results from PREMIUM, a European multicentre study

Objectives: To compare the concordance of ceftaroline MIC values 24 by reference broth microdilution (BMD) and Etest (BioMérieux, France) for MSSA and MRSA isolates, respectively, in isolates from PREMIUM (D372SL00001), a European multi-centre study.  Methods: Ceftaroline MICs were determined by reference BMD and by Etest for 1,242 MSSA and MRSA from adult patients with community-acquired pneumonia or complicated skin and soft tissue infections collected between February and May 2012; tests were performed across six European laboratories. Selected isolates with ceftaroline resistance in broth (MIC >1 mg/L) were retested in three central laboratories to confirm their behaviour.  Results: Overall concordance between BMD and Etest was good, with >97% essential agreement and >95% categorical agreement. Nevertheless, 12 of the 26 MRSA isolates found resistant by BMD scored as susceptible by Etest, with MICs ≤1 mg/L, thus counting as very major errors, whereas only five of 380 MRSA found ceftaroline susceptible in BMD were mis-categorised as resistant by Etest. Twenty-one of the 26 isolates with MICs of 2 mg/L by BMD were then re-tested twice by each of three central laboratories: BMD MICs of 2 mg/L were consistently found for 19 of the 21 isolates. Among 147 Etest results for these 21 isolates (original plus six repeats per isolate) 112 were >1 mg/L.  Conclusions: BMD and Etest have good overall agreement for ceftaroline against Staphylococcus aureus; nevertheless, reliable Etest-based discrimination of the minority of ceftaroline-resistant (MIC 2 mg/L) MRSA is extremely challenging, requiring careful reading of strips, ideally with duplicate testing

Measurements of the charge asymmetry in top-quark pair production in the dilepton final state at s √ =8 TeV with the ATLAS detector

Measurements of the top-antitop quark pair production charge asymmetry in the dilepton channel, characterized by two high-pT leptons (electrons or muons), are presented using data corresponding to an integrated luminosity of 20.3  fb−1 from pp collisions at a center-of-mass energy s√=8  TeV collected with the ATLAS detector at the Large Hadron Collider at CERN. Inclusive and differential measurements as a function of the invariant mass, transverse momentum, and longitudinal boost of the tt¯ system are performed both in the full phase space and in a fiducial phase space closely matching the detector acceptance. Two observables are studied: AℓℓC based on the selected leptons and Att¯C based on the reconstructed tt¯ final state. The inclusive asymmetries are measured in the full phase space to be AℓℓC=0.008±0.006 and Att¯C=0.021±0.016, which are in agreement with the Standard Model predictions of AℓℓC=0.0064±0.0003 and Att¯C=0.0111±0.0004

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Las inteligencias m\ufaltiples en educaci\uf3n infantil :

Trabajo Fin de Grado-Universidad Pontificia de Salamanca, Facultad de Educaci\uf3n, 2019El tema del presente Trabajo de Fin de Grado, que pretende ser una iniciaci\uf3n al campo de la investigaci\uf3n educativa, es la aplicaci\uf3n de la Teor\ueda de Inteligencias M\ufaltiples de Howard Gardner en el aula de Educaci\uf3n Infantil, en concreto en el primer curso del primer ciclo, con ni\uf1os de 3 a\uf1os, basado en la experiencia durante las pr\ue1cticas realizadas en el Colegio Auseva de Oviedo en el presente curso. La Teor\ueda de Inteligencias M\ufaltiples rompe con la tradicional definici\uf3n de inteligencia basada en el c\ue1lculo de un Cociente Intelectual a trav\ue9s d la aplicaci\uf3n de pruebas limitadas a medir capacidades l\uf3gico-matem\ue1ticas y ling\ufc\uedsticas, afirmando que todos somos inteligentes pero en diferentes aspectos y no solo en los dos anteriormente citados. De este modo, propone la existencia de, al menos, ocho tipos de inteligencias, aunque interrelacionadas, de forma especial en Educaci\uf3n Infantil dado que por las caracter\uedsticas intr\uednsecas de esta etapa educativa (globalizada y flexible) el tratamiento de contenidos en el curr\uedculo es m\ue1s transversal y diversificado que en ninguna otra etapa educativa y, aunque tambi\ue9n se aprecia una mayor incidencia en la inteligencia ling\ufc\uedstica, se incluye en una misma \ue1rea un mayor n\ufamero de inteligencias

Repercusiones forenses del Trastorno L\uedmite de la Personalidad (TLP) en las sentencias del Tribunal Supremo y de la Audiencia Provincial de Espa\uf1a /

Proyecto Fin de Grado-Universidad Pontificia de Salamanca, Facultad de Psicolog\ueda, 2021.La literatura cient\uedfica cl\uednica y la literatura forense, de contenido jurisprudencial y legislativo, mantienen perfiles distintos de la Personalidad L\uedmite, atendiendo a la presencia o no de contenido delictivo, en cuyo \ue1mbito la muestra est\ue1 ampliamente sesgada. La mera presencia de una alteraci\uf3n de la personalidad ya es causa suficiente para una reducci\uf3n de la condena, si bien es cierto que se valoran otro tipo de circunstancias tales como: relaci\uf3n entre el trastorno y el delito cometido, estar bajo los efectos de sustancias t\uf3xico-adictivas o presentar una patolog\ueda dual. Se ha observado como el Trastorno L\uedmite de la Personalidad se presenta mayoritariamente, en el \ue1mbito forense, en sujetos masculinos, con antecedentes penales, conductas impulsivas y agresivas adscritas a situaciones circunstanciales, sobre todo en el \ue1mbito dom\ue9stico y familiar, un consumo moderado-grave de sustancias t\uf3xico-adictivas y tendencia a la individualidad. Aceptando estas caracter\uedsticas, no es el trastorno con m\ue1s \uedndice de peligrosidad, siendo \ue9ste el Trastorno Antisocial de la Personalidad (TAP). Se estima que las conjeturas de la poblaci\uf3n lega en cuanto a la peligrosidad de la Personalidad L\uedmite residen en su ausencia de s\uedntomas y caracter\uedsticas mucho m\ue1s determinadas, entendi\ue9ndose como un diagn\uf3stico de \u201ccaj\uf3n de sastre\u201d

La mejora del bienestar a trav\ue9s de la facilitaci\uf3n de la experiencia de sentido en la vida :

Trabajo Fin de Grado-Universidad Pontificia de Salamanca, Facultad de Psicolog\ueda, 2023El bienestar es un componente esencial en la vida para tener salud. Encontrar experiencia de sentido favorece el bienestar. Numerosos estudios han corroborado la \uedntima relaci\uf3n entre sentido en la vida y salud. En cambio, el vac\uedo existencial y la desesperanza correlacionan significativamente con el suicidio y/o con problemas de salud mental. Por ello, este trabajo tiene como objetivo proponer un dise\uf1o de intervenci\uf3n para promover el bienestar de las personas a trav\ue9s de la experiencia de sentido utilizando la Terapia de Aceptaci\uf3n y Compromiso (ACT)

La comunicaci\uf3n digital de los centros de orientaci\uf3n familiar cat\uf3licos en Espa\uf1a

La presencia de las instituciones en el entorno digital y en los medios sociales hace posible una comunicaci\uf3n institucional bidireccional, que resulta imprescindible en la actualidad. La Conferencia Episcopal Espa\uf1ola tambi\ue9n incluye estas herramientas en su estrategia comunicativa para dar a conocer los proyectos sociales de la Iglesia y, especialmente, los servicios que ofrecen las di\uf3cesis en los Centros de Orientaci\uf3n Familiar cat\uf3licos. Por este motivo, se ha realizado un an\ue1lisis exploratorio de la actividad de los COF en Twitter, Facebook e Instagram, durante el primer trimestre del a\uf1o 2019, con la finalidad de comprobar la capacidad de comunicaci\uf3n externa a trav\ue9s de los nuevos medios. Los resultados demuestran que ser\ueda necesario reforzar la comunicaci\uf3n digital en las redes sociales de los COF. Aprovechando la repercusi\uf3n de las publicaciones del Papa Francisco, los cardenales, los obispos, las di\uf3cesis y otras organizaciones que pertenecen a la Iglesia y que saben aprovechar las redes sociales, los COF deber\uedan considerar trabajar m\ue1s en este \ue1mbito digital para llegar a m\ue1s y mejo