The evolving role of information specialists:change agents in process redesign

The research investigates the past, present and potential future role of Information Specialists (ISps) in process oriented companies. It tests the proposition that ISps in companies that have undertaken formal process reengineering exercises are likely to become more proactive and more business oriented (as opposed to technically oriented) than they had previously been when their organisations were organised along traditional, functional lines. A review of existing literature in the area of Business Process Reengineering and Information Management reveals a lack of consensus amongst researchers concerning the appropriate role for ISps during and after BPR. Opinion is divided as to whether IS professionals should reactively support BPR or whether IT/IS developments should be driving these initiatives. A questionnaire based ‘Descriptive Survey’ with 60 respondents is used as a first stage of primary data gathering. This is followed by follow-up interviews with 20 of the participating organisations to gather further information on their experiences. The final stage of data collection consists of further in-depth interview with four case study companies to provide an even richer picture of their experiences. The results of the questionnaire are analysed and displayed in the form of simple means, frequencies and bar graphs. The ‘NU-DIST’ computer based discourse analysis package was tried in relation to summarising the interview findings, but this proved cumbersome and a visual collation method is preferred. Overall, the researcher contends that the supposition outlined above is proven, and she concludes the research by suggesting the implications of these findings. In particular she offers a ‘Framework for Understanding and Action’ which is deemed to be relevant to both practitioners and future researchers

The evolving role of information specialists : change agents in process redesign

The research investigates the past, present and potential future role of Information Specialists (ISps) in process oriented companies. It tests the proposition that ISps in companies that have undertaken formal process reengineering exercises are likely to become more proactive and more business oriented (as opposed to technically oriented) than they had previously been when their organisations were organised along traditional, functional lines. A review of existing literature in the area of Business Process Reengineering and Information Management reveals a lack of consensus amongst researchers concerning the appropriate role for ISps during and after BPR. Opinion is divided as to whether IS professionals should reactively support BPR or whether IT/IS developments should be driving these initiatives. A questionnaire based ‘Descriptive Survey’ with 60 respondents is used as a first stage of primary data gathering. This is followed by follow-up interviews with 20 of the participating organisations to gather further information on their experiences. The final stage of data collection consists of further in-depth interview with four case study companies to provide an even richer picture of their experiences. The results of the questionnaire are analysed and displayed in the form of simple means, frequencies and bar graphs. The ‘NU-DIST’ computer based discourse analysis package was tried in relation to summarising the interview findings, but this proved cumbersome and a visual collation method is preferred. Overall, the researcher contends that the supposition outlined above is proven, and she concludes the research by suggesting the implications of these findings. In particular she offers a ‘Framework for Understanding and Action’ which is deemed to be relevant to both practitioners and future researchers.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Synthesis of the EFG-ring system of pectenotoxin-4

The EFG-ring system of pectenotoxin-4 was synthesised via a novel pathway which ultilised a cobalt-mediated oxidative cyclisation to access the trans F-ring, and an osmium-mediated oxidative cyclisation to form the cis E-ring. Subsequent union of these fragments, under modified Julia-Kocienski olefination conditions, facilitated the synthesis of the EFG-ring system of pectenotoxin-4. Introduction This chapter reports the previous total syntheses of pectenotoxin molecules, along with completed syntheses of pectenotoxin fragments, including the Donohoe group’s synthesis of the ABC-ring system of pectenotoxin-4. Results and Discussion The synthesis of the FG-ring system and subsequent coupling to the E-ring fragment are detailed in this chapter. The final steps from the Julia adduct to the EFG-ring system conclude this chapter.</p

Synthesis of the EFG-ring system of pectenotoxin-4

The EFG-ring system of pectenotoxin-4 was synthesised via a novel pathway which ultilised a cobalt-mediated oxidative cyclisation to access the trans F-ring, and an osmium-mediated oxidative cyclisation to form the cis E-ring. Subsequent union of these fragments, under modified Julia-Kocienski olefination conditions, facilitated the synthesis of the EFG-ring system of pectenotoxin-4. Introduction This chapter reports the previous total syntheses of pectenotoxin molecules, along with completed syntheses of pectenotoxin fragments, including the Donohoe groupâs synthesis of the ABC-ring system of pectenotoxin-4. Results and Discussion The synthesis of the FG-ring system and subsequent coupling to the E-ring fragment are detailed in this chapter. The final steps from the Julia adduct to the EFG-ring system conclude this chapter.</p

Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4

Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt or osmium based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target

Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4

Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt or osmium based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target