Human leukocyte antigens and genetic susceptibility to lymphoma

Familial aggregation, coupled with ethnic variation in incidence, suggests that inherited susceptibility plays a role in the development of lymphoma, and the search for genetic risk factors has highlighted the contribution of the human leukocyte antigen (HLA) complex. In a landmark study published almost 50 years ago, Hodgkin lymphoma (HL) was the first disease to be associated with HLA variation. It is now clear that Epstein-Barr virus (EBV)-positive and -negative HL are strongly associated with specific HLA polymorphisms but these differ by EBV status of the tumours. HLA class I alleles are consistently associated with EBV-positive HL while a polymorphism in HLA class II is the strongest predictor of risk of EBV-negative HL. Recent investigations, particularly genome-wide association studies (GWAS), have also revealed associations between HLA and common types of non-Hodgkin lymphoma (NHL). Follicular lymphoma is strongly associated with two distinct haplotypes in HLA class II whereas diffuse large B-cell lymphoma is most strongly associated with HLA-B*08. Although chronic lymphocytic leukaemia is associated with variation in HLA class II, the strongest signals in GWAS are from non-HLA polymorphisms, suggesting that inherited susceptibility is explained by co-inheritance of multiple low risk variants. Associations between B-cell derived lymphoma and HLA variation suggest that antigen presentation, or lack of, plays an important role in disease pathogenesis but the precise mechanisms have yet to be elucidated

Engine component improvement program: Performance improvement

Fuel consumption of commercial aircraft is considered. Fuel saving and retention components for new production and retrofit of JT9D, JT8D, and CF6 engines are reviewed. The manner in which the performance improvement concepts were selected for development and a summary of the current status of each of the 16 selected concepts are discussed

Improved components for engine fuel savings

The Engine Component Improvement (ECI) Project formulated to address near term improvements for current engines is described with emphasis on the development of component technologies to reduce the fuel consumption of CF6, JT9D, and JT8D engines. The technical and economical acceptability and the fuel saving potential of nine concepts are demonstrated. Descriptions of these concepts, results of testing, and the status as to entering airline service are presented. Also presented is the status of the remaining concepts still under development

Researches in relativity.-Il. The basis of the physical world as indicated by carrying as far as possible the tenets of relativity

Alex McAulay, M.A. (Professor of Mathematics University or Tasmania). The problem of matter: protons, electrons, and the Bohr orbits. Starting from Einstein's illuminating article in "Nature" we have now arrived at a beautifully rounded off relativity schema of physics. In direct contrast however to Einstein's concluding words, we appear to have obtained a very promising insight into the true nature of the problem presented by matter, and in what direction to attack the position. Submitting ourselves with severe interpretation to the ordinance "do naught but carry relativity tenets as far as possible",we have found many detailed results harmonizing with natural (as opposed to a priori) physics, and not a little which was lacking from former presentations or relativity. Examples are the conservation of energy, the existence of a true energy tensor, and the formulation as an identity or the laws of motion, understood here to include eleotric field and gravitation. We shall now show that great atomic concentrations of matter and of electric charge each necessarily presuppose the other. Later, general reasons will be given for expecting such concentrations, and something very like the Bohr orbits accompanying them

Benefits of the International Image Interoperability Framework (IIIF) Featuring Medieval Palimpsest Manuscripts

The International Image Interoperability Framework (IIIF) is a community that develops shared application programming interfaces (APIs), or technical standards, for interoperability between digital image repositories. The IIIF specifications aim to give scholars an unprecedented level of uniform and rich access to image-based resources hosted around the world, with partners from national and state libraries, research institutions, museums, archives, software firms, and other groups working with digital image repositories and resources. The IIIF has grown from the community and relies on active participation and discussion to develop, cultivate and document shared technologies, such as image servers and web clients, that provide an exceptional user experience in viewing, comparing, manipulating and annotating images. Cultural heritage institutions are increasingly adopting the IIIF standards to both improve the ease of maintenance for their repositories and meet the needs of end users. With IIIF-compliant resources, researchers can compare images from different repositories in the same viewer, create annotations, search within annotations, easily cite, share, embed, manipulate, and interact with digital surrogates in new ways. The University of California Los Angeles (UCLA) has been working with IIIF for over a year to meet the needs of the Sinai Palimpsests Project, an initiative to digitize 74 manuscripts using spectral imaging, with the goal of providing manuscript scholars with enriched access to these enhanced images for primary research

Mc Aulay vs. Board of Education: If You Want to Be a Test Case...

My initial confrontation with the New York City Board of Education bureaucracy came when I objected strongly to a written directive from my principal telling his administrators to hire only male teachers. After 13 years of teaching, I was abruptly given an unsatisfactory rating and a punitive transfer. N.Y. State Supreme Court Judge Wilfred A. Waltemade ruled that all I had done was criticize the administration and that punishment without any sort of a hearing was repugnant to the principles of justice. The Board of Education duly gave me a hearing which found me guilty as charged. N.Y. State Supreme Court Judge Bernard Nadel ruled that I had had no semblance of a fair hearing and ordered the Board of Education to revise their entire procedure to conform to the due process provisions of the Constitution

The Butler Family: account written by Ida Mary McAulay nee Butler, granddaughter of Gamaliel Butler

Account of the Butler Family written by Gamaliel Butlers granddaughter, Ida Mary McAulay. From the Butler Family Papers - Private Deposit B

Quaternions applied to physics in non-euclidean space. 1 - The mathematical methods.

The utility of quaternions in mathematical physics in non-Euclidean space is much the same as in Euclidean, that is to say they are suitable for establishing fundamental relations. Details must be worked out by some system of scalar coordinates. It is hoped that the applications, to Physics, for which the methods of this paper have been prepared, will appear in subsequent papers; but, quite naturally, it has been found that the methods alone demand for exposition more space than can be placed at the writer's disposal for the first paper of the series

Risk Factors and Interventions for Suicide Among College Students

According to the Center for Disease Control (2016), suicide is the third leading cause of death among 15 to 24 year olds in the United States. Research indicates that the rate for suicide among college students is seven to eight students per 100,000 college students (Cimini & Rivero, 2013). Suicide in college students is a great concern of campus counselors, student affairs administrators, and chief executive officers. However, the responses of colleges and universities to student suicides have changed over time (Brandt-Brown, 2014). In the past, college campuses focused on a standard clinical intervention strategy, which focused on preventing suicide through traditional mental health services. Currently, campuses are incorporating more proactive, problem-solving strategies to their suicide prevention efforts (Brandt-Brown, 2014). This paper will (a) describe a variety of risk factors and warning signs; (b) define different campus intervention strategies; (c) outline post-suicide interventions